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PODCAST

NEJM This Week

Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). NEJM publishes new medical research findings, review articles, and editorial opinion on topics of importance to biomedical science and clinical practice.

health & fitness medicine

All Episodes

30:21

NEJM This Week — December 12, 2024

NEJM This Week ·

2024/12/11

Featuring articles on PCI before transcatheter aortic-valve implantation, treatments in patients with type 2 diabetes, in leprosy, in refractory adult ALL, and in ATTR cardiomyopathy; a review article on drug reaction with eosinophilia and systemic symptoms; a case report of a boy with recurrent fever; and Perspectives on an autopsy of a drug withdrawal, on clearing dense drug-patent thickets, on how a survey change sheds light on iatrogenic opioid use disorder and on being tethered.

en-US

34:26

NEJM This Week — December 5, 2024

NEJM This Week ·

2024/12/04

Featuring articles on treatments for atrial fibrillation and stable coronary disease, for chronic hepatitis B, and for metastatic breast cancer; the 30-year cardiovascular disease risk in healthy women; and prenatal screening and detection of maternal cancer; a review article on sepsis and septic shock; a case report of a woman with headache, fever, and respiratory failure; and Perspectives on Medicare’s bundled-payment programs, on handcuffs and unexpected deaths, on the Marburg outbreak in Rwanda,

en-US

30:46

NEJM This Week — November 28, 2024

NEJM This Week ·

2024/11/27

Featuring articles on pembrolizumab perioperative therapy in breast cancer, reduced dose schedules or fractional doses of pneumococcal conjugate vaccine, and nivolumab plus ipilimumab in colorectal cancer; a review article on degenerative rotator-cuff disorders; a case report of a man with seizures and agitation; a Clinical Implications of Basic Research on boning up on boning up; and Perspectives on the Duffy null phenotype; on sickle cell trait, inequity, and the need for change, on “target trial

en-US

29:57

NEJM This Week — November 21, 2024

NEJM This Week ·

2024/11/20

Featuring articles on a nationwide couple-based genetic screening; adjunctive embolization for subdural hematoma; a late-liver-stage attenuated malaria vaccine; and climate change, floods, and human health; a review article on Candida auris infections; a case report of a girl with abdominal pain; and Perspectives on Medicare’s first round of drug-price negotiation; on invisible deaths; on minding the sentinel; and on Saint Didacus, fetal death, and dual loyalty.

en-US

25:25

NEJM This Week — November 14, 2024

NEJM This Week ·

2024/11/13

Featuring articles on perioperative durvalumab in bladder cancer, transcatheter valve repair for mitral regurgitation, chemoradiotherapy in gastric cancer, and lessons from England’s National Health Service; a review article on lung transplantation; a case report of a newborn with hypoxemia and a lung opacity; and Perspectives on our latest brief case studies on efforts toward equity and on forensic nurse examiners.

en-US

27:04

NEJM This Week — November 7, 2024

NEJM This Week ·

2024/11/06

Featuring articles on an invasive treatment strategy in older patients with myocardial infarction, a randomized trial of very early medication abortion, therapies in stage III melanoma, and on long Covid defined; a review article on uterine fibroids; a Clinical Problem-Solving on two sides to the story; and Perspectives on the U.S. Latino HIV crisis, on reframing cerebral palsy as a lifelong disability, and on an older patient and his physician finding an immediate, resonant connection in a haunting

en-US

33:00

NEJM This Week — October 31, 2024

NEJM This Week ·

2024/10/30

Featuring articles on semaglutide in persons with obesity and knee osteoarthritis, the addition of PI3K inhibition in breast cancer, treatments in older patients with myeloma, and total hip replacement for hip osteoarthritis; a review article on lead poisoning; a case report of a man with dyspnea after old myocardial infarction; and Perspectives on large language models and the medical record, on measuring AI against the health care we have, on the failing U.S. health system, and on the contemporary

en-US

31:38

NEJM This Week — October 24, 2024

NEJM This Week ·

2024/10/23

Featuring articles on treatments in heart failure, advanced non–small-cell lung cancer, and Dupuytren’s contracture; a neurodevelopmental disorder caused by deletion in a long noncoding RNA; a review article on burnout and depression among physicians; a case report of a woman with confusion, aphasia, and a brain mass; a Medicine and Society article on how the idea of social contagion shaped trans medicine; and Perspectives on navigating clinicians’ conscience-based refusals, on opportunity costs of

en-US

29:33

NEJM This Week — October 17, 2024

NEJM This Week ·

2024/10/16

Featuring articles on nivolumab in advanced Hodgkin’s lymphoma, kidney transplantation from donors with HIV, a modular communicative leadless pacing–defibrillator system, stereotactic body radiotherapy in prostate cancer, and on how DNA sensing drives inflammation; a review article on cryoglobulinemia; a case report of a woman with dyspnea, dysphagia, and dysarthria; and a Special Report and Perspectives on the U.S. elections and health policy.

en-US

31:10

NEJM This Week — October 10, 2024

NEJM This Week ·

2024/10/09

Featuring articles on beta-blocker use after myocardial infarction and treatments for cerebral adrenoleukodystrophy and for small-cell lung cancer; a review article on hairy-cell leukemia; a case report of a man with fever, myalgia, jaundice, and respiratory failure; and Perspectives on Mpox, on addressing health care cost growth, and on confirmatory trials of accelerated approval drugs.

