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PODCAST

Oncology Brothers: Practice-Changing Cancer Discussions

Oncology Brothers

On a mission to disseminate information to the community and bridge the gap between academia and community oncology in this rapidly changing field of hematology & oncology. Drs. Rahul & Rohit Gosain interview world-renowned hematologists/oncologists to present the practice-changing data in a small bite-sized format where one could immediately apply that information in their daily practice to provide the best cancer care to their patients close to home. Privacy Policy:

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All Episodes

00:11:36

FDA Approval of Telisotuzumab (Teliso-V) in c-MET...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/06/27

Welcome to another episode of the Oncology Brothers podcast! In this episode, Drs. Rahul and Rohit Gosain are joined by Dr. Ross Camidge, a leading thoracic medical oncologist from the University of Colorado, to discuss the recent approval of telisotuzumab-vedotin (Teliso-V) for metastatic non-small cell lung cancer (NSCLC) with C-met overexpression, based on the LUMINOSITY trial.Join us as we explore:• The mechanism of action of telisotuzumab and its role as an antibody-drug conjugate.• The

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00:22:28

ASCO 2025 - Breast Cancer Highlights: INAVO120,...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/06/20

Welcome to the Oncology Brothers podcast! In this episode, Drs. Rahul and Rohit Gosain are joined by Dr. Erika Hamilton from the Sarah Cannon Research Institute to discuss the latest breakthroughs in breast cancer presented at the ASCO 2025 annual meeting.We dived into five key abstracts that could change the landscape of breast cancer treatment:1.⁠ INAVO120: observed overall survival data with the combination of inavolisib, with palbociclib and fulvestrant for patients with PIK3CA mutated hormone

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00:23:58

ASCO 2025 - GI Cancer Highlights: DYNAMIC III,...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/06/14

Welcome to another episode of the Oncology Brothers podcast! In this episode, Drs. Rahul and Rohit Gosain are joined by Dr. Cathy Eng, a renowned GI medical oncologist from the Vanderbilt Ingram Cancer Center, to discuss the most impactful updates from the ASCO 2025 annual meeting, specifically focusing on gastrointestinal (GI) malignancies.Join us as we dive into five pivotal abstracts that are set to change the landscape of GI cancer treatment:1.⁠ ⁠DYNAMIC III: Discover how ctDNA-guided adjuvant

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00:26:00

ASCO 2025 Lung Cancer Highlights: CheckMate 816, ToD,...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/06/07

Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Stephen Liu from Georgetown Lombardi Comprehensive Cancer Center to discuss the latest and most impactful findings from the ASCO 2025 meeting, focusing on lung cancer.Join us as we dive into five key studies that could change clinical practice:1. CheckMate 816: Discover the significant overall survival benefits of neoadjuvant chemotherapy combined with nivolumab in resectable non-small cell

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00:14:02

Nivolumab plus Ipilimumab in...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/05/26

In this episode of the Oncology Brothers podcast, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Nicholas Hornstein, a GI medical oncologist from Northwell Health, to discuss the recent FDA approval of nivolumab and ipilimumab for metastatic colorectal cancer with MSI-high or MMR-deficient disease, based on the CheckMate 8HW study.YouTube: https://youtu.be/wJRlECiY2VAJoin us as we delve into:•⁠ ⁠The significance of MSI-high status in colorectal cancer and its prevalence.•⁠ ⁠The study design and

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00:23:33

Managing Toxicities of EGFR Inhibitors: Afatinib,...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/05/21

Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Gilberto Lopes, a thoracic medical oncologist from the Sylvester Cancer Center. Together, they dived into the latest updates on anti-EGFR drugs used in non-small cell lung cancer (NSCLC) with EGFR mutations.In this informative discussion, they covered:•⁠ ⁠The evolution of EGFR inhibitors, including Afatinib, Osimertinib, Amivantamab, and Lazertinib.•⁠ ⁠Common side effects associated with

