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PODCAST

Decera Clinical Education Oncology Podcast

Decera Clinical Education

Updates on new data and best practices in the care of patients with cancer across a wide variety of solid tumors and hematologic malignancies from Decera Clinical Education. Gain practical clinical insights and strategies and earn CME/CE credit for selected episodes.

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All Episodes

00:07:53

Developments in Acute Leukemias: Expert Answers to...

Decera Clinical Education Oncology Podcast ·

2020/10/02

In this episode, David Marks, MD, PhD, and Stéphane de Botton, MD, answer questions from clinicians on management pearls for patients with acute leukemias. Topics include:MRD in the management of ALLTherapy choice for older patients with AMLOptimal use of inotuzumab ozogamicin and blinatumomab for ALLUse of CAR T-cell therapy for acute leukemiasContent based on an online CME program supported by an educational grant from Pfizer Inc.Link to full program:https://bit.ly/3jiCBaD

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00:19:14

Biomarkers in Ovarian Cancer: Expert Discussion of...

Decera Clinical Education Oncology Podcast ·

2020/10/02

Listen to Prof Nicoletta Colombo and Bradley J. Monk, MD, FACS, FACOG, discuss current best practices for biomarker testing for your patients with advanced ovarian cancer.In this episode, Prof Nicoletta Colombo and Bradley J. Monk, MD, FACS, FACOG, discuss current best practices for biomarker testing in the management of patients with advanced ovarian cancer. Topics include:Subtypes of ovarian cancerBRCA mutation testing Homologous recombination deficiency testing Presenters:Professor Nicoletta

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00:11:49

Experts Discuss Evolving State-of-the-Art Management...

Decera Clinical Education Oncology Podcast ·

2020/09/21

In this podcast episode, listen to breast cancer experts Thomas Bachelot, MD, PhD; Adam M. Brufsky, MD, PhD; and Cristina Saura, MD, PhD, discuss clinical considerations for patients with HER2-positive MBC, with topics including:Local therapy in the context of MBCChoice of therapy after progression on available standards of careChoice of trastuzumab deruxtecan and tucatinib based on patient presentationManaging patients with CNS metastasesManaging interstitial lung diseasePresenters:Thomas Bachelot,

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00:21:52

The Art of Medicine: Clinical Considerations for...

Decera Clinical Education Oncology Podcast ·

2020/09/21

In this episode, an expert medical oncology panel led by Elizabeth R. Plimack, MD, MS, with Brian A. Costello, MD, and Martin H. Voss, MD, discusses clinical pearls for the management of patients with metastatic renal cell carcinoma (RCC). Topics include:Treating beyond progression with immunotherapyManagement of patients with less common histologic subtypes of RCCPotential biomarkers for RCCAdverse event managementPresenters:Elizabeth R. Plimack, MD, MSChief, Division of Genitourinary Medical

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00:07:57

Chronic Lymphocytic Leukemia: New Horizons With BTK...

Decera Clinical Education Oncology Podcast ·

2020/09/17

In this episode, Jeff P. Sharman, MD, Danielle M. Brander, MD, and Nicole Lamanna, MD, answer questions focused on the optimizing BTK inhibitor therapy for previously untreated patients with CLL considering presentation characteristics and drug pharmacology.Presenters:Jeff P. Sharman, MD, Program DirectorMedical DirectorHematology ResearchUS Oncology ResearchEugene, OregonDanielle M. Brander, MDAssistant Professor of MedicineDivision of Hematologic Malignancies & Cellular TherapyDepartment of

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00:14:45

Chronic Lymphocytic Leukemia: New Horizons With BTK...

Decera Clinical Education Oncology Podcast ·

2020/09/17

In this episode, Jeff P. Sharman, MD, Danielle M. Brander, MD, and Nicole Lamanna, MD, answer audience questions from a live Webinar focused on optimal use of BTK inhibitor therapy in patients with CLL, with topics including:• The impact of COVID-19 on CLL treatment decisions• The use of anti-CD20 antibodies in combination with BTK inhibitors• Considerations when recommending BTK inhibitors• MRD testing in patients with CLL• The potential impact of

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00:24:57

Clinical Considerations for RET Fusion–Positive NSCLC

Decera Clinical Education Oncology Podcast ·

2020/09/17

In this podcast episode, listen to lung cancer experts Joshua Bauml, MD, a medical oncologist, and Dara L. Aisner, MD, PhD, a molecular pathologist, discuss clinical considerations for patients with RET fusion–positive NSCLC, with topics including:Optimal testing for RET fusionsDNA NGS vs RNA NGSMolecular testing workflowsUsing new selective RET inhibitors to treat patients with RET fusion–positive NSCLCCommon toxicities with new selective RET inhibitorsInterdisciplinary communication between

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00:10:13

Chronic Lymphocytic Leukemia: New Horizons With BTK...