en-US

34:28

NEJM This Week — October 3, 2024

NEJM This Week ·

2024/10/02

Featuring articles on lenacapavir for HIV prevention in cisgender women, tirzepatide for treatment of obstructive sleep apnea, lymphadenectomy for muscle-invasive bladder cancer, secondary T-cell lymphoma after CAR T-cell therapy, and immunity and early colorectal carcinogenesis; a review article on prolonged grief disorder; a Clinical Problem-Solving on avoiding rash decisions; and Perspectives on health care reform and the 2024 U.S. elections, on financial toxicity for patients from the use of AI,

en-US

33:29

NEJM This Week — September 26, 2024

NEJM This Week ·

2024/09/25

Featuring articles on systematic vs. targeted biopsy for prostate cancer screening, ziresovir in hospitalized infants with RSV, gene therapy for factor IX deficiency, and a phase 2 trial of tulisokibart for ulcerative colitis; a review article on neuroleptic malignant syndrome; a case report of a woman with kidney lesions and lytic bone disease; and Perspectives on Dobbs revisited, on the role of physicians on ethics committees after Dobbs, on accessible weight scales and exam tables, and on

en-US

32:37

NEJM This Week — September 19, 2024

NEJM This Week ·

2024/09/18

Featuring articles on long-term oxygen therapy in severe hypoxemia, reducing opioid overdose deaths, blocking CSF1R in chronic GVHD, and pomalidomide in hereditary hemorrhagic telangiectasia; a review article on central nervous system vasculitis; a case report of a man with confusion and kidney failure; a Medicine and Society on house staff unionization revisited; and Perspectives on ethical challenges in pragmatic and cluster RCTs, on the sense and sensibility of sensitivity analyses, and on there

en-US

29:39

NEJM This Week — September 12, 2024

NEJM This Week ·

2024/09/11

Featuring articles on treatments in newly diagnosed chronic myeloid leukemia and RNA therapeutics in mixed hyperlipidemia; a review article on clinical approaches to firearm injury prevention; a case report of a woman with edema, arthritis, and proteinuria; and Perspectives on keeping SNAP in line with global evidence, on ingesting risk, on centering the peripheral brain, and on how health care burdens patients.

en-US

35:29

NEJM This Week — September 5, 2024

NEJM This Week ·

2024/09/04

Featuring articles on doxorubicin plus trabectedin in leiomyosarcoma, a monoclonal antibody for migraine prevention, adjunctive argatroban or eptifibatide for ischemic stroke, and a new orthonairovirus associated with febrile illness; a review article on pancreatic cysts; a case report of a man with pain and dyspnea; a Medicine and Society on building a community of medical learning; and Perspectives on supreme power, on shared savings for nursing homes, on moral injury and the global health

en-US

33:46

NEJM This Week — August 22, 2024

NEJM This Week ·

2024/08/21

Featuring articles on amino acid infusion and kidney protection, azithromycin to reduce childhood mortality in Niger, belzutifan in renal-cell carcinoma, and a transfusion strategy in traumatic brain injury; a review article on sexual dysfunction in women; a case report of a woman with aphasia, anemia, and a breast mass; and Perspectives on a series of brief cases on efforts toward equity and on controlling global antimicrobial resistance.

en-US

28:13

NEJM This Week — August 15, 2024

NEJM This Week ·

2024/08/14

Featuring articles on osimertinib in stage III EGFR-mutated lung cancer, cognitive motor dissociation in disorders of consciousness, rapid deployment of a brain–computer interface in ALS, and the longevity of a brain–computer interface for ALS; a review article on the genetics of chronic kidney disease; a case report of a boy with autism and decreased vision; and Perspectives on medical expertise, on collecting data on sexual orientation and gender identity, and on the pursuit of polka dots.

en-US

33:12

NEJM This Week — August 8, 2024

NEJM This Week ·

2024/08/07

Featuring articles on crinecerfont in pediatric and adult congenital adrenal hyperplasia, the postacute sequelae of SARS-CoV-2 infection, and nipocalimab in early-onset severe hemolytic disease of the fetus and newborn; a review article on frailty in older adults; a case report of a woman with postpartum anxiety and intrusive thoughts; and Perspectives on refusing to learn the lessons of Covid-19; on preparing for the next pandemic; on collective trauma and commemoration; and on an unknown family

en-US

30:01

NEJM This Week — August 1, 2024

NEJM This Week ·

2024/07/31

Featuring articles on belantamab mafodotin for multiple myeloma, autoantibodies targeting nephrin in podocytopathies, neutralizing anti–interleukin-10 autoantibodies in IBD; a review article on Parkinson’s disease; a Clinical Problem-Solving on going down the rabbit hole; a Medicine and Society article on race-based screening under the ethics microscope; and a Perspective on a legacy of cruelty to sexual and gender minority groups.

en-US

26:34

NEJM This Week — July 25, 2024

NEJM This Week ·

2024/07/24

Featuring articles on treatments for metabolic dysfunction–associated steatohepatitis, blinatumomab in adults with ALL, and sotorasib for KRAS G12C–driven vascular malformations; a review article on HIV-associated tuberculosis; a case report of a woman with rapidly progressive dementia; and Perspectives on the abandonment of people subjected to sexual and intimate partner violence, on multicancer early detection tests, and on coping in the setting of serious illness.

en-US

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