Immune

01:16:21

Immune 93: Macrophages managing memory B cells

Immune ·

2025/06/24

Vincent and Cindy discuss differences between MPox-specific T cell responses following infection and vaccination, and lymph node macrophage control of memory B cell localization and trafficking that might be important for choosing which arm to get a vaccine. Hosts: Vincent Racaniello and Cindy Leifer Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Different T memory response to MPox infection or vaccination (Nat Comm 2025)

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25:53

Immune Booster #13 Microbiome and regulation of gut...

Immune ·

2025/06/10

From the 2024 Society for Leukocyte Biology meeting, Cindy and Brianne sit down with Justin Wilson to talk about how he got into research and his more recent studies on innate immune sensors and the interaction between the gut microbiome and inflammation related to inflammatory bowel disease and cancer. Hosts: Cindy Leifer and Brianne Barker Guest: Justin Wilson Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Francisella

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01:20:33

Immune 92: Gut symbiont breaks antibody

Immune ·

2025/05/27

Steph talks about identification of gut bacteria that can digest protective mucosal antibodies and Vincent covers a new paper on Zika virus that implicates fetal phagocytes in brain invasion, which may provide insight into the devastating microcephaly outcome of infection during pregnancy. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Gut

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23:41

Immune Booster #12: Innate immunity to Archaea with...

Immune ·

2025/05/13

From the 2024 Society for Leukocyte Biology meeting, Immune talks with Holger Heine about the discovery of immune recognition of bacterial lipopolysaccharide and innate immunity to organisms within the kingdom Archaea. Hosts: Cindy Leifer and Brianne Barker Guest: Holger Heine Become a patron of Immune! Links for this episode MicrobeTV Discord Server TLR8 recognizes human gut-associated archaeon (Front Immunol) The human archaeome and its relevance for health and disease (FEBS) Structural insights

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01:00:03

Immune 91: People, parasites, plagues, and podcasts

Immune ·

2025/04/29

Immune talks with David Peterson and Kim Klonowski from the University of Georgia about their careers, their People, parasites, and plagues podcast, placental malaria immunity, and and how interferons in the thymus affect T cell repertoire selection. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Guests: David Peterson and Kim Klonowski Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server People,

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25:23

Immune Booster #11 Immunity to Fungi with Amy Hise

Immune ·

2025/04/09

From the 2024 Society for Leukocyte Biology meeting, Immune talks with Amy Hise about her career in science, her current research using mouse models for investigating fungal immunity and navigating the challenges of being a mom in science. Hosts: Cindy Leifer and Brianne Barker Guest: Amy Hise MicrobeTV Discord Server Mouse model for testing drugs to treat Candida fungal infection Inflammasomes in Aspergillosis Society for Leukocyte Biology Subscribe (free): Apple Podcasts, RSS, email Become

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53:22

Immune 90: Immunology of Injury

Immune ·

2025/03/25

Immune 90: Immunology of Injury March 25, 2025 From the 2024 Society for Leukocyte Biology meeting at Michigan State University, home of the Spartans, Immune’s Cindy and Brianne talk with Liz Kovacs and Jim Lederer about their careers, dirty mice, old mice, and immunity during trauma. Hosts: Cindy Leifer and Brianne Barker Guests: James Lederer and Elizabeth Kovacs Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Jim

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30:58

Immune Booster #10 HIV in the brain with Amanda Brown

Immune ·

2025/03/17

Immune Booster #10 HIV in the brain with Amanda Brown March 18, 2025 From the The Society for Leukocyte Biology 2024 conference at Michigan State University, Cindy and Brianne sit down with Amanda Brown from Johns Hopkins School of Medicine to talk about her career and the research of her laboratory on mechanisms of neuroinflammation in disease, especially during HIV infection. Hosts: Cindy Leifer and Brianne Barker Guest: Amanda Brown Society for Leukocyte Biology Subscribe (free): Apple

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01:22:50

Immune 89: Misplaced antibodies and foreign food foes

Immune ·

2025/02/26

Immune discusses how non-neutralizing antibodies can still be protective…intracellularly, and a technically innovative paper that uses Lipstic to label antigen-presenting cells responsible for gut tolerance to food antigens. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Non-neutralizing antibodies protect against CCHFV (Nat Comm) APC-T cell interactions

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01:28:35

Immune 88: Bespoke antibodies and stinging...

