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PODCAST

Oncology Brothers: Practice-Changing Cancer Discussions

Oncology Brothers

On a mission to disseminate information to the community and bridge the gap between academia and community oncology in this rapidly changing field of hematology & oncology. Drs. Rahul & Rohit Gosain interview world-renowned hematologists/oncologists to present the practice-changing data in a small bite-sized format where one could immediately apply that information in their daily practice to provide the best cancer care to their patients close to home. Privacy Policy:

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All Episodes

00:26:40

Prostate Cancer Management from Early Stage to...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/03/24

Join us in this insightful episode of the Oncology Brothers podcast as we dive deep into the current treatment landscape of prostate cancer with Dr. Alan Bryce, Chief Clinical Officer and GU Medical Oncologist from City of Hope.In this episode, we explore:•⁠ ⁠The treatment paradigm for early-stage prostate cancer, including the role of active surveillance and the use of abiraterone based on the STAMPEDE trial.•⁠ ⁠The importance of understanding risk factors and treatment options for low,

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00:19:56

How to Treat Renal Cell Carcinoma (RCC) using a...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/03/17

Join us for an insightful episode of the Oncology Brothers podcast as we dive deep into the world of renal cell carcinoma (RCC) with Dr. Katy Beckermann, the Medical GU Director of Cancer Research at Tennessee Oncology.In this episode, hosts Drs. Rahul & Rohit Gosain, practicing medical oncologists, discuss the latest advancements in RCC treatment, including:•⁠ ⁠The role of Pembrolizumab in the adjuvant setting based on the Keynote 564 study and its implications for early-stage disease.•⁠

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00:22:15

How to Treat Bladder Cancer in 2025 with Dr....

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/03/10

Join Drs. Rahul & Rohit Gosain in this insightful episode of the Oncology Brothers podcast as they continue their treatment algorithm series, focusing on the rapidly evolving landscape of bladder cancer. They are joined by Dr. Joaquim Bellmunt, a medical oncologist and director of bladder cancer at the Dana-Farber Cancer Institute, who shares his expertise on the latest treatment paradigms for both muscle invasive and non-muscle invasive bladder cancer.In this episode, you'll learn about:•⁠

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00:19:49

FDA Approval of Tislelizumab - RATIONALE 305 and 306...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/03/06

Welcome to the Oncology Brothers podcast! In this episode, Drs. Rahul and Rohit Gosain are joined by Dr. Anwaar Saeed, Chief of GI Medical Oncology at UPMC, to discuss the recent approval of Tislelizumab, a new checkpoint inhibitor for upper GI malignancies, including esophageal squamous cell cancer, GE junction, and gastric cancer.We dive deep into the studies that led to Tislelizumab’s approval, including the Rationale 302, 305, and 306 trials. Dr. Saeed explains the unique mechanism of action of

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00:21:49

GU ASCO 2025 Highlights - TALAPRO-2, NIAGARA,...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/03/03

Welcome to another episode of the Oncology Brothers podcast! In this episode, Drs. Rahul and Rohit Gosain are joined by Dr. Toni Choueiri, a leading GU medical oncologist from Dana-Farber Cancer Institute. Together, they dive into the highlights from the GU ASCO 2025 conference, covering key studies and updates in the world of genitourinary oncology.Episode Highlights:•⁠ ⁠TALAPRO-2: An in-depth discussion on the role of PARP inhibitors in prostate cancer, focusing on the study's design,

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00:20:56

How to Treat Hormone Receptor Positive Cancer -...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/02/24

Welcome to the Oncology Brothers podcast! In this episode, Drs. Rahul and Rohit Gosain are joined by Dr. Kevin Kalinsky, a leading breast medical oncologist and director of the breast cancer program at the Winship Cancer Institute of Emory University.Join us as we dive deep into the complexities of hormone receptor-positive breast cancer treatment. We discuss the latest advancements in treatment algorithms, including the use of OncotypeDX in premenopausal versus postmenopausal women, the role of

