PODCAST

Ground Truths

Eric Topol

Facts, data, and analytics about biomedical matters. erictopol.substack.com

science life sciences

All Episodes

41:00

Faisal Mahmood: A.I.'s Transformation of Pathology

Ground Truths ·

2024/07/28

Full videos of all Ground Truths podcasts can be seen on YouTube here. The audios are also available on Apple and Spotify.Thank you for reading Ground Truths. This post is public so feel free to share it.Transcript with audio and external linksEric Topol (00:05):Hello, it's Eric Topol with Ground Truths, and I am really thrilled to have with me Professor Faisal Mahmood, who is lighting it up in the field of pathology with AI. He is on the faculty at Harvard Medical School, also a pathologist at Mass

48:18

Euan Ashley: Exercise may be the single most potent...

Ground Truths ·

2024/07/05

Recently, a series of papers were published in Nature and Nature journals illuminating the physiologic effects of exercise from an NIH initiative called MoTrPAC. To understand the wealth of new findings, I spoke with Professor Euan Ashley, who, along with Matt Wheeler, heads up the bioinformatics center.Earlier this week, Stanford announced Evan Ashley will be the new Chair of the Department of Medicine. He has done groundbreaking work in human genomics, including rapid whole genome sequencing for

45:19

Christopher Labos: Debunking Myths About What We Eat...

Ground Truths ·

2024/06/26

A book that reads like a novel; it’s humorous, it’s a love story. Dr. Christopher Labos, an imaginative cardiologist and epidemiologist at McGill University, takes us through multiple longstanding misconceptions about different foods and drinks, and along the way provides outstanding educational value.Video snippet from our conversation. Full videos of all Ground Truths podcasts can be seen on YouTube here. The audios are also available on Apple and Spotify.Transcript with external links and links

55:38

Charlie Swanton: A Master Class on Cancer

Ground Truths ·

2024/06/14

The most enthralling conversation I’ve ever had with anyone on cancer. It’s with Charlie Swanton who is a senior group leader at the Francis Crick Institute, the Royal Society Napier Professor in Cancer and medical oncologist at University College London, co-director of Cancer Research UK.Video snippet from our conversation. Full videos of all Ground Truths podcasts can be seen on YouTube here. The audios are also available on Apple and Spotify.Transcript with audio links and many external linksEric

49:04

Tom Cech: RNA Takes Center Stage

Ground Truths ·

2024/06/05

In this podcast, Thomas Czech, Distinguished Professor at the University of Colorado, Boulder, with a lineage of remarkable contributions on RNA, ribozyme, and telomeres, discuss why RNA is so incredibly versatile.Video snippet from our conversation. Full videos of all Ground Truths podcasts can be seen on YouTube here. The audios are also available on Apple and Spotify.Transcript with links to the audio and external linksEric Topol (00:07):Well, hello, this is Eric Topol from Ground Truths, and

49:54

Venki Ramakrishnan: The New Science of Aging

Ground Truths ·

2024/05/28

Professor Venki Ramakrishnan, a Nobel laureate for his work on unraveling the structure of function of the ribosome, has written a new book WHY WE DIE which is outstanding. Among many posts and recognitions for his extraordinary work in molecular biology, Venki has been President of the Royal Society, knighted in 2012, and was made a Member of the Order of Merit in 2022. He is a group leader at the MRC Laboratory of Molecular Biology research institute in Cambridge, UK.A brief video snippet of our

53:11

Svetlana Blitshteyn: On the Front Line With Long...

Ground Truths ·

2024/05/20

After finishing her training in neurology at Mayo Clinic, Dr. Svetlana Blitshteyn started a Dysautonomia Clinic in 2009. Little did she know what was in store many years later when Covid hit!Ground Truths podcasts are on Apple and Spotify. The video interviews are on YouTubeTranscript with audio and external linksEric Topol (00:07):Well, hello, it's Eric Topol from Ground Truths, and I have with me a really great authority on dysautonomia and POTS. We will get into what that is for those who aren't

51:06

Kate Crawford: A Leading Scholar and Conscience for A.I.

Ground Truths ·

2024/05/12

“We haven't invested this much money into an infrastructure like this really until you go back to the pyramids”—Kate CrawfordTranscript with links to audio and external links. Ground Truths podcasts are on Apple and Spotify. The video interviews are on YouTube Eric Topol (00:06):Well, hello, this is Eric Topol with Ground Truths, and I'm really delighted today to welcome Kate Crawford, who we're very lucky to have as an Australian here in the United States. And she's multidimensional, as I've

41:48

Akiko Iwasaki: The Immunology of Covid and the Future

Ground Truths ·

2024/05/04

If there’s one person you’d want to talk to about immunology, the immune system and Covid, holes in our knowledge base about the complex immune system, and where the field is headed, it would be Professor Iwasaki. And add to that the topic of Women in Science. Here’s our wide-ranging conversation.A snippet of the video, Full length Ground Truths videos are posted here and you can subscribe. Ground Truths is a reader-supported publication. To receive new posts and support my work, consider becoming a

36:24

Aviv Regev: The Revolution in Digital Biology

Ground Truths ·

2024/04/28

“Where do I think the next amazing revolution is going to come? … There’s no question that digital biology is going to be it. For the very first time in our history, in human history, biology has the opportunity to be engineering, not science.” —Jensen Huang, NVIDIA CEOAviv Regev is one of the leading life scientists of our time. In this conversation, we cover the ongoing revolution in digital biology that has been enabled by new deep knowledge on cells, proteins and genes, and the use of generative

