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PODCAST

The Optispan Podcast with Matt Kaeberlein

Optispan is a vision for what health should be. The typical person gives up 10-20 years of quality life in exchange for disability, frailty, and early death. We call this "the lost decade". Time that should be spent with loved ones doing the activities you enjoy are instead spent suffering from multiple diseases and taking a cabinet full of medications that probably do as much harm as good. We believe that the current practice of medicine is disease care, not health care. We believe that

science

All Episodes

01:00:50

Crypto-Powered Science: How Blockchain & DAOs Are...

The Optispan Podcast with Matt Kaeberlein ·

2025/02/06

Subscribe to our channel: https://www.youtube.com/@optispanIn this video I sit down with the COO of Molecule AG, Benji Leibowitz, to discuss how blockchain and cryptocurrency can be applied to intellectual property (IP) in biotech research, particularly in funding longevity studies. The discussion covers concepts like DAOs (Decentralized Autonomous Organizations), tokenized intellectual property, and how this model might revolutionize scientific collaboration and fundraising. 0:00 What is

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01:17:45

Peter Attia: Training, Eating & Optimizing To Live...

The Optispan Podcast with Matt Kaeberlein ·

2025/01/23

Subscribe to our channel: https://www.youtube.com/@optispanIn this video I sit down with Dr. Peter Attia to explore strategies for improving healthspan and lifespan, focusing on practical interventions like exercise, nutrition, and emerging therapies. Topics we discuss include defining healthspan (physical, cognitive, and emotional health), the benefits of purposeful exercise, and prioritizing dietary factors (what, when, and how much to eat). Our discussion also addresses nuanced views on

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00:21:46

These Supplements Help Dogs Live Longer?

The Optispan Podcast with Matt Kaeberlein ·

2025/01/16

Subscribe to our channel: https://www.youtube.com/@optispanIn this video of Longevity this Week, Matt, Nick, and Mitchell sit down to discuss longevity supplements for pets, scientific evidence backing them, supplement industry ethics, and broader implications in the longevity field. 0:00 - Introduction to Longevity Supplements for Pets 0:16 - Supplement Ingredients 1:30 - Evaluating Scientific Evidence 4:18 - Ethical Concerns in the Supplement Industry 7:20 - Potential Risks of Unproven

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00:26:22

Aging "Hotspot" Found in Brain? Hypochondriacs Don't...

The Optispan Podcast with Matt Kaeberlein ·

2025/01/14

Subscribe to our channel: https://www.youtube.com/@optispanWe explore the psychological and health implications of hypochondriasis, especially in the context of biological age testing and wearables. We then delve into how anxiety and fixation on health metrics can influence behavior and potentially exacerbate health risks. This discussion transitions to a groundbreaking study on brain aging from the Allen Institute, highlighting insights from single-cell transcriptomics, particularly inflammation

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00:38:31

Correcting the Record on Past Videos: Biological Age...

The Optispan Podcast with Matt Kaeberlein ·

2025/01/09

Subscribe to our channel: https://www.youtube.com/@optispanMatt & Nick cover past episode fixes, address audience comments, and share updates about the channel and what you can expect to see from the channel moving forward into the New Year. 00:00 Intro & Setting New Years Goals 07:34 Full body MRI's 11:55 DrugAge Database 1:17:22 Biological Age Tests 1:29:38 Matt Talking Too Much? 1:32:17 Podcast Guests 1:35:08 Scott Carney Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob

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01:38:48

LIVE AMA: Longevity Scientists Answer Your Health &...

The Optispan Podcast with Matt Kaeberlein ·

2025/01/02

Subscribe to our channel: https://www.youtube.com/@optispanIn this episode, Matt and Brian Kennedy delve into the potential benefits and side effects of interventions like Rapamycin, the role of biomarkers, and optimal approaches to enhancing healthspan and cognitive function. Together they highlight the challenges of supplement use, aging research methodologies, and regulatory hurdles like the FDA’s stance on aging. They address emerging ideas such as leveraging AI for aging research, the

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00:46:08

My Review of Peter Attia’s AMA: What I Agree &...

The Optispan Podcast with Matt Kaeberlein ·

2025/01/02

Subscribe to our channel: https://www.youtube.com/@optispan In this episode, Matt shares his thoughts on Peter Attia's AMA , exploring areas of agreement and differing perspectives on health and longevity. Topics include the significance of grip strength, biomarkers for health assessment, exercise strategies while traveling, and advancements in longevity research like Klotho and GLP-1 agonists. Matt also discusses the role of AI in healthcare and addresses concerns about direct-to-consumer

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01:16:01

Longevity Scientists Answer 30 MORE of Your Health &...

The Optispan Podcast with Matt Kaeberlein ·

2024/12/24

Subscribe to our channel: https://www.youtube.com/@optispanIn this Q&A, Matt and Brian Kennedy cover a range of topics on caloric restriction, lifespan studies, interventions like rapamycin, and the importance of control groups in research. They critique the validity of certain longevity claims, discusses the complexities of aging mechanisms, and questions the effectiveness of supplements. The conversation also touches on dietary impacts, the role of exercise, and the significance of

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01:27:55

MEGA Q&A: We Answer 30 of Your Health & Longevity...

The Optispan Podcast with Matt Kaeberlein ·

2024/12/19

Subscribe to our channel: https://www.youtube.com/@optispan In this Part 1 episode, Matt and Brian Kennedy cover various aspects of aging research, including the connection between the immune system and aging, the role of inflammation, the potential of supplements and wearables in healthspan, and insights on longevity interventions. They also discuss the challenges in the field regarding clinical practices, the influence of AI on aging research, and personal experiences with health

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00:29:29

I Got a Full Body MRI: IS IT WORTH IT? I Share My...

