Johns Hopkins Mosquito Minute

12:24

EXTENDED: CRISPR and Consent (Gene Drives Part I -...

Johns Hopkins Mosquito Minute ·

2024/07/30

Gene drives are a novel way of genetically editing the mosquitoes that transmit malaria. They have the potential to dramatically reduce cases and deaths. But the technology they’re based on is new and requires new thinking on regulation. In this first episode of our two-part focus on gene drives, we ask how drives work – examining the CRISPR technology behind them – and explore the hurdles for their release, including the risks, regulations and questions of consent. With Professor Anthony James

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01:19

How Can We Tell Gene Drives Work?

Johns Hopkins Mosquito Minute ·

2024/07/16

Gene drives are a promising tool for malaria control - how can we tell they actually work? Transcript Gene drives are a promising new tool for malaria control. They involve releasing genetically modified mosquitoes into the wild – mosquitoes engineered to halt the parasites from developing inside the insects, or that cause the mosquitoes to die. These GM mosquitoes are then released into new habitats. Over time and across multiple generations, the gene drive spreads, reducing malaria

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07:07

EXTENDED: How Climate Change Could Lead To Faster,...

Johns Hopkins Mosquito Minute ·

2024/07/02

Temperature, rainfall, and humidity determine malaria transmission - but climate change is altering each one of those variables. What might this mean for cases of the disease? With Alex Eapen, from the ICMR (Indian Council of Medical Research) in Chennai, India. About The Podcast The Johns Hopkins Malaria Minute is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.

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01:21

Increase in Temperature Associated With Decrease in...

Johns Hopkins Mosquito Minute ·

2024/06/18

Researchers compare the temperature of mosquito breeding spots with a decade early to examine its impact on malaria transmission. Transcript The effects of climate change on malaria are becoming clearer. Anopheles stephensi – an urban form of the malaria mosquito – is changing its geography, moving from Southeast Asia to parts of Africa and India. To investigate the link between temperature and malaria, between 2021 and 2022 researchers in Chennai, India placed data loggers that recorded temperature

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11:04

EXTENDED: Investigating PfHDAC1 – The Essential...

Johns Hopkins Mosquito Minute ·

2024/05/29

A single protein helps malaria parasites develop in the blood and cause disease symptoms. Could inhibiting this essential protein help curb the spread of disease? With Abhishek Kanyal and Krishanpal Karmodiya. About The Podcast The Johns Hopkins Malaria Minute is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.

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01:16

Blood-Stage Protein Identified as Key Target for...

Johns Hopkins Mosquito Minute ·

2024/05/21

A poorly studied malaria protein could serve as a key drug target to help combat the growing problem of resistance. Transcript A poorly studied malaria protein – Plasmodium falciparum histone deacetylase 1 – could serve as a key drug target to help combat the growing problem of resistance. The protein helps regulate the ‘intraerythrocytic’ stage of the parasite: a 48-hour cycle in which the parasite invades, replicates, and bursts free from red blood cells, causing disease symptoms. By making this

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08:32

EXTENDED: What Sickle Cell Disease Reveals About...

Johns Hopkins Mosquito Minute ·

2024/04/23

How sickle cell disease can be a blessing and a curse. And why we need equity in genomic research and to diversify the genomes we sequence. With Ambroise Wonkam (Johns Hopkins University). About The Podcast The Johns Hopkins Malaria Minute is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.

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01:18

The Malaria Legacy of Sickle Cell Disease

Johns Hopkins Mosquito Minute ·

2024/04/09

Malaria is one of humanity’s oldest diseases – and one with which we have evolved. Transcript Malaria is one of humanity’s oldest diseases – and one with which we have evolved. Over time, it’s put selective pressure on our genome to respond better to its infection. Sickle cell disease is one example. It causes a defect in hemoglobin – transforming red blood cells into a banana or sickle shape – reducing the amount of oxygen transported to the body’s cells. The mutation has been around for more than

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12:04

EXTENDED: From Lab to Legislature – Meet the...

Johns Hopkins Mosquito Minute ·

2024/03/26

On the steps of Capitol Hill, we meet the scientists bringing their scientific battle against malaria into the world of political advocacy. They join a 100+ group of advocates lobbying their members of Congress to fund critical interventions against malaria – becoming ‘malaria champions’ as well. We ask: Why have they decided to join the world of political advocacy? How are they using their expertise to strengthen the champion’s efforts? What scientific message do they have to share? With

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01:17

Advocacy on Capitol Hill: Uniting Scientific Research...

Johns Hopkins Mosquito Minute ·

2024/03/11

Malaria champions from 43 states gather in Washington D.C. to lobby their members of Congress about malaria. Transcript The malaria community is diverse. Some work on the parasites, others the mosquito. Others still focus on public health. The battle is being waged on the bench and the field. But there's another community fighting the disease on a different frontline: in the corridors and offices of Capitol Hill. This week, ‘malaria champions’ from 43 states gather in Washington DC for the annual

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07:56

EXTENDED: Odisha's Innovative Approach to Controlling...

