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PODCAST

Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist

The Go-to Podcast for Biotech Scientists Who Want to Master Biopharma CMC Development and Biomanufacturing.**TOP 10 LIFE SCIENCES PODCAST**Are you ready to simplify bioprocess development and scale with confidence to reduce time to market?Are you feeling overwhelmed by the complexity and guesswork of biologics development and biomanufacturing?Do you wish you had more time to enjoy the beauty of science, without worrying about failing your cell culture process development and

science life sciences

All Episodes

14:29

176: How Virtual Reality Training Solves Europe's...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/07/31

What if the missing link to resilient European bioproduction is not just another breakthrough technology, but the ability to continuously learn, adapt, and collaborate? In a rapidly shifting biotech landscape, innovation isn’t only driven by technical prowess. Behind every robust production process and every cutting-edge therapy, there’s a team empowered with both technical expertise and the soft skills necessary to thrive. In this episode, host David Brühlmann explores the human side of biop...

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19:40

175: How Virtual Reality Training Solves Europe's...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/07/29

What if the road to bioproduction mastery started not in the lab, but with how you train your people? Traditional biotech education often ends at theory, leaving graduates unprepared for the fast-paced world of manufacturing. But what if the key to faster, safer, and more scalable bioprocessing is digital immersion, letting scientists train in a virtual facility before they ever enter a real one? This week, David Brühlmann welcomes Sandrine Lemoine, CEO of Immerscio.bio, to the Smart Biotech ...

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18:49

174: Mastering Hybrid Model Digital Twins: From Lab...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/07/24

How do you transform hybrid model digital twins from promising lab concepts into commercial bioprocessing game-changers that actually deliver ROI? As biotech companies race to implement Industry 4.0 technologies, the critical challenge isn't just developing sophisticated hybrid models - it's deploying them strategically to create user-friendly, cost-effective solutions that genuinely accelerate your path to commercial bioprocessing success. In Part 2 of this essential conversation, David Brüh...

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21:04

173: Mastering Hybrid Model Digital Twins: From Lab...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/07/22

Are you struggling to bridge the gap between lab-scale models and commercial bioprocessing reality? For many biotech innovators, the promise of digital twins meets harsh industrial constraints - where hybrid models that excel in controlled lab environments must prove themselves in the complexity of large-scale manufacturing. This week on the Smart Biotech Scientist Podcast, host David Brühlmann welcomes Krist Gernaey, Professor of Industrial Fermentation Technology at the Technical University...

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19:43

172: Reimagining Chromatography for Advanced...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/07/17

Downstream processing remains one of the most complex and critical steps in biomanufacturing, especially as new therapeutic modalities like cell and gene therapies push current technologies to their limits. The industry faces ongoing pressure to innovate, reduce costs, and improve efficiency, while still ensuring robust and reliable results. In this practical, energetic episode, host David Brühlmann welcomes Scott Wheelwright, Chairman, CTO and Co-Founder of BioChromatographix International (...

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20:35

171: Reimagining Chromatography for Advanced...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/07/15

For decades, chromatographic purification has made use of bead-based diffusion - a reliable but limiting approach, especially as new modalities like gene therapies, mRNA, and viral vectors push the boundaries of what’s possible. But what if the future of downstream processing lies not in incremental improvement, but in a dramatic reimagining - from slow diffusion to rapid convection? In this episode, David Brühlmann meets Scott Wheelwright, Chairman, CTO and Co-Founder of BioChromatographix I...

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22:40

170: Why Your DNA Is a Terrible Disease Predictor...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/07/10

For years, disease diagnosis and treatment have focused on a few biomarkers, overlooking thousands of vital biological signals. Despite biotech advances, most therapies are still based on limited data, missing countless breakthroughs. Multiomics changes that. By analyzing tens of thousands of proteins, metabolites, and lipids, it reveals hidden insights, paving the way for smarter, faster, and more effective medical discoveries. In this must-listen episode, David Brühlmann welcomes Mo Jain, f...

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25:33

169: Why Your DNA Is a Terrible Disease Predictor...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/07/08

What if the secret to truly personalized precision medicine lies not in your genetic code, but in your zip code? For years, biotech has focused on genomics to explain disease and drug response, but DNA only accounts for a fraction of the story. The real breakthrough? Multi-omics: the large-scale analysis of proteins, metabolites, and lipids, powered by advanced mass spectrometry and AI, offering a fuller picture of human health. In this episode, David Brühlmann meets Mo Jain, founder and CSO ...

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24:51

168: How Generative AI Is Revolutionizing Biotech...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/07/03

The promise of generative AI in pharma and biotech is huge, but it's also fraught with complexity, especially when it comes to integrating these systems into highly regulated environments. From monitoring evolving guidelines to balancing operational efficiency and data integrity, the journey from hype to real-world impact is filled with both opportunity and skepticism. In this episode, David Brühlmann sits down with Abhijeet Satwekar, Innovation Manager at Merck Healthcare’s Global Analytical...

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13:30

167: How Generative AI Is Revolutionizing Biotech...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/07/01

Ever feel like you’re drowning in an ocean of constantly shifting regulatory guidelines? The world of biotech is a whirlwind of evolving standards, making compliance not just a headache, but sometimes the stumbling block between life-changing therapies and the patients who need them. But what if artificial intelligence could turn regulatory chaos into your biggest competitive advantage? In this episode, David Brühlmann sits down with Abhijeet Satwekar, Innovation Manager at Merck KGaA’s Globa...

