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PODCAST

JACC This Week

American College of Cardiology

Weekly summary and focused insights of the high-impact cardiovascular research published in the JACC from Editor-in-Chief Harlan M. Krumholz, MD, SM, FACC, shaping cardiovascular care today.

health & fitness medicine

All Episodes

12:33

Effect of valve type and anesthesia strategy for TAVR...

JACC This Week ·

2025/01/06

In this episode, Dr. Valentin Fuster discusses the five-year results of the SOFT TAVI trial, which compared self-expanding and balloon-expanding valves for transcatheter aortic valve replacement (TAVR) in patients with severe aortic stenosis. The findings reveal similar long-term outcomes for both valve types and anesthesia strategies, with subtle differences in stroke rates and pacemaker implantations, emphasizing the growing safety and efficacy of conscious sedation in TAVR procedures.

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11:08

Machine Learning-based Prediction of Death and...

JACC This Week ·

2025/01/06

In this episode, Dr. Valentin Fuster discusses a groundbreaking study that uses machine learning to predict mortality and hospitalization risks in patients with implantable cardioverter defibrillators (ICDs). By leveraging large datasets and time-varying ICD data, the study developed a robust predictive model, though challenges remain regarding data gaps and its applicability to diverse patient populations.

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28:06

JACC - January 7 - 14, 2025 Issue Summary

JACC This Week ·

2025/01/06

In this episode, Dr. Valentin Fuster discusses five key studies from the January 2025 JACC issue, covering advancements in coronary angioplasty, revascularization strategies for STEMI, machine learning for ICD patient outcomes, thromboxane’s link to heart failure, and TAVR valve types and anesthesia approaches. These studies provide valuable insights into improving cardiovascular care and treatment.

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09:14

Association of Systemic Thromboxane Generation with...

JACC This Week ·

2025/01/06

In this episode, Dr. Valentin Fuster discusses a study published in the Journal of the American College of Cardiology examining the link between urinary thromboxane B2 metabolites and the risk of developing heart failure. The research suggests that high levels of these metabolites, potentially from the myocardium or other organs rather than platelets, are associated with an increased risk of heart failure, offering a potential new biomarker for early detection and targeted prevention strategies.

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10:25

Drug-Coated Balloon Angioplasty Of the Side Branch...

JACC This Week ·

2025/01/06

In this episode, Dr. Valentin Fuster discusses the findings of a major randomized trial examining the use of drug-coated balloons (DCB) in treating side branch stenosis during coronary bifurcation procedures. The study suggests that DCBs offer better one-year outcomes compared to non-coated balloons, showing a significant reduction in myocardial infarction rates, but highlights ongoing challenges in managing bifurcation lesions, especially considering the high cost and potential risks.

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10:36

Optimal Strategy for Complete Revascularization in...

JACC This Week ·

2025/01/06

In this episode, Dr. Valentin Fuster discusses a comprehensive network meta-analysis published in JACC, which evaluates the optimal strategy for complete revascularization in patients with STEMI and multi-vessel disease. The study concludes that both immediate and staged complete revascularization improve patient outcomes over partial revascularization, with no significant advantage between angiographic and functional guidance, suggesting that angiographic guidance alone may be sufficient in

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11:16

Impact of Renal & Liver Function on Clinical Outcomes...

JACC This Week ·

2024/12/09

In this podcast, Dr. Valentin Fuster discusses a study on the impact of renal and liver function on clinical outcomes following tricuspid valve transcatheter H2O repair in patients with severe tricuspid regurgitation. While the study found no significant differences in organ function between repair and control groups at 12 months, successful repairs showed small but favorable improvements in kidney and liver function, suggesting potential long-term benefits in reducing heart failure hospitalizations

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25:10

JACC - December 17 - 24, 2024 Issue Summary

JACC This Week ·

2024/12/09

In this episode, Dr. Valentin Fuster highlights five cutting-edge cardiology studies from the December 2024 issue of JACC, covering topics such as cardiac MRI's role in predicting sudden cardiac events in Fontan patients, the impact of oxidized phospholipids on calcific aortic valve disease, and the effects of renal and liver function on outcomes after tricuspid valve repair. With insights on mortality risks from influenza in heart failure patients and the outcomes of anatomical versus physiological

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10:17

Oxidized Phospholipids and Calcific Aortic Valvular...

JACC This Week ·

2024/12/09

In this podcast, Dr. Valentin Furster discusses a groundbreaking study on the role of oxidized phospholipids in calcific aortic valvular disease, highlighting their significant association with disease prevalence and progression. The findings suggest that targeting oxidized phospholipids, not just the Lp(a) particle, could offer a promising new therapeutic approach to treat this condition.

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11:07

Excess Mortality and Hospitalizations Associated with...

JACC This Week ·

2024/12/09

In this podcast, Dr. Valentin Fuster discusses a study on the significant impact of seasonal influenza on mortality and hospitalizations among patients with heart failure. The research highlights that influenza is responsible for substantial excess deaths and hospitalizations in this vulnerable group, emphasizing the need for better vaccination uptake and preventive measures to reduce these risks.

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10:32

Cardiac MRI Predictors of Arrhythmic Sudden Cardiac...

JACC This Week ·

2024/12/09

In this episode, Dr. Valentin Fuster discusses a groundbreaking study on cardiac MRI predictors of arrhythmic sudden cardiac events in patients with Fontan circulation, highlighting key risk factors for these life-threatening incidents. The study, part of the multi-center FORCE registry, reveals significant findings, including the impact of clinical status and ventricular function, while emphasizing the importance of large-scale research in improving outcomes for single ventricle patients.

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10:45

Anatomic and Physiologic Repair of Congenitally...

JACC This Week ·

2024/12/09

In this podcast, Dr. Valentin Fuster discusses a study on the long-term outcomes of two surgical approaches—anatomic and physiologic repair—for congenitally corrected transposition of the great arteries. The findings suggest that while the complex anatomic repair offers better survival and reintervention-free outcomes, patient selection is crucial, with careful consideration needed, especially for asymptomatic infants or those with preoperative pulmonary artery banding.

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06:52

Major Bleeding and Mortality After Revascularization...

JACC This Week ·

2024/12/02

In the December 10, 2024 JACC issue, a study from the EXCEL trial examines the link between bleeding complications and mortality in patients with left main coronary artery disease undergoing PCI or CABG. The findings highlight that while PCI showed lower rates of bleeding, both procedures had bleeding-related mortality risks, underscoring the need for strategies to minimize bleeding during and after revascularization.

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43:12

JACC - December 10, 2024 Issue Summary

JACC This Week ·

2024/12/02

In the December 2024 issue of JACC, Dr. Valentin Fuster summarizes five pivotal clinical studies, including one on bleeding and mortality following revascularization for left main coronary artery disease, which highlights higher bleeding rates post-CABG compared to PCI. Other key articles explore the use of the MitraClip in treating moderate-to-severe functional mitral regurgitation, evaluating its impact on hospitalization and quality of life, as well as comparing aspirin monotherapy to no

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08:14

Aspirin Monotherapy versus No Antiplatelet Therapy in...

JACC This Week ·

2024/12/02

In this episode, Dr. Valentin Fuster discusses the ASSURE DES trial, which compared aspirin monotherapy to withholding antiplatelet therapy in stable patients with drug-eluting stents undergoing non-cardiac surgery. The trial found no significant difference in major adverse outcomes between the two strategies, though minor bleeding was more common in the aspirin group, leading to a recommendation to continue aspirin therapy for most patients undergoing low-to-intermediate risk surgery, with

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11:10

Efficacy and Safety of a Novel Low-Dose Triple...

JACC This Week ·

2024/12/02

In this podcast, Dr. Valentin Fuster discusses a groundbreaking study on the efficacy and safety of a novel low-dose triple combination pill for the initial treatment of hypertension. The study highlights how a single pill containing three blood pressure-lowering agents can significantly reduce blood pressure while improving patient adherence, offering a promising solution for hypertension management globally, especially in low-income settings.

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31:40

Percutaneous Transcatheter Edge-to-Edge Repair for...

JACC This Week ·

2024/12/02

In this episode, Dr. Valentin Fuster delves into the latest research surrounding the use of the mitral clip for patients with severe functional mitral regurgitation, comparing the results of three major trials: the French MITRA-FR trial, the American COAPT trial, and the Reshape HF 2 trial. While the COAPT and Reshape HF 2 trials show positive outcomes, especially in reducing hospitalizations and improving heart failure symptoms, the French trial saw no benefit, prompting debate over the influence

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31:40

Hospitalizations in Symptomatic Patients with Heart...

JACC This Week ·

2024/12/02

In this episode, Dr. Valentin Fuster delves into the latest research surrounding the use of the mitral clip for patients with severe functional mitral regurgitation, comparing the results of three major trials: the French MITRA-FR trial, the American COAPT trial, and the Reshape HF 2 trial. While the COAPT and Reshape HF 2 trials show positive outcomes, especially in reducing hospitalizations and improving heart failure symptoms, the French trial saw no benefit, prompting debate over the influence

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10:32

Two-Fold More Cardiovascular Disease Events Decades...

JACC This Week ·

2024/11/25

This podcast discusses a significant study that reveals cardiovascular disease occurs up to 30 years before a type 2 diabetes diagnosis, emphasizing the importance of early intervention for those at risk. The findings suggest that addressing metabolic risk factors well before the clinical onset of diabetes could help prevent the rise of cardiovascular events, a growing global health concern.

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21:33

JACC - December 3, 2024 Issue Summary

JACC This Week ·

2024/11/25

In this podcast, Dr. Valentin Fuster summarizes the December 3rd, 2024 issue of JACC, highlighting four impactful studies that reshape our understanding of cardiovascular disease. From early cardiovascular risks in type 2 diabetes to innovative treatments for endocarditis, these studies emphasize the importance of early intervention, advanced diagnostics, and evolving treatment strategies in heart health.

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1,263 results

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