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PODCAST

This Week in Parasitism

Vincent Racaniello

TWiP is a monthly netcast about eukaryotic parasites. Vincent Racaniello and Dickson Despommier, science Professors from Columbia University, deconstruct parasites, how they cause illness, and how you can prevent infections.

science life sciences

All Episodes

01:11:01

TWiP 53: Anti-saliva immunity

This Week in Parasitism ·

2013/04/20

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson discuss the finding that immunity to a sandfly salivary protein protects against fatal visceral leishmaniasis in hamsters. Links for this episode: Immunity to a salivary protein protects against leishmaniasis (PNAS) Image of blood-fed Lutzomyia longipalpis (right) credit Short history of Leishmania vaccines Leishmania on TWiP #14 Letters read on TWiP 53 Contact Send your questions and comments (email or mp3 file)

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01:09:57

TWiP 52: Not your ordinary unsegmented roundworm

This Week in Parasitism ·

2013/03/16

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson review the life cycle and pathogenesis of the giant kidney worm, Dioctophyme renale. Links for this episode: Dioctophymiasis (CDC) Dioctophyme renale (Wikipedia) Fatal bilateral dioctophymiasis (J Parasitol) Clinical Parasitology by Paul C. Beaver D. renale in a dog (Vet. Parasitol.) Surgical removal of D. renale (YouTube) Letters read on TWiP 52 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv

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01:11:39

TWiP 51: Modifying mosquitoes with Anthony A. James

This Week in Parasitism ·

2013/03/02

Hosts: Vincent Racaniello and Dickson Despommier Guest: Anthony A. James Special guest Anthony A. James joins Vincent and Dickson to discuss how mosquitoes can be genetically modified to control infectious diseases. Links for this episode: Field cage studies of modified mosquitoes (PLoS NTD) Flightless mosquitoes (PNAS) When mutant mosquitoes attack (NY Times) Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv

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01:11:05

TWiP 50: Antagonism in the mosquito midgut

This Week in Parasitism ·

2013/02/16

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson reveal how malaria parasites avoid lysis by complement in the mosquito. Links for this episode: Malaria parasites co-opt factor H (Cell Host Microbe) Complement system (Wikipedia) Letters read on TWiP 50 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv

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01:34:25

TWiP 49: Making sense of toxo and heme

This Week in Parasitism ·

2013/01/26

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson discuss innate immune sensing of Toxoplasma gondii in mice, and heme metabolism in protozoan parasites. Links for this episode: Sensing Toxoplasma in mice (Cell Host Microbe) Make it, take it, or leave it (PLoS Path) Heme (Wikipedia) Letters read on TWiP 49 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv

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01:07:03

TWiP 48: A parasitic cloaking device

This Week in Parasitism ·

2012/12/18

Hosts: Vincent Racaniello, Dickson Despommier, and Josef Sabo Vincent, Dickson, and Josef discuss tetraspanins on the surface of schistosomes as vaccine candidates and immune evasion proteins. Links for this episode: S. japonicum tetraspanin-2 as a vaccine target (PLoS NTP) Protection with S. mansoni tetraspanin-2 (PLoS NTP) S. mansoni tetraspanins confer protection (Nat Med) Tetraspanins Letters read on TWiP 48 Contact Send your questions and comments (email or mp3 file) to

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01:09:29

TWiP 47: For whom the trich tolls

This Week in Parasitism ·

2012/11/28

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson review evidence that a virus of the protozoan parasite Trichomonas vaginalis may exacerbate disease. Links for this episode: Endobiont viruses sensed by the human host (PLoS One) Letters read on TWiP 47 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv

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01:04:13

TWiP 46: Malaria gets the (zinc) finger

This Week in Parasitism ·

2012/10/17

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson meet with Judith Straimer and Marcus Lee to discuss their method for site-specific genome editing in Plasmodium falciparumusing zinc finger nucleases. Right-click to download TWiP #46 (46 MB .mp3, 64 minutes). Links for this episode: Judith Straimer and Marcus Lee Genome editing in P. falciparum with zinc finger nucleases (Nature Methods) Zinc finger nucleases (Sigma-Aldrich) Gene-editing nucleases (Nature Methods) Illustration

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01:00:47

TWiP 45: Free range Toxoplasma with John Boothroyd

This Week in Parasitism ·

2012/09/26

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson discuss Toxoplasma biology with Stanford University Professor John Boothroyd. Links for this episode: T. gondii and free range animals Kiss and spit: Toxoplasma rhoptries (Nat Rev Micro) Toxoplasma cell invasion (Curr Opin Micro) Loading of IRG onto parasitophorous vacuole (Cell Micro) Toxoplasma gondii on TWiP #12 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv. Subscribe (free) Subscribe to TWiP

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01:20:11

TWiP 44: Parasites provide a cricket subsidy for trout

This Week in Parasitism ·

2012/09/07

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson explain how a nematode manipulates cricket behavior and alters the food web of a stream. Links for this episode: Nematomorph parasites alter food web of streams (Ecol Lett) Manipulation of cockle behavior by a trematode (Parasitology) Cockles infected by one parasite are more susceptible to a second (J Parasitol) Letters read on TWiP 44 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv.