Johns Hopkins Mosquito Minute ·

2024/02/27

Until recently, health workers were the only means to prevent and treat malaria in Odisha, India. In 2017, the state government tried a new strategy: pooling health resources into regional ‘malaria camps’. In this podcast, we ask: What is the current state of malaria in Odisha, India? What challenges does Odisha face in malaria control, especially in hard-to-reach areas? What inspired the Odisha government to introduce the concept of malaria camps? What makes this approach encouraging and

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01:42

‘Malaria Camps’ to Control Malaria in Remote Parts of...

Johns Hopkins Mosquito Minute ·

2024/02/13

Malaria in India has fallen in recent decades — but the risk is still high among hard-to-reach communities. A new study has evaluated the system of ‘malaria camps’ — in which health workers provide targeted interventions before the monsoon. Transcript Malaria in India has diminished in past decades — yet the risk is still high among hard-to-reach communities in forested areas that are isolated particularly during the monsoon season. To control the disease in these areas, the government has started a

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12:38

EXTENDED: Behind the Scenes with a Documentary Crew...

Johns Hopkins Mosquito Minute ·

2024/01/30

A new documentary tells a story of global scientific collaboration in the development of a new malaria vaccine, R21. Today, we take you behind the scenes with director and producer, Catherine Gale. In this podcast, we ask: Why are malaria vaccines gaining so much attention now? What was the serendipidous origin of the documentary? What are the key moments of the documentary? What is the role of collaboration in scientific discovery? With Catherine, Producer and Director at Wingspan Productions,

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0:59

Documentary Reveals Story of Malaria Vaccine's Creation

Johns Hopkins Mosquito Minute ·

2024/01/17

A new documentary from NOVA shines a light on the creation of R21, a new malaria vaccine. Transcript This month, a new documentary from NOVA shines a light on the creation of a new malaria vaccine. ‘The Battle to Beat Malaria’ tells the story of the development of R21 – from creation to WHO approval. Taking you behind the scenes in Oxford, UK, where the jab was developed as a PhD project, to the Serum Institute of India where millions of doses are prepared and stored. The documentary reveals the

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09:41

EXTENDED: Rising Temperatures and Extreme Weather...

Johns Hopkins Mosquito Minute ·

2023/12/18

As COP28 emphasises the human cost of climate change, what will be the impact of rising temperatures and extreme weather events on malaria transmission? In this podcast, we ask: How was health represented this year at COP? What is the impact of rising temperatures on malaria? How will extreme weather events, like flooding, affect malaria prevalence? Why is health resilience so important in mitigating climate-related disruption? With Martin Edlund, CEO of Malaria No More and Courtney Murdock,

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01:25

Climate Change Threatens Malaria Progress – WHO Report

Johns Hopkins Mosquito Minute ·

2023/12/06

The WHO launches its annual World Malaria Report at COP28, the UN's Climate Change Conference. Transcript The World Health Organization (WHO) has released its World Malaria Report for 2023 at the start of COP28, the UN’s Climate Change Conference. The headline figures are concerning. The WHO estimates that there were 249 million cases of malaria last year, resulting in 608000 deaths. These figures surpass pre-pandemic levels, with five countries bearing the brunt of this increase. This year, the

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08:40

EXTENDED: The ‘Chemical Vaccine’ for Long-Lasting...

Johns Hopkins Mosquito Minute ·

2023/11/27

An old malaria drug gets a new formulation. But how good is it – and will it drive resistance? In this podcast, we ask: What are the limitations of current malaria vaccines? What is the concept of long-acting injectable (LAI) drugs? What are the clinical and chemical properties of atovaquone that make it suitable for this purpose? With Theresa Shapiro, Professor, Johns Hopkins School of Medicine and Division Director, Division of Clinical Pharmacology. About The Podcast The Johns Hopkins

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01:08

Turning Drugs Into Vaccines to Offer Longer-Term...

Johns Hopkins Mosquito Minute ·

2023/11/14

How ‘chemical vaccines’ could offer long-term protection against malaria in endemic areas, and combat the problems of dosing and drug resistance. Transcript Drugs used to prevent and treat malaria are vital tools in the malaria toolkit – but they aren’t perfect. When used to prevent malaria, people must remember to take them regularly, or they won’t be as effective. And when they’re used to treat the disease, the sheer scale of infection – with billions of parasites in the body – makes it likely

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07:06

EXTENDED: How Blood Spots are Mapping Artemisinin...

Johns Hopkins Mosquito Minute ·

2023/10/23

Drug efficacy studies are revealing the spatial distribution of mutations causing artemisinin resistance - and it all starts with a drop of blood. In this podcast, we ask: What is artemisinin resistance? What are some of the key molecular markers underpinning it? How can we overcome it? With Didier Ménard, Director of the Institute of Parasitology and Tropical Diseases at the University of Strasbourg, and a visiting researcher at the Pasteur Institute. About The Podcast The Johns Hopkins Malaria

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01:08

Is Artemisinin Drug Resistance in Africa on the Rise?

Johns Hopkins Mosquito Minute ·

2023/10/09

Researchers examine the rise of artemisinin drug resistance in Eritrea - and search for its genetic basis. Transcript Artemisinin – a key antimalarial drug – and other drugs derived from it, are fast losing their effectiveness across South East Asia and increasingly in Africa, too. To investigate this, researchers conducted a review of drug efficacy studies in the East African country of Eritrea. They looked for the rates of delayed parasite clearance in the three days following treatment – a key

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