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17:02

166: Why Your Funding Pitches Fail Despite Brilliant...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/06/26

Have you ever presented a major scientific breakthrough, only to be met with blank stares and distracted executives? You're not alone. In this episode, David Brühlmann shares how he went from drowning in data to winning an innovation contest, not through better tech, but through the power of scientific storytelling. Many scientists default to methods and data, but as David notes, “it’s like being fluent in a language nobody else in the room speaks.” Without a clear link to human impact, even ...

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18:44

165: Why Your Funding Pitches Fail Despite Brilliant...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/06/24

Have you ever poured months of research into a brilliant innovation, only to watch executives’ eyes glaze over during your presentation? You’re not alone. In this episode, host David Brühlmann describes a familiar frustration: scientists are trained to perfect data, not to sell ideas. But in today’s fast-paced biotech landscape, even the most groundbreaking technology risks fading into obscurity if it isn’t communicated effectively. Here’s what you’ll learn in this episode: Why Good Science N...

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19:17

164: How Moss Enables Production of Unproducible...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/06/19

From lab curiosity to commercial reality. Here's what happens when moss meets the brutal economics of bioprocessing. In Part 1, you've heard the science behind moss-based protein production. Now comes the real test: Can it survive the gauntlet of regulatory scrutiny, cost pressures, and manufacturing scale-up that crushes most biotech innovations? In Part 2 of this groundbreaking conversation, David Brühlmann and Andreas Schaaf, Managing Director and CSO of Eleva, dive into the nuts and bolts...

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23:48

163: How Moss Enables Production of Unproducible...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/06/17

What if the future of "impossible" protein therapeutics is hiding in your backyard? For decades, CHO cells have ruled the biotech kingdom as the undisputed champions of complex protein production. But here's the uncomfortable truth: countless breakthrough therapies are gathering dust on laboratory shelves—not because the science failed, but because traditional hosts can’t produce them. Enter moss. Yes, moss. That humble green organism clinging to rocks and trees might just be the biotech indu...

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15:35

162: How to Achieve 85%+ Cell Recovery Without DMSO's...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/06/12

The world of cell therapy is changing rapidly, with revolutionary advancements in cryopreservation and bioprocessing protocols leading the way. In a recent episode of the Smart Biotech Scientist Podcast, host David Brühlmann sat down with Jeffrey Allen, Chairman and CEO of Evia Bio, to dive deep into the “how” of implementing cutting-edge techniques in the lab and the strategic mindset needed to move therapies from concept to clinic successfully. Jeffrey Allen is a passionate leader with a di...

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25:52

161: How to Achieve 85%+ Cell Recovery Without DMSO's...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/06/10

If you’ve ever worked in a cell therapy lab or handled biologics, you’ve probably experienced the pitfalls of cryopreservation. We’ve all mourned the loss of precious samples after a freeze-thaw cycle gone wrong or watched viability figures plummet, wondering where it all went awry. In this episode of The Smart Biotech Scientist Podcast, Jeffrey Allen, Chairman and CEO of Evia Bio, shares how nature-inspired solutions are changing the cell preservation game. With a background spanning finance...

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18:19

160: The Ultimate Guide to Accelerating Perfusion...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/06/05

In this concluding episode of our deep dive into miniaturized perfusion systems, we tackle the most challenging aspect: implementing meaningful process analytical technology (PAT) at microscale while keeping costs realistic for high-throughput applications. Tom Valentin, group leader at CSEM for Automated Sample Handling, continues sharing CSEM's pioneering work in automated sample handling, revealing both the breakthrough opportunities and stubborn technical barriers that define the current ...

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22:30

159: The Ultimate Guide to Accelerating Perfusion...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/06/03

In bioprocess development, the ability to rapidly screen conditions and predict scale-up performance can mean the difference between a successful therapy launch and costly delays. Today's Smart Biotech Scientist episode features Tom Valentin from CSEM, who's pioneering revolutionary approaches to miniaturized perfusion systems that could transform how we develop biologics. Tom is a group leader at CSEM for Automated Sample Handling within the Life Sciences and Industry 4.0 business unit. As a...

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16:25

158: How to Detect Endotoxins Without Bleeding a...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/05/29

In this concluding episode of our series on revolutionary endotoxin detection, we continue our conversation with Anika Hoffmann about transitioning from theory to practice in the quest for more reliable, sustainable testing methods. Anika is a postdoctoral researcher in analytical chemistry at HES-SO Valais-Wallis, Switzerland. Having established why traditional LAL testing falls short in Part 1, we now explore how Anika's innovative KDO-based chemical analytical approach compares in real-wor...

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22:38

157: How to Detect Endotoxins Without Bleeding a...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/05/27

Send us a text In biopharmaceutical manufacturing, endotoxins represent a silent but deadly threat – bacterial fragments capable of triggering severe immune responses at picogram levels, potentially leading to septic shock, organ failure, or even death in patients. In this eye-opening first episode, we speak with Anika Hoffmann, a postdoctoral researcher in analytical chemistry at HES-SO Valais-Wallis, Switzerland, who's challenging the decades-old status quo of endotoxin testing. For nearly ...

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184 results

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