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PODCAST

Mendelspod Podcast

Offering a front row seat to the Century of Biology, veteran podcast host Theral Timpson interviews the who"s who in genomics and genomic medicine. www.mendelspod.com

science & medicine natural sciences

All Episodes

24:01

Beyond the Parts List: Chris Mason and Simon...

Mendelspod Podcast ·

2025/03/27

Today Theral is joined by returning guests Chris Mason of Weill Cornell Medicine and Simon Fredriksson, CEO of Pixelgen Technologies, for a deep dive into the emerging field of cell surface proteomics and its power to illuminate both space biology and cancer research.Chris Mason shares new insights from his work on the Space Omics and Medical Atlas (SOMA), the largest collection of astronaut health data to date. His latest findings confirm that space is more than a hostile environment—it’s a

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38:51

DNA Is Still Where It's At: Christian Henry, CEO of...

Mendelspod Podcast ·

2025/03/20

In our last episode, we explored the growing shift from genomics to multi-omics. But for Pacific Biosciences CEO Christian Henry, the foundation of discovery remains clear: “DNA is still where it’s at.” PacBio is doubling down on long-read sequencing, committed to delivering on its promise of accuracy and completeness.2024 marks a “watershed year” for PacBio, with the launch of the Vega system—a benchtop long-read sequencer at an unprecedented $169,000 price point—alongside major advancements in

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8:02

A New Sequencing Technology Has Entered the World:...

Mendelspod Podcast ·

2025/03/13

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comIt’s time for our annual deep dive into sequencing—no, wait—multi-omics! Back on the show is our resident sequencing guru, Keith Robison, scientist at Ginkgo Bioworks and author of the OmicsOmics blog. Keith is our all time return champion, and as always, he brings technical experience alongside the storytelling instincts of a seasoned journalist.Keith …

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21:29

Unlocking the Future of Forensic Genetics with Mirna...

Mendelspod Podcast ·

2025/03/06

This week on Mendelspod, as we celebrate International Women’s Day, we’re spotlighting groundbreaking contributions from women in science. Our guest, Dr. Mirna Ghemrawi, is at the forefront of forensic genetics, where DNA analysis meets the pursuit of justice. As Associate Director at the Center for Forensic Science Research and Education, Ghemrawi applies next-gen sequencing and AI to some of the most challenging questions in forensic biology.Originally from Lebanon, Ghemrawi’s path to forensic

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33:48

Public Science in Peril: Hank Greely of Stanford on...

Mendelspod Podcast ·

2025/03/04

In this urgent and unflinching conversation, Stanford law professor Hank Greely returns to Mendelspod to address the mounting threats of the Trump administration to public science funding and the institutions that regulate medicine. As the NIH faces existential challenges and the FDA comes under fire, Greely lays out a compelling case for why government-supported research remains essential—not just for innovation, but for maintaining a functional society.“Research is like fishing,” Greely explains

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31:55

Breaking the ‘Undruggable’ Barrier with AI and...

Mendelspod Podcast ·

2025/02/27

For decades, drug developers have struggled with so-called "undruggable" proteins—those regions of the proteome that evade traditional small molecules and antibodies. But Aikium, led by Eswar Iyer, could be changing the game. In today’s show, Iyer, a prolific scientist with over 100 patents and a background in George Church’s lab, shares how his company is tackling one of the toughest challenges in therapeutics.At the heart of Aikium’s approach is Yotta-ML2, an AI-powered wet lab platform that

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40:11

"They're not cutting a branch. They're cutting the...

Mendelspod Podcast ·

2025/02/10

Today Theral talks with Laura Hercher, Director of Research for Human Genetics at Sarah Lawrence College, about the growing political assault on diversity, equity, and inclusion (DEI) initiatives in scientific research. With the NIH facing sweeping budget cuts and DEI programs cancelled, Hercher makes a compelling case for why diversity isn’t just a social or moral issue—but a scientific imperative."What you're cutting is cancer funding. What you're cutting is Alzheimer's research. What you're

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5:31

Early Detection for Lung Cancer with Susan Tousi,...

Mendelspod Podcast ·

2025/02/06

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comLung cancer is the most deadly of all the cancers worldwide. Very few of those who should be— are getting screened. There is enormous medical need here, and early cancer detection through advanced liquid biopsy could be a tremendous part of the answer.Today, as part of our series on the future of genetic testing, we welcome Susan Tousi, CEO of Delfi Diagnostics, a company pioneering next-generation liquid biopsy

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6:13

Big RNA with Brendan Frey of Deep Genomics

Mendelspod Podcast ·

2025/01/30

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comIn our first conversation with Deep Genomics, Theral sits down with Brendan Frey, the company's founder and Chief Innovation Officer, to explore the power of AI in RNA biology and drug discovery. Frey, a pioneer in deep learning who trained in the lab of AI luminary Geoffrey Hinton, shares how his personal experience in genetics back in 2002 led him to merge machine learning with genomic medicine. The company has a head

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31:04

Genome Informatics in the Age of AI With Ben Busby,...

Mendelspod Podcast ·

2025/01/23

In this Mendelspod episode, Theral explores the state of genome informatics with Ben Busby, principal scientist at DNAnexus.Busby reflects on his journey into the field, which was influenced by key projects and experiences during his time at the NCBI and his genomics hackathons. He outlines the current genome informatics landscape, emphasizing DNAnexus' role in fostering collaboration. Busby highlights transformative movements to refine disease subtyping based on haplotype data, underscoring their

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5:34

AI & the Future of Genetic Testing: Ezra Cohen, CMO...

Mendelspod Podcast ·

2025/01/16

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comAs 2025 begins, we are launching a new series The New Genetic Testing. To do that we’re welcoming today Dr. Ezra Cohen, Chief Medical Officer at Tempus to offer a behind-the-scenes look at how the company is transforming healthcare through cutting-edge AI. With its recent successful IPO, Tempus has firmly established itself as a leader in genomic testing and multimodal data integration and empowering providers and life

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5:26

PredxBio and the Promise of Spatially Intelligent...

Mendelspod Podcast ·

2025/01/10

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comThis week we welcome the innovative minds behind PredixBio, a new and groundbreaking company at the forefront of spatial biology. CEO Dusty Majumdar and co-founder Chakra Chennubhotla join us to discuss their mission to revolutionize cancer therapeutics through spatially intelligent biology. Founded in 2018 and supported by NIH grants, PredixBio focuses on unraveling the tumor microenvironment's heterogeneity using

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28:46

Surprise: Our Most Popular Show of 2024 Was on...

Mendelspod Podcast ·

2024/12/19

This year in a series co-produced with GenomeWeb we had an exclusive look into Illumina’s work in genomic AI with Kyle Farh, the VP and Distinguished Scientist leading the Illumina Artificial Intelligence Lab. "We lack a way of training genomic AI as readily as you would for natural language processing,” says Farh. "There are vast amounts of data, but there are no labels, no supervision. One of the most powerful tools that we’ve found is using clues from natural selection.”Farh says the company

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4:39

New Startup Launches Epigenetic Screening: Mohamad...

Mendelspod Podcast ·

2024/12/05

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comIn this episode of Mendelspod, Theral sits down with Dr. Mohamad Takwa, co-founder and CEO of Epigenica, a Swedish startup revolutionizing epigenetic research. Epigenica is positioning itself at the forefront of this new and rapidly growing field with a mission to empower researchers through large-scale epigenetic profiling.

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23:34

AI Powered Multiomics: Joachim Schmid on Data...

Mendelspod Podcast ·

2024/11/21

Coming from the field of digital pathology, Joachim Schmid has a unique perspective on the evolution of multi-omics. Schmid was recently appointed as Vice President of Multiomics Data Solutions at Illumina.In this episode, Theral dives into the burgeoning field of multi-omics—integrating data from various omic layers such as genomics, proteomics, and transcriptomics—and the massive data challenges that come with it. Schmid discusses how sequencing costs are plummeting, leading to an explosion in

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34:55

Renowned GI Oncologist Discusses MRD Testing and the...

Mendelspod Podcast ·

2024/11/14

Dr. Mark Lewis is a well known GI oncologist at Intermountain Health in Salt Lake City, Utah. Gifted with a passionate communication style, he has over 93,000 Twitter followers. Next month, he will live-tweet his upcoming colonoscopy. In this episode, Dr. Lewis joins Theral in our ongoing series on minimal residual disease (MRD) testing, a revolutionary blood test that is helping detect residual cancer causing a paradigm shift in patient management.Dr. Lewis belongs to a pioneering group that

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28:27

Precision Medicine Then and Now: We Talk with the...

Mendelspod Podcast ·

2024/11/12

When Bill Clinton announced the sequencing of the human genome in 2000, the New York Times ran the following headline on the front page: "Genetic Code of Human Life is Cracked By Scientists.”We’re still living up to that headline.Ed Abrahams has led the Personalized Medicine Coalition (PMC) for twenty years. Before his retirement in December, we asked him to join us to reflect on his tenure and take stock of the field. PMC was established as a “catalyst” and organizer to bring the various

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31:47

MicroRNA: A New Era in Biomarker Discovery with Tim...

Mendelspod Podcast ·

2024/11/07

In this episode, Theral delves into the groundbreaking role of microRNA as a cancer biomarker with Tim Williams, professor of clinical pathology at the University of Cambridge Veterinary School, and Paola Ulivi, a leading researcher at the Instituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori (IRST) in Italy. MicroRNA, which recently garnered its discoverers a Nobel Prize, has emerged as a powerful tool for detecting and tracking cancer progression.Williams and Ulivi share their latest research,

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28:11

Somatic Genomics: A Revolution in Biology with Jacob...

Mendelspod Podcast ·

2024/10/31

Jacob Rubens is having quite a career. Studying at MIT in the Synthetic Biology Center with Professor Tim Lu, he invented gene circuits that allow engineered cells to do novel analog, digital, and hybrid computations, enabling the emerging field of “intelligent” cell therapies. In 2017, he was honored in Forbes 30 under 30 and, in 2021, in Business Insider’s list of 12 young serial entrepreneurs building the next generation of biotech. He has co-founded Kaleidoscope Biosciences, Sana

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31:15

Exploring the Future of Single Cell Technology with...

Mendelspod Podcast ·

2024/10/29

Human genomics is complex. With new, scalable tools, we are unraveling that complexity. For example, we don’t just each have one genome; we have trillions, as each cell has a unique genome. Analyzing biology at the single-cell level continues to be one of the major frontiers in research.To learn how Single Cell Discoveries (SCD), a contract research organization in Utrecht, the Netherlands, has scaled and innovated in this field, Theral sits down with Mauro Muraro, cofounder and CEO of SCD. Muraro

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516 results

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