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00:22:37

FDA Approval of Zolbetuximab SPOTLIGHT / GLOW study -...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/02/21

In this episode of the Oncology Brothers podcast, Drs. Rahul and Rohit Gosain dive into the recent advancements in the treatment of gastroesophageal junction (GEJ) and gastric cancer, focusing on the newly approved drug Zolbetuximab. They are joined by Dr. Kohei Shitara, the lead author of the pivotal SPOTLIGHT study, who shared insights on the mechanism of action of Zolbetuximab, its clinical trial findings, and the implications for patient care.Key topics discussed include:•⁠ ⁠The mechanism of

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00:22:39

How to Treat HER2+ Breast Cancer - Discussion with...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/02/17

In this episode of the Oncology Brothers podcast, Drs. Rohit and Rahul Gosain welcome Dr. Sarah Sammons from Dana-Farber Cancer Institute to discuss the treatment landscape for HER2-positive breast cancer. Building on their previous discussions about triple-negative breast cancer, Drs. Gosain and Sammons dive deep into the treatment algorithms for early-stage, locally advanced, and metastatic HER2-positive breast cancer.Key topics include:•⁠ ⁠Treatment paradigms for early-stage HER2-positive breast

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00:16:50

How to Treat Triple Negative Breast Cancer -...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/02/10

Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Virginia Kaklamani from the UTHealth San Antonio MD Anderson Cancer Center to discuss the latest advances in the treatment of triple negative breast cancer (TNBC) as we kick off 2025.•⁠ ⁠The treatment paradigms for early-stage TNBC, including the role Sacituzumab and radiation therapy.•⁠ ⁠Insights from the SABCS 2024 conference, focusing on the keynote 522 regimen and its implications for

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00:20:47

GI ASCO 2025 Highlights - BREAKWATER, CheckMate-8HW,...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/02/03

Welcome to another episode of the Oncology Brothers podcast! In this episode, Drs. Rahul and Rohit Gosain are joined by Dr. Alok Khorana, a GI medical oncologist from the Cleveland Clinic, to discuss the latest highlights from the GI ASCO 2025 conference.We dive into four key studies that are practice-informing and potentially practice-changing: 1. BREAKWATER: We explore the implications of using Encorafenib and Cetuximab in combination with FOLFOX for patients with BRAF V600E mutations, which are

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00:15:04

FDA Approval of Subcutaneous Nivolumab CheckMate-67T...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/01/31

Welcome to the Oncology Brothers Podcast! In this episode, Drs. Rohit and Rahul Gosain are joined by Dr. Saby George from Roswell Park Comprehensive Cancer Center to discuss the recent approval of subcutaneous nivolumab based on the CheckMate-67T study.Join us as we delve into:•⁠ ⁠The study design and findings of CheckMate-67T•⁠ ⁠The implications of subcutaneous nivolumab for patients and healthcare providers•⁠ ⁠Safety signals and side effects associated with the new formulation•⁠ ⁠The

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00:27:12

Intermediate HCC – the evolving role of Immunotherapy...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/01/27

In this final episode of the four-part series on hepatocellular carcinoma (HCC), hosted by the Oncology Brothers, Drs Rohit and Rahul Gosain, the discussion focuses on the evolving role of immunotherapy (IO) in intermediate HCC. The episode explores multimodal approaches that combine IO and IO-based therapies with loco-regional treatments and highlights the essential role of a multidisciplinary care team. Drs Nina Sanford (radiation oncologist), Mark Yarchoan (medical oncologist), and Ed Kim

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00:22:52

Managing Side Effects of Anti-VEGF Bevacizumab &...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/01/22

Welcome to another episode of the Oncology Brothers podcast! In this episode, Drs. Rahul and Rohit Gosain are joined by Dr. Pashtoon Kasi from City of Hope to discuss the management of side effects associated with key treatments utilized in colorectal cancer, but also in other tumor types. We dived deep into two important drug classes: Bevacizumab, an anti-VEGF antibody, and the anti-EGFR antibodies, Panitumumab and Cetuximab. Dr. Kasi provided a comprehensive overview of these targeted therapies,

