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Bloody Minded

Bloody Minded Crew

Baffled by blood? Confused by coags? Traumatised by TTP? Planning on quitting medical school because you"ve just finished haem block? Join the registrars of the Bloody Minded Crew as they tour the world of haematology one topic at at a time while procrastinating from their day jobs. Your time is precious, so to maximise your return we look at each topic at a variety of levels so you can tailor your learning. Check out more at www.bloodyminded.com.au

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All Episodes

42:26

Episode 28 - In the Lab: Flow Cytometry, Mass...

Bloody Minded ·

2024/12/17

Can’t get enough of obscure haematological lab chat, can you? Well we’ve got good news for you! Join us today as we delve even deeper into the arcane depths of flow cytometry, mass spectrometry and cytogenetics as they apply to myeloma. We promise we didn’t just make these words up.02:23 - Flow cytometry: overview04:01 - The flow cytometer: practical aspects09:01 - How we interpret flow11:44 - Myeloma flow markers14:32 - Quality in flow21:26 - Mass spectrometry25:59 - Cytogenetics27:46 - Cyto...

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48:14

Episode 27 - In The Lab: Electrophoresis,...

Bloody Minded ·

2024/12/10

Thought you were free of myeloma acronyms? Don’t be ridiculous - this is the haematology lab! We were born in the acronyms, moulded by them. We didn’t see a complete word until advanced training and even then it was nothing but BLINDING. Your lab tests betray you because they belong to us… but in this episode we’ll let you in on some secrets. Join Nick, Cale and Bashar in the haematology (and closely adjacent immunology) lab as they chat about just how we do that electrophoresis, why an iEPG...

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35:14

Episode 26 - Trip to the Congo | Amyloidosis Overview

Bloody Minded ·

2024/12/03

MGUS and Myeloma too simple for your tastes? Do you like vague presentations and biopsying many tissues in a sometimes wild goose chase? Why does Congo have all the birefringent apples? Go 'AAaah' as we TTRy to unpack ALl the problems that come with that most protean of disease - Systemic Amyloidosis!Timestamps3:04 - Pathophysiology of Amyloid6:52 - All The Subtypes of Amyloid7:56 - AA Amyloid10:08 - ABeta2M Amyloid11:04 - Age-Related Amyloidosis = wtATTR = WTTA = SSA14:38 - AL Amyloidosis16:...

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47:20

Episode 25 - Alphabet Soup | Overview of Myeloma...

Bloody Minded ·

2024/11/26

RVd, KTd, CyBorD, DVd, EloRd - Looks like the cat got on the keyboard. Oh wait, this is just the myeloma regimens in day therapy today. Come on a journey as we attempt (mostly successfully) to avoid drug trade names! Let go of your proteasome inhibitions, phenotype your red cells and let us modulate your understanding of what it is to treat myeloma with an alphabet soups worth of drugs. We sincerely apologise to our endocrinology colleagues for how much dexamethasone we use in this episo...

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28:35

Episode 24 - Blue Fried Eggs | Intro to Multiple Myeloma

Bloody Minded ·

2024/11/19

==I do not like blue eggs and ham,I do not like them, Sam I Am.They crowd and clump, they grow too fast,Causing troubles that can last.They make my bones feel weak and sore,And through my kidneys they gnaw!I do not like blue eggs, you see,They're signs of something wrong with me.==Timestamps3:35 - Recap of MGUS + smouldering myeloma4:42 - Clinical case - Mr. Peter Rotein8:15 - What is rouleaux?10:30 - Bone marrow biopsies - what, how, how much ow?15:29 - Multiple myeloma16:41 - CRAB Criteria1...

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31:48

Episode 23 - Help I found a paraprotein | MGUS + The...

Bloody Minded ·

2024/11/12

Ordered something you shouldn’t have and accidentally found a paraprotein again? Shame on you, but now you have to do something with it. Maybe you were genuinely suspicious for myeloma. If incidentally discovered lab findings are leaving you smouldering, this is the episode for you! Join Nick, Cale and Bashar as they chat about the spectrum of plasma cell dyscrasias, and cover the precursor conditions MGUS and Smouldering Myeloma.Timestamps2:53 - What is a paraprotein?5:56 - The heavy ch...