The Optispan Podcast with Matt Kaeberlein ·

2024/12/17

Subscribe to our channel: https://www.youtube.com/@optispanIn this episode of the Optispan Podcast, Matt Kaeberlein shares his experience of undergoing a whole body MRI, discussing its potential as a screening and preventative tool for health optimization. He covers the benefits and drawbacks of whole body MRIs, shares specific details about his experience with the provider Ezra, and reflects on his results, emphasizing the importance of having quality follow-up care. Kaeberlein concludes with

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00:46:57

Understanding Women's Hormonal Health, Hormonal...

The Optispan Podcast with Matt Kaeberlein ·

2024/12/12

In the final installment of this three-part series, Matt and Kim Celmer explore the essential topic of hormonal health for women, highlighting its impact on both overt and silent symptoms of hormonal changes. Celmer offers practical advice for initiating meaningful conversations with healthcare providers about hormone levels with both diving into the intricacies of hormone replacement therapy (HRT)—what it is, how it works, and its potential benefits and risks. Addressing public concerns, they

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00:14:47

Longevity Scientist On Ethan Klein's "Revolutionary...

The Optispan Podcast with Matt Kaeberlein ·

2024/12/10

Subscribe to our channel: https://www.youtube.com/@optispanMatt Kaeberlein & Nick Arapis discuss the potential of new drugs aimed at extending the lifespan of dogs and cats. The conversation highlights recent advancements, including Loyal’s injection-based treatment targeting the IGF-1 hormone, which may add years to a dog’s life. They also address misconceptions regarding claims about cat lifespan extensions, emphasizing the lack of scientific backing for such assertions. The episode

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00:50:48

Epigenetic & Glycan Age Tests Results: Are Biological...

The Optispan Podcast with Matt Kaeberlein ·

2024/12/05

Subscribe to our channel: https://www.youtube.com/@optispanIn this episode of the Optisan Podcast, Dr. George Sutphin discusses biological age tests, focusing on epigenetic and glycan age assessments. The conversation explores the accuracy, relevance, and implications of these tests for understanding biological versus chronological age. Key topics include the limitations of current biomarkers, the impact of lifestyle on aging metrics, and the challenges of interpreting results. The discussion

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01:07:49

Cold Plunge & Brown Fat, Different Types of Stress,...

The Optispan Podcast with Matt Kaeberlein ·

2024/12/03

Subscribe to our channel: https://www.youtube.com/@optispan In this episode with our guest Dr. Thomas Seager, we delve into the transformative power of cold plunge therapy and its profound effects on resilience and longevity. We explore real-life case studies, including lessons learned from infrastructure failures like Hurricane Katrina and the Oroville Dam crisis. Discover how psychological resilience shapes our responses to stress, the importance of hormesis in health, and the role of brown fat

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00:40:03

Bryan Johnson Stopped Taking THIS & It DOESN'T Make...

The Optispan Podcast with Matt Kaeberlein ·

2024/11/28

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01:00:28

Doctor of Naturopathy: Microbiome & SIBO,...

The Optispan Podcast with Matt Kaeberlein ·

2024/11/26

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00:37:49

I Took 4 Different Biological Age Tests & Compared...

The Optispan Podcast with Matt Kaeberlein ·

2024/11/21

Subscribe to our channel: https://www.youtube.com/@optispanRelated Episode(s):Biological Age & what it REALLY means | 9 - Longevity Science #3: https://youtu.be/DcxgEwQKx8Q?si=y1iF4RviJc0n__gW In this deep dive, Matt examines the growing trend of direct-to-consumer biological (epigenetic) age testing kits, exploring their purpose, popularity, and limitations. He outlines his experimental design to evaluate the accuracy and precision of these tests, addressing important questions about what

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00:46:35

Dr Seager: Rethinking Health for Longevity | 81

The Optispan Podcast with Matt Kaeberlein ·

2024/11/19

Subscribe to our channel: https://www.youtube.com/@optispanIn this episode, Matt sits down with Thomas Seager, an associate professor at Arizona State University (ASU), to explore the challenges and future directions of healthcare. Drawing from his background in environmental engineering and public health, Thomas discusses the pressing health issues affecting longevity in Americans and a potential shift from a reactive healthcare model to one that emphasizes proactive health management. Together,

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00:49:12

Death, Grief, & Purpose from a Longevity Science...

The Optispan Podcast with Matt Kaeberlein ·

2024/11/14

Subscribe to our channel: https://www.youtube.com/@optispan Grief: one of the most profound emotions humanity shares; a universal experience that transcends time, culture, and place; a phenomenon as ancient as human existence. Grief is as intrinsic to the human experience as joy or hope, and no one escapes it—to grieve is to be human. In this episode, Matt and Nick discuss their recent personal experiences with grief and loss. Matt lost his German Shepherd Dobby to degenerative myelopathy, while

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00:34:45

Nutrition Myths, Gut Fixes, Natural Health Tips from...

The Optispan Podcast with Matt Kaeberlein ·

2024/11/07

Subscribe to our channel: https://www.youtube.com/@optispan Related episode: People are GETTING THIS WRONG about Supplements & My Supplement List: https://www.youtube.com/watch?v=_UXk_ynCNUs In this episode, Matt sits down with naturopathic doctor and primary care provider Kim Celmer to discuss the distinct approach naturopathic doctors (NDs) bring to patient care, addressing common misconceptions about complementary and alternative treatment modalities and explaining how NDs treat prevalent

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144 results

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