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PODCAST

Springer Nature

Springer Nature

Welcome to the Springer Nature Soundcloud page! Here you will find several podcasts from our journals across a range of scientific subjects, including Gene Pod, ModPath Chat, Pediapod, Hereditypod and Brainpod.

science

All Episodes

00:22:01

Tips on collaborations and range expansions

Springer Nature ·

2019/12/06

Collaboration is an essential aspect of modern science, and the authors featured in today’s episode epitomise this relationship. In our most ambitions interview to date, all four first authors of a recent Heredity paper come together to discuss their work looking at range expansions in the blacktip reef shark (Carcharhinus melanopterus). Their results provide a cautionary tale for researchers interpreting population genetic data, especially when dealing with potential meta-populations. Associated

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00:14:52

Hot and cold hardiness across complex life cycles

Springer Nature ·

2019/12/06

Some like it hot. Some like it cold. But whatever an organism’s preference, our changing climate is likely going to force them to adapt to new temperature regimes. This raises a particularly interesting question for those species with complex life-cycles: do different life stages respond to thermal pressures in a similar way? Or do they display distinct evolutionary trends? In this episode we speak to Dr Philip Freda and Zainab Ali about their work looking at stage-specific genotype-by-environment

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00:18:55

Scientific storytelling: an interview with Prof....

Springer Nature ·

2019/12/06

Storytelling facilitated both the emergence of the scientific discipline and the evolution of human intelligence. At least, that’s what Prof. Enrico Coen argues. A former President of the genetics society, Prof. Coen, from the John Innes Centre, has two articles in the recent Heredity Special issue commemorating 100 years of The Genetics Society. In the first, he creatively recounts the rise of Homo geneticus, and in the second he delves into the history and importance of human storytelling. Tune in

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00:18:54

Genetics and evolution, a century of bias: an...

Springer Nature ·

2019/12/06

We tend to think of science as objective, but as with any human endeavour it is fraught with biases: cognitive, technical, personal and cultural. Interestingly, it turns out that inheritance can also be biased, with the transmission of genes often displaying anything but ‘fair’ segregation. As the Genetics Society celebrates its centenary, join president Prof. Laurence Hurst as he discusses 100 years of bias in genetics and evolution, how he fell in love with the field (despite poor first

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00:07:00

What’s holding clinicians back from recommending...

Springer Nature ·

2019/12/06

A precision medicine approach has advanced the development of new cancer therapies and researchers who study neurodegenerative diseases would like to replicate that model. Yet, few neurologists recommend genetic testing to patients with neurodegenerative disorders such as Parkinson’s disease. Dr. Roy Alcalay, a neurologist and associate professor at Columbia University Irving Medical Center, and colleagues wanted to discover what’s holding them back. In a recent study published in GIM, the team

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00:09:34

Intra-individual changes in methylome profiles: an...

Springer Nature ·

2019/11/14

It’s widely understood that early life adversity has an impact on mental illness and cognitive problems later in life. There are theories as to the mechanisms of how this works, but it’s difficult to test in humans. Tallie Baram is a professor of neurophysiology and biophysics at the UC Irvine department of pediatrics. And she co-authored a recent study in the journal Neuropsychopharmacology with Ali Mortazavi, professor of developmental and cell biology at UC Irvine. Dr. Baram says that imaging

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00:07:52

RNA sequencing improves diagnostic rate for rare...

Springer Nature ·

2019/11/05

Although genetic sequencing has aided the diagnosis of many genetic diseases, only about one third of children with unknown or rare genetic diseases end up with a diagnosis after exome sequencing. To help these patients, Stanley Nelson, professor of human genetics at the David Geffen School of Medicine at UCLA, wanted to explore the genome more effectively. In a recent publication in GIM, Dr. Nelson and team show RNA sequencing helped to solve an additional 15% of cases that genome sequencing alone

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00:06:09

Variants on the corresponding allele may explain...

Springer Nature ·

2019/10/04

One of the most common chromosomal deletions in humans happens on chromosome 22. It’s known as 22q and affects as many as one in 2,000 live births. People with the deletion can present with a wide variety of traits. Some have heart defects. Others have defects in the palate, while still others have developmental delays. But in 2005, Donna McDonald-McGinn, director of the 22Q and You Center at the Children’s Hospital of Philadelphia and clinical professor at the University of Pennsylvania, noticed

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00:10:51

Placental clearance/synthesis of neurobiomarkers GFAP...

Springer Nature ·

2019/09/30

Neonatal encephalopathy (NE) is associated with substantial morbidity and mortality and affects around 1.5/1000 live term births. Predicting the severity and outcome of neonates with NE is therefore vital in order to provide the best care for neonates with NE, and a biochemical marker obtained at birth would therefore be useful to bolster the current scoring system. In this episode, Geoff Marsh speaks to Early Career Investigator Dr. Imran Nazir Mir, from the University of Texas, Southwestern

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00:09:56

Brainpod - Effects of MDMA on attention to positive...

Springer Nature ·

2019/09/18

The recreational drug MDMA, also known as Ecstasy or Molly, is particularly popular in social settings and raves, in large part because of how socially connected it makes the users feel. It’s being studied for use in psychotherapy —there’s a phase III clinical trial for the use of MDMA to treat PTSD. What’s clear is that the drug affects how users experience social interactions. But there are questions: Does the drug make positive social interactions feel better, or reduce the negative feelings

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00:07:09

Genotyping aids medication decisions and benefits...

