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PODCAST

Mendelspod Podcast

Offering a front row seat to the Century of Biology, veteran podcast host Theral Timpson interviews the who"s who in genomics and genomic medicine. www.mendelspod.com

science & medicine natural sciences

All Episodes

6:13

Big RNA with Brendan Frey of Deep Genomics

Mendelspod Podcast ·

2025/01/30

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comIn our first conversation with Deep Genomics, Theral sits down with Brendan Frey, the company's founder and Chief Innovation Officer, to explore the power of AI in RNA biology and drug discovery. Frey, a pioneer in deep learning who trained in the lab of AI luminary Geoffrey Hinton, shares how his personal experience in genetics back in 2002 led him to merge machine learning with genomic medicine. The company has a head

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31:04

Genome Informatics in the Age of AI With Ben Busby,...

Mendelspod Podcast ·

2025/01/23

In this Mendelspod episode, Theral explores the state of genome informatics with Ben Busby, principal scientist at DNAnexus.Busby reflects on his journey into the field, which was influenced by key projects and experiences during his time at the NCBI and his genomics hackathons. He outlines the current genome informatics landscape, emphasizing DNAnexus' role in fostering collaboration. Busby highlights transformative movements to refine disease subtyping based on haplotype data, underscoring their

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5:34

AI & the Future of Genetic Testing: Ezra Cohen, CMO...

Mendelspod Podcast ·

2025/01/16

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comAs 2025 begins, we are launching a new series The New Genetic Testing. To do that we’re welcoming today Dr. Ezra Cohen, Chief Medical Officer at Tempus to offer a behind-the-scenes look at how the company is transforming healthcare through cutting-edge AI. With its recent successful IPO, Tempus has firmly established itself as a leader in genomic testing and multimodal data integration and empowering providers and life

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5:26

PredxBio and the Promise of Spatially Intelligent...

Mendelspod Podcast ·

2025/01/10

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comThis week we welcome the innovative minds behind PredixBio, a new and groundbreaking company at the forefront of spatial biology. CEO Dusty Majumdar and co-founder Chakra Chennubhotla join us to discuss their mission to revolutionize cancer therapeutics through spatially intelligent biology. Founded in 2018 and supported by NIH grants, PredixBio focuses on unraveling the tumor microenvironment's heterogeneity using

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28:46

Surprise: Our Most Popular Show of 2024 Was on...

Mendelspod Podcast ·

2024/12/19

This year in a series co-produced with GenomeWeb we had an exclusive look into Illumina’s work in genomic AI with Kyle Farh, the VP and Distinguished Scientist leading the Illumina Artificial Intelligence Lab. "We lack a way of training genomic AI as readily as you would for natural language processing,” says Farh. "There are vast amounts of data, but there are no labels, no supervision. One of the most powerful tools that we’ve found is using clues from natural selection.”Farh says the company

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4:39

New Startup Launches Epigenetic Screening: Mohamad...

Mendelspod Podcast ·

2024/12/05

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comIn this episode of Mendelspod, Theral sits down with Dr. Mohamad Takwa, co-founder and CEO of Epigenica, a Swedish startup revolutionizing epigenetic research. Epigenica is positioning itself at the forefront of this new and rapidly growing field with a mission to empower researchers through large-scale epigenetic profiling.

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23:34

AI Powered Multiomics: Joachim Schmid on Data...

Mendelspod Podcast ·

2024/11/21

Coming from the field of digital pathology, Joachim Schmid has a unique perspective on the evolution of multi-omics. Schmid was recently appointed as Vice President of Multiomics Data Solutions at Illumina.In this episode, Theral dives into the burgeoning field of multi-omics—integrating data from various omic layers such as genomics, proteomics, and transcriptomics—and the massive data challenges that come with it. Schmid discusses how sequencing costs are plummeting, leading to an explosion in

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34:55

Renowned GI Oncologist Discusses MRD Testing and the...

Mendelspod Podcast ·

2024/11/14

Dr. Mark Lewis is a well known GI oncologist at Intermountain Health in Salt Lake City, Utah. Gifted with a passionate communication style, he has over 93,000 Twitter followers. Next month, he will live-tweet his upcoming colonoscopy. In this episode, Dr. Lewis joins Theral in our ongoing series on minimal residual disease (MRD) testing, a revolutionary blood test that is helping detect residual cancer causing a paradigm shift in patient management.Dr. Lewis belongs to a pioneering group that

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28:27

Precision Medicine Then and Now: We Talk with the...

Mendelspod Podcast ·

2024/11/12

When Bill Clinton announced the sequencing of the human genome in 2000, the New York Times ran the following headline on the front page: "Genetic Code of Human Life is Cracked By Scientists.”We’re still living up to that headline.Ed Abrahams has led the Personalized Medicine Coalition (PMC) for twenty years. Before his retirement in December, we asked him to join us to reflect on his tenure and take stock of the field. PMC was established as a “catalyst” and organizer to bring the various

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31:47

MicroRNA: A New Era in Biomarker Discovery with Tim...

Mendelspod Podcast ·

2024/11/07

In this episode, Theral delves into the groundbreaking role of microRNA as a cancer biomarker with Tim Williams, professor of clinical pathology at the University of Cambridge Veterinary School, and Paola Ulivi, a leading researcher at the Instituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori (IRST) in Italy. MicroRNA, which recently garnered its discoverers a Nobel Prize, has emerged as a powerful tool for detecting and tracking cancer progression.Williams and Ulivi share their latest research,

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28:11

Somatic Genomics: A Revolution in Biology with Jacob...

