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PODCAST

No Priors: Artificial Intelligence | Technology | Startups

At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world"s leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com. Sarah Guo is a startup investor and the founder of Conviction, an investment firm

technology entrepreneurship

All Episodes

40:32

Building the Platform for Scientific Breakthrough,...

No Priors: Artificial Intelligence | Technology |... ·

2025/02/27

This week on No Priors, Sarah sits down with Noubar Afeyan, Co-founder and CEO of Flagship Pioneering, the biotech firm behind groundbreaking companies like Moderna. They explore how Flagship creates the conditions for scientific breakthroughs, tackles regulatory uncertainty, and pushes the boundaries of discovery. Noubar shares insights on AI’s role in healthcare, the challenges of bringing new therapies to market, and lessons learned from past pandemics. He also discusses Flagship’s platform

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57:40

Virtual Cell Models, Tahoe-100 and Data for AI-in-Bio...

No Priors: Artificial Intelligence | Technology |... ·

2025/02/25

On this week’s episode of No Priors, Sarah Guo is joined by leading members of the teams at Vevo Therapeutics and the Arc Institute – Nima Alidoust, CEO/Co-Founder at Vevo Therapeutics; Johnny Yu, CSO/Co-Founder at Vevo Therapeutics; Patrick Hsu, CEO/Co-Founder at Arc Institute; Dave Burke, CTO at Arc Institute; and Hani Goodarzi, Core Investigator at Arc Institute. Predicting protein structure (AlphaFold 3, Chai-1, Evo 2) was a big AI/biology breakthrough. The next big leap is modeling entire human

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38:14

Building Hard Tech in Hard Markets: Kyle Vogt on...

No Priors: Artificial Intelligence | Technology |... ·

2025/02/20

Kyle Vogt joins Sarah and Elad on this week’s episode of No Priors. A serial entrepreneur, Kyle co-founded Twitch, transforming live streaming, and later Cruise, the autonomous vehicle company acquired by GM for $1 billion. Now he’s taking on AI-powered home robotics with The Bot Company. In this episode, Kyle shares his journey building transformative tech companies, the challenges of scaling autonomous systems, and why he believes home robots are the next frontier. They also discuss the parallels

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49:35

How Harvey AI is Changing the Legal Industry with...

No Priors: Artificial Intelligence | Technology |... ·

2025/02/14

This week on No Priors, Sarah sits down with Harvey cofounder and CEO Winston Weinberg. Harvey is one of the leading application layer AI companies, building domain-specific AI for law firms, professional service providers, and the Fortune 500. They are already working with companies like Bridgewater, KKR, PWC, and O’Melveny with over $500M in funding from OpenAI, Sequoia, Kleiner, GV and Elad and Sarah. In this episode, Sarah and Winston cover AI product strategy, the future of professional

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22:32

DeepSeek, Deep Research, and 2025 Predictions with...

No Priors: Artificial Intelligence | Technology |... ·

2025/02/07

This week on No Priors, Sarah and Elad celebrate the 100th episode! They dive into the biggest AI stories of 2025, breaking down DeepSeek—truth vs. hype, the rapid consumer adoption, and the real cost of training the models. They debate model commoditization and the value of being a frontier model provider vs. building on existing work. Plus, they unpack OpenAI’s new Deep Research release and the latest on Stargate. Finally, they share bold predictions for 2025, covering robots, autonomous vehicles,

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27:11

Rick Caruso on LA’s Wildfires, Policy Failures, and...

No Priors: Artificial Intelligence | Technology |... ·

2025/01/30

This week on No Priors, Elad sits down with Rick Caruso, LA real estate developer and runner-up in the 2022 mayoral race. With experience serving under three LA mayors, as well as on the police commission and the board of water and power, Rick offers a unique perspective on the systemic failures that contributed to the devastation of the January 2025 wildfires in communities like the Palisades and Altadena. He discusses the steps he took to build more resilient infrastructure in his properties and

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37:59

What Can We Do About Wildfires? With Convective...

