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PODCAST

From Concept to Medicine - A Comprehensive Drug Development Journey

Welcome to a Complete Drug Development Journey!Have you ever wondered how groundbreaking medicines go from a scientist’s vision to life-saving treatments in hospitals and pharmacies worldwide? The journey of drug development is an intricate, high-stakes adventure—filled with scientific breakthroughs, regulatory twists, and the relentless pursuit of innovation.In this podcast, we take you behind the scenes of pharmaceutical research and development, unraveling the complex and fascinating process that

science chemistry

All Episodes

14:09

30- Season 2 Recap and Integration (S2E15)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/23

This episode recaps the entire journey covered in Season 2, from target selection to candidate nomination, reinforcing key concepts for future phases. The discussion will integrate lessons learned from past failures and preview the complexities of preclinical development that will be explored in Season 3. This episode serves as a valuable review and sets the stage for the next chapter in the drug discovery journey.We will revisit key concepts like target validation, hit identification, lead

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14:54

29 - Preclinical Preparation and IND Planning (S2E14)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/23

This episode outlines the critical steps involved in ramping up from candidate selection to comprehensive IND-enabling studies. We will discuss the process of scaling up preclinical work, manufacturing pilot batches, and preparing the necessary regulatory dossiers. The conversation will also explore how regulatory strategy influences preclinical plans, providing real-world literature examples from OPR&D sources. This episode provides a practical roadmap for navigating the complex regulatory

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17:21

28 - Selecting a Development Candidate (S2E13)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/23

This episode explores the crucial process of selecting the best drug candidate from a pool of optimized leads. We'll discuss the criteria used by research teams, including efficacy, safety, and manufacturability. The conversation will focus on data-driven candidate selection, using case studies to illustrate the decision-making process. Economic and business considerations, such as market exclusivity and scalability, will also be discussed. This episode provides a behind-the-scenes look at the

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16:21

27 - Early Safety Screening (ADME-Tox) (S2E12)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/23

This episode focuses on the critical role of early safety testing in drug development. We'll explain key tests like the hERG inhibition assay, which helps identify potential cardiac risks. We will discuss assay design, providing examples like the history of terfenadine and the importance of early toxicological profiling. The episode will also explore AI-driven toxicity prediction models and examine cases where toxicities were discovered too late, emphasizing the need for continuous

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25:58

26 - Challenges in Early Discovery (S2E11)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/23

This episode delves into the common hurdles encountered in early drug discovery, such as false positives, synthetic challenges, and assay artifacts. We'll discuss troubleshooting strategies and how scientists adapt their screening methods based on actual lab data. Examples of failed high-profile drug candidates will be used to illustrate these hurdles and the lessons learned from these setbacks.The episode will also explore the importance of target validation and the intricate process of drug

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14:51

25- Case Study: A Drug Discovery Success (S2E10)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/23

This episode follows the journey of an HIV protease inhibitor as a real-world example, tying together key drug discovery steps. We'll use this case study to illustrate target validation, design, and lead optimization, providing detailed literature references. The episode will also include a parallel failed drug in the same area, contrasting what worked versus what didn't. This episode provides a compelling narrative of scientific ingenuity and perseverance in the face of formidable challenges.We'll

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25:46

24 - Natural Products and Drug Discovery (S2E9)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/23

This episode showcases the important role nature plays in drug discovery, using examples like penicillin and taxol. We'll discuss the subsequent chemical optimization of these natural products and how scientists are harnessing these complex compounds for modern therapeutic use. We will address why natural products are underutilized today and explore strategies to revitalize natural compound screening. This episode highlights nature's remarkable chemical diversity and its potential for inspiring new

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10:30

23 - Drug-like Properties & ADME (S2E8)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/23

This episode focuses on early assessments of absorption, distribution, metabolism, and excretion (ADME) in drug development. We will discuss how these assessments ensure that drug candidates are "drug-like" and explore Lipinski's Rule of 5 as a key guiding principle. Real-world examples of ADME screening in practice will be provided, along with exceptions to Lipinski's rule, particularly for biologics and PROTACs. Early ADME/Tox models and high-throughput permeability testing will also be

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17:25

22 - Medicinal Chemistry 101: SAR (S2E7)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/23

This episode provides a foundational understanding of structure-activity relationships (SAR) in medicinal chemistry. We will explore how systematic chemical changes inform potency and selectivity of drug candidates. The conversation will cover SAR data, reaction mechanisms, and how adjustments are made based on real experimental outcomes. Modern techniques like AI-driven SAR modeling will be introduced, along with the challenges of multiparameter optimization (efficacy, toxicity, solubility).We'll

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27:08

21 - Hit-to-Lead and Lead Optimization (S2E6)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/23

This episode describes the iterative process of refining "hits" into promising "leads" in drug discovery. We will explore how scientists balance potency, safety, and drug-like properties while making successive chemical modifications. The concept of structure-activity relationships (SAR) will be central to the discussion. We'll also integrate a case study, such as the development of SARS-CoV-2 antivirals, to illustrate the process of lead optimization and the challenges involved.Further, we'll

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16:15

20 - Computational Drug Design & Virtual Screening...

