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PODCAST

Mendelspod Podcast

Offering a front row seat to the Century of Biology, veteran podcast host Theral Timpson interviews the who"s who in genomics and genomic medicine. www.mendelspod.com

science & medicine natural sciences

All Episodes

44:56

August 2020 Review: Radical Shift on LDT Policy,...

Mendelspod Podcast ·

2020/09/01

After a long break, the world's first genomics pundits are back for the season. And they are calm and collected in the face of the strorm on Pennsylvania Ave. We're sixty days from an election. How serious should we be taking politicization of the COVID vaccine, this radical shift on LDTs at the FDA?We also discuss some regular approvals and on rejection that sent the industry reeling with disappointment. Then it's on to Laura's, Nathan's, and Theral's picks for science of the month.Welcome

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27:03

Using CRISPR Genome Editing Tools, Willow Biosciences...

Mendelspod Podcast ·

2020/08/26

We see this new ingredient appearing advertised and in products everywhere. On the billboards, in the new shops next to our favorite restaurant, on the counters at the barbershop and when we pick up our prescriptions at the pharmacy.C-B-D.It has to do with the ongoing revolution that’s happening around the country—around the world—regarding the deregulation of marijuana. But there’s another revolution that will change our consumption of cannabinoids. That of synthetic biology. This is a public

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29:14

The Pros and Cons of Expanded Carrier Screening with...

Mendelspod Podcast ·

2020/06/16

Mary Norton is a perinatologist and clinical geneticist at UCSF who says that in the age when we are diagnosing ever more rare diseases, adding to the carrier screening panel can be a good thing, but it’s complicated.But it can be a good thing.But it’s complicated. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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47:41

Is This A Unique Time for Science? We Ask Sci-fi...

Mendelspod Podcast ·

2020/06/13

Has this pandemic presented a unique moment for science in our history? Or is it just a strange and temporary moment of science fiction? Or both?Sci-fi author Kim Stanley Robinson (The Mars Trilogy, The Ministry of the Future) recently penned an essay in the New Yorker about how the virus has “changed our imaginations” and created a new “structure of feeling.” This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit

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55:19

May 2020 with Nathan and Laura: Vaccine News, Notre...

Mendelspod Podcast ·

2020/06/01

Happy summertime! We had positive news this month about an mRNA vaccine from Moderna. We also saw how during a pandemic, the process of science is especially abnormal. Nathan says let's be happy about the good news. Laura's ringing with alarm bells, sensing conflicts of interest right and left. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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36:12

Matt Loose on "Read Until" or Adaptive Sequencing

Mendelspod Podcast ·

2020/05/28

Back before the world turned upside down, you know, all those years ago--early this February--a paper popped up on bioRxiv called, “Nanopore adaptive sequencing for mixed samples, whole exome capture and targeted panels." It’s an interesting paper.In the paper, the authors, led by Matt Loose from the DeepSeq lab at the University of Nottingham, describe a method unique to nanopore sequencing where one can do "selective sequencing of single molecules in real time by individually reversing the

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33:11

The Current State of Coronavirus Vaccines with Jeff...

Mendelspod Podcast ·

2020/05/21

What is the key to getting a coronavirus vaccine? “Manufacturing,” says today’s guest, Jeff Stein of Cidara Therapeutics.Jeff joined us just last fall to talk about his company’s exciting new technology, an immunotherapy, that is a universal flu preventative and therapy. Yes, you read that right. A universal flu preventative. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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47:24

April 2020 Review with Nathan and Laura: Ioannidis...

Mendelspod Podcast ·

2020/05/01

Our commentators, Nathan Pearson of Root and Laura Hercher of Sarah Laurence College, join us to look back on month two of the first modern pandemic.We begin with a scandal that rocked the Twitter science community and talk about how science itself may be having a big moment. Will this be a silver lining for this strange year?Then it’s on to antibody testing. What would a good antibody test need to do? And will there be tough ethical questions when some “have their immunity papers” and go back to

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29:59

Lab Director Speaks to the Challenges of COVID-19...

Mendelspod Podcast ·

2020/04/14

Why have diagnostic tests for the Coronavirus been slow on the scene? What have been the challenges for lab directors? Were they scientific? Were they regulatory? Were they scaling challenges? Are they still scaling challenges? Supply chain problems?Elaine Lyon worked for many years at the molecular genetics lab at ARUP at the University of Utah and is now the Clinical Services Lab Director at Hudson Alpha. In both of these jobs she has designed and overseen the design of many diagnostic

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31:07

FDA in the Time of Coronavirus: Understanding the New...

Mendelspod Podcast ·

2020/04/07

After the virus reached American shores, was the FDA quick enough to allow companies and labs to develop their own tests without restrictive oversight? The question sparked a sweeping new bill in congress, the VALID Act that could overhaul FDA oversight of diagnostics altogether—something that has been clamored for for a generation.Turna Ray has been covering the FDA and diagnostics for GenomeWeb since 2006. She has recently written a piece on the new VALID Act that includes responses from various

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53:39

March 2020 Review with Nathan & Laura: Corona Gets...

