PODCAST

Investigating Breast Cancer

BCRF

Official podcast of the Breast Cancer Research Foundation

science & medicine medicine

All Episodes

32:38

Closing the Gap in Breast Cancer Care with Dr....

Investigating Breast Cancer ·

2020/08/05

Research shows that when chemotherapy is delayed, a patient’s chance of survival falls significantly. Dr. Mariana Chavez MacGregor, a BCRF investigator since 2018, joined our podcast to talk about her work with underserved and underinsured patients—those who are most likely to experience delays—to develop personalized ways to improve healthcare access and, ultimately, outcomes. Dr. MacGregor is an associate professor at the University of Texas MD Anderson Cancer Center, holding a primary appointment

29:24

The Promise and Potential of Breast Cancer Vaccines...

Investigating Breast Cancer ·

2020/06/30

One key goal in developing precision vaccines and immune therapies is to reduce the risk of breast cancer recurrence. Yet currently, there is only one FDA-approved immunotherapy drug for breast cancer, and it benefits just a small subset of women. In this episode of Investigating Breast Cancer, we talk with Dr. Karen Anderson about vaccines, harnessing the power of a person’s immune system, and reducing the risk of breast cancer recurrence. And of course, we’d all like to know: What’s the progress

34:23

The Underlying Biology of Drug Resistance with Dr....

Investigating Breast Cancer ·

2020/05/28

Advances in cancer therapy have dramatically contributed to the decline in breast cancer deaths over the last three decades. But even with these advances, drug resistance—when tumors stop responding to anti-cancer drugs—remains a serious clinical challenge. Dr. Sarat Chandarlapaty talks about the strategies to prevent cancer cells from evading the drugs designed to kill them. Dr. Chandarlapaty is a laboratory head at the Human Oncology and Pathogenesis Program at the Memorial Sloan Kettering Cancer

41:36

A Cross-disciplinary Approach to Breast Cancer...

Investigating Breast Cancer ·

2020/04/28

In the fight to understand and solve breast cancer, “it takes a village.” In this case, the village is more like a globally connected series of research labs, scientists, patients, funders and more. In other words, something that looks a lot like the Translational Breast Cancer Research Consortium (TBCRC). The TBCRC is a collaborative group founded in 2005 to conduct innovative and high-impact clinical trials for breast cancer led by Dr. Antonio Wolff. Dr. Wolff, a BCRF investigator since 2007,

22:04

Breast Cancer Care and COVID-19: From the Frontlines...

Investigating Breast Cancer ·

2020/03/24

Breast cancer—and any cancer—can be incredibly stressful under the best of circumstances for patients, survivors, and their families. In this time of the novel coronavirus (COVID-19), concerns can feel like they’re rising exponentially. So, what do we all need to know? With tons of new information bombarding us at once, what should cancer patients and families consider? Are there practical tactics or is there tangible guidance to stay safe? In this special episode of Investigating Breast Cancer, we

29:07

Developing Personalized Risk Prediction with Dr. Mark...

Investigating Breast Cancer ·

2020/02/28

Dr. Mark Robson talks about how he’s working to help identify the right tests for the right person at the right age How can researchers provide more precise risk estimates so that individuals with inherited risks can make informed decisions about their health, so that the right women are getting the right tests at the right age? Dr. Robson is conducting studies that employ advanced technologies that incorporate information from genetic tests to enhance the precision of genetic risk assessment in

30:17

Unraveling Metastatic Breast Cancer, with Dr. Martine...

Investigating Breast Cancer ·

2020/01/17

Dr. Martine Piccart talks to us about the power of collaboration in metastatic breast cancer research Metastasis, the spread of cancer cells from the breast to other sites in the body, is responsible for nearly all breast cancer deaths. Approximately 150,000 men and women are diagnosed with metastatic breast cancer each year. Today, BCRF is the largest private funder of this critical area of research. Dr. Martine Piccart is passionate about metastasis research and the vital role that international

41:53

Young women and breast cancer, with Dr. Ann Partridge

Investigating Breast Cancer ·

2019/12/20

For young women, a breast cancer diagnosis presents a unique set of challenges not only due to age, but the biology of the disease as well. While a diagnosis under the age of 40 is rare, the disease tends to behave more aggressively. Compared to older breast cancer patients, young women treated for the disease tend to have an increased risk of experiencing emotional distress, treatment-induced sexual dysfunction, and concerns about future pregnancies. This is where Dr. Ann Partridge steps in. Her

01:11:56

BCRF Symposium & Awards Luncheon: Live from New York...