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00:23:19

How to treat Small Cell Lung Cancer in 2025

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/05/19

Join us in this episode of the Oncology Brothers podcast as we dive deep into the rapidly evolving treatment landscape for small-cell lung cancer. Hosted by community oncologists Drs. Rahul and Rohit Gosain, we are thrilled to welcome Dr. Ticiana Leal, a thoracic medical oncologist from the Winship Cancer Institute - Emory University.In this episode, we covered:•⁠ Current treatment paradigm of small cell lung cancer, in localized setting and extensive stage.•⁠ ⁠We covered the recent approval of

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00:21:47

Treatment of Metastatic Non-Small Cell Lung Cancer...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/05/15

Join us in this episode of the Oncology Brothers podcast as we dive deep into the rapidly evolving treatment landscape for metastatic non-small cell lung cancer (NSCLC) with actionable mutations in frontline therapy. Hosted by community oncologists Drs. Rahul and Rohit Gosain, we are thrilled to welcome Dr. Susan Scott, a thoracic medical oncologist from the Johns Hopkins Hospital.In this episode, we covered:•⁠ ⁠Common EGFR mutations and the latest treatment options, including osimertinib,

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00:21:05

How to Treat Metastatic Non-Small Cell Lung Cancer...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/05/12

Welcome to the Oncology Brothers podcast! In this episode, Drs. Rahul and Rohit Gosain are joined by Dr. Mark Awad, a world-renowned thoracic medical oncologist from Memorial Sloan Kettering. Together, they dived deep into the treatment landscape for metastatic non-small cell lung cancer (NSCLC) without actionable mutations in frontline settings.Episode Highlights:•⁠ ⁠The importance of next-generation sequencing (NGS) and PD-L1 levels in treatment decision-making.•⁠ ⁠Current treatment options for

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00:15:05

Managing Side Effects of HER2 Targeted Therapy -...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/05/08

In this episode of the Oncology Brothers podcast, Drs. Rahul & Rohit Gosain wrap up their three-part CME series on HER2-positive biliary tract cancer. Joined by Dr. Rachna Shroff, they delved into the critical topic of managing adverse events associated with treatments like TDXD and Zanidatamab.The discussion covered:•⁠ ⁠Overview of the treatment landscape for biliary tract cancer•⁠ ⁠Common side effects of TDXD, including interstitial lung disease, nausea, and fatigue•⁠ ⁠Management strategies

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00:21:58

Perioperative Durvalumab FDA Approval New Standard...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/05/05

Welcome to another episode of the Oncology Brothers podcast! In this episode, we dived into the recent FDA approval of Durvalumab combined with chemotherapy for resectable muscle-invasive bladder cancer, based on the NIAGARA trial.Join us as we chat with Dr. Thomas Powles, a GU medical oncologist and the lead author of the NIAGARA trial. We discussed the study design, the significant improvements in overall survival, and the implications of this new treatment approach. Dr. Powles shared insights on

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00:18:29

Treatment Options for HER2 Positive Biliary Tract...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/05/01

Welcome to another episode of the Oncology Brothers podcast! In this episode, Drs. Rohit and Rahul Gosain, both practicing community medical oncologists, continue their discussion on HER2-positive biliary tract cancer. They are joined by Dr. Shubham Pant from MD Anderson, who shares his expertise on this rapidly evolving field.In this episode, we cover:•⁠ ⁠The importance of HER2 testing in biliary tract cancers, including intrahepatic and extrahepatic cholangiocarcinomas and gallbladder cancers.•⁠

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00:18:36

The HER2 Diagnostic and Treatment Landscape in NSCLC

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/04/29

This is the second episode of a two-part series on the HER2 diagnostic and treatment landscape in non-small cell lung cancer (NSCLC), hosted by the Oncology Brothers, Drs Rohit and Rahul Gosain. In this episode, Dr Isabel Preeshagul and Dr Eric Singhi provide the benefit of their experience when discussing how to approach different treatment scenarios in HER2-mutant NSCLC. The conversation unfolds to cover:• Ways to distinguish HER2 alterations from other alterations on biomarker reports • The