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35:24

Episode 22 - B is for B-Cell | Immunology 101

Bloody Minded ·

2024/11/05

A is for Antibody. B is for B-cell. C is for Cryoglobul… wait no we’ve covered that already. If you struggle to tell your thymus from an isthmus, can’t see the humour in humoural immunity and think a bursa is just some fancy elbow cushion then THIS is the episode for you. Join the Bloody Minded Crew as they dust off their undergraduate immunology degrees, get back to the classroom and cover the foundations of the immune system in preparation for tackling our upcoming malignant diseases. ...

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44:54

Episode 21 - On the Wards: Welcome to the Jungle |...

Bloody Minded ·

2024/10/22

Help! After a disastrous 3 way ward swap you now have to cover the haem ward as an intern in... 45 minutes time. If only there were some way you could get a crash course on everything you might need to know. Well are you in luck today! Join our new guest host Dr Alison Chandler for a whole new subtype of episodes, our new "On the Wards" series.“ These are for those new interns and residents who have been drafted to cover the dreaded haem wards and need to prepare all the practical day to day ...

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43:24

Episode 20 - TMI about TLAs | TTP & PNH with Dr Hsu

Bloody Minded ·

2024/10/08

Tired of listening to the three of us? Why not listen to an actual expert!? Today we're joined by Dr Danny Hsu, consultant haematologist, clinical lead of Immune Haematology & Therapeutic Apheresis at Liverpool Hospital, THANZ council member and all around top bloke to dig down into the nitty gritty of TTP and PNH. Any question you might have about these conditions Dr Hsu is your go to. Sadly we didn't ask him every question you might have, but he certainly came up with incredible an...

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31:35

Episode 19 - In The Lab: Advanced Haemolysis Testing

Bloody Minded ·

2024/10/01

Have you been spending too much time outside of the lab lately? So have we! Come with us on a whirlwind tour through the high altitudes of thermal amplitudes, the chilly depths of cold agg titres, the bright lights of EMA testing, the flocculated wetlands of unstable haemoglobins (don’t ask) and more! All from the safety of the lab, of course. We don’t go outside.Timestamps2:14 - Cold agglutinin testing8:05 - PCH (Pretty Cool Haem)/Donath-Landsteiner testing14:52 - G6PD testing23:25 - Unstabl...

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21:22

Episode 18 - Pretty Not Happy (with blood) |...

Bloody Minded ·

2024/09/24

Do you have a FLAER for the exotic? All at sea without your GPI-anchor? Come on a deep dive into the world of paroxysmal nocturnal haemoglobinuria - which isn’t really a disease of haemolysis at all but hey we're putting it here anyway and you can't stop usTimestamps1:46 - What is PNH? Baby don't hurt me...4:48 - Signs and Symptoms7:27 - Pathophysiology11:27 - Diagnosis17:04 - Managing Pretty Not Happy BloodCheck out show notes, additional references and (sometimes) extra content at www.blood...

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36:30

Episode 17 - Enough about DAT | Approach to DAT...

Bloody Minded ·

2024/09/17

MAHA TMA Gandhi once said a cell for a cell makes the whole body anaemic, or something along those lines. There’s so much more to DAT negative haemolysis than just DIC. Get out those buckets and put your sorting hats on - it’s time to go where detective Coombs never dared to and look over the DAT negative haemolytic processes. Timestamps2:42 - Approach to DAT negatives - main categories4:53 - Intrinsic Bucket 1: Membrane disorders16:16 - Intrinsic Bucket 2: Enzyme disorders18:51 - Intrin...

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38:33

Episode 16 - Brrrrr-eaking it down | Cold Haemolysis...

Bloody Minded ·

2024/09/10

Grab your hot beverage of choice and come out of the cold as we give you a warm welcome to the world of cold-dependent antibodies! No need to cry(o) as we unpack CAD vs CAS, get personal with PCH and gaze without alliteration at whatever the hell cryoglobulins are. If you're desperate for a medical reason to move to the tropics, this is the episode for you.00:58 - Deliberately inflammatory pop-culture discussions02:45 - Clearing up nomenclature6:12 - How cold is cold?8:40 - Clinical cas...