Decera Clinical Education Oncology Podcast ·

2020/09/16

In this episode, Jeff P. Sharman, MD, Danielle M. Brander, MD, and Nicole Lamanna, MD, answer audience questions from a live Webinar focused on optimal use of BTK inhibitor therapy in patients with CLL, with topics including:Rechallenging patients with venetoclax and BTK inhibitors Mechanism by which BTK inhibitors may reduce infusion reactionsRisk of secondary malignancies with BTK inhibitionDifferent cytogenetic findings and adverse event riskPresenters:Jeff P. Sharman, MD, Program DirectorMedical

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00:31:39

CAR T Cell Therapy for Lymphoma, Leukemia, and...

Decera Clinical Education Oncology Podcast ·

2020/09/14

In this episode, Michael R. Bishop, MD; Daniel J. DeAngelo, MD, PhD; and Noopur Raje, MD, answer clinician questions on current best practices and emerging applications with CAR T-cell therapy, with topics including:Optimal use of approved CAR T-cell therapies for lymphoma and ALLInvestigational CAR T-cell therapies for multiple myelomaManaging CAR T-cell therapy–related toxicitiesPresenters:Michael R. Bishop, MDProfessor of MedicineSection of Hematology/OncologyDirector, Cellular Therapy

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00:22:51

Practical Application of Immuno-Oncology in RCC:...

Decera Clinical Education Oncology Podcast ·

2020/09/08

In this episode, an expert medical oncology panel, led by Elizabeth R. Plimack, MD, with Brian A. Costello, MD, and Martin H. Voss, MD, discusses current best practices for the second-line treatment and beyond of patients with metastatic renal cell carcinoma (RCC). Topics include:• Treatment sequencing with IO and TKI therapies• Optimizing dose for patients with preexisting toxicities• Considerations for local control of metastatic sites • Ongoing clinical

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00:14:12

FAQ on New Therapeutic Developments in...

Decera Clinical Education Oncology Podcast ·

2020/09/03

In this episode, Jesús F. San-Miguel, MD, PhD; Paula Rodriguez-Otero, MD, PhD; and Prof. Dr. med. Katja Weisel answer questions focused on current and emerging therapies for early and late relapsed, refractory multiple myeloma, with topics including:• Responses across different subgroups treated with idecabtagene vicleucel in the KarMMa trial • Selecting therapy for a patient with lenalidomide-refractory disease at first relapse• How CAR T-cell therapy, melflufen, and selinexor will fit into

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00:19:17

New Advances in Relapsed/Refractory Multiple Myeloma:...

Decera Clinical Education Oncology Podcast ·

2020/09/01

In this episode, Natalie S. Callander, MD, and Shaji Kumar, MD, answer audience questions from a live CCO Webinar on relapsed/refractory myeloma regarding challenges in treating patients in this setting, including optimizing treatment choices and sequencing of treatments, MRD testing in myeloma, promising BCMA-targeted agents, the promise and value of CAR T-cell therapy in myeloma, and more.Presenters:Natalie S. Callander, MDProfessor of Medicine Director, Myeloma Clinical Program University of

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00:25:42

Practical Application of Immuno-Oncology in RCC:...

Decera Clinical Education Oncology Podcast ·

2020/08/31

In this episode, Elizabeth R. Plimack, MD, MS; Brian A. Costello, MD; and Martin H. Voss, MD, discuss current best practices for the first-line treatment of patients with metastatic renal cell carcinoma (RCC). Topics include:Choice of first-line therapyCombinations of targeted agents and immunotherapyCombinations of immune checkpoint inhibitorsActive surveillance and monitoringCytoreductive nephrectomyPresenters:Elizabeth R. Plimack, MD, MSChief, Division of Genitourinary Medical Oncology Director,

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00:35:10

Application of New Data in B-Cell Malignancies From...

