STAT Stitch Deep Dive Podcast Beyond The Bedside

20:49

CC Pharm | Epinephrine

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/27

Epinephrine is a potent, nonselective adrenergic agonist acting on alpha-1, alpha-2, beta-1, and beta-2 receptors. This high-yield 80/20 summary covers the essential clinical and exam concepts:1. Expected Pharmacological Action & MechanismAlpha-1 activation causes arteriolar vasoconstriction.Beta-1 activation induces positive inotropic and chronotropic responses, increasing cardiac workload and coronary vasodilation.Beta-2 activation drives bronchodilation, skeletal muscle vasodilation, and

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22:07

CC Pharm | Propofol

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/27

Clinical Action & PharmacokineticsMechanism: Propofol is an IV anesthetic/sedative that enhances GABAA currents by slowing deactivation and reducing receptor desensitization. It also inhibits NMDA glutamate receptors, depressing excitatory transmission, and exerts antiemetic effects by reducing serotonin in the area postrema.Pharmacokinetics: Follows a 3-compartment linear model. Onset is rapid (~40s) via quick blood-brain equilibration. Clearance is 23–50 mL/kg/min via hepatic conjugation to

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23:14

CC Pharm | Norepinephrine

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/27

Norepinephrine (Levophed) 80/20 SummaryAction & MOA: Direct α-agonist causing potent vasoconstriction. Modest β1 activity triggers cardiac stimulation at lower doses; vasoconstriction dominates at higher doses. Elevated SVR triggers reflex vagal bradycardia (slowing HR). Coronary flow increases without raising myocardial oxygen demand.Uses: First-line for septic shock, sepsis, acute hypotension, cardiogenic shock. Alternative in hepatorenal syndrome (with albumin).Complications: Tissue necrosis

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21:15

CC Pharm | Vasopressin

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/27

Vasopressin (Vasostrict) Clinical Reference1. Action: Exogenous ADH analog. Promotes renal water reabsorption via cAMP. Directly contracts vascular smooth muscle non-adrenergically. 2. Use: Raising BP in vasodilatory shock refractory to fluids/catecholamines; post-op abdominal distention. 3. Complications: Cardiac arrest, bradycardia, MI, AFib, water intoxication, severe hyponatremia, necrosis. 4. Admin: IV infusion must go through central vein. If peripheral, use >=20G catheter & check

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34:58

CC PHARM [RSI] | Vecuronium

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/25

Vecuronium is an intermediate-acting, nondepolarizing neuromuscular blocking agent used for skeletal muscle relaxation during surgery, mechanical ventilation, and endotracheal intubation, including rapid-sequence intubation (RSI).1. Critical Safety & Boxed Warning (The Vital 20%)Respiratory Paralysis: Causes respiratory paralysis (potentially fatal). Administer only by experienced clinicians in settings with immediate intubation, ventilation, oxygen, and reversal agents.Induction Prerequisite:

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10:34

NURSE | Know Your Specialty

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/25

pick your specialty that you want to get into, learn the certs you need for them and go for it.

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26:31

CC Pharm [RSI] | Succinylcholine

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/25

Succinylcholine is a short-acting, depolarizing neuromuscular blocking agent (NMBA) used as an adjunct to general anesthesia to facilitate tracheal intubation and provide skeletal muscle relaxation. Applying the 80/20 rule, the core clinical essence of succinylcholine centers on its rapid mechanism, critical safety warnings, and precise dosing.1. Core Mechanism & Pharmacokinetics (The "20%" Driving Action)Mechanism: Succinylcholine competes with acetylcholine (ACh) at cholinergic receptors on

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28:55

CC Pharm [RSI] | Etomidate

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/25

Etomidate (Amidate) is a short-acting sedative-hypnotic intravenous general anesthetic. Applying the 80/20 rule, this summary focuses on the core 20% of clinical details that deliver 80% of the practical knowledge needed for its safe administration:1. Clinical Pharmacology & MechanismMechanism: Facilitates GABAminergic neurotransmission by increasing available GABA receptors, possibly by displacing endogenous inhibitors of GABA binding.Cerebral Effects: Reduces cerebral blood flow by 20% to 30%,

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26:45

CC Pharm [RSI] | Rocuronium

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/25

The 80%: Core Clinical Guidelines & Actionable InsightsRole: Intermediate-acting, nondepolarizing neuromuscular blocker (NMBA) for routine/RSI intubation, surgery, or mechanical ventilation.Mechanism: Competes with acetylcholine at motor end-plates. Paralysis moves from fine muscles (face/neck) to limbs, chest, abdomen, and diaphragm; recovery is in reverse. A vecuronium analog with 10–15% potency, it was developed to match succinylcholine's onset. Minimal histamine release/ganglion blockade

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22:04

CC Pharm | Ketamine POSSIBLE [RSI]

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/25

Expected Action & PhysiologyKetamine is a nonbarbiturate phencyclidine derivative that acts as an NMDA receptor antagonist, blocking glutamate to selectively interrupt thalamoneocortical pathways while stimulating the limbic system. This induces "dissociative anesthesia" where the patient is unresponsive to pain, but eyes remain open with intact corneal, light, and airway reflexes.It stimulates the sympathetic system, causing bronchodilation (ideal for asthma/bronchospasm), tachycardia, and