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29:32

Episode 15 - Antibodies behaving badly | Warm...

Bloody Minded ·

2024/09/03

Is there a glow surrounding your red cells? Things feeling heated in your reticuloendothelial system? An antibody to keep your bed warm at night? We don’t know where this is going either but grab a coconut and hop in the pool because we are excited to welcome you back with a chat about warm autoimmune haemolysis! Timestamps00:57 - Introduction & Case05:08 - wAIHA - What is it?07:04 - Reminder about the RES08:35 - Surface Targets & Drugs11:45 - Brief Mid-Ep Summary13:05 - Causes22...

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24:39

Episode 14 - Throwing Frags

Bloody Minded ·

2024/08/27

Feel your knowledge fragmenting? A MAHA doesn't make you haha? I mean, that's probably a good thing - they're quite serious. Time to unpack the troublesome schistocytes. Hope you brought your helmets as we teach you the bare minimum about fragments so you can save lives on the ward. Timestamps02:26 - What is a red cell fragment? 06:09 - How are schistocytes born? 09:40 - DIC. The haem one, we mean. 13:32 - TTP or not TTP 16:15 - Sorry, he's not...

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30:47

Episode 13 - In the Lab: Dr Coombs? Who is DAT?

Bloody Minded ·

2024/08/20

“It’s Test. Coombs Test. And I like my erythrocytes shaken, not stirred.” Return the lab (where some of the Bloody Minded Crew truly belong) and uncover the secrets of the most important test in haemolysis - the Direct Antiglobulin Test. Learn to whisper its secrets and it can guide you to identifying the true culprit behind these broken red cells. Timestamps:0:57 - Coombs Noir2:05 - Naming History4:32 - DAT in the Lab11:52 - Doing a DAT - Exam Version14:35 - Eluates (Briefly)15:45 - Fal...

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28:51

Episode 12 - Haemolysis: Breaking it down!

Bloody Minded ·

2024/08/13

Haemolysis? Do I really hapto send off more tests? This is reticulous! Now you know what a red cell is - lets learn about how they can break down. Join us as we explore what your boss actually wanted you to do when they asked for a haemolysis screen, and about Cale's deep seated distrust of hepatologists. Timestamps2:30 - Haemolysis - what is it (good for?)7:58 - Reticulocytes? What a reticulous name for a cell9:36 - LDH - Nick will talk about biochemistry here, I'm SORRY okay?11:36 - Bi...

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27:06

Episode 11 - What is Blood ft. Erythrocytes

Bloody Minded ·

2024/08/06

What is blood (Baby don't hurt me)? Rejoice as we escape the land of coagulation and look at some of the questions we have all asked during our medical training- what is blood? Does everybody have blood? Why is there so much of it on this floor? Who are you and how did you get in here? Join us as we we answer all these questions and more this episode with a focus on red cells. Timestamps1:33 - Blood - What is it (good for)?3:49 - Differentiation of blood cells (my progenitors would be pr...

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35:21

Episode 10 - Snakes on the (Clinical) Brain

Bloody Minded ·

2024/07/16

Echis carinatus, Daboia russelii, Uxyuranus scullatellas. Never has so much been owed by so many humans to so few... snakes. In this split episode, For the first time the Bloody Minded Crew is delighted to welcome guests! Join our coagulation experts Dr Maeve Crowley and Kent Chapman for a tour of the wonderful world of exotic clotting times.This episode was so big we split it in half! In Part 2 of this episode we step out of the lab and chat with consultant haematologist Dr Maeve Crowley abo...

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36:02

Episode 9 - Snakes on the (Laboratory) Brain

Bloody Minded ·

2024/07/09

Echis carinatus, Daboia russelii, Uxyuranus scullatellas. Never has so much been owed by so many humans to so few... snakes. For the first time the Bloody Minded Crew is delighted to welcome guests! Join consultant haematologist Dr Maeve Crowley and senior hospital scientist Kent Chapman for a tour of the wonderful world of exotic clotting times. This episode was so big we had to split it in two! In this first half of the episode we interview Kent Chapman, senior hospital scientist in ha...

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