No Priors: Artificial Intelligence | Technology |... ·

2025/01/23

This week on No Priors, Sarah and Elad sit down with Bill Clerico, founder of Convective Capital, an early stage venture fund focused on technology-driven solutions for wildfire mitigation and climate resilience. The wildfires in Los Angeles have caused unprecedented property damage and immense hardship for countless individuals and families. This episode is devoted to diving into understanding what happened and what we can do in the future. Bill shares his insights into the increasing severity of

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30:09

How AI Agents Are Transforming Customer Support, with...

No Priors: Artificial Intelligence | Technology |... ·

2025/01/16

Today on No Priors, co-founder and CEO of Decagon, Jesse Zhang, joins Elad to discuss the future of agentic customer support. Decagon provides AI-powered customer interactions for companies like Rippling, Notion, Duolingo, Classpass, Substack, Vanta, Eventbrite, and more. Jesse shares the thesis behind starting Decagon, why he sees customer support as the ideal entry point for agentic technology, and what areas of AI excite him most. They also discuss voice-based interfaces, issues with latency in

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23:36

Erik Bernhardsson on Creating Tools That Make AI Feel...

No Priors: Artificial Intelligence | Technology |... ·

2025/01/09

Today on No Priors, Elad chats with Erik Bernhardsson, founder and CEO of Modal Labs, a platform simplifying ML workflows by providing a serverless infrastructure designed to streamline deployment, scaling, and development for AI engineers. Erik talks about his early work on Spotify’s ML algorithms, what Modal offers today, and his vision for building an end-to-end solution for AI engineers. They dive into GPU trends, cloud vs on-premise setups, and when to train custom models vs use off-the-shelf

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27:07

The Best of 2024 with Sarah Guo and Elad Gil

No Priors: Artificial Intelligence | Technology |... ·

2024/12/26

2024 has been a year of transformative technological progress, marked by conversations that have reshaped our understanding of AI's evolution and what lies ahead. Throughout the year, Sarah and Elad have had the privilege of speaking with some of the brightest minds in the field. As we look back on the past months, we’re excited to share highlights from some of our favorite No Priors podcast episodes. Featured guests include Jensen Huang (Nvidia), Andrej Karpathy (OpenAI, Tesla), Bret Taylor

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31:18

Revolutionizing Customer Success with Agency’s Elias...

No Priors: Artificial Intelligence | Technology |... ·

2024/12/19

Today on No Priors, Sarah sits down with Elias Torres, CEO and founder of Agency, an AI agent for customer success teams. Elias shares his journey from growing up in Nicaragua to founding several companies, leading engineering at HubSpot, and selling Drift for $1B. He also discusses his work consulting with OpenAI in 2022, which deepened his understanding of the business opportunity LLMs presented and inspired him to start Agency. In this episode, Elias offers a unique perspective on the future of

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42:21

How Diamond Cooling Could Power the Future of AI,...

No Priors: Artificial Intelligence | Technology |... ·

2024/12/12

In this episode of No Priors, Sarah sits down with Felix Ejeckam and Ty Mitchell, founders of Akash Systems, a company pioneering diamond-based cooling technology for semiconductors used in space applications and large-scale AI data centers. Felix and Ty discuss how their backgrounds in materials science led them to tackle one of the most pressing challenges in tech today: thermal efficiency and heat management at scale. They explore how Akash is overcoming the limitations of traditional

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38:17

Bolt’s Eric Simons on Enabling Everyone to Generate...

No Priors: Artificial Intelligence | Technology |... ·

2024/12/05

In this episode of No Priors, Sarah talks with Eric Simons, co-founder and CEO of StackBlitz. The company has experienced explosive growth since the launch 2 months ago of Bolt.new, an AI application that lets users prompt, run, edit, and deploy full-stack applications directly in the browser. Eric talks about the years-long journey that led to overnight success, why so many non-technical users are forming a community around Bolt, and the democratization of coding.Sign up for new podcasts every

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44:15

Model Plateaus and Enterprise AI Adoption with...