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01:32:17

TWiP 43: Two remarkable host-parasite conflicts

This Week in Parasitism ·

2012/08/23

Vincent and Dickson review how sickle cell microRNAs contribute to malaria resistance, and inhibition of innate immune responses by an enzyme from trypanosomes. Links for this episode: microRNAs involved in sickle cell resistance to Plasmodium (Cell Host Microbe) Trypanosome adenylate cyclases modulate innate immune response (Science) Letters read on TWiP 43 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv.

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01:14:45

TWiP 42: The tick keeps on ticking

This Week in Parasitism ·

2012/08/10

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson answer listener emails about Leishmania, dual infection of vectors, tapeworms, liver flukes, toxoplasmosis, and much more. Links for this episode: Metabolic pathways required by Leishmania (Ann Rev Micro) Tapeworms in people's brains (Carl Zimmer) Poison Ivy Bovine tuberculosis disguised by liver fluke (Nature) Giant kidney worm (YouTube) Crowd-sourced games for telepathology Ivermectin for alcohol abuse Ivermectin and alcohol

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01:33:37

TWiP 41: Flying and crawling beasts

This Week in Parasitism ·

2012/06/27

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson review medically important arthropods. Links for this episode: Thomas Eisner Incomplete metamorphosis in insects (jpg) Complete metamorphosis in an insect with aquatic immature stages (jpg) Complete metamorphosis in an insect with terrestrial immature stages (jpg) Letters read on TWiP 41 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv.

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01:12:33

TWiP 40: Doctor, there's a worm in my eye!

This Week in Parasitism ·

2012/05/17

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson discuss loaiasis caused by the filarial nematode Loa loa. Right-click to download TWiP #40 (52 MB .mp3, 73 minutes). Links for this episode: Albendazole therapy for US-bound refugees (NEJM) Microfilaria of Loa loa (png) Loa loa life cycle (png) Letters read on TWiP 40 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv.

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01:25:15

TWiP 39: I encyst, said the amoeba

This Week in Parasitism ·

2012/04/26

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson review the biology and pathogenesis of the amoebae Naegleria fowlerii and Acanthamoeba castellani. Links for this episode: N. fowlerii life cycle (CDC) N. fowlerii at Artful Amoeba Naegleria and amoebic meningoencephalitis (MDPH) First case of Naegleria PAM in Italy (Emerg Inf Dis) N. fowlerii in well water (Emerg Inf Dis) Recent N. fowlerii case in Minnesota (Clin Inf Dis) Beat the holiday bug (Sydney Morning Herald) Is your neti

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01:13:41

TWiP 38: How to Trichomonas

This Week in Parasitism ·

2012/04/03

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson tackle the backlog of listener email, then consider the life cycle and pathogenesis of Trichomonas vaginalis, the flagellated protozoan transmitted by sexual contact. Links for this episode: T. vaginalis life cycle (jpg) T. vaginalis hydrogenosome (jpg) Letters read on TWiP 38 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv.

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01:42:17

TWiP 37: Dracunculiasis

This Week in Parasitism ·

2012/02/19

Vincent and Dickson discuss the life cycle and pathogenesis of Dracunculus medinensis, the filarial nematode that causes dracunculiasis, or Guinea worm disease. Links for this episode: Dracunculus emerging from foot (jpg) Dracunculus medinensis life cycle (jpg) Guinea worm - WHO Guinea worm eradication - The Carter Center War against Guinea worm (YouTube) Caduceus vs staff of Asclepius Vincent and Dickson - the dogs (jpg) Letters read on TWiP 37

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01:09:09

TWiP 36: Trichuris and microbes plan a hatch

This Week in Parasitism ·

2012/02/01

Vincent and Dickson review how gut bacteria help establish T. muris in the large intestine of mice.

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01:16:49

TWiP 35: Malaria control with David Fidock

This Week in Parasitism ·

2012/01/13

Vincent and Dickson discuss control of malaria with their Columbia University colleague David Fidock.

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01:30:51

TWiP #34 - Up against the Wolbachia

This Week in Parasitism ·

2011/12/13

Vincent and Dickson discuss control of malaria and filariasis with the bacterial endosymbiont Wolbachia.

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