Mendelspod Podcast ·

2020/04/02

Laura comes to us from her flat in New York, Nathan is stuck in San Diego, but they are here and ready to discuss what a month ago was a warning and now is a full blown world crisis. What have they faced personally? What are their thoughts on testing? And what are some of their early big picture reactions as to how this will all go down?We make some time for some Corona-free science as well. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus

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35:20

90% Go Undiagnosed, Says Geisinger’s Amy Sturm of FH...

Mendelspod Podcast ·

2020/03/26

More than one in two hundred people have an inherited form of heart disease. But most don’t know it.Often on Mendelspod we talk about cancer genomics, but in the area of cardio, too, genetic testing can save lives.Amy Sturm is the Director of Genomic Counseling and Screening Program at Geisinger Health Systems. There she has led the effort to return the results of cardio genetic tests to over 1,000 patients. This is a public episode. If you'd like to discuss this with other subscribers or get

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39:21

Lisa Alderson on Her Telegenetics Firm, Genome...

Mendelspod Podcast ·

2020/03/10

Lisa Alderson has been helping to build genetic testing companies for a while. In 2016 she co-founded her own company, Genome Medical, a tele-genomics firm to help patients and providers understand genetic testing results.Anyone in the genetic testing industry will know that Genome Medical’s offering addresses a burning need. As Lisa remarks in today’s show, genetics is complicated. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes,

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61:42

February 2020 Review with Nathan and Laura:...

Mendelspod Podcast ·

2020/02/28

What do we actually know about the novel coronavirus, we ask our two monthly commentators at the outset of February’s review show. Then, speaking of pandemics, as Bernie fever sweeps America, we explore the charge that Medicare for All means an end to innovation.Laura gives an update on the status of the genetic counseling bill, and Nathan comes to us live from AGBT with highlights from Marco Island. This is a public episode. If you'd like to discuss this with other subscribers or get access to

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24:41

Pouria Sanae on the DTC Slowdown and His New...

Mendelspod Podcast ·

2020/02/13

“To be fully honest, I think some of these tests are scary tests. I’ve had the luxury of testing myself . . . some of this needs to have the physician and the genetic counselor involved.”That’s Pouria Sanae, a newcomer to our field via Yahoo and Helix. He’s also a Swede which gives him a fresh perspective on American genomic culture. Last month Pouria and his co-founders launched ixlayer, a new platform that integrates many of the players in the genomic medicine space: DTC companies, clinical

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50:15

January 2020 Review: Genetic Counselors vs ACMG,...

Mendelspod Podcast ·

2020/01/31

23andMe lays off over 100 employees. Illumina comes to the JP Morgan empty-handed. Has Precision Medicine seen it’s heyday already? Or are we gearing up for another wave of innovation? Nathan and Laura are again ready for the tough questions of genomics.We begin with the current spat between genetic counselors and the ACMG. Like, . . . huh? This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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67:42

End-of-Decade Review, What's Next? with Nathan and Laura

Mendelspod Podcast ·

2019/12/27

It's our special look back over the entire decade which has Nathan and Laura firing on all fours. Not only do we discover their genomic highlights of the last ten years--ups and downs-- they also pull out their special "future glasses" and come up with a provocative list for the next ten. You don't want to miss this.But first, we do cover December and that kerfuffle over the George Church dating app. And the genomics of income--really? Did you go for that?Theral, Nathan, and Laura for an

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50:21

Ewan Birney on Race, UK Genomics

Mendelspod Podcast ·

2019/12/17

Our end-of-year special guest is one of the U.K.’s top genomicists, Ewan Birney, Co-Director of the European Bioinformatics Institute at EMBL. He is also the non-Executive Director for Genomics England. Ewan's perhaps best known for his work with the ENCODE consortium. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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50:47

November 2019 with Nathan and Laura: Happy Birthday...

Mendelspod Podcast ·

2019/12/02

The gene edited babies, Lulu and Nana, turn one. Laura Hercher says it feels like it’s been five years. Nathan says, “Happy Birthday.”Along with our genomics headline party this month, we also discuss a comment that came in from our last show which leads us to the question, can we discuss science without discussing politics?It’s Nathan, Laura and Theral for almost a full hour sifting through November’s news. This is a public episode. If you'd like to discuss this with other subscribers or get

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32:44

Learning from the Field's Mistakes, Ancestry.com...

Mendelspod Podcast ·

2019/11/26

Just in time for Black Friday, Ancestry.com has launched new health testing. Thanksgiving week (the company calls the shopping holidays the “Turkey Five”) has been kind to what is the largest DNA testing company in the world. Back in 2017, their ancestry test competed with the Instapot for Amazon’s top sellers on the biggest shopping day of the year. To date Ancestry has sold over 15 million DNA tests. This is a public episode. If you'd like to discuss this with other subscribers or get access

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