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PODCAST

Mendelspod Podcast

Offering a front row seat to the Century of Biology, veteran podcast host Theral Timpson interviews the who"s who in genomics and genomic medicine. www.mendelspod.com

science & medicine natural sciences

All Episodes

4:19

The Third Way: Christian Schafmeister’s Spiroligomer...

Mendelspod Podcast ·

2025/05/22

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comFor decades, drug discovery has followed two main roads: small molecules that can slip into cells but often lack precision, and biologics that offer specificity but struggle with delivery and manufacturing. In this episode, Christian Schafmeister introduces us to a third path: spiroligomers—synthetic, fused-ring molecules designed to combine the best of…

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21:34

Can Math and AI Replace Some Biology in Drug...

Mendelspod Podcast ·

2025/05/15

What if drug design didn’t depend on pre-existing biological data? In this episode of Mendelspod, Theral sits down with Aridni Shah, co-founder and CEO of Immunito AI, a Bengaluru-based biotech startup reinventing how we develop antibody therapies. Shah and her team are using artificial intelligence to design antibodies from scratch, bypassing traditional animal-based and data-heavy methods. “We no longer need to rely on pre-existing data,” she explains. “We’ve gone to the fundamental atomic level

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4:12

$10 Genome, $8 Coffee: Rethinking the Economics of...

Mendelspod Podcast ·

2025/05/13

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comYes, the Trump economy has been tough on life science tools—but according to today’s guest, the business model was failing us anyway. It’s time to go back to rethinking the basics.Today we’re joined by Stephane Budel, founding partner at DeciBio, one of the leading market research and consulting firms focused on life science tools and precision medicine…

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4:54

Quantum Scale: A New Era for Single-Cell Analysis...

Mendelspod Podcast ·

2025/05/08

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comOn today’s episode of Mendelspod, Theral sits down with Giovanna Prout, CEO of Scale Biosciences, to explore a how the company is achieving new orders of magnitude of scale in the single cell space."In the past, single cell was one cell per well—maybe 96 cells per experiment," Prout explains. "Now, with our Quantum Scale platform, we can scale from 85,…

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42:06

Building Intuition at the Nanoscale: Steve McCloskey...

Mendelspod Podcast ·

2025/05/01

What if you could step inside a molecule? On today’s episode of Mendelspod, we talk with Steve McCloskey, founder and CEO of Nanome, the company bringing virtual reality into the world of drug discovery and molecular modeling. A former nanoengineering student at UC San Diego and a self-described futurist, Steve founded Nanome to create what he calls the "ultimate scientific interface"—a way for scientists not just to visualize molecules, but to interact with them naturally in 3D space.* 0:00 The

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5:03

Beyond the $100 Genome--the Everyday Sequencing...

Mendelspod Podcast ·

2025/04/29

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comWait! What? Sequencing as a service?That was the reaction when Mark Budde first set out to upend a basic ritual in molecular biology—confirmation Sanger sequencing—with his company Plasmidsaurus. You’ve heard it many times: Illumina machines sequence around 80% of the bases in the world. But as Mark points out in today’s interview, it’s not 80% of th…

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37:50

What Next for LDTs? A Conversation with Sarah Overton...

Mendelspod Podcast ·

2025/04/22

Just weeks before the FDA’s sweeping rule to regulate laboratory-developed tests (LDTs) was set to take effect, a federal court struck it down. What does this mean for the field of precision medicine and for labs themselves? There are have been those on the side of regulation arguing its importance for reimbursement. Yet many, such as the plaintiffs in this case, the ACLA and AMP, have argued that FDA regulation could stifle innovation in a new field and even force labs to shut down. Today we

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26:46

AI’s Quiet Revolution in the Pharma Supply Chain with...

Mendelspod Podcast ·

2025/04/17

In today’s show, Theral is joined by Chris Petersen, Chief Technology Officer at Scientist.com, a company sometimes called the "Amazon for science"—though with a great deal more complexity. Chris pulls back the curtain on how AI is transforming the research services marketplace and offers a rare look into how AI is already reshaping the infrastructure of pharma and biotech.Calling this the "tinkering phase" of AI, Chris likens the current moment to the early days of the web—when best practices were

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25:24

We've Been Misclassifying Childhood AML for Years:...

Mendelspod Podcast ·

2025/04/15

In today’s program, we continue our series on disease subtyping with Dr. Jeffery Klco, a pediatric pathologist and researcher at St. Jude Children’s Research Hospital. Dr. Klco joins us to discuss groundbreaking work recently published in Nature Genetics, which redefines the genomic landscape of childhood acute myeloid leukemia (AML).Klco and his team have identified twelve novel molecular subtypes of pediatric AML—some driven by genetic alterations that had long gone undetected by standard

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40:41

Aaron Viny: A 21-Year Leukemia Survivor on the...