No Priors: Artificial Intelligence | Technology |... ·

2024/11/21

In this episode of No Priors, Sarah is joined by Aidan Gomez, cofounder and CEO of Cohere. Aidan reflects on his journey to co-authoring the groundbreaking 2017 paper, “Attention is All You Need,” during his internship, and shares his motivations for building Cohere, which delivers AI-powered language models and solutions for businesses. The discussion explores the current state of enterprise AI adoption and Aidan’s advice for companies navigating the build vs. buy decision for AI tools. They also

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39:21

AI and the Future of Math, with DeepMind’s AlphaProof...

No Priors: Artificial Intelligence | Technology |... ·

2024/11/14

In this week’s episode of No Priors, Sarah and Elad sit down with the Google DeepMind team behind AlphaProof, Laurent Sartran, Rishi Mehta, and Thomas Hubert. AlphaProof is a new reinforcement learning-based system for formal math reasoning that recently reached a silver-medal standard in solving International Mathematical Olympiad problems. They dive deep into AI and its role in solving complex mathematical problems, featuring insights into AlphaProof and its capabilities. They cover its

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36:53

NVIDIA's Jensen Huang on AI Chip Design, Scaling Data...

No Priors: Artificial Intelligence | Technology |... ·

2024/11/07

In this week’s episode of No Priors, Sarah and Elad sit down with Jensen Huang, CEO of NVIDIA, for the second time to reflect on the company’s extraordinary growth over the past year. Jensen discusses AI’s takeover of datacenters and NVIDIA’s rapid development of x.AI’s supercluster. The conversation also covers Nvidia’s decade-long infrastructure bets, software longevity, and innovations like NVLink. Jensen shares his views on the future of embodied AI, digital employees, and how AI is transforming

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35:36

Forecasting the Future with Kalshi: America’s First...

No Priors: Artificial Intelligence | Technology |... ·

2024/10/31

In this week’s episode of No Priors, Sarah sits down with Tarek Mansour, CEO of Kalshi—the first CFTC-regulated prediction market exchange in the U.S. They dive into Kalshi’s recent victory to legalize election betting, explore ethical questions around trading on elections, and discuss whether prediction markets can offer more accuracy than traditional polls. Tarek shares insights on the history of futures markets, the line between gambling and financial trading, and the psychology behind betting

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44:30

Waymo’s Journey to Full Autonomy: AI Breakthroughs,...

No Priors: Artificial Intelligence | Technology |... ·

2024/10/24

In this episode of No Priors, Dmitri Dolgov, Co-CEO of Waymo, joins Sarah and Elad to explore the evolution and advancements of Waymo's self-driving technology from its inception at Google to its current real-world deployment. Dmitri also shares insights into the technological breakthroughs and complexities of achieving full autonomy, the design innovations of Waymo’s sixth generation driverless cars, and the broader applications of Waymo’s advanced technology. They also discuss Waymo's strategic

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29:29

Gaming, Nobel Prizes and At-Risk Businesses in the AI...

No Priors: Artificial Intelligence | Technology |... ·

2024/10/17

In this episode of No Priors, Sarah and Elad explore how AI is transforming consumer apps and entertainment, with a focus on potential integrations in gaming and dating that could shift traditional societal incentives. They reflect on AI researchers winning Nobel Prizes in Science and Chemistry for the first time, discussing what this trend means for scientific discovery. The episode also covers recent AI releases, including their thoughts on OpenAI’s O1 model and Google’s NotebookLM, and examines

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38:28

Launching AI products with Braintrust’s CEO Ankur Goyal

No Priors: Artificial Intelligence | Technology |... ·

2024/10/08

Today on No Priors, Elad is joined by Ankur Goyal, founder and CEO of Braintrust. Braintrust enables companies like Notion, Airtable, Instacart, Zapier, and Vercel to deploy AI solutions at scale by efficiently evaluating and managing complex, non-deterministic AI applications. Ankur shares his insights into emerging trends in the use of AI tooling and coding languages, the rise of open-source, and the future of data infrastructure. Ankur also reflects on building resilient AI products, his

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145 results

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