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PODCAST

Cell Culture Dish Podcast

The Cell Culture Dish (CCD) podcast covers areas important to the research, discovery, development, and manufacture of disease and biologic therapeutics. Key industry coverage areas include: drug discovery and development, stem cell research, cell and gene therapy, recombinant antibodies, vaccines, and emerging therapeutic modalities.

science life sciences

All Episodes

17:49

Reducing Fill Risk in Drug Product Manufacture...

Cell Culture Dish Podcast ·

2020/09/16

In this podcast we talked with DQ Wang, PhD, and Vice President, Formulation, Fill and Finish of WuXi Biologics about their DP4 multi-product fill & finish facility featuring the Vanrx SA25 robotic, gloveless, isolator-based filling system. The system significantly reduces drug product fill risk and provides greater aseptic assurance.

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10:35

The Challenge of Staying Current with Regulatory...

Cell Culture Dish Podcast ·

2020/09/10

In this podcast, we talked with Ken Chen, MBA, Senior Director, Regulatory Affairs, WuXi Biologics about staying current with regulatory changes. We discussed how WuXi Biologics recently began publishing a quarterly summary of regulatory updates on new or revised guidance documents from the various global regulatory agencies and how this is a valuable resource for anyone in the biological drug development arena.

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26:17

Computer Aided Biology Platform Helps Companies Meet...

Cell Culture Dish Podcast ·

2020/09/08

In this podcast, we interviewed Markus Gershater, Chief Scientific Officer with Synthace about computer-aided biology and how it addresses several common biomanufacturing challenges. We also discussed ways to build a common culture between science and software.

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11:27

Balancing Risk, Cost and Speed During Clinical...

Cell Culture Dish Podcast ·

2020/07/27

In this podcast, we talked with Thierry Cournez Vice President, BioReliance® End-to-End Solutions, MilliporeSigma. We discussed effective ways for emerging biotechs to collect material quickly and cost-effectively for pre-clinical and clinical studies. We also discussed managing the need to move quickly with cost and quality.

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17:05

Solving the challenges of standardizing cell counting...

Cell Culture Dish Podcast ·

2020/07/07

In this podcast we talked with Christian Berg, Global Product Manager at Chemometec about the importance of standardizing cell counting because while often overlooked, it is essential for reproducibility in experiments, assays and manufacturing processes. Cell counting is a challenging technique, with many pitfalls, that can delay entire projects. We discussed how new technologies are solving these challenges and enabling standardization of cell counting across organizations.

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20:12

A Look Towards the Future of 3D Cell Culture – A...

Cell Culture Dish Podcast ·

2020/07/01

This article is the fourth in a series that was published in the eBook “3D Model Systems: Spheroids, Organoids and Tissue Models”. You can download all the articles in the series, by downloading the eBook. Introduction and Overview Debbie King Researchers have used 2D cell culture since the early 1900s, but we know that growing cells on planar surfaces have some drawbacks. Cells grown in vitro in 2D space don’t behave like cells found in vivo. They lack critical cell-cell and cell-matrix

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32:41

Multistem – A Stable, Off-the Shelf Regenerative...

Cell Culture Dish Podcast ·

2020/06/04

In this podcast, we talked with Dr. Gil Van Bokkelen, Chairman and CEO, Athersys about recent clinical breakthroughs in regenerative medicine and manufacturing challenges. We also discussed Multistem and how it has been demonstrated to help patients with ARDS (Acute Respiratory Distress Syndrome).

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32:47

Bi-Specific Antibodies – The development, manufacture...

Cell Culture Dish Podcast ·

2020/05/27

In this podcast, we conducted a panel discussion with experts from Selexis and KBI Biopharma on bi-specific antibodies. We examined bi-specific antibody development and manufacturing, including current challenges and key solutions. We also discussed the promise of these cutting-edge therapeutics and their future in medicine.

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16:48

Rapid At-line Media Analyzer Speeds Process...

Cell Culture Dish Podcast ·

2020/05/14

In this podcast, we talked with Dr. Glenn Harris, Director of Integrated Life Sciences Platforms at 908 Devices, about the benefits and challenges of implementing rapid media analysis in process development, including the bottleneck created by outsourcing samples to core labs. We also discussed an easy to implement, benchtop media analyzer that permits comprehensive media analysis in real-time, thus speeding process development efforts.

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22:10

Non-Animal Origin cell culture supplements and...

Cell Culture Dish Podcast ·

2020/05/11

In this podcast, we talked with Dr. Tobias Hertzig, Regulatory Affairs Manager and Dr. Ulrich Tillmann, Global Product Manager, Supplements and Manufacturing Aids both representing Merck KGaA, Darmstadt, Germany. We discussed non-animal origin cell culture media supplements, including regulatory advantages, performance metrics and their use in biologics manufacturing.