Investigating Breast Cancer ·

2019/12/02

Every October, BCRF-funded researchers are honored at the annual Symposium & Awards Luncheon in New York City. This is when BCRF makes its formal announcement of research grants for the upcoming year and recognizes its investigators for their devotion to ending breast cancer with their trailblazing scientific inquiry. The event provides a unique opportunity for BCRF researchers to convene, share ideas and collaborate with fellow colleagues from around the world. This year’s program began with a

29:16

Mapping and understanding brain metastasis in breast...

Investigating Breast Cancer ·

2019/10/11

Metastasis, when cancer cells leave the breast and spread to other sites in the body, is the major cause of mortality from breast cancer. The brain is one of the most common organs breast cancer invades, occurring in more than one third of patients with advanced breast cancer, up to 300,000 patients a year. The prognosis of cancer patients who develop brain metastasis is poor, with only 20 percent of patients surviving at one year. For Dr. Priscilla Brastianos, a BCRF investigator since 2017, this

32:23

The De-Escalation of Therapy, with Dr. Eric Winer

Investigating Breast Cancer ·

2019/09/25

How should we – patients, family, doctors – consider the careful balance in identifying patients who might benefit from less rigorous course of treatment? Dr. Eric Winer, a BCRF investigator since 2003, studies this concept. Known as “de-escalation of therapy,” this form of personalized medicine challenges the “one-size-fits-all” approach to breast cancer treatment. His current BCRF-supported study aims to improve quality of life by reducing post-surgery chemotherapy in carefully selected patients

35:21

What Should I Eat? We asked Dr. Walter Willett

Investigating Breast Cancer ·

2019/08/16

“What should I eat?” It’s a question that Dr. Walter Willett thinks about every day as a researcher focused on the intersection of diet, lifestyle and health. Dr. Willett, a BCRF investigator since 2001, is widely considered a global leader on nutrition research. His research aims to characterize the impact of diet and lifestyle on health outcomes, especially in relation to breast cancer risk. As the most cited nutritionist worldwide, his work has influenced numerous health recommendations and

29:13

Improving breast cancer diagnosis and care in remote...

Investigating Breast Cancer ·

2019/07/12

Did you ever think you’d end up working in Africa?Neither did Dr. Lawrence Shulman. But then we never had Paul Farmer as our intern. Dr. Shulman – an oncologist who specializes in breast cancer – did.Farmer, if you don’t know, is the American anthropologist and doctor who in 1987 co-founded Partners in Health, an international non-profit that, in its own words, brings “health care to the world’s poorest families.” That means in places like Haiti and Rwanda.Which is why some eight years ago, Shulman

31:10

Focusing on early treatment, with Dr. Luca Gianni

Investigating Breast Cancer ·

2019/06/14

You likely know the expression, Pay It Forward. It’s an important concept for any kind of social awareness, but it can carry special meaning as well in the breast cancer world, particularly in research.That’s because so much of today’s important breakthroughs are built not only on yesterday’s participation of other patients, but, of course, the work of other researchers. It’s a sentiment Dr. Luca Gianni not only knows well, but also puts into practice every day.As you’ll hear, in this important and

31:33

Evaluating natural cancer treatments with Dr. Susan...

Investigating Breast Cancer ·

2019/05/09

Can life change with a single letter in the mail? For my guest today, it did, and subsequently, so did the lives of millions of people with various forms of cancer, including breast cancer. The letter in question came from the National Cancer Institute in 1977. The recipient was Dr. Susan Horwitz. The result: The creation of one of the most important cancer drugs that come from a natural product: Taxol, which is isolated from the yew plant. Today it is given to over a million patients. As you’ll

40:45

Inspiration and insight from breast cancer patients,...

Investigating Breast Cancer ·

2019/04/12

At first glance, it would seem that any of us who follow the breast cancer experience would look to the investigators – the scientists, researchers and their teams – for inspiration. They are, after all, dedicating their lives to fighting cancer. In this conversation, you’ll hear the opposite. To listen to Dr. Gabriel Hortobagyi, you hear the inspiration and insight that he and his teams gain from the grace of breast cancer patients – in particular, people who have triple negative breast cancer and

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Investigating Breast Cancer

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