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PODCAST

DDx

DDx is medical shorthand for differential diagnosis, and this is a podcast about how doctors think and learn on the job. It’s hosted by Dr. Raj Bhardwaj and is produced by Figure 1, the global knowledge-sharing platform for medicine.

health & fitness medicine

All Episodes

10:32

Unexpected Therapies for Fibrodysplasia Ossificans...

DDx ·

2024/05/15

A local pool in the summer is teeming with kids. A 9-year-old does a cannonball into the shallow end. As she surfaces, a stab...

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00:10:22

Overcoming the Odds of Prenatal Hypophosphatasia

DDx ·

2024/05/08

In an examination room, an ultrasound technician moves a wand over a patient’s belly. The patient is 20 weeks pregnant. Usually, these appointments bring good news, but the news this day is devastating: the baby’s bones are broken and bowed. Despite this, the baby is born and does well. After testing, all signs point to hypophosphatasia for Dr. Eric Rush, a clinical geneticist at Children’s Mercy Hospital and the University of Kansas Medical Center, and an Associate Professor of Pediatrics at the

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10:22

Overcoming the Odds of Prenatal Hypophosphatasia

DDx ·

2024/05/08

In an examination room, an ultrasound technician moves a wand over a patient’s belly. The patient is 20 weeks pregnant....

en

00:09:49

The Power and Potential of GACI Clinical Trials

DDx ·

2024/05/01

In a bustling maternity ward, an infant has a case of newborn hiccups. But this quickly transforms into labored breathing. A chest X-ray unravels an unexpected discovery – calcium deposits around her shoulder. Follow-up tests paint a complex picture, revealing narrowed blood vessels and widespread calcifications. Genetic testing confirms a grim diagnosis: generalized arterial calcification of infancy, or GACI, a rare genetic condition with a challenging prognosis. Nearly half of infants don't

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9:49

The Power and Potential of GACI Clinical Trials

DDx ·

2024/05/01

In a bustling maternity ward, an infant has a case of newborn hiccups. But this quickly transforms into labored breathing. A...

en

10:35

Biosimilars and the Quiet Revolution in Medicine

DDx ·

2024/04/24

On a December morning, a 62-year-old goes for a walk. There’s snow on the ground and she loses her balance. She falls and...

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00:10:35

Biosimilars and the Quiet Revolution in Medicine

DDx ·

2024/04/24

On a December morning, a 62-year-old goes for a walk. There’s snow on the ground and she loses her balance. She falls and fractures her wrist. This simple fracture reveals underlying osteoporosis, requiring lifelong (and expensive) medication. But as you’ll learn from Dr. Richard Eastell, an endocrinologist and professor of Bone Metabolism at the University of Sheffield, this is where biosimilars come in. Biosimilars are extremely similar — hence the name — to the original biological drug they're

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00:10:40

How One Child Overcame Hemophilia Complications...

DDx ·

2024/04/17

A 5-year-old child and his parents boarded a plane heading for a new life. They were Syrian refugees, who fled conflict in their country and then lived a difficult life in a refugee camp. Now they were heading to Canada. But soon after arriving, there’s a problem. The child has hemophilia and due to hemophilia complications, a minor injury while traveling became a major concern. Add to this a language barrier and trying to understand a new culture. Dr. Robert Klaassen, a pediatric hematologist and

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10:40

How One Child Overcame Hemophilia Complications...

DDx ·

2024/04/17

A 5-year-old child and his parents boarded a plane heading for a new life. They were Syrian refugees, who fled conflict in...

en

9:15

Unraveling How a Hemophilia Diagnosis Went Undetected...

DDx ·

2024/04/10

It was supposed to be a simple, low-risk procedure, but for this 61-year-old patient with undiagnosed hemophilia, undergoing...

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00:09:15

Unraveling How a Hemophilia Diagnosis Went Undetected...

DDx ·

2024/04/10

It was supposed to be a simple, low-risk procedure, but for this 61-year-old patient with undiagnosed hemophilia, undergoing a lithotripsy for kidney stones proved to be anything but. The patient was born in the 1950s in Taiwan, when many people in the country had never heard of the disease. So, despite signs throughout his life, the patient’s hemophilia diagnosis evaded him for decades. Dr. Yeu-Chin Chen, a hematologist at the Tri Service General Hospital's Hemophilia Care and Research Center in

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11:09

To Play or Not to Play, the Challenges of Managing...

DDx ·

2024/04/03

A young child living with severe hemophilia is adopted by a family in the United States. Prior to his adoption, due to a lack...

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00:11:09

To Play or Not to Play, the Challenges of Managing...

DDx ·

2024/04/03

A young child living with severe hemophilia is adopted by a family in the United States. Prior to his adoption, due to a lack of resources and other challenges, his hemophilia was not properly managed. Dr. Meera Chitlur, a pediatric hematologist and the director of the Hemophilia Treatment Center at the Children's Hospital of Michigan in Detroit, has treated this patient since he first came to the U.S. As he grew older, like many children, he wanted to play sports. But for people with hemophilia,

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00:11:04

The History of Hemophilia and Its Evolution Toward...

DDx ·

2024/03/27

About 40 years ago a mother brought her 6-month-old child into the hospital. He was covered in bruises. Dr. Victor Blanchette, a pediatric hematologist at the Hospital for Sick Children in Toronto, Canada, met the patient that day and, following a severe hemophilia diagnosis, has treated the patient ever since. Dr. Blanchette recounts how during the patient’s childhood in the 80s, the approach to treating hemophilia was reactive, not proactive. This meant that normal childhood activities could lead

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11:04

The History of Hemophilia and Its Evolution Toward...

DDx ·

2024/03/27

About 40 years ago a mother brought her 6-month-old child into the hospital. He was covered in bruises. Dr. Victor...

en

00:10:55

Undoing the Long-Held Misunderstandings of Hemophilia...

DDx ·

2024/03/20

A 30-year-old was in labor with her first child. Everything was going to plan … until it wasn’t. Dr. Azusa Nagao, a hematologist at Ogikubo Hospital in Tokyo, Japan, shares a case that illustrates how historically it was thought that women and people assigned female at birth could only be carriers of the disease, not have the disease themselves. This misunderstanding of hemophilia in women has led to women going undiagnosed and untreated with severe repercussions. For the patient in this story, it

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10:55

Undoing the Long-Held Misunderstandings of Hemophilia...

DDx ·

2024/03/20

A 30-year-old was in labor with her first child. Everything was going to plan … until it wasn’t. Dr. Azusa Nagao, a...

en

00:13:09

The Ups and Downs of Hemophilia Treatment

DDx ·

2024/03/13

A patient was experiencing severe knee pain. Unfortunately, this wasn't anything new. For decades, he’d been suffering from joint disease, caused by severe bleeding in his knees from a rare blood disorder — hemophilia A. The patient was born in the 1960s, a time when the life expectancy for patients with hemophilia was only 10 years. But as Dr. Annette Von Drygalski, a board certified hematologist and the director of the Hemophilia and Thrombosis Treatment Centre at the University of California, San

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1:20

Go Inside the Minds of Doctors Who Specialize in...

DDx ·

2024/03/08

Go inside the minds of doctors who specialize in hemophilia — a rare, inherited bleeding disorder that once meant possibly...

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00:01:20

Go Inside the Minds of Doctors Who Specialize in...

DDx ·

2024/03/08

Go inside the minds of doctors who specialize in hemophilia — a rare, inherited bleeding disorder that once meant possibly not surviving past the age of 20. This season, we’ll explore the medical milestones that enable patients today to live longer, richer lives and examine the challenges yet to be tackled.

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153 results

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