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PODCAST

Freely Filtered, a NephJC Podcast

Twice monthly (aspirational) recap of the NephJC journal club. NephJC reviews the most important manuscripts which are driving nephrology forward and improving our understanding of the kidney.

health & fitness medicine

All Episodes

01:09:12

Freely Filtered 029: Belimumab for lupus nephritis

Freely Filtered, a NephJC Podcast ·

2021/02/15

The Filtrate:Matt SparksJennie LinSamira FaroukJoel TopfSwapnil HiremathAnd two special guests:Dawn J. Caster, Assistant Professor at University of LouisvilleAlfred Kim, Assistant Professor of Medicine at Washington University (Twitter)Show Notes:NephJC coverage of the trial: The Bliss trialIn the NEJM: https://www.nejm.org/doi/full/10.1056/NEJMoa2001180 Turtles all the way down: https://en.wikipedia.org/wiki/Turtles_all_the_way_down Nature previews Nephrology on BAFF:

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01:02:27

Freely Filtered 028: Finerenone for diabetic kidney...

Freely Filtered, a NephJC Podcast ·

2020/12/25

The Filtrate:Swapnil HiremathSamira FaroukMatt SparksJoel TopfJennie LinAnd two special guests:Katherine Tuttle Clinical Professor Division of Nephrology, Medical & Scientific Director, Providence Medical Research Center/Sacred Heart Center, Professor of Basic Medical Sciences, WWAMI Program Washington State Universityendocrinologist and nephrologist at the University of Washington Ian de Boer Professor in the Division of Nephrology, Adjunct Professor, Epidemiology and Associate Director, Kidney

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01:33:16

Freely Filtered 027: Long and deep on the KDIGO...

Freely Filtered, a NephJC Podcast ·

2020/11/29

The Filtrate:Swapnil HiremathSamira FaroukMatt SparksJoel TopfJennie LinAnd two special guests:Katherine Tuttle Clinical Professor Division of Nephrology, Medical & Scientific Director, Providence Medical Research Center/Sacred Heart Center, Professor of Basic Medical Sciences, WWAMI Program Washington State Universityendocrinologist and nephrologist at the University of Washington Ian de Boer Professor in the Division of Nephrology, Adjunct Professor, Epidemiology and Associate Director, Kidney

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01:05:58

Freely Filtered 026: Interventional Nephrology meet...

Freely Filtered, a NephJC Podcast ·

2020/11/06

The Filtrate:Swapnil HiremathSamira FaroukMatt SparksJoel TopfAnd two special guests:Vandana Dua Niyyar, Professor of Medicine at Emory University and the president elect of American Society of Diagnostic and Interventional Nephrology. Wears lead.Sophia Ambruso, assistant professor and nephrologist at the University of Colorado.Show Notes:Drug-Coated Balloons for Dysfunctional Dialysis Arteriovenous FistulasThe NephJC summaryThe article in the NEJMThe Haskal study, Stent Graft versus Balloon

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00:59:15

Freely Filtered 025: Making sense of albuminuria,...

Freely Filtered, a NephJC Podcast ·

2020/09/21

The Filtrate:Matt SparksJoel TopfSwapnil HiremathJennie LinJordy CohenAnd two special guests:Morgan Grams, study author.Talar Kharadjian, nephrology fellow UC San DiegoShow Notes:History of albuminuria from Matt’s opening monolog: https://academic.oup.com/ndt/article/18/7/1281/1809803Microalbuminuria As A Predictor Of Clinical Nephropathy In Insulin-Dependent Diabetes Mellitus in the Lancet 1982.Microalbuminuria Predicts Clinical Proteinuria and Early Mortality in Maturity-Onset Diabetes in the NEJM

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01:11:13

Freely Filtered 024: STARRT me up!

Freely Filtered, a NephJC Podcast ·

2020/09/01

The Filtrate:Matt SparksJoel TopfSwapnil Hiremath COI: he was a sub-investigator on STARRTJennie LinAnd two special guests:Dr. Jay Koyner of the University of Chicago and #NephBBQ fame.Anitha Vijayan, professor of medicine at Wash U in St LouisShow Notes:The STARRT-AKI trial acronym is: Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney InjuryMatt suggests STAKRT-AKI Standard versus Accelerated Initiation of Kikdney-Replacement Therapy in Acute Kidney InjuryCoverage

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01:15:59

Freely Filtered 023: Race and Estimated GFR

Freely Filtered, a NephJC Podcast ·

2020/08/20

The Filtrate:Matt SparksJoel TopfSwapnil HiremathSamira FaroukJennie LinAnd three special guests:Carina Seah a second year MD PhD student Mt Sinai who led the initiative to remove race from the eGFR formulasPoyan Mehr, founder of GlomCon and author of this post on the use of race in eGFR estimating formulas.Deidra Crews Professor of Medicine and researcher in health disparities.Show Notes:Petition for Removal of “Race Correction” in eGFR at Mount Sinai

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01:15:58

Freely Filtered 022: Uric Acid faces the Music.