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18:57

Mesenchymal Stem Cell Culture – Challenges and...

Cell Culture Dish Podcast ·

2020/03/25

In this podcast and accompanying article, we talked with Dr. Jennifer Chain, Scientific Director of Research and Development, Oklahoma Blood Institute about isolation of mesenchymal stromal cells from cadaveric bone marrow and the differences between live and cadaveric donors. We also discussed the expansion and maintenance of mesenchymal stromal cells in culture including media design and selection.

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26:37

CryoVault Freeze and Thaw Platform Provides a...

Cell Culture Dish Podcast ·

2020/02/11

In this podcast, I talked with Max Blomberg, Executive Director of Operations and Andrew Govea, Senior Product Engineer, at Meissner about the challenges of handling bulk drug substance, specifically freeze and thaw and how the need for scalability, flexibility and a robust approach led to the development of CryoVault™. CryoVault™ offers a unique and intelligently designed end-to-end freeze and thaw process solution.

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14:37

Generating actionable data and analysis in complex...

Cell Culture Dish Podcast ·

2019/12/12

In this podcast and accompanying article, we talked with Paul Jantzen, Product Manager for IncuCyte at Sartorius about the benefits of real-time live-cell analysis and image processing workflows. We also discussed how live-cell analysis is enabling the use of neuronal cell models to study cell health, morphology, function and cell dynamics.

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8:57

Improved gene therapy analytics permit monitoring of...

Cell Culture Dish Podcast ·

2019/12/11

In this podcast and accompanying article, we interviewed Jonathan Royce, Director, Instruments Business Unit, Vironova about analytics in gene therapy manufacturing. Specifically Jonathan details new technologies to monitor critical quality attributes, reduce development time and increase the number of projects that can be run.

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30:45

New Advancements in Cell and Gene Therapy...

Cell Culture Dish Podcast ·

2019/12/10

In this podcast and accompanying article, we talked with Dr. Paul Wotton, Chief Executive Officer, Obsidian Therapeutics about the evolution of cancer therapy and new advancements in the space including precision medicine. Our discussion included Obsidian's cytoDRiVE™ platform that provides a technology, in which the level and timing of protein activity are fully controlled in a dose-dependent manner by an FDA-approved small molecule.

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11:48

Live Cell Analysis for Neuroscience Research

Cell Culture Dish Podcast ·

2019/10/29

In this podcast, we talk with Susana Alcantara, Senior R&D Scientist and Neuroscience Program Leader, BioAnalytics, Sartorius about the ways real-time live cell analysis is enabling neuroscience research. We also discussed how real-time cell analysis can be used in neurological disease model development and in studying disease pathology to enable drug discovery. Show Notes: I began the interview by asking Susana what she saw as the biggest challenges surrounding neuroscience research as it relates

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16:27

Using 3D cell-based human liver microtissue models in...

Cell Culture Dish Podcast ·

2019/10/13

In this podcast and accompanying article, we interviewed Dr. Shareen Doak, Professor of Genotoxicology and Cancer at Swansea University Medical School and Dr. Wolfgang Moritz, Co-founder and Head of External Collaborations and IP, InSphero about the use of 3D cell-based human liver microtissue models to predict the adverse effects of chronic exposure to nanomaterial. We also discussed the use of liver microtissue models for drug discovery and development.

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17:29

Raw Material Quality – Identifying and Mitigating...

Cell Culture Dish Podcast ·

2019/09/24

In this podcast, we interviewed Cory Card, Principal Scientist Life Sciences, GE Healthcare about raw material quality, its impact on cell culture and technologies to identify and mitigate raw material variation.

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16:56

Antibody Drug Conjugate (ADC) Development and...

Cell Culture Dish Podcast ·

2019/09/09

In this podcast, we interviewed Dr. J.J. Luo, Executive Director and Dr. Lily Yin, Head of Biologics Conjugation Development, at WuXi Biologics about the state of the ADC marketplace and the challenges in developing antibody drug conjugates. We then dove into reasons behind why they built a dedicated manufacturing facility for ADCs and other bioconjugates and how a single-source development platform can benefit bioconjugate drug development efforts.

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14:14

Mustang Bio’s gene therapy has tremendous potential...

Cell Culture Dish Podcast ·

2019/07/31

In this podcast, we interviewed Dr. Manny Litchman, President and CEO, Mustang Bio and Dr. Knut Niss, Chief Technology Officer, Mustang Bio about the exciting study results for their gene therapy candidate to treat X-SCID, why this disease is a good fit for gene therapy and next steps.

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85 results

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