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/23

This episode explores the world of computer-aided drug design and virtual screening, where computers act as molecular matchmakers. We'll discuss methods to model target interactions and virtually screen compounds, focusing on molecular docking, in silico predictions, and early AI applications. The role of deep learning models like AlphaFold in structure prediction will also be examined. This episode provides a glimpse into the exciting future of drug discovery where computers are revolutionizing how

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15:16

19- Fragment-Based Drug Discovery (S2E4)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/23

This episode introduces the innovative approach of fragment-based drug discovery, where drugs are built piece by piece from small chemical fragments. We'll use the analogy of assembling a puzzle, comparing fragment screening with high-throughput screening (HTS). The discussion will also delve into the intricate details of protein-ligand interactions at the atomic level, providing insights from X-ray crystallography and NMR. Real-world literature examples from OPR&D sources will further

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14:26

18 – High-Throughput Screening (S2E3)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/23

In this episode of The Deep Dive, we explore the world of High Throughput Screening (HTS), a crucial process in modern drug discovery. HTS is a highly automated method that allows scientists to rapidly test thousands, even millions, of chemical compounds against biological targets to identify potential drug candidates. Think of it like a speed-dating event for molecules, where researchers seek to find that one special interaction that could lead to a new medicine. We discuss how automation and

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15:02

17- Target Validation Techniques (S2E2)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/23

This episode explains the experimental methods, both genetic and chemical, used to confirm a target's role in a disease. We'll explore techniques like knockout studies and the use of tool compounds, providing real-world examples from OPR&D. We'll also delve into the world of AI-driven target validation and the role of computational biology in this process. This episode provides a foundational understanding of how scientists validate targets before embarking on the long and costly journey of drug

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24:01

16- Selecting the Right Drug Target (S2E1)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/23

This episode delves into the crucial process of drug target selection, exploring the criteria for a "good" drug target. We'll discuss the target's role in disease, its druggability, and potential safety implications. We'll examine the importance of biological relevance, market needs, and provide examples like HER2 in cancer. The episode also addresses challenges in target selection, such as historically difficult targets and undruggable proteins. We'll introduce emerging target strategies, including

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17:19

15- Season 1 Recap and Future Preview (S1E15)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/17

Join us as we recap the key takeaways from Season 1 of The Deep Dive, revisiting the fascinating world of drug development and looking ahead to the exciting topics we'll explore in Season 2. We'll summarize the core concepts we've covered, from Quality by Design (QbD) and crystallization control to microfluidics, modeling, and the crucial role of teamwork in science. This episode reinforces the roadmap of drug development, highlighting the intricate journey a drug takes from the initial spark of an

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19:16

14-Team Science: Collaboration in R&D (S1E14)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/17

Drug development isn't a solo act. It's a symphony of scientific expertise, a collaborative effort involving a diverse team of specialists, from chemists and biologists to clinicians and regulatory experts. This episode explores the crucial role of team science in driving innovation and bringing new medicines to market. We'll discuss the challenges of coordinating expertise across different disciplines, highlighting the importance of communication, flexibility, and a shared vision. Using the example

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18:49

13 - Risk and Failure in Drug Development (S1E13)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/17

Drug development is a high-stakes endeavor, and this episode confronts the harsh reality of risk and failure in this complex field. Explore why the vast majority of drug candidates never make it to market, and how those early failures can shape future research strategies and ultimately drive innovation. We'll discuss the common pitfalls that derail drug development, from safety concerns and efficacy issues to technical challenges in manufacturing and formulation. Using real-world examples like the

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23:03

12 - Funding and Economics of Drug Development (S1E12)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/17

Explore the complex world of drug development finance, from the multibillion-dollar investments and lengthy timelines to the diverse funding sources that fuel this high-stakes endeavor. Discover how economic considerations influence every stage of the process, from target selection and preclinical research to clinical trials and regulatory approval. We'll discuss the challenges of balancing scientific breakthroughs with commercial viability, highlighting the importance of assessing market trends,

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19:23

11- Patents and Intellectual Property (S1E11)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/17

Protecting innovation is crucial in the world of drug development, and this episode delves into the critical role of patents in safeguarding drug discoveries and enabling companies to recoup their substantial R&D investments. Explore the intricacies of patent law, understanding how these legal safeguards grant exclusive rights to inventors and prevent others from making, using, or selling their inventions for a specified period. We'll discuss the delicate balance between incentivizing innovation

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