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PODCAST

Brain Ponderings podcast with Dr. Mark Mattson

Conversations with neuroscientists, neurologists, evolutionary biologists, anthropologists, computer scientists, and others that ponder the brain. Here are a few of the questions that BRAIN PONDERINGS will tackle: How have brains evolved to enable success in diverse environments? How does the brain develop in the womb and in early life? What are the mechanisms responsible for learning and memory, language, and emotions? How does the brain respond to life"s challenges? In what ways does the brain

science natural sciences

All Episodes

01:09:03

William Brady: MADness: Understanding and...

Brain Ponderings podcast with Dr. Mark Mattson ·

2025/04/08

William Brady deploys behavioral experiments, big data analytics, and natural language processing to elucidate how human psychology interacts with social media technology to affect morality, emotions, and decision-making. Until very recently in their evolution any one human interacted with no more than a few dozen others during their lifetime. Moreover, those interactions were face-to-face. By its very nature social media is often subjecting our brains to situations for which they are not evolved

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01:14:24

Dietary Phytochemicals and Mycochemicals,...

Brain Ponderings podcast with Dr. Mark Mattson ·

2025/03/27

In this episode I provide an overview of the evidence that certain chemicals produced by plants and fungi are beneficial for brain function and health. I focus on the fact that the function of these phytochemicals or mycochemicals in the plants or mushrooms is to defend them from being consumed by insects and other animals. We and other animals evolved mechanisms to tolerate the noxious chemicals. We avoid too much of them because they have a bitter taste, and our cells respond to the chemicals by

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01:22:13

Dietmar Schmitz: Interneuron Diversity and Circuit...

Brain Ponderings podcast with Dr. Mark Mattson ·

2025/03/18

The vast majority of research on the cellular and molecular mechanisms of the storage and retrieval of memories has focused on the excitatory glutamatergic neurons that convey signals into and throughout the brain. However, recent research has revealed the importance of widespread oscillations in neural network activity (particularly gamma and theta frequencies) in cognition. In this episode Professor Dietmar Schmitz talks about features of short- and long-range neural connectivity and their roles

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01:15:37

Dudley Lamming: mTOR – How Dietary Protein and Amino...

Brain Ponderings podcast with Dr. Mark Mattson ·

2025/03/11

Research has shown that excessive dietary protein intake and high amounts of branch-chain amino acids (BCAA) in particular can accelerate aging and exacerbate chronic diseases of aging. In this episode University of Wisconsin Assoc. Professor Dudley Lamming talks about the cellular amino acid sensing mTOR pathway and its influences on aging and disease processes. The Lamming laboratory is making major contributions to establishing how amino acid intake affects cells and organ systems in health and

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01:12:27

Roshan Cools: Dopamine’s Roles in Cognitive Control,...

Brain Ponderings podcast with Dr. Mark Mattson ·

2025/03/06

Dopamine is best known as a neurotransmitter involved in the experiencing of pleasure and reward, and for its role in addiction to drugs, gambling, food, etc. But dopamine is also very important in the brain’s ability to evaluate computational tradeoffs (cost versus benefit) and make decisions. In this episode Roshan Cools a Professor of cognitive neuropsychiatry at Radbout University in the Netherlands talks about how dopamine normally controls the neuronal circuits in the striatum and prefrontal

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01:16:25

Maryanne Garry: Misinformation, Disinformation, False...

Brain Ponderings podcast with Dr. Mark Mattson ·

2025/03/03

In this episode I talk with Professor Maryanne Garry at the University of Waikato New Zealand about several interrelated realms of human cognition that are fundamental to changes in the behaviors of individuals and social groups as influenced by electronic media and artificial intelligence. Dr. Garry has devoted her career to understanding how memories of one’s past experiences can be distorted, how false information can become engrained in one’s system of beliefs. She talks about individual and

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56:59

Michal Schwartz: How Immune System Cells Promote...

Brain Ponderings podcast with Dr. Mark Mattson ·

2025/02/25

It had long been thought that the brain was ‘immunologically privileged’ (physically separated from the immune system). However, this dogma was overturned by a series of discoveries including those made by Professor Michal Schwartz at the Weizmann Institute. In this episode I talk with Michal about the different types of immune cells that are located in ‘immunological niches’ of the brain (choroid plexus, perivascular space, meninges..) and how these cells play critical roles in maintaining normal

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01:22:39

Diego Mendoza-Halliday: How the Brain Stays on Task -...

Brain Ponderings podcast with Dr. Mark Mattson ·

2025/02/18

Throughout our waking hours neural networks in our brains are processing incoming information, particularly sights and sounds, integrating those inputs with stored information, making decisions, and executing responses. Staying on task requires that we attend to the details of the task while filtering out ‘noise’. In this episode I talk with Diego Mendoza-Halliday at the University of Pittsburgh about visual working memory – what it is, what neuronal circuits are involved, and how it works. His

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01:07:18

Thomas Hartung: Merging Brain Organoid and AI...

Brain Ponderings podcast with Dr. Mark Mattson ·

2025/02/11

Professor Thomas Hartung has made a major impact in biomedical research by developing and promoting alternatives to animal research. His efforts are leading to more ethical and efficient approaches to basic and applied research in the fields of environmental toxicology, drug development, and neuroscience. In this episode I talk with Thomas about two major flourishing technologies – brain organoids and artificial intelligence – and how they are being rapidly incorporated into both basic and

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54:55

Magdalena Götz: Direct Conversion of Astrocytes Into...

