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PODCAST

Cannabinoid and Psychedelic Pharmacology and Drug Development

Jim Mitchell and Google NotebookLM

Explore Cannabinoid and Psychedelic Pharmacology with AI-Powered Learning.Welcome to a groundbreaking approach to mastering cannabinoid and psychedelic pharmacology and the FDA drug development pathway! This podcast series, powered by Google’s Notebook LM, offers a cutting-edge, AI-guided learning experience tailored for formal classes or self-directed study.Each 30-day series delves deep into the science of cannabinoid and psychedelic pharmacology, exploring molecular signaling pathways,

science chemistry

All Episodes

14:19

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

In this fascinating episode of the ALPHA podcast series, dive deep into the intricate world of cellular signaling as we explore the crosstalk between JAK-STAT and RTK pathways. Through engaging dialogue and vivid analogies, discover how these two major cellular communication systems interact and influence critical processes like immune response and cell growth. Learn how adapter proteins serve as cellular "translators," facilitating communication between these pathways, and understand the

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17:59

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

In this fascinating episode, dive deep into the intricate world of cellular signaling as we explore the PI3K-AKT-mTOR pathway, a fundamental cellular mechanism controlling growth, survival, and energy use. Through engaging dialogue and vivid analogies, discover how this molecular 'construction crew' operates within our cells, and learn about its crucial role in various diseases including cancer, diabetes, heart conditions, and neurological disorders. The episode breaks down complex scientific

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10:05

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Dive deep into the fascinating world of cellular signaling as we explore the Ras/Raf/MEK/ERK pathway, a fundamental cellular relay race that controls cell fate. This episode breaks down the intricate dance of kinases and proteins that regulate crucial cellular processes, from gene expression to cell division. Learn how this pathway acts as a cellular guidance counselor, helping cells make critical decisions about growth, specialization, and survival. Perfect for biology enthusiasts and anyone

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16:29

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Dive deep into the fascinating world of Fibroblast Growth Factor Receptors (FGFRs) in this enlightening episode. Learn how these remarkable cellular "conductors" act as bridges across cell membranes, orchestrating vital processes in development and tissue repair. Discover the incredible complexity of FGFR signaling, from alternative splicing that creates different receptor variants to their crucial role in regeneration - including the amazing ability of salamanders to regrow entire limbs! We'll

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16:00

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

In this fascinating deep dive into cellular biology, explore the intricate world of insulin and IGF receptors - the molecular gatekeepers that control our body's energy metabolism and growth. Join us as we break down complex concepts into digestible analogies, from comparing these receptors to molecular switchesto understanding how their dysfunction can lead to conditions like diabetes and cancer. Through engaging dialogue, discover how these remarkable cellular mechanisms maintain our body's

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18:56

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Explore the fascinating world of PDGF and VEGF receptors in this deep-dive episode about wound healing and blood vessel formation. Learn how these molecular gatekeepers orchestrate tissue repair and angiogenesis through complex signaling cascades. The episode breaks down the intricate mechanisms of receptor activation, from initial binding to downstream effects, using clear analogies and accessible explanations. Special attention is given to how these vital healing processes can be hijacked in

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35:09

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Dive deep into the fascinating world of cell signaling with this comprehensive exploration of the EGFR (Epidermal Growth Factor Receptor) family. Learn how these cellular "antennas" control vital processes like cell growth and division, and discover why they're called the VIPs of cancer biology. The episode breaks down complex concepts into digestible analogies, explaining how mutations can lead to cancer and how targeted therapies work to combat it. From molecular mechanisms to practical

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16:04

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Dive into the fascinating world of cellular communication as we explore Receptor Tyrosine Kinases (RTKs), the molecular switches that control cell growth and division. This engaging episode breaks down complex concepts into digestible analogies, explaining how RTKs work through processes like dimerization and autophosphorylation. Learn about their crucial role in cancer development and how understanding these molecular mechanisms is leading to breakthrough targeted therapies. The discussion extends

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8:27

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

In this enlightening episode on ion channelopathies, we dive deep into the fascinating world of ion channels and what happens when they malfunction. Learn about how these molecular gates control crucial bodily functions and how their dysfunction leads to various disorders like epilepsy, cardiac arrhythmias, and muscle disorders. Our expert guest explains complex concepts through engaging analogies, from comparing seizures to electrical storms in the brain to describing ion channels as gates that can