Mendelspod Podcast ·

2024/10/31

Jacob Rubens is having quite a career. Studying at MIT in the Synthetic Biology Center with Professor Tim Lu, he invented gene circuits that allow engineered cells to do novel analog, digital, and hybrid computations, enabling the emerging field of “intelligent” cell therapies. In 2017, he was honored in Forbes 30 under 30 and, in 2021, in Business Insider’s list of 12 young serial entrepreneurs building the next generation of biotech. He has co-founded Kaleidoscope Biosciences, Sana

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31:15

Exploring the Future of Single Cell Technology with...

Mendelspod Podcast ·

2024/10/29

Human genomics is complex. With new, scalable tools, we are unraveling that complexity. For example, we don’t just each have one genome; we have trillions, as each cell has a unique genome. Analyzing biology at the single-cell level continues to be one of the major frontiers in research.To learn how Single Cell Discoveries (SCD), a contract research organization in Utrecht, the Netherlands, has scaled and innovated in this field, Theral sits down with Mauro Muraro, cofounder and CEO of SCD. Muraro

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45:00

Grail and Verily Alum on Billion Dollar Startup...

Mendelspod Podcast ·

2024/10/17

Vik Bajaj is bullish on genomics in the age of artificial intelligence. A pioneering figure in biotech—co-founder of Verily and Grail—Bajaj now leads Xaira Therapeutics, where he's exploring how AI can revolutionize drug development. In today’s episode, he joins Theral to break down how the intersection of AI and genomics is unlocking new possibilities in drug development, with the potential to accelerate every stage of drug discovery.Bajaj explains that at Xaira, machine learning and advanced

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24:19

Singular Genomics Introduces a Dual-Purpose Platform...

Mendelspod Podcast ·

2024/10/15

Singular Genomics launched its fast and flexible mid-throughput sequencing platform, the G4, in the heady days of the pandemic when we saw a renaissance in new technologies and companies.At AGBT earlier this year, the company unveiled its latest offering in development, the G4X Spatial Sequencer, an upgrade to the G4 that unlocks the system to perform high-throughput in situ multiomics. The platform will be capable of simultaneous direct RNA sequencing, targeted transcriptomics, proteomics, and

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35:44

The Evolving Future of Genetic Counseling with Ellen...

Mendelspod Podcast ·

2024/09/30

Ellen Matloff is back on the show today to discuss the changing landscape of genetic testing and counseling in 2024. She is the founder and CEO of MyGeneCounsil and a strong advocate for the critical role of genetic counselors in healthcare. She also writes a regular column for Forbes magazine.In 2024, we’ve seen a dramatic transformation of the genetic testing landscape, with big labs buying the small ones. Ellen says this is “forcing genetic testing to go mainstream.”Surely that’s a good thing

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26:47

As Sequencing Continues to Scale, Volta Labs Improves...

Mendelspod Podcast ·

2024/09/26

Depending on your age, DNA sequencing is experiencing a second or third renaissance. New sequencing tools continue to make genomics one of the fastest-growing industries of all time. All this scaling can create a bottleneck in sample prep. Volta Labs, a company founded out of the MIT Media Lab by Udayan Umapathi, has just commercialized a new instrument for sample prep called Callisto. The instrument manipulates samples with electric, magnetic, and acoustic fields. Udayan joins us today to

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22:33

What’s Next for Large-Scale Proteomics? With Chris...

Mendelspod Podcast ·

2024/09/19

Genetic studies of human populations have become a major tool for drug development. In the last few years, these studies have moved toward comprehensive proteomics profiling as well. In late 2023, a paper was published in Nature by the Pharma Proteomics Project, which characterized the plasma proteomic profiles of 54,219 UK Biobank participants. This was a precompetitive biopharmaceutical consortium that sought to provide a mapping of 2,923 proteins that identified 14,287 primary genetic

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5:17

Will this At-Home Blood Collection Device Transform...

Mendelspod Podcast ·

2024/09/17

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comA new blood collection device offered by startup company Tasso is a blood lancet that collects whole liquid blood samples. Its ease of use for at-home collection could dramatically improve patient testing compliance and impact the scale of clinical trials.Ben Casavant is the co-founder and CEO of Tasso. He joins us to discuss the possibilities for at-home testing. Ben and the company have raised over $100 million

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70:39

Geneticist Kevin Mitchell Attempts to Naturalize Free...

Mendelspod Podcast ·

2024/09/12

Today, we continue “The New Biology” series with a non-reductive geneticist from Trinity College in Dublin. Kevin Mitchell is the author of Free Agents: How Evolution Gave Us Free Will.The problem of free will has dogged philosophers and scientists as much as any question going back to the Greeks. Determinism, typically argued by physicists, usually goes something like: the laws of physics predict the future, and therefore, there is no free will. In our lives, however, the experience of making

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25:29

ctDNA Testing Could Lead to New Ways of Staging...

Mendelspod Podcast ·

2024/08/27

Today, we go to the frontlines of cancer treatment for a case study on the use of ctDNA testing in the clinic. ctDNA, or circulating tumor DNA, is now used as a biomarker in new testing to detect cancer in a patient’s blood. Oncologists, such as today’s guest, Dr. Ben Weinberg, are increasingly using this testing. Dr. Weinberg is an associate professor of medicine and an attending physician specializing in colorectal cancer at MedStar Georgetown University Hospital.“Even though I give chemotherapy

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