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00:18:05

ASH Lymphoma 2024 Highlights - POLARIX Update,...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/01/21

Welcome to another episode of the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Pallawi Torka from Memorial Sloan Kettering Cancer Center to discuss the latest highlights from ASH 2024, focusing on key studies in lymphoma. In this episode, we dive into: •⁠ ⁠POLARIX Study: An update on the POLARIX trial, exploring the use of Polatuzumab in frontline diffuse large B-cell lymphoma (DLBCL) and its impact on progression-free survival (PFS). •⁠ ⁠inMIND

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00:23:36

SABCS 2024 Highlights - DESTINY-Breast06,...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/01/17

Join us for another insightful episode of the Oncology Brothers podcast as we dive into the latest breakthroughs in breast cancer research from the San Antonio Breast Cancer Symposium 2024. In this episode, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Sara Tolaney from Dana-Farber Cancer Institute to discuss three pivotal studies: 1.⁠ ⁠DESTINY-Breast06 - An update on the efficacy of T-DXd in HER2 low and ultra-low breast cancer patients, highlighting its potential to change treatment

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00:17:35

SABCS 2024 Highlights - EUROPA, TAILORx, PADMA,...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/01/15

Welcome to another episode of the Oncology Brothers podcast! In this episode, hosts Rahul and Rohit Gosain are joined by Dr. Jame Abraham from the Cleveland Clinic to discuss key abstracts in the hormone receptor-positive breast cancer space from the San Antonio Breast Cancer Symposium 2024. Episode Highlights: •⁠ ⁠EUROPA Trial: A phase 3 study comparing endocrine therapy versus radiation therapy in early-stage breast cancer patients over 70. Discover how the results may impact clinical practice

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00:20:19

Intermediate Hepatocellular Carcinoma (HCC) –...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/01/13

In the third of this 4-part podcast series on hepatocellular carcinoma (HCC), the Oncology Brothers, Drs. Rahul and Dr Rohit Gosain, are joined by hepatologist Dr. Maria Reig and interventional radiologist Dr. Emil Cohen to explore treatment strategies for patients with intermediate-stage HCC. The experts share valuable insights into the available treatment options for this heterogeneous patient group and explore the role of systemic treatments and multimodal approaches in achieving optimal patient

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00:20:39

SABCS 2024 Highlights - INSEMA, KEYNOTE-522, OlympiA

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/01/09

Welcome to another episode of the Oncology Brothers podcast! In this episode, hosts Drs. Rahul & Rohit Gosain are joined by Dr. Laura Huppert from UCSF to discuss key highlights from the San Antonio Breast Cancer Symposium 2024. We dive into three crucial studies: 1.⁠ ⁠INSEMA Study: Explore the findings on the potential omission of axillary surgery in early-stage hormone receptor-positive breast cancer and its implications for patient quality of life. 2.⁠ ⁠KEYNOTE-522 Update: Learn about the

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00:22:18

Multiple Myeloma ASH 2024 Highlights with Dr. Robert...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/01/07

Welcome to another episode of the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Robert Orlowski from MD Anderson Cancer Center to discuss groundbreaking studies presented at ASH 2024 focused on multiple myeloma. We dived into four key studies: 1.⁠ ⁠AQUILA: Explore the impact of early intervention using daratumumab for smoldering myeloma, which showed improved progression-free survival (PFS) and overall survival (OS). 2.⁠ ⁠Dara Based Quad Therapy: We

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00:17:15

FDA Approval of Zanidatamab - HERIZON-BTC-01...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2025/01/02

Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain dive into the recent FDA approval of Zanidatamab, a bispecific HER2 antibody, for HER2 amplified, unresectable, locally advanced, or metastatic biliary tract cancer.Join us as we discuss the HERIZON-BTC-01 study with Dr. Shubham Pant, a GI medical oncologist at MD Anderson Cancer Center and one of the study's authors. We explore the significance of HER2 testing in biliary tract cancers, the study's design,

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