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PODCAST

Daily Value

William Wallace, Ph.D.

Daily Value is a podcast examining the biological foundations of human function. Hosted by Dr. William Wallace, episodes explore nutrition, supplementation, and related health topics through the lens of biochemistry, physiology, and human evidence

health & fitness alternative health

All Episodes

8:12

How Male Alcohol Consumption Can Shape Offspring...

Daily Value ·

2025/02/03

In this episode of Daily Value, we look at how paternal alcohol consumption before conception could influence offspring health, longevity, and even accelerate aging. Referencing studies from Andrology (PMID: 38044754) and Aging and Disease (PMID: 39122451), we examine how sperm RNA modifications and mitochondrial dysfunction may persist long after alcohol cessation—potentially programming offspring for metabolic disorders, reduced NAD+ levels, and faster cellular aging. Discussion Points: Spe...

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9:05

Can Nutritional Psychiatry Offer New Solutions for...

Daily Value ·

2025/01/31

In this episode of Daily Value, we explore the potential of omega-3 fatty acids, particularly EPA and DHA, as an adjunctive therapy for reducing anxiety symptoms. A recent meta-analysis (PMID: 38890670) reviewed 23 randomized controlled trials involving over 2,100 participants, revealing that a certain amount of omega-3s per day can significantly reduce anxiety symptoms, especially when combined with traditional treatments like antidepressants.Talking points:Anxiety disorders: what are they a...

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8:29

Why 20 Grams of Olive Oil Could Be a Daily Health Habit

Daily Value ·

2025/01/29

In this episode of Daily Value, we look at how extra virgin olive oil and its polyphenols—including hydroxytyrosol—could impact your health and longevity. Referencing evidence from the Moli-Sani Study and other meta-analyses (PMID: 38704428), we uncover how these bioactives are suggested to reduce risks for cancer, cardiovascular disease, and all-cause mortality.Discussion Points:Bioactive Compounds: How hydroxytyrosol prevents LDL oxidation and reduces inflammation, key mechanisms for cardio...

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9:02

Brewed for Benefits: Coffee’s Impact on Fat and Muscle

Daily Value ·

2025/01/27

In this episode of Daily Value, we look at how the roasting style of coffee—light versus regular—might influence body composition. Examining evidence from a recent randomized controlled trial published in Nutrients (PMID: 39275165). Could your choice of coffee enhance fat loss and muscle mass?Discussion Points:Roasting and Polyphenols: How lightly roasted coffee, with higher chlorogenic acid content, outperformed regular roasts in reducing body fat (-1.4% vs. -1.0%) and increasing muscle mass...

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11:17

The Surprising Gut Health Benefits of B-Vitamins

Daily Value ·

2025/01/24

In this episode of Daily Value, we explore the recent findings on the role of B-group vitamins as potential prebiotic candidates and their effects on the human gut microbiome. The discussion is centered around some of the latest research, which highlights how these essential vitamins, traditionally known for their metabolic roles, are now being recognized for their ability to modulate the gut microbiome and how different bacterial species may also play key roles as B-vitamin Producers.Discuss...

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9:55

Your DNA on Caffeine

Daily Value ·

2025/01/22

In this episode of Daily Value, we look at the relationship between genetics, habitual caffeine intake, and cognitive performance, using insights from a recent study (PMID: 39648354) in the Journal of Psychopharmacology. Whether you’re a "fast" or "slow" caffeine metabolizer could significantly influence how caffeine impacts your brain.Discussion Points:Gene-Caffeine Interactions: how variants in CYP1A2 and ADORA2A genes modulate caffeine metabolism and sensitivity, leading to differential ef...

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8:19

Can Green Tea Preserve the Brain Better than Coffee?

Daily Value ·

2025/01/20

Does green tea protect the aging brain better than coffee? In this episode of Daily Value, we look at the evidence behind green tea's impact on brain aging, focusing on cerebral white matter lesions, Alzheimer’s risk, and brain atrophy. Drawing on studies like Shibata et al.'s recent publication in Science of Food (PMID: 39774601), we discuss how a certain threshold of green tea, but not coffee is associated with less white matter lesions in aged individuals.Discussion Points:MRI findin...

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8:13

Building Brains: B12 During Pregnancy & Childhood IQ

Daily Value ·

2025/01/17

In this episode of Daily Value, we look at the role of maternal Vitamin B12 intake during pregnancy and its impact on a child’s IQ. Drawing on findings from the ELSPAC study (PMID: 39674678), we discuss how Vitamin B12 supports critical neurodevelopmental processes and how deficiency may impact verbal IQ.Discussion Points:The role of Vitamin B12 in one-carbon metabolism, axon myelination, and DNA methylation, and their importance for fetal brain development.Findings from the ELSPAC study, whe...

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9:18

How Much Coffee Does It Take to Keep Your Brain Young?

Daily Value ·

2025/01/15

How much coffee is too much? In this episode of Daily Value, we look at the link between coffee consumption and cognitive health. Drawing on a recent study published in the Journal of the American Heart Association (PMID: 39673298), we examine how bioactive compounds in coffee, such as chlorogenic acids and trigonelline, may protect against cognitive decline and inflammation.Discussion Points:Insights from the Swiss Atrial Fibrillation Cohort, showing enhanced processing speed and visuomotor ...

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8:35

Can Dietary Fiber Rewrite Your Genetic Code to Combat...