Decera Clinical Education Oncology Podcast ·

2020/08/31

In this episode, Jennifer R. Brown, MD, PhD, and John Allan, MD, discuss recent key clinical trial results in Waldenström macroglobulinemia, mantle cell lymphoma, Hodgkin lymphoma, and DLBCL presented at the 2020 annual meetings of the American Society of Clinical Oncology (ASCO) and the European Hematology Association (EHA). Studies include:ASPEN: Zanubrutinib vs ibrutinib in WMOASIS: Ibrutinib, venetoclax, and obinutuzumab in MCLGHSG HD17: PET-guided therapy in HLKEYNOTE-024: Pembrolizumab vs

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00:26:42

MET Exon 14 Mutation–Positive NSCLC: FAQ Part 1

Decera Clinical Education Oncology Podcast ·

2020/08/28

In this episode, Luis Paz-Ares, MD, PhD; D. Ross Camidge, MD, PhD; and Karen L. Reckamp, MD, MS, address questions on MET exon 14 testing and selecting MET-targeted therapies for patients with advanced NSCLC with topics including:Incorporating MET exon 14 testing into standard of careComparison of RNA-based and DNA-based NGS platformsAvailability of RNA-based NGS testing around the worldUsing FISH to quantify MET copy gain/amplificationRegulatory and clinical differences between new, selective MET

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00:15:32

MET Exon 14 Mutation–Positive NSCLC: FAQ Part 2

Decera Clinical Education Oncology Podcast ·

2020/08/28

In this episode, Luis Paz-Ares, MD, PhD; D. Ross Camidge, MD, PhD; and Karen L. Reckamp, MD, MS, address questions on biomarking testing and the use of immunotherapy in METex14 mutation–positive NSCLC with topics including:Whether testing for MET exon 14 status should be standard of careParallel vs sequential testing by DNA-based vs RNA-based NGSCo-occurring driver mutations in patients with METex14 mutation–positive NSCLCOptimal use of immune checkpoint inhibitor–based therapy in the setting of

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00:20:45

Immunotherapy in SCLC: FAQ on Current Best Practice...

Decera Clinical Education Oncology Podcast ·

2020/08/27

In this episode, Anna F. Farago, MD, PhD, and Taofeek K. Owonikoko, MD, PhD, answer questions focused on the topic of current and evolving use of immunotherapy in patients with advanced small-cell lung cancer with topics including:Selecting between atezolizumab and durvalumab in the frontline settingIntegration of lurbinectedin, a novel anticancer drug that was recently approved for the treatment of relapsed SCLC after platinum-based chemotherapy, into patient careWhich patients should receive

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00:31:15

Application of New Data in B-Cell Malignancies From...

Decera Clinical Education Oncology Podcast ·

2020/08/26

In this episode, Jennifer R. Brown, MD, PhD, and John Allan, MD, discuss recent key clinical trial results in CLL presented at the 2020 annual meetings of the American Society of Clinical Oncology (ASCO) and the European Hematology Association (EHA). Studies and topics include:ASCEND: acalabrutinib vs idelalisib plus rituximab or BRACE-CL-001: acalabrutinib long-term efficacyCLL14: Venetoclax plus obinutuzumabCLARITY: Ibrutinib plus venetoclaxMeasurable residual disease (MRD)Complex

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00:21:57

Future Treatment Strategies for Acute Myeloid...

Decera Clinical Education Oncology Podcast ·

2020/08/14

In this episode, Naval G. Daver, MD, discusses promising investigational agents and treatment combinations in clinical trials for patients with newly diagnosed and relapsed/refractory AML, including:FLT3 inhibitors crenolanib and quizartinibAnti-CD47 antibody magrolimabIMGN632, a CD123 antibody–drug conjugateAnti-CD70 antibody cusatuzumabAPR-246, targeting the TP53 mutationContent is part of an online CME program supported by an educational grant from Daiichi-Sankyo.Link to full program, including a

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00:27:28

Tumor Agnostic TRK Inhibitor Therapy and NTRK Fusion...

Decera Clinical Education Oncology Podcast ·

2020/08/14

In this episode, George D. Demetri, MD; Alexander Drilon, MD; and Pashtoon Kasi, MD, answer questions about NTRK fusion testing and TRK inhibitor therapy for patients with advanced solid tumors, with topics including:Best practices in testing for NTRK fusions in solid tumorsOptimal use of approved TRK inhibitorsKey adverse events with TRK inhibitors and management strategiesEmerging next-generation TRK inhibitors and their potential use in managing resistance to first-generation

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