Immune ·

2025/01/29

Immune describes the use of bespoke antibodies to characterize immune cell populations in cave nectar bats, and co-option of retrotransposons to activate hematopoietic stem cells and erythropoiesis. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Immune cells in cave nectar bats (Cell Rep) Cave nectar bat colony (J Am Asso Lab An Sci)

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01:09:25

Immune 87: When the immune system misbehaves

Immune ·

2025/01/14

Immune discusses basophils as regulators of of lung inflammation over space and time, and neoself-antigens as the primary target for autoreactive T cells in human lupus. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Basophils promote asthma (J Exp Med) Basophils regulate lung inflammation (J Exp Med) Neoself antigens are primary T cell targets in

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01:05:13

Immune 86: Where did the SARS-CoV-2 antibodies go?

Immune ·

2024/11/26

Immune explains how distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense, and failure to establish durable SARS-CoV-2-specific plasma cells in the bone marrow long-lived compartment after mRNA vaccination. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Nasal mucsosal macrophages, neuronal maintenance, and

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01:11:57

Immune 85: Immune trade-offs

Immune ·

2024/10/29

Immune explores the immunological diversity in the upper airway, including memory B and T cells and germinal center B cells, and how chronic infection with Plasmodium parasites leads to development of B cell cancers. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Immune memory diversity in human upper airway (Nature) How Plasmodium infection promotes B

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01:04:50

Immune 84: Gender-affirming therapy and immune...

Immune ·

2024/09/24

Petter Brodin joins Immune to discuss immune system adaptation in individuals assigned female sex at birth and undergoing gender affirming testosterone therapy (trans-men). Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Guest: Petter Brodin Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Petter Brodin on TWiV 568 Gender-affirming testosterone treatment (Nature) Time stamps by Jolene. Thanks! Music by

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25:05

Immune Booster #9: Autoimmune diseases with Mark...

Immune ·

2024/09/10

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Mark Shlomchik to talk about his career and the research of his laboratory on systemic autoimmune diseases, long-lived B cell immunity, and immunopathogenesis. Hosts: Cindy Leifer and Steph Langel Guest: Mark Shlomchik Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to

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26:42

Immune Booster #8: Immunology, metabolism, and...

Immune ·

2024/09/03

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Heather Caslin to talk about her training and the research of her laboratory on how diet and exercise affect innate immune cells in health and disease. Hosts: Cindy Leifer and Brianne Barker Guest: Heather Caslin Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

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01:23:37

Immune 83: Immune cells eating other cells

Immune ·

2024/08/27

Immune discusses two stories of immune cells eating other cells: microglia engulfing brain neurons to shape cortical development and behavior, and mast cells trapping neutrophils to increase their functional and metabolic fitness. Hosts: Vincent Racaniello, Cindy Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Microglia shape cortical development and behavior (Cell) Neutrophil trapping by mast cells

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23:46

Immune Booster #7: Emerging viruses with David Martinez

Immune ·

2024/08/20

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with David Martinez to talk about his career, the research of his laboratory on viral pathogens of global health importance, and his advice to be persistent and enjoy the journey. Hosts: Cindy Leifer and Steph Langel Guest: David Martinez Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to

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27:29

Immune Booster #6: From Ghana to heat shock with...

Immune ·

2024/08/13

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Robert Binder to talk about his career, the research of his laboratory on the role of heat shock proteins in cancer immunosurveillance, and the importance of inspiring students as early as possible to think about science. Hosts: Cindy Leifer and Brianne Barker Guest: Robert Binder Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Music by Tatami. Logo image by Blausen

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28:35

Immune Booster #5: Infections and the gut microbiome...

Immune ·

2024/08/06

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Rafael Polidoro to talk about his career, the research of his laboratory on how the gut microbiome modulates the local and systemic immune responses during infections. Hosts: Cindy Leifer and Steph Langel Guest: Rafael Polidoro Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to

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