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14:10

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Dive deep into the fascinating world of TRP channels, the molecular sensors that shape how we experience temperature, pain, and other sensations. This engaging episode explores how these remarkable proteins act as cellular antennae, from detecting the heat of spicy peppers to the cooling sensation of menthol. Learn about different TRP channel subtypes, their roles in pain perception and nociception, and discover cutting-edge research into targeted therapies that could revolutionize pain management

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14:20

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Dive deep into the fascinating world of ionotropic glutamate receptors, the brain's essential communication system. This episode explores how these molecular gatekeepers - AMPA, NMDA, and kainate receptors - work together to enable learning, memory, and neural plasticity. Through engaging dialogue, discover how AMPA receptors act as quick messengers, while NMDA receptors serve as sophisticated "high-security vaults" requiring multiple keys to unlock. Learn about their crucial role in synaptic

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17:19

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Dive deep into the fascinating world of GABA and glycine receptors, the brain's essential inhibitory neurotransmitters. This engaging episode explores how these molecular "conductors" maintain balance in our nervous system, preventing neural chaos much like orchestrating a symphony. Learn about the intricate mechanisms of these receptors, from their role in anxiety and sleep to their importance in developing new therapeutic approaches. The discussion covers everything from basic receptor function to

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26:25

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Dive deep into the fascinating world of nicotinic acetylcholine receptors (nAChRs) in this comprehensive episode. Learn about these crucial molecular gatekeepers that control ion flow and regulate nerve signaling throughout the body. From their intricate pentameric structure to their diverse roles in muscle movement and brain function, discover how these receptors influence everything from basic muscle contractions to complex cognitive processes. The episode explores their involvement in various

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19:24

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

In this enlightening episode on ligand-gated ion channels, dive deep into the fascinating world of cellular communication and discover how these molecular gatekeepers regulate crucial nervous system functions. Learn about the intricate "lock and key" mechanism of these channels, their lightning-fast response times, and how they differ from voltage-gated channels. The episode explores the glycine receptor as a key example, explaining its vital role in controlling muscle movement and maintaining

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13:42

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Dive into the fascinating world of voltage-gated calcium channels in this comprehensive episode exploring these microscopic gatekeepers of cellular communication. Learn how these channels transform electrical signals into cellular actions, from triggering muscle contractions to releasing neurotransmitters. The episode delves deep into the concept of cellular microdomains, specialized neighborhoods within cells where calcium channels and other molecules work together to orchestrate precise biological

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11:22

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Journey into the intricate world of voltage-gated potassium channels in this fascinating deep dive episode. Learn how these microscopic gatekeepers regulate electrical activity in our cells, from maintaining heart rhythms to controlling neural signaling. The episode explores how these channels act as cellular circuit breakers, their diverse subfamilies, and their critical role in diseases like epilepsy and cardiac arrhythmias. Through engaging dialogue and clear analogies, discover how these tiny

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15:37

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Dive deep into the fascinating world of voltage-gated sodium channels in this comprehensive episode exploring the intricate mechanisms that control our nervous system. Learn how these microscopic channels regulate everything from pain sensation to heart rhythms. The episode breaks down complex concepts like membrane potentials, channel activation, and cellular signaling, while explaining how medications can target these channels to treat conditions like chronic pain and cardiac arrhythmias. With

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13:44

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

Dive deep into the fascinating world of ion channels, the microscopic gatekeepers that control essential functions in our bodies. In this comprehensive episode, explore how these remarkable protein structures regulate everything from nerve signaling to muscle movement. Learn about their crucial role in our senses, including how they help us hear, see, and taste. The episode breaks down complex concepts into digestible explanations, covering topics like voltage-gated channels, cellular communication,

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16:35

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

In this deep dive into GPCR pharmacology, explore the fascinating world of G-protein coupled receptors and their revolutionary potential in modern medicine. Learn how these cellular gatekeepers, which are targets for one-third of all prescription drugs today, are transforming drug development through innovative approaches like novel ligands and biased signaling. From treating cardiovascular disease and metabolic disorders to addressing complex neurological conditions, discover how researchers are

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13:03

90 Day Deep Dive Podcast Series into the World of...

Cannabinoid and Psychedelic Pharmacology and Drug... ·

2025/02/01

n this fascinating deep dive into G-protein coupled receptors (GPCRs), explore how these tiny cellular sensors impact everything from basic bodily functions to disease development. Join us as we unravel the complex world of receptor mutations, discovering how small variations can lead to significant health issues. Learn about groundbreaking research tools like CRISPR and knockout mice that scientists use to study these crucial proteins. From thyroid hormone regulation to HIV resistance, this episode

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