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PODCAST

Cannabinoid and Psychedelic Pharmacology and Drug Development

Jim Mitchell and Google NotebookLM

Explore Cannabinoid and Psychedelic Pharmacology with AI-Powered Learning.Welcome to a groundbreaking approach to mastering cannabinoid and psychedelic pharmacology and the FDA drug development pathway! This podcast series, powered by Google’s Notebook LM, offers a cutting-edge, AI-guided learning experience tailored for formal classes or self-directed study.Each 30-day series delves deep into the science of cannabinoid and psychedelic pharmacology, exploring molecular signaling pathways,

science chemistry

All Episodes

25:55

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode explores Toll-like receptors (TLRs), which act as cellular sentinels in the immune system. The discussion covers how TLRs detect threats and trigger immune responses, but also how their dysfunction can lead to serious health issues like chronic inflammation, sepsis, and autoimmune diseases. The conversation delves into the complex world of immune tolerance, TLR signaling pathways, and potential therapeutic approaches using TLR antagonists. The episode also examines the

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14:59

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This episode provides an in-depth exploration of TLR (Toll-like Receptor) signaling pathways, focusing on two key adapter proteins: MyD88 and TRIF. The discussion breaks down how these pathways function in immune response, with MyD88 triggering inflammatory responses through NF-kB activation and cytokine production, while TRIF specializes in antiviral defense through interferon production. The conversation covers the molecular mechanisms, regulatory controls, and potential therapeutic applications,

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18:42

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

A comprehensive deep dive into Toll-like Receptors (TLRs), exploring their crucial role in the immune system. The episode breaks down how different TLRs act as specialized cellular guards, with some stationed on the cell surface and others inside endosomes. It covers specific TLRs including TLR4's role in detecting bacterial components, TLR3's specialization in viral detection, and the intricate signaling pathways they use to trigger immune responses. The discussion also explores therapeutic

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10:50

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode explores orphan nuclear receptors, focusing on Rev-Erb and ROR, which are important for circadian rhythms and metabolism. The discussion covers how scientists are working to discover their activating ligands through methods like large-scale screening and computational modeling. The episode delves into the challenges and potential therapeutic applications, particularly for sleep disorders, metabolic diseases, and cancer. It also examines how studying well-understood receptors

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15:54

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode provides an in-depth exploration of retinoid and vitamin D receptors, covering their crucial roles in cell growth, differentiation, bone health, and immune function. The discussion details how these receptors work as molecular switches by binding to specific DNA sequences (response elements), interacting with vitamins as ligands, and recruiting co-regulators to control gene expression. The episode also examines how disruptions in these receptor pathways can lead to various

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9:39

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode explores the complex world of thyroid hormone receptors (TRs), covering their role as transcription factors that control metabolism, growth, and brain development. The discussion breaks down the relationship between T3 (active) and T4 (inactive) hormones, explains how TRs function through corepressors and coactivators, and delves into emerging research on cellular microdomains and their potential impact on thyroid hormone signaling. The episode concludes with insights into

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21:45

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

This podcast episode explores the fascinating world of steroid hormone receptors, discussing how these molecular switches control crucial bodily functions. The conversation covers several key topics, including:- The complex signaling pathways in heart cells involving microdomains and AKAPs- The mechanism of steroid hormone receptor activation and DNA binding- The role of receptor dimerization in gene regulation- Modern research techniques like fluorescence microscopy and biochemical assays for

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16:33

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

In this engaging discussion about nuclear receptors, experts explore how these specialized proteins act as cellular conductors, orchestrating crucial biological processes like growth, development, and metabolism. The conversation delves into the three main types of nuclear receptors, their mechanisms of action, and their vital roles in health and disease. Particular attention is given to thyroid hormone receptors and their impact on development, along with the intricate cellular organization system

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18:35

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Dive deep into the fascinating world of the TNF superfamily, where cellular life and death hang in perfect balance. This episode explores how these crucial signaling molecules orchestrate cell survival and apoptosis through specific receptor interactions. Learn about key players like CD40 and Fas, and discover how their intricate molecular dance impacts inflammation, autoimmune diseases, and potential therapeutic approaches.