Brain Ponderings podcast with Dr. Mark Mattson ·

2025/02/04

Someday it may be possible to restore neuronal networks that have been lost or damaged by brain injury or in neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. There are as many astrocytes in the human brain as there are neurons and the astrocytes generally do not die in brain injuries and neurodegenerative disorders. Professor Magdalena Götz has shown that astrocytes can be converted directly into neurons using molecular biology technologies to manipulate a few transcription

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01:12:42

Antonio Di leva: Fractal Patterns and the Brain –...

Brain Ponderings podcast with Dr. Mark Mattson ·

2025/01/30

The Euclidean geometry that we learned in our primary education concerns man-made shapes such as rectangles, triangles, and perfect circles. However the shapes of molecules, cells, and organ systems (and their dynamic changes over time) are more complex. Some biological structures exhibit fractal geometry which is defined as “shapes and patterns that appear similar at different scales” (recursive iteration). Examples of biological structures exhibiting fractal geometry include the branches and roots

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01:08:36

Stephan Sigrist: Dietary Spermidine, Neuroplasticity,...

Brain Ponderings podcast with Dr. Mark Mattson ·

2025/01/27

Polyamines are small organic molecules that are acquired in the diet and can also be synthesized in cells. Spermidine is a polyamine that is increasingly recognized as playing important roles in counteracting aging. Foods with high amounts of spermidine include whole grains, broccoli, and natto (fermented soybeans). Professor Stephan Sigrist at the Free University of Berlin who is widely known for his fundamental contributions to understanding how specific proteins and their interactions control the

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01:06:16

Jon Simons: Reality Monitoring- How the Brain...

Brain Ponderings podcast with Dr. Mark Mattson ·

2025/01/22

In the moment most people can readily distinguish between information that is coming into the brain from their senses and what information their brain is generating. However, when recalling information stored in the brain’s neuronal networks the ability to distinguish between what was real and what was imagined becomes more problematic. How does the brain keep track of what we actually experienced in the past and what we imagined happened? In this episode Jon Simons who is Professor of Cognitive

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01:20:26

Keqiang Ye: From Gut to Brain – Rogue Protein...

Brain Ponderings podcast with Dr. Mark Mattson ·

2025/01/08

In this episode Emory University and Chinese Academy of Sciences Professor Keqiang Ye talks about his fascinating and ground-breaking trail of discoveries that have revealed previously unknown mechanism responsible for the production and accumulation of damaging fragments of the APP and Tau proteins in Alzheimer’s disease (AD) and the alpha-synuclein protein in Parkinson’s disease (PD). He discovered an enzyme called AEP that cleaves Tau and alpha-synuclein into self-aggregating toxic fragments.

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01:15:18

For-Profit Drivers of Poor Health in America 2:...

Brain Ponderings podcast with Dr. Mark Mattson ·

2025/01/02

Among high income countries the United States spends the most on health care and yet has the lowest life expectancy. A high percentage of Americans suffer with chronic diseases including obesity, diabetes, cardiovascular disease, mental disorders, and Alzheimer’s or Parkinson’s diseases. There are several reasons why people living in the wealthiest country have poor health all attributable to unrestrained capitalism. In this episode I talk about issues with pharmaceutical industry that contribute to

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01:00:41

Jason Shepherd: The Arc Protein – From Viral Origins...

Brain Ponderings podcast with Dr. Mark Mattson ·

2024/12/20

In this episode I talk with Professor Jason Shepherd about his discoveries concerning a fascinating protein called Arc. In response to synaptic activity Arc levels rapidly increase in postsynaptic dendrites as a result of local translation of the Arc mRNA in the dendrites. Arc plays a critical role in long-term memory although it is not necessary for learning. But perhaps the most interesting twist in the Arc story comes from the Shepherd labs discovery that Arc can self-assemble into highly

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01:14:09

For-Profit Drivers of Poor [Brain] Health in America...

Brain Ponderings podcast with Dr. Mark Mattson ·

2024/12/11

Among high income countries the United States spends the most on health care and yet has the lowest life expectancy. A high percentage of Americans suffer with chronic diseases including obesity, diabetes, cardiovascular disease, mental disorders, and Alzheimer’s or Parkinson’s diseases. There are several reasons why people living in the wealthiest country have poor health all attributable to unrestrained capitalism. In this episode I talk about how large-scale monoculture crops used to produce

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01:10:09

Bruno Rossion: Elucidating the Remarkable Ability of...

Brain Ponderings podcast with Dr. Mark Mattson ·

2024/12/03

Humans have the amazing ability to instantly recognize the faces of hundreds or even thousands of people they have previously met or seen in pictures or movies. Studies of people with brain injuries that render them incapable of recognizing faces and recordings of neuronal activity in people during face recognition have shown that networks in the occipital and temporal lobes adjacent to the visual cortex mediate facial recognition. Professor Bruno Rossion is at the forefront of research that is

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01:27:21

Bioenergetics and Brain Health 4: Brain Aging,...

Brain Ponderings podcast with Dr. Mark Mattson ·

2024/11/26

In this final episode of the Bioenergetics and Brain Health series I talk about changes that occur in brain cells during normal aging, and in Alzheimer’s disease, Parkinson’s disease, and stroke with emphasis on alterations upstream and downstream of cellular energy metabolism. The episode concludes with examples of therapeutic interventions that target those age- and disease-related alterations. LINKS: Hallmarks of Brain Aging

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01:12:40

Bioenergetics and Brain Health 3: How Exercise and...

Brain Ponderings podcast with Dr. Mark Mattson ·

2024/11/19

In this third podcast in the Bioenergetics and Brain Health series I talk about how intermittent exercise and fasting affect brain function, neuroplasticity, and resilience. Research has shown that both of these bioenergetic challenges can enhance learning and memory, improve mood, counteract aging, and protect neurons against injury and disease. I provide an overview of evidence that over periods of weeks and months cycling between challenge (exercise and fasting) and recovery (resting, eating,

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