31:10

Jennifer Doudna: The Exciting Future of Genome Editing

Ground Truths ·

2024/04/14

Professor Doudna was awarded the 2020 Nobel Prize in Chemistry with Professor Emmanuelle Charpentier for their pioneering work in CRISPR genome editing. The first genome editing therapy (Casgevy) was just FDA approved, only a decade after the CRISPR-Cas9 editing system discovery. But It’s just the beginning of a much bigger impact story for medicine and life science.Ground Truths podcasts are now on Apple and Spotify. And if you prefer videos, they are posted on YouTubeTranscript with links to audio

36:30

Daniel Drucker: Illuminating the GLP-1 Drug's Break Out

Ground Truths ·

2024/04/06

Note: This podcast is a companion to the Ground Truths newsletter “A Big Week for GLP-1 Drugs”Eric Topol (00:06):It is Eric Topol with Ground Truths, and with me today is Dr. Daniel Drucker from the University of Toronto, who is one of the leading endocrinologists in the world, and he along with Joel Habener and Jens Juul Holst from the University of Copenhagen and Denmark, have been credited with numerous prizes of their discovery work of glucagon-like peptide-1 (GLP-1) as we get to know these

47:27

Sid Mukherjee: On A.I., Longevity and Being A Digital...

Ground Truths ·

2024/03/29

Siddhartha Mukherjee is a Professor at Columbia University, oncologist, and extraordinary author of Emperor of All Maladies (which was awarded a Pulitzer Prize), The Gene, and The Song of the Cell, along with outstanding pieces in the New Yorker. He is one of the top thought leaders in medicine of our era. “I have begun to imagine, think about what it would be to be a digital human..”—Sid MukherjeeEric Topol (00:06):Well, hello, this is Eric Topol with Ground Truths, and I am delighted to have my

60:37

Holden Thorp: Straight Talk from the Editor-in-Chief...

Ground Truths ·

2024/03/17

There was so much to talk about—this is the longest Ground Truths podcast yet. Hope you’ll find it as thought-provoking as I did!Transcript, with audio and external links, edited by Jessica Nguyen, Producer for Ground TruthsVideo and audio tech support by Sinjun Balabanoff, Scripps ResearchEric Topol (00:00:05):This is Eric Topol from Ground Truths, and I am delighted to have with me Holden Thorp, who is the Editor-in-Chief of the Science journals. We're going to talk about Science, not just the

35:16

Daphne Koller: The Convergence of A.I. and Digital...

Ground Truths ·

2024/03/10

Transcript Eric Topol (00:06):Well, hello, this is Eric Topol with Ground Truths and I am absolutely thrilled to welcome Daphne Koller, the founder and CEO of insitro, and a person who I've been wanting to meet for some time. Finally, we converged so welcome, Daphne.Daphne Koller (00:21):Thank you Eric. And it's a pleasure to finally meet you as well.Eric Topol (00:24):Yeah, I mean you have been rocking everybody over the years with elected to the National Academy of Engineering and Science and

44:30

Coleen Murphy: The Science of Aging and Longevity

Ground Truths ·

2024/03/03

“A few years ago, I might have chuckled at the naiveté of this question, but now it's not so crazy to think that we will be able to take some sort of medicine to extend our healthy lifespans in the foreseeable future.”—Coleen MurphyTranscript with external linksEric Topol (00:06):Hello, this is Eric Topol from Ground Truths, and I'm just so delighted to have with me Professor Coleen Murphy, who has written this exceptional book, How We Age: The Science of Longevity. It is a phenomenal book and I'm

43:57

Michelle Monje: The Brain in Long Covid and Cancer

Ground Truths ·

2024/02/25

Transcript with audio and relevant external links, recorded on 6 Feb 2024Eric Topol (00:05):Hello, this is Eric Topol with Ground Truths, and I have a remarkable guest with me today, Professor Michelle Monje, who is from Stanford, a physician-scientist there and is really a leader in neuro-oncology, the big field of cancer neuroscience, neuroinflammation, and she has just been rocking it recently with major papers on these fields, no less her work that's been on a particular cancer, brain cancer in

28:52

Jim Collins: Discovery of the First New Structural...

Ground Truths ·

2024/02/13

Jim Collins is one of the leading biomedical engineers in the world. He’s been elected to all 3 National Academies (Engineering, Science, and Medicine) and is one of the founders of the field of synthetic biology. In this conversation, we reviewed the seminal discoveries that he and his colleagues are making at the Antibiotics-AI Project at MIT.Recorded 5 February 2024, transcript below with audio links and external links to recent publicationsEric Topol (00:05):Hello, it's Eric Topol with Ground

54:24

Katalin Karikó: The unimaginable, obstacle-laden,...

Ground Truths ·

2024/02/02

“The history of science, it turns out, is filled with stories of very smart people laughing at good ideas.”—Katalin Karikó Ground Truths podcasts are now available on Apple and Spotify!The list of obstacles that Kati Karikó faced to become a scientist, to make any meaningful discovery, to prevail over certain scientists and administrators who oppressed her, unable to obtain grants, her seminal paper rejected by all of the top-tier journals, demoted and dismissed, but

43:21

Jonathan Howard, author of We Want Them Infected

Ground Truths ·

2024/01/25

Jonathan Howard is a neurologist and psychiatrist who practices at NYU-Bellevue and posts frequently on Science Based Medicine.Transcript, unedited, with links to audioEric Topol (00:05):Well, hello, Eric Topol with Ground Truths and I'm really pleased to have the chance to talk with Jonathan Howard today, who is a neurologist and psychiatrist at NYU at Bellevue and has written quite an amazing book published a few months months ago called We Want Them Infected, so welcome Jonathan.Jonathan Howard

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