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15:42

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Explore the fascinating world of interferon receptors and their crucial role in our body's antiviral defense system. Learn how these cellular sentinels detect viral threats and trigger complex signaling pathways through the JAK-STAT system. This episode breaks down the three types of interferon receptors, their unique functions in different cell types, and their emerging potential in cancer immunotherapy. Discover how this intricate molecular defense network protects us from viral invaders and could

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13:07

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Dive deep into the fascinating world of interleukin receptors, the gatekeepers of our immune system. This episode explores how these diverse molecular messengers orchestrate immune responses, from T-cell and B-cell activation to managing inflammation. Learn about the main interleukin families, their unique functions, and how understanding these complex signaling pathways is revolutionizing treatments for autoimmune diseases and cancer. Join us for an enlightening discussion on the latest

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17:16

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Dive deep into the fascinating world of the JAK-STAT pathway, a critical cellular communication system that serves as the central control hub for immune responses and inflammation. This episode breaks down how cytokines trigger this intricate signaling cascade, exploring the roles of JAK kinases and STAT proteins in regulating immune function. Learn how disruptions in this pathway can lead to disease, and discover how researchers are developing targeted treatments for conditions ranging from

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19:05

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Dive deep into the fascinating world of cytokine receptor families and their crucial role in immune system function. This episode explores how these molecular messengers orchestrate everything from inflammation to infection response, breaking down the three main receptor families - Type I, Type II, and TNF receptors. Learn how these specialized "teams" work together in a precisely choreographed cellular dance, and discover how their dysfunction can lead to various diseases. From T-cell activation to

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26:17

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Explore the fascinating world of cell signaling as we delve into microdomains, thyroid hormone receptors, and the TGF beta/BMP pathways. This episode unravels how these complex cellular communication systems work like neighborhoods within cells, their roles in diseases like fibrosis and cancer, and their promising potential in regenerative medicine. Join us for an enlightening discussion about the delicate balance of cellular signaling and its implications for future therapeutic approaches.

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25:58

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Dive deep into the fascinating world of SMAD-independent pathways and discover how alternative routes like MAPK and Rho reshape our understanding of TGF-beta signaling. This episode explores the intricate dance of cellular communication, from localized signaling in heart muscle cells to the versatile roles of thyroid hormone receptors. Learn how these pathways work together or compete to control vital cellular processes, and how this knowledge could lead to more targeted therapeutic approaches.

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19:50

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Dive deep into the fascinating world of BMP receptors and their crucial role in development and regeneration. Join us as we explore how these molecular "antennas" orchestrate everything from embryonic development to bone healing, and discover their groundbreaking applications in tissue engineering and medical treatments. Learn how these tiny cellular receptors act as control panels, directing cell fate and tissue formation through complex signaling pathways. From spinal fusion surgeries to potential

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11:30

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Join us for a fascinating exploration of TGF-beta receptor signaling, where we break down the intricate cellular dance that determines cell fate. Discover how these molecular gatekeepers work together with their partners to control cell growth and death, and learn about the consequences when these precise systems go awry. From cancer to fibrosis, understand how tiny changes in these pathways can have profound effects on human health, and glimpse into the future of potential therapeutic

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28:01

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Dive deep into the fascinating world of the TGF-beta superfamily, the tiny but mighty proteins that act as cellular puppet masters shaping tissue growth and maintaining bodily balance. This episode explores how these essential signaling molecules control everything from cell growth and development to immune responses, functioning like a precisely tuned system of brakes and accelerators. Learn how these remarkable proteins communicate between cells and maintain the delicate harmony of life itself,

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11:01

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

In this fascinating episode, explore the cutting-edge world of receptor tyrosine kinase (RTK) therapeutics and their crucial role in fighting cancer. Learn about two major drug categories - tyrosine kinase inhibitors (TKIs) and monoclonal antibodies (mAbs) - and how they precisely target cancer cells. The episode delves into the challenges of drug resistance and exciting new approaches like bispecific antibodies and antibody-drug conjugates (ADCs). Using the remarkable case study of BCR-ABL

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23:03

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

In this fascinating episode of the ALPHA podcast series, dive into the complex world of receptor tyrosine kinases (RTKs) and their role in cancer development. Through engaging dialogue and accessible analogies, learn how these cellular "antennas" can malfunction in three key ways - mutations, overexpression, and fusion proteins - leading to uncontrolled cell growth. The episode explores how targeted therapies like monoclonal antibodies work to combat these rogue RTKs, while also discussing emerging

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252 results

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