Springer Nature ·

2019/08/30

Every year more than half a million people in the US have stents placed in narrow blood vessels to improve blood flow to the heart. Following the procedure, patients typically need treatment with anti-clotting drugs. The go-to medication is clopidogrel, a prodrug that requires activation by an enzyme called CYP2C19. However, about a third of patients carry variants that render CYP2C19 ineffective. These patients are at increased risk for future heart attacks, strokes and other cardiovascular events

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00:11:28

Adrenal function links to early postnatal growth and...

Springer Nature ·

2019/08/30

For term-born infants, low birth weight has been shown to correlate with a broad array of adverse cardiometabolic outcomes, and excess glucocorticoid exposure has been linked to these relationships. Also, intra-uterine growth restriction (IUGR) in term-born infants has been linked to subsequent increases in adrenal androgen activity. In this episode, we meet Kristi Watterberg, a professor of Pediatrics at the University of New Mexico who evaluated the relationship between preterm birth to salivary

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00:12:08

Pediapod - Maternal acetaminophen use during...

Springer Nature ·

2019/08/08

Over-the-counter (OTC) medications are used in an estimated 70% of pregnancies. Acetaminophen, also known as paracetamol is found in a large number of OTC and prescription drugs. Given its prevalence and its ability to freely cross the placenta, researchers are now focusing on the safety of maternal exposure to this drug and its effects on fetal health. There have been inconsistent results in both human and animal studies on the short and long-term effects of acetaminophen use during pregnancy. In

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00:08:07

Genepod - Creating a framework to assess resource...

Springer Nature ·

2019/08/08

As the appetite for clinical genetic testing grows, it seems the demand for geneticists able to provide the needed services outpaces the supply. Yet health services do not have a way to measure that growth or the resources needed to provide those services. In a recent study published in GIM, researchers describe a new framework for evaluating the resource needs of clinical genetics services, including recent huge increases in genetic testing and the accompanying counseling. In the August Genepod,

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00:09:47

Brainpod - Superolateral medial forebrain bundle deep...

Springer Nature ·

2019/07/15

Depression is an incredibly important disorder—according to Thomas Schlaepfer, head of the department of interventional biological psychiatry at the University of Freiburg, at least 20 percent of people have a depressive episode at least once in their lives. And while most patients’ symptoms improve with a combination of psychotherapy and medicine, up to 20 percent of depressed patients do not improve from existing treatments. Dr. Schlaepfer and his colleagues have been conducting research on deep

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00:06:54

Genepod - Testing guidelines for neurodevelopmental...

Springer Nature ·

2019/07/03

Nearly a third of neurodevelopmental disorders are thought to have a genetic basis and the most recent ACMG guidelines, from 2010, recommend Chromosomal Microarray (CMA) and fragile X testing as first tier genetic tests. In a recent study published in GIM, Srivastava et al carried out a meta-analysis of 30 papers published since those guidelines were issued and determined exome sequencing had a significantly higher diagnostic yield than these previous testing standards. In this month’s GenePod,

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00:09:44

Enhanced early prediction of clinically relevant...

Springer Nature ·

2019/07/03

Almost 10% of newborn infants develop significant hyperbilirubinemia, and many require phototherapy treatment. This is costly and can increase the likelihood of patients developing allergic diseases. However the costs of not treating neonatal jaundice can be more severe as it can cause lifelong disability. Precise patient monitoring and deliberate treatment assignment are therefore essential for at-risk neonates. In this episode, we meet Sven Wellman, then of the University of Basel's Children

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00:15:07

New Heredity Podcast: Is evolution faster in the...

Springer Nature ·

2019/06/10

Why do the tropics contain such a diversity of life? In this episode, we explore this question with Matt Orton and Prof. Sarah Adamowicz from the University of Guelph. Listen to them discuss their recent research paper – Is molecular evolution faster in the tropics? – and hear about the challenge it poses to the long standing Evolutionary Speed Hypothesis. Associated article: Is molecular evolution faster in the tropics? https://www.nature.com/articles/s41437-018-0141-7

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00:13:25

New Heredity Podcast: Orchids in the clouds

Springer Nature ·

2019/06/10

In this episode we explore the genetic structuring of orchids in the cloud rainforests of Ecuador. While we mainly think of orchids as ornamental houseplants, many wild species are vulnerable to poaching or deforestation. In a recent Heredity paper, Professor José Iriondo (King Juan Carlos University, Madrid) and colleagues investigated the fine-scale genetic structure of an unassuming orchid in a regenerating patch of Ecuadorian rainforest—working in a landscape unlike any other, they have

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00:22:00

New Heredity Podcast: Snails, supergenes and a...

Springer Nature ·

2019/06/10

From the days of Darwin and Mendel, studies on colouration have played a vital role in deciphering the mechanisms of natural selection and genetic heredity. While this work has encompassed many species from all branches of the tree of life, a particularly noteworthy one is the incredibly colour diverse grove snail, Cepaea nemoralis. In this special double-whammy episode, we discuss two recent Heredity papers on this unassuming, yet beautiful, little mollusc by Dr Angus Davison (University of

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