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00:18:23

Overview of Biliary Tract Cancer & Importance of...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/04/24

Welcome to the Oncology Brothers podcast! In this episode, Drs. Rohit and Rahul Gosain are joined by Dr. Ghassan Abou-Alfa, a medical oncologist specializing in the hepatobiliary space at Memorial Sloan Kettering. Together, they explored the current treatment landscape of biliary tract cancer, focusing on the advancements in HER2-driven therapies.Key topics discussed included:• The evolution of treatment options for biliary tract cancer, including chemotherapy and immunotherapy.• The significance of

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00:21:25

What does it mean to be HER2 Positive in Lung Cancer

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/04/21

Join us for an insightful episode of the Oncology Brothers podcast as we dive into the fast-evolving landscape of HER2-positive non-small cell lung cancer (NSCLC). In this first part of the two-part series, Drs. Rahul and Rohit Gosain were joined by Dr. Devika Das, a thoracic medical oncologist, and Dr. Fernando Lopez-Rios, a pathologist, to discuss the critical importance of testing and identifying HER2 alterations in lung cancer patients.In this episode, we covered:•⁠ ⁠The significance of HER2

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00:19:24

European Lung Cancer Conference (ELCC) 2025...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/04/14

Welcome back to the Oncology Brothers podcast! In this episode, Drs. Rahul and Rohit Gosain are joined by Dr. Joshua Sabari, a thoracic medical oncologist from NYU, to discuss the latest findings from the European Lung Cancer Conference (ELCC) 2025.We dived into several key studies that are shaping the future of lung cancer treatment, including:• KEYNOTE-799: Exploring the combination of concurrent chemotherapy and radiation with the PD-1 inhibitor pembrolizumab for unresectable non-small cell lung

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00:19:14

FDA Approval of Cabozantinib - CABINET in pNET and epNET

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/04/10

Welcome to another episode of the Oncology Brothers podcast! In this episode, Drs. Rohit and Rahul Gosain are joined by Dr. Aman Chauhan, a medical oncologist specializing in neuroendocrine tumors from Sylvester Comprehensive Cancer Center in Miami.As of April 2025, the oncology landscape has seen 10 new FDA approvals, including the recent approval of cabozantinib for neuroendocrine tumors based on the CABINET study. The discussion dived deep into the implications of this approval, the study design,

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00:24:06

How to Manage & Treat Pancreatic Cancer

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/04/07

Join us in this insightful episode of the Oncology Brothers podcast as we dive deep into the current treatment landscape of pancreatic cancer. Drs. Rohit and Rahul Gosain are joined by Dr. Emil Lou, a medical and neuro-oncologist from the University of Minnesota, to discuss the challenges and advancements in managing this complex disease.YouTube: https://youtu.be/HCKQxmOqRTIIn this episode, we covered:•⁠ ⁠The importance of a multidisciplinary approach in treating early-stage pancreatic cancer.•⁠

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00:21:01

How to Treat Upper Gastrointestinal Cancers in 2025 -...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/03/31

Welcome to another episode of the Oncology Brothers! In this episode, Drs. Rahul and Rohit Gosain are joined by their brother, Dr. Timothy Brown from UT Southwestern, to discuss the latest treatment paradigms for upper gastrointestinal (GI) malignancies, specifically focusing on esophageal and gastroesophageal junction adenocarcinoma, as well as gastric cancer.Episode Highlights:•⁠ ⁠Early Disease Management: perioperative FLOT versus concurrent chemoradiation.•⁠ ⁠Adjuvant Nivolumab: Insights from

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00:19:55

ToxCheck: Managing Side Effects of Pancreatic...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/03/27

Welcome to another episode of the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain continue their ToxCheck series, focusing on the management of side effects associated with treatments for pancreatic cancer.Join us as we dive deep into the use of key drugs such as 5-FU, oxaliplatin, irinotecan, liposomal irinotecan, and the combination of gemcitabine and nab-paclitaxel. We are joined by esteemed guests Dr. Rachna Shroff from the University of Arizona and Dr. Midhun Malla

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