Freely Filtered, a NephJC Podcast ·

2020/07/28

The Filtrate:Joel TopfSwapnil HiremathSamira FaroukAnd special guests:Katalin Susztak, Professor of Medicine Perlman School of Medicine, University of Pennsylvania. @KSusztakShow Notes:CKD-FIX: Effects of Allopurinol on the Progression of Chronic Kidney DiseasePERL: Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 DiabetesCoverage at NephJC: Effects of Allopurinol on the Progression of Chronic Kidney DiseaseRichard Johnson’s theory in pay-walled Nature Reviews Nephrology:

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00:48:15

Freely Filtered 021: Aldosteronism is everywhere

Freely Filtered, a NephJC Podcast ·

2020/07/14

The Filtrate:Joel TopfSwapnil HiremathSamira FaroukMatt SparksJordy CohenAnd special guests:Brian Byrd, a cardiologist investigating aldosteronism at the University of MichiganandSusan Steigerwalt, a nephrologist and hypertension specialist who unfortunately due to technical problems largely was cut out of this episode 😢.The Study: The Unrecognized Prevalence of Primary AldosteronismCoverage at NephJC: http://www.nephjc.com/news/aldosterone“What gets measured, gets managed.” Peter Drucker, or

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01:06:43

Freely Filtered 020: SGLT2i are diuretics, but not...

Freely Filtered, a NephJC Podcast ·

2020/06/15

The Filtrate:Joel TopfSwapnil HiremathSamira FaroukMatt SparksAnd special guests:Sadiya Kahn a heart failure specialist at Northwestern University. @HeartDocSadiyaandPaul Welling a professor of medicine and nephrology at Johns Hopkins. @PAWellingMDShow Notes:The Study: https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.120.045691Coverage at NephJC: http://www.nephjc.com/news/sglt2mechanismDiuretics for heart failure NEJM Review article:

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01:08:45

Freely Filtered 019: CRIC on NSAIDs v Opioids

Freely Filtered, a NephJC Podcast ·

2020/05/24

The Filtrate:Joel TopfSwapnil HiremathMatt SparksAnd special guests:Joshua Waitzman, third year nephrology fellow at Beth IsraelHarold “Harv” Feldman. Editor in Chief at AJKD and national study chair of CRIC and principal investigator of the Scientific and Data Coordinating Center of the CRIC Study. https://www.dbei.med.upenn.edu/bio/harold-i-feldman-md-msceShow Notes:CRIC: Chronic Renal Insufficiency Cohort http://www.cristudy.org/NSAID Studies at NephJC:Precision:

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01:13:16

Freely Filtered 018: ISCHEMIA-CKD, Courage, and...

Freely Filtered, a NephJC Podcast ·

2020/05/14

The Filtrate:Joel TopfSwapnil HiremathSamira FaroukJennie LinMatt SparksAnd special guests:David J. Cohen: Professor of Medicine at the University of Missouri-Kansas City and Director of Cardiovascular Research at Saint Luke’s Mid America Heart Institute. In addition, he is Medical Director of the Medical Economics and Technology Assessment Group at Mid America Heart Institute. He was previously Associate Director of Interventional Cardiology at Beth Israel Deaconess Medical Center where he was also

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01:07:05

Freely Filtered 017: COVID Autopsy, Acute PD, and...

Freely Filtered, a NephJC Podcast ·

2020/04/26

The Filtrate:Joel TopfSwapnil HiremathSamira FaroukJennie LinMatt SparksAnd special guests:Agnes Fozo: John L. Shapiro Chair of Pathology at Vanderbilt University and on Twitter: https://twitter.com/AgnesFogoHua Su: Professor of Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaOsama El Shamy: Home Therapy Fellow at Mount Sinai and on Twitter: https://twitter.com/osamaelshamy88Chirag Parikh: Director of Nephrology Johns Hopkins and on

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01:05:07

Freely Filtered 016 MinTac trial and COVID-19 Podcast...

Freely Filtered, a NephJC Podcast ·

2020/04/14

Cast:Joel TopfSwapnil HiremathSamira FaroukJennie LinMatt SparksAnd special guest Joshua WaitzMartin Pollak: http://www.nasonline.org/member-directory/members/20033579.htmlJosh Waitz @jwaitz100 Days of COVID-19: https://www.voanews.com/episode/100-days-covid-19-4236811MinTac: http://www.nephjc.com/news/mintacMy magical experience with minimal change disease. This is not the actual tweet, but a dramatization: http://pbfluids.com/2020/04/the-magic-of-treating-minimal-change-disease/Non-inferiority,

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00:56:25

Freely Filtered 014 COVID-19 Podcast No. 2

Freely Filtered, a NephJC Podcast ·

2020/04/09

Loeb’s Laws of Medicine or Loeb’s Rules of TherapeuticsRobert Frederick Loeb (March 14, 1895-October 21, 1973) