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PODCAST

From Concept to Medicine - A Comprehensive Drug Development Journey

Welcome to a Complete Drug Development Journey!Have you ever wondered how groundbreaking medicines go from a scientist’s vision to life-saving treatments in hospitals and pharmacies worldwide? The journey of drug development is an intricate, high-stakes adventure—filled with scientific breakthroughs, regulatory twists, and the relentless pursuit of innovation.In this podcast, we take you behind the scenes of pharmaceutical research and development, unraveling the complex and fascinating process that

science chemistry

All Episodes

17:33

10 - Formulation and Drug Delivery Basics (S1E10)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/17

Discover how a tiny molecule becomes a medicine you can take, from pills and capsules to injections and inhalers. This episode explores the fascinating world of drug formulation and delivery, revealing how scientists transform active drug molecules into marketable products. We'll discuss the importance of bioavailability, the amount of drug that actually reaches the bloodstream in its active form, and explain how different formulation and delivery methods can impact a drug's effectiveness. Using the

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14:36

9 - Basics of Drug Manufacturing (S1E9)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/17

From the laboratory flask to the large-scale manufacturing plant, this episode explores the intricate world of drug manufacturing. Discover the challenges of scaling up drug production, from synthesizing a few grams of a compound to producing kilograms or even tons while maintaining purity and maximizing yield. We'll discuss the complexities of process engineering, highlighting factors like mixing, heat transfer, and reaction kinetics that can significantly impact the final product. This episode

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11:15

8 - Regulatory Affairs 101 (S1E8)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/17

Step into the world of regulatory affairs, a critical but often overlooked aspect of drug development. Discover the essential role of agencies like the FDA in ensuring that the medications we rely on are both safe and effective. This episode explores the rigorous process of drug approval, from the initial Investigational New Drug (IND) application to the final decision on whether a drug can be marketed to the public. Learn how regulatory agencies are involved every step of the way, from monitoring

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23:56

7- Clinical Trial Phases Overview (S1E7)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/17

Embark on a journey through the crucial phases of clinical trials, from the initial safety assessments in small groups of healthy volunteers to the large-scale pivotal studies that confirm a drug's effectiveness in diverse patient populations. Explore the distinct goals of each phase, from establishing a drug's safety profile and dosage range in Phase 1 to evaluating its efficacy and potential side effects in Phase 2 and confirming its long-term safety and effectiveness in Phase 3. This episode also

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20:38

6- Preclinical Research Overview (S1E6)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/17

Before a potential new drug can be tested in humans, it must undergo rigorous preclinical research. This episode explores the crucial role of these studies, both in the lab (in vitro) and in living organisms (in vivo), in assessing a drug candidate's safety and efficacy. Discover how scientists use a variety of tests to evaluate a drug's properties, from its solubility and stability to its interactions with target molecules and potential toxicity. We'll delve into the ethical considerations

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17:37

5 – Overview of Drug Discovery Process (S1E5)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/17

This episode maps the intricate journey of drug discovery, from identifying a promising molecule (the "hit") to refining it into a potential drug candidate (the "lead"). We'll explore the key stages of this process, including high-throughput screening, where robots test thousands of compounds simultaneously, and lead optimization, where medicinal chemists fine-tune the structure and properties of promising molecules. We'll also revisit the importance of Quality by Design (QbD) and critical quality

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14:20

4 - Pharmacology Basics: How Drugs Work (S1E4)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/17

Have you ever swallowed a pill and wondered how that tiny thing actually works inside your body? In this episode, we'll unravel the fascinating world of pharmacology, exploring the intricate ways drugs interact with our biological systems. Discover the key players in this microscopic drama – receptors and enzymes – and learn how drugs can either mimic or block their actions. We'll explain the importance of selectivity in drug design, emphasizing how scientists strive to minimize off-target effects

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15:07

3 - From Idea to Target Selection (S1E3)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/17

Uncover the intricate process of selecting a drug target, the crucial first step in developing new medications. Explore how unmet medical needs and profound biological insights spark drug ideas and guide researchers in their quest to identify the perfect target. This episode delves into the world of models, explaining how mechanistic, empirical, and hybrid models help scientists make sense of the complex landscape of the human body. We'll use clear analogies to explain these concepts, making this

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26:32

2- History of Drug Discovery (S1E2)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/17

Step back in time and explore the fascinating history of drug discovery, from ancient remedies and traditional healing practices to the cutting-edge scientific breakthroughs of today. Trace the evolution of medicine from trial-and-error methods to the systematic, science-based approaches that drive modern drug development. Discover how ancient civilizations utilized plants and minerals for healing, and how those practices, though often rooted in beliefs, sometimes held genuine therapeutic value

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28:19

1 - Introduction to Drug Development (S1E1)

From Concept to Medicine - A Comprehensive Drug... ·

2025/03/17

Embark on a journey through the intricate world of drug development, from the spark of an idea to a life-changing medication available at your local pharmacy. Discover the crucial stages of this process, including discovery, preclinical testing, clinical trials, regulatory hurdles, and post-market surveillance. We'll unravel the complexities of each step, revealing the collaborative efforts of scientists, engineers, and regulatory experts. This episode also introduces Quality by Design (QbD), a

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270 results

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