Daily Value ·

2025/01/13

In this episode of Daily Value, we take a look at how fiber fuels anti-cancer gene activity - emphasizing the role of short-chain fatty acids (SCFAs) produced during fiber fermentation. Drawing on new research PMID: 39789354) published in Nature Metabolism out of Stanford Medicine, we examine how fiber-derived metabolites influence gene activity to reduce cancer risk and promote overall health.Discussion Points:The epigenetic role of SCFAs, such as butyrate and propionate, in activating anti-...

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8:16

The Nutrient Duo That Could Save Your Mind

Daily Value ·

2025/01/10

In this episode of Daily Value, we look into the synergistic relationship between two nutrient classes in supporting brain health and mitigating cognitive decline. Drawing on evidence from past clinical evidence suggesting these two nutrient classes work in tandem to support brain function and health.Discussion Points:-Homocysteine’s role in disrupting fatty acid incorporation into cell membranes and amyloid-beta clearance.-Findings from one study, where some 70-year-old participants experien...

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8:20

A New Frontier in Wine and Cardiovascular Science:...

Daily Value ·

2025/01/08

In this episode of Daily Value, we examine the latest research on wine consumption and its relationship to cardiovascular health. Leveraging urinary tartaric acid as an objective biomarker, a recent study (PMID: 39689849) published in the European Heart Journal provides interesting evidence of a J-shaped association between wine intake and cardiovascular outcomes.Discussion Points:Biomarkers and Bias: The role of urinary tartaric acid in providing a reliable objective measure of wine co...

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8:52

Targeting Longevity: NMN vs. NR for NAD+ Restoration

Daily Value ·

2025/01/06

In this episode of Daily Value, we look at science of Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR), two NAD+ precursors gaining traction in longevity research. Both supplements aim to restore NAD+ levels, critical for energy metabolism and cellular repair, yet their distinct pathways and tissue-specific effects suggest considerations for choosing one over the other.Discussion Points:-The metabolic pathways of NMN and NR, highlighting how their mechanisms of action influenc...

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7:04

Can Urolithin A Transform Performance?

Daily Value ·

2025/01/03

In this episode of Daily Value, we delve into the emerging evidence surrounding Urolithin A, a metabolite derived from gut bacteria that is showing potential for enhancing athletic performance and recovery in young healthy populations. Originating from dietary ellagitannins found in foods such as pomegranates, berries, and nuts, but also available as a supplement, Urolithin A’s ability to optimize mitochondrial function suggests new approaches to sports nutrition and physical performance.Disc...

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11:15

Does Vitamin D Reprogram Your Body? Muscle Gains, Not...

Daily Value ·

2025/01/01

This episode explores the critical connections between Vitamin D, muscle health, and energy metabolism, emphasizing its role in muscle protein synthesis, hypertrophy, and body composition. We discuss the latest research, clinical findings, and the importance of maintaining adequate Vitamin D levels for optimal skeletal muscle function.• Understanding Vitamin D's unique secosteroid structure• Role of Vitamin D in muscle function and regeneration• Impact of Vitamin D deficiency on muscle streng...

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9:27

Improving Gut Health: The Fiber-Vitamin-Immune...

Daily Value ·

2024/10/04

In today’s episode of Daily Value, we explore the connection between B vitamins, and immune system, focusing on how dietary fiber fuels this relationship. While it’s well-known that fiber is essential for digestive health, new research (PMID: 39307855 - rodent data) demonstrates that it plays an even more complex role—boosting the available pool of B vitamins produced by gut bacteria, which in turn improved immune function. This episode will look at the interplay between gut bacteria, fiber, ...

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15:28

Hidden Vitamin Deficiencies: The Unnoticed Threats in...

Daily Value ·

2024/10/02

In today’s episode of Daily Value, we continue our exploration of vitamins by diving into the concept of hypovitaminosis and the importance of adequate vitamin intake for overall health. The second half of the 20th century brought critical insights into how vitamin insufficiencies, or hypovitaminosis, can impact human health, even in populations where outright deficiencies are uncommon. We’ll explore the distinction between insufficiency and deficiency, how vitamin status is assessed, and the...

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7:34

How Moderate Coffee Drinking Could Transform Your Health

Daily Value ·

2024/09/30

In today’s episode of Daily Value, we look at the protective effects of coffee, tea, and caffeine consumption on cardiometabolic health. A recent study published in the Journal of Clinical Endocrinology & Metabolism (doi:10.1210/clinem/dgae552) reveals how moderate caffeine intake—equivalent to a specific amount of caffeine—is related to the reduced risk of cardiometabolic multimorbidity, which includes coexistence of conditions like type 2 diabetes, coronary heart disease, and stroke.Epi...

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14:45

From Scurvy to Success: How Vitamins Revolutionized...

Daily Value ·

2024/09/27

In today’s episode of Daily Value, we begin a special series called “The Vitamins,” where we’ll dive deep into the discovery, functions, and importance of vitamins in human health. This first episode lays the groundwork by exploring the history of vitamin discovery, from the 19th-century realization that certain diseases were tied to diet, to the revolutionary concept of vitamins and their role in preventing specific deficiency diseases. We’ll also cover key definitions, the defined physiolog...

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14:59

B12 Deficiency: Uncovering the Silent Threat to...

Daily Value ·

2024/09/25

In today’s episode of Daily Value, we take a closer look at a commonly overlooked but essential nutrient: vitamin B12. Known as cobalamin, vitamin B12 deficiency can lead to severe neurological, hematological, and cognitive issues if left unchecked. We’ll cover the causes behind this growing issue, from dietary intake to malabsorption.Episode Talking Points:The role of B12 in nervous system function and red blood cell production.Causes of B12 deficiency, including dietary factors, autoimmune ...

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81 results

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