Mendelspod Podcast ·

2025/04/10

Dr. Aaron Viny, oncologist and researcher at Columbia University, begins today’s conversation with a personal milestone—he’s now been leukemia-free for 21 years. This experience gives his work on cancer a powerful human dimension that comes through in his interview with Theral today—not only in his dedication to patient care, but in his boundary-pushing research on the epigenetic roots of cancer.Dr. Viny’s research focuses on the epigenetic architecture of hematologic malignancies, exploring how

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29:33

Toward Disease Sub-typing with Ben Busby, DNAnexus

Mendelspod Podcast ·

2025/04/03

We’re happy to welcome back Ben Busby, Principal Scientist at DNAnexus, to dive deeper into the evolving world of disease subtyping and multi-omic data sets. Building on our previous conversation with Busby about the genomic data ecosystem, we explore the shift from single-cause disease models to multifaceted approaches that incorporate genomics, proteomics, imaging, and more."We’re no longer in a world where we’re doing genomics or imaging or proteomics," he explains. "These things are all coming

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37:36

Synthetic Biology Ready for Its ChatGPT Moment: A...

Mendelspod Podcast ·

2025/04/01

John Cumbers, founder of SynBioBeta, joins Theral for our annual look ahead at the field of synthetic biology and the upcoming SynBioBeta 2025 conference, happening May 6–9 in San Jose. It's obviously a big year for AI, and synthetic biology is no exception. As John puts it, “Biology and AI coming together represents a huge opportunity for us to be able to understand biology and then ultimately engineer biology.” This year’s conference features a strong emphasis on AI's role in scaling and

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24:01

Beyond the Parts List: Chris Mason and Simon...

Mendelspod Podcast ·

2025/03/27

Today Theral is joined by returning guests Chris Mason of Weill Cornell Medicine and Simon Fredriksson, CEO of Pixelgen Technologies, for a deep dive into the emerging field of cell surface proteomics and its power to illuminate both space biology and cancer research.Chris Mason shares new insights from his work on the Space Omics and Medical Atlas (SOMA), the largest collection of astronaut health data to date. His latest findings confirm that space is more than a hostile environment—it’s a

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38:51

DNA Is Still Where It's At: Christian Henry, CEO of...

Mendelspod Podcast ·

2025/03/20

In our last episode, we explored the growing shift from genomics to multi-omics. But for Pacific Biosciences CEO Christian Henry, the foundation of discovery remains clear: “DNA is still where it’s at.” PacBio is doubling down on long-read sequencing, committed to delivering on its promise of accuracy and completeness.2024 marks a “watershed year” for PacBio, with the launch of the Vega system—a benchtop long-read sequencer at an unprecedented $169,000 price point—alongside major advancements in

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8:02

A New Sequencing Technology Has Entered the World:...

Mendelspod Podcast ·

2025/03/13

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comIt’s time for our annual deep dive into sequencing—no, wait—multi-omics! Back on the show is our resident sequencing guru, Keith Robison, scientist at Ginkgo Bioworks and author of the OmicsOmics blog. Keith is our all time return champion, and as always, he brings technical experience alongside the storytelling instincts of a seasoned journalist.Keith …

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21:29

Unlocking the Future of Forensic Genetics with Mirna...

Mendelspod Podcast ·

2025/03/06

This week on Mendelspod, as we celebrate International Women’s Day, we’re spotlighting groundbreaking contributions from women in science. Our guest, Dr. Mirna Ghemrawi, is at the forefront of forensic genetics, where DNA analysis meets the pursuit of justice. As Associate Director at the Center for Forensic Science Research and Education, Ghemrawi applies next-gen sequencing and AI to some of the most challenging questions in forensic biology.Originally from Lebanon, Ghemrawi’s path to forensic

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33:48

Public Science in Peril: Hank Greely of Stanford on...

Mendelspod Podcast ·

2025/03/04

In this urgent and unflinching conversation, Stanford law professor Hank Greely returns to Mendelspod to address the mounting threats of the Trump administration to public science funding and the institutions that regulate medicine. As the NIH faces existential challenges and the FDA comes under fire, Greely lays out a compelling case for why government-supported research remains essential—not just for innovation, but for maintaining a functional society.“Research is like fishing,” Greely explains

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31:55

Breaking the ‘Undruggable’ Barrier with AI and...

Mendelspod Podcast ·

2025/02/27

For decades, drug developers have struggled with so-called "undruggable" proteins—those regions of the proteome that evade traditional small molecules and antibodies. But Aikium, led by Eswar Iyer, could be changing the game. In today’s show, Iyer, a prolific scientist with over 100 patents and a background in George Church’s lab, shares how his company is tackling one of the toughest challenges in therapeutics.At the heart of Aikium’s approach is Yotta-ML2, an AI-powered wet lab platform that

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40:11

"They're not cutting a branch. They're cutting the...

Mendelspod Podcast ·

2025/02/10

Today Theral talks with Laura Hercher, Director of Research for Human Genetics at Sarah Lawrence College, about the growing political assault on diversity, equity, and inclusion (DEI) initiatives in scientific research. With the NIH facing sweeping budget cuts and DEI programs cancelled, Hercher makes a compelling case for why diversity isn’t just a social or moral issue—but a scientific imperative."What you're cutting is cancer funding. What you're cutting is Alzheimer's research. What you're

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5:31

Early Detection for Lung Cancer with Susan Tousi,...

Mendelspod Podcast ·

2025/02/06

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comLung cancer is the most deadly of all the cancers worldwide. Very few of those who should be— are getting screened. There is enormous medical need here, and early cancer detection through advanced liquid biopsy could be a tremendous part of the answer.Today, as part of our series on the future of genetic testing, we welcome Susan Tousi, CEO of Delfi Diagnostics, a company pioneering next-generation liquid biopsy

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528 results

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