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21:03

CC Pharm | Diltiazem

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/25

Diltiazem (Cardizem) Clinical Summary1. Action & Class: Benzothiazepine Class IV anti-arrhythmic/anti-anginal. Inhibits calcium influx across myocardial and vascular smooth muscle membranes. This slows AV conduction (prolonging the PR interval), decreases heart rate, and dilates coronary and systemic arteries, reducing afterload and blood pressure. It has fewer negative inotropic effects than verapamil.2. Therapeutic Uses: Hypertension, stable/variant (Prinzmetal's) angina, and ventricular rate

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20:51

CC Pharm | Midazolam

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/19

Midazolam (Versed) 80/20 Clinical SummaryClasses: Benzodiazepine sedative/hypnotic, anesthetic, anxiolytic, anticonvulsant.Mechanism: Enhances GABA-A receptors, increasing GABA affinity and opening chloride channels. This hyperpolarizes cell membranes, preventing excitation. Has twice the receptor affinity of diazepam.Pharmacokinetics: Metabolized by CYP3A4 to active, equipotent alpha-hydroxymidazolam. 97% protein-bound. Excreted via urine.IV: Onset 1.5–5m, duration 30–45m. Tissue accumulation in

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19:11

CC Pharm | Nitroprusside

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/19

Sodium nitroprusside is an ultra-potent, direct-acting peripheral vasodilator characterized by rapid hemodynamic action and highly toxic metabolites. This 80/20 summary distills its essential clinical, pharmacological, and nursing guidelines:1. Mechanism & Hemodynamic EffectsMechanism: Direct action on arterial and venous smooth muscle; myocardial contractility is unaffected.Hypertension: Reduces afterload and causes venous pooling, decreasing arteriolar resistance.Heart Failure: Improves left

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21:49

CC Pharm | Dobutamine

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/19

Dobutamine is a direct-acting parenteral sympathomimetic inotrope. It primarily acts as an agonist at beta1-adrenergic receptors (with minor beta2 and alpha1 stimulatory effects) to increase myocardial contractility, stroke volume, and cardiac output. Unlike dopamine, it does not stimulate dopaminergic receptors or release norepinephrine. It has comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects, and minimally affects pulmonary vascular resistance.Primary

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36:08

CC Pharm | Milrinone

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/19

Core Profile & Mechanism Milrinone is a parenteral positive inotrope and vasodilator with selective phosphodiesterase III (PDE3) inhibitor activity. By preventing cyclic adenosine monophosphate (cAMP) breakdown in cardiac and vascular muscle cells, it increases myocardial contractility, causes vasodilation, and improves diastolic relaxation (lusitropy). This dual action reduces preload, afterload, and systemic vascular resistance with little to no chronotropic activity. Therapeutic effects occur

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24:15

CC Pharm | Norepinephrine

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/19

Norepinephrine (Levophed) 80/20 SummaryAction & MOA: Direct α-agonist causing potent vasoconstriction. Modest β1 activity triggers cardiac stimulation at lower doses; vasoconstriction dominates at higher doses. Elevated SVR triggers reflex vagal bradycardia (slowing HR). Coronary flow increases without raising myocardial oxygen demand.Uses: First-line for septic shock, sepsis, acute hypotension, cardiogenic shock. Alternative in hepatorenal syndrome (with albumin).Complications: Tissue necrosis

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24:15

CC Pharm | Precedex

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/19

Pharmacological Action & Use: Dexmedetomidine (Precedex) is a selective, centrally-acting alpha-2 adrenergic receptor agonist. Presynaptic activation inhibits norepinephrine release and pain signals; postsynaptic CNS activation inhibits sympathetic activity, decreasing heart rate and blood pressure. This produces arousable sedation, anxiolysis, and mild analgesia without significant effects on respiratory drive. It is indicated for ICU ventilator sedation, procedural sedation, and acute

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43:29

CC Pharm | Fentanyl

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/19

Fentanyl (Sublimaze): Elite Nursing 80/20 Summary1. ID & Action: Phenylpiperidine synthetic opioid agonist. Binds mu/kappa receptors. Inhibits adenylyl cyclase, decreasing cAMP to block release of neurotransmitters (substance P, GABA, dopamine, acetylcholine, norepinephrine). Highly lipophilic (580:1 vs. morphine); rapid onset. 2. Therapeutic Use: General/spinal anesthesia adjunct; chronic and breakthrough pain (transmucosal/nasal only). 3. 80/20 Formulations (NOT Interchangeable

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8:03

CC | Lido c/ & Lido c/ out

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/18

this episode talks about the trauma uses of Lidocaine c/ Epi or Lidocaine c/out Epi. its commonly known as Lido c/ or Lido c/ out. THIS IS NOT THE SAME MED YOU GIVE IN THE ACLS ALGO

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21:34

CC | PRIMER Burns

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/13

Burn Classification & TBSA Assessment Burn severity depends on depth, extent (TBSA), location, and patient risk factors. Depth is classified as partial-thickness (epidermal/dermal; painful, red, blistered) or full-thickness (dermal destruction, painless, leathery eschar, visible thrombosed vessels). TBSA is estimated using the Rule of Nines for adults or the Lund-Browder chart for children. Referral to a burn center is indicated for partial-thickness burns >10% TBSA, chemical/electrical

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