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PODCAST

Meet the Microbiologist

Ashley Hagen, M.S.

Who is microbiology? Meet the Microbiologist (MTM) introduces you to the people who discover, innovate and advance the field of microbiology. Go behind-the-scenes of the microbial sciences with experts in virology, bacteriology, mycology, parasitology and more! Share in their passion for microbes and hear about research successes and even a few setbacks in their field. MTM covers everything from genomics, antibiotic resistance, synthetic biology, emerging infectious diseases, microbial ecology,

science life sciences

All Episodes

46:10

110: Metagenomic Sequencing for Infectious Diseases...

Meet the Microbiologist ·

2019/06/13

Most diagnostic tests look for a single microorganism, or at most a limited panel of microorganisms. Charles Chiu discusses his research on metagenomic sequencing as a diagnostic tool that can identify all potential pathogens in a given patient sample. Links for this Episode: MTM Listener Survey, only takes 3 minutes! Thanks;) Charles Chiu Profile at UCSF Chiu Lab at UCSF Validation of Metagenomic Next-Generation Sequencing Tests for Universal Pathogen Detection The Eukaryotic Gut Virome in

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01:08:30

109: Antimicrobial-Eating Microorganisms and the...

Meet the Microbiologist ·

2019/05/31

While searching for lignin-degrading soil microbes, Gautam Dantas discovered growth in an antimicrobial compound-containing control! He has since studied the resistance determinants (resistome) of soil and clinical samples to determine their similarities. Julie’s Biggest Takeaways: Sequencing information is extremely useful for descriptive studies, but there’s an increasing trend in microbiome studies to use the sequencing data as a basis for forming hypotheses. These hypotheses can then be tested

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01:09:43

108: Microbes, Heme, and Impossible Burgers with Pat...

Meet the Microbiologist ·

2019/05/16

Pat Brown founded Impossible Foods with a mission to replace animals as a food production technology. Here, he discusses the ways microbial engineering helps produce the plant hemoglobin that provides the Impossible Burger’s meaty qualities. Links for this episode: Take the MTM listener survey(~3 min.) The Microbial Reasons Why the Impossible Tastes So Good Impossible Foods The Conversation: What Makes the Impossible Burger Look and Taste Like Real Beef? Wired:The Impossible Burger: Inside the

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47:52

107: CRISPR, anti-CRISPR, and anti-anti-CRISPR...

Meet the Microbiologist ·

2019/05/02

CRISPR is a genome-editing tool, but what is its role in microbial biology and evolution? Joe Bondy-Denomy discusses his discovery of the first anti-CRISPR protein and the many unanswered questions surrounding CRISPR biology. Julie’s Biggest Takeaways CRISPR is a bacterial immune system that identifies and destroys specific nucleotide sequences. These sequences are most commonly associated with foreign DNA from bacteriophage or plasmids. Bacterial acquisition of new CRISPR spacer sequences is fairly

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36:03

106: Creepy dreadful wonderful parasites (and a few...

Meet the Microbiologist ·

2019/04/18

Julie’s Biggest Takeaways: Parasites are incredibly varied in many characteristics, including their size! Some are microscopic, while others are macroscopic and can be seen with the naked eye. Not just small macroscopic, although some worms at 35 cm can be considered quite large. Some tapeworms can reach 50 feet! Bobbi Pritt’s blog started as an exercise to share the cases she observed while a student at the London School of Tropical Medicine. She wanted to share these cases with students back at

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01:15:04

105: HPV vaccination with Doug Lowy

Meet the Microbiologist ·

2019/04/05

How did discoveries made with bovine papillomavirus help scientists develop the human papillomavirus vaccine? Doug Lowy discusses his journey that began with basic research and led to the production of the HPV vaccine. Julie’s Biggest Takeaways In the early 1950s, the U.S. was a high-incidence country for cervical cancer. Through application of screens using the Pap smear, doctors have been able to catch and excise suspicious tissue, leading to a significant drop in incidence. Cervical cancer

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01:12:36

104: Burkholderia pseudomallei and the Neglected...

Meet the Microbiologist ·

2019/03/21

Burkholderia pseudomallei is an endemic soil-dwelling bacterium in southeast Asia, where it causes melioidosis. Direk Limmathurotsakul discusses his work to improve the official reporting numbers and how Julie’s Biggest Takeaways: Melioidosis can present in a number of ways, such as sepsis, pneumonia, or abscesses. Because the symptoms are not specific, diagnosis requires isolation of the Burkholderia pseudomallei bacterium. Risk factors for disease include diabetes and exposure to the soil and

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46:49

103: Predicting Spillover Events with Barbara Han

Meet the Microbiologist ·

2019/03/08

When will the next disease outbreak occur? Why are some pests better at spreading disease than others? Disease Ecologist Barbara Han talks about her research that addresses these questions with computer modeling, as well as how modeling predictions can inform field and bench research. Take the listener survey: asm.org/mtmpoll Visit asm.org/mtm for all links and notes.

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38:13

102: HIV vaccines with Dan Barouch

Meet the Microbiologist ·

2019/02/21

Why have scientists struggled to generate a protective HIV vaccine? Dan Barouch lays out the unique challenges and discusses the ongoing clinical trial with an adenovirus-based vaccine developed in his lab. Julie’s Biggest Takeaways HIV poses unique and unprecedented challenges for vaccine development including: Viral diversity: extremely wide range of viral diversity. No natural precedent: No human has cleared HIV based on their immune responses. Unknown correlates of protection: scientists are

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46:58

101: Structural Biology Insights into Ebola Virus...

Meet the Microbiologist ·

2019/02/07

Erica Ollmann Saphire discusses her research on Ebola virus glycoprotein and the changing nature of structural biology. The Ebola virus glycoprotein sequence can vary up to 50% between Ebola virus species, presenting a challenge to develop pan-Ebola therapeutics or vaccines. Erica Ollmann Saphire discusses her work on antibodies that neutralize all Ebola virus species and the changing nature of the structural biology toolkit used to study them. Check out all our great podcasts at asm.org/podcast

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31:35

100: It’s our 100th Episode! A retrospective into...

Meet the Microbiologist ·

2019/01/25

We pull back the curtain as former show hosts Merry Buckley and Carl Zimmer talk Meet the Scientist origins, favorite interviews and microbial topics. Julie’s Biggest Takeaways: Though the show started before podcasts were as popular as they are now, this didn’t pose a problem for Merry or Carl when soliciting guests - scientists were happy to have their work featured and to discuss their research. Inviting guests may involve bringing in a mix of experienced and early-career researchers, but both

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01:20:47

099: Microbial engineering for biofuels and beyond...

Meet the Microbiologist ·

2019/01/11

How does an engineer approach microbial genetics? cworks with microbes of all kinds to optimize metabolic and agricultural systems. Here he discusses his work with Rhodobacter to make biofuels and for membrane protein expression, with Agrobacterium and plant pathogenic viruses to make drought-resistant plants, and with Clostridium and yeast cocultures for lignocellulose digestion. Take the listener survey at asm.org/mtmpoll Full shownotes at asm.org/mtm Links for this Episode: Wayne Curtis Lab site

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59:48

098: Insect and human microbial symbionts with Seth...

Meet the Microbiologist ·

2018/12/30

Over the course of a few decades, scientists have learned how insect endosymbiont bacteria affects insect reproduction and have used this understanding to control mosquito-born diseases. Seth Bordenstein talks about his research on the insect endosymbiont Wolbachia, human-microbiome interactions, and how the ecosystem of a host and its microbes can be refered to as a holobiont. Take the listener survey at asm.org/mtmpoll Links for this Episode: Bordenstein Lab at Vanderbilt University mSystems:

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41:08

097: The Cool World of Glacial Microbiology with...

Meet the Microbiologist ·

2018/12/13

Christine Foreman explains how microbes can survive and grow on glaciers, and what we can learn from microbes in glacier ice cores. Take the MTM listener (that's you!) survey asm.org/mtmpoll it only take 3 minutes. Thanks! Julie’s Biggest Takeaways Liquid inclusions between ice crystals create a vein-like network that allow microbes to survive between the ice crystals. Microbes living in glaciers have to adapt to a number of extreme environments: low water, low nutrients, extreme cold, and 6 months

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47:53

096: HIV interaction with the immune system with Mark...

Meet the Microbiologist ·

2018/11/30

A very small proportion of people infected with HIV do not develop AIDS. Mark Connors talks about 2 patient populations that his lab studies, the elite controllers and the elite neutralizers, who control HIV infection with their respective T cell or B cell responses. Connors hopes his work on killer T cells and broadly neutralizing antibodies will help scientists develop better HIV therapies or an effective HIV vaccine. Links for This Episode: Mark Connors labsite at NIAID Immunity article:

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55:31

095: The Evolution of Virulence with Andrew Read

Meet the Microbiologist ·

2018/11/15

In the early 2000s, Andrew Read predicted that non-sterilizing vaccines would lead to more virulent disease. He was able to test his hypothesis with the real-world example of Marek’s disease, a disease of chickens. Read tells the story of his discovery, and talks about his work on myxoma virus. Take the MTM Listener Survey Subscribe (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Also available on the ASM Podcast Network app. Julie’s Biggest Takeaways: Every chicken on the

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38:45

094: Containing a Nipah virus outbreak with G Arunkumar

Meet the Microbiologist ·

2018/11/01

A recent Nipah virus outbreak in Kerala, India, was halted due to improved detection capabilities. G. Arunkumar tells the story of his involvement. Host: Julie Wolf Take the MTM Listener Survey Subscribe (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Also available on the ASM Podcast Network app. Julie’s Biggest Takeaways: Because bats are the normal reservoir, Nipah virus outbreaks appear to be seasonal, with an increase in cases coinciding with the spring, when the bat

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01:00:41

093: Biofilms and metagenomic diagnostics in clinical...

Meet the Microbiologist ·

2018/10/18

Robin Patel discusses her work on prosthetic joint infections and how metagenomics is changing infectious disease diagnostic procedures. Take the listener survey: asm.org/mtmpoll Julie’s Biggest Takeaways: The term antimicrobial resistance can mean many things. Although acquisition of genetic elements can lead to drug resistance, so can different growth lifestyles of bacteria; the same bacteria growing in liquid culture may be more susceptible to a drug than those bacteria growing on a biofilm

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52:47

092: A new type of malaria vaccine utilizing the...

Meet the Microbiologist ·

2018/10/05

To eliminate malaria, you have to stop transmission, and that’s what Carolina Barillas-Mury hopes to do. Her work on the interaction of the malaria parasite Plasmodium falciparum may lead to a transmission-blocking vaccine. She explains how, and discusses the co-evolution of malaria, mosquitos, and man. Take the listener survey: asm.org/mtmpoll Julie’s Biggest Takeaways: When born, babies carry antibodies from their mothers, which may protect them through passive immunity; additionally, babies

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58:29

091: SARS and MERS coronaviruses with Stanley Perlman

Meet the Microbiologist ·

2018/09/20

How do researchers study a new pathogen? Stanley Perlman talks about how virus researchers studied SARS and MERS after they emerged, what they learned, and why there are no more cases of SARS. He also discusses his work on a coronavirus model of multiple sclerosis. We want to hear from you! Please take our listener survey. Julie’s Biggest Takeaways: Coronaviruses have the largest RNA genomes, with up to 40 kB of sequence, but why their genomes is so big is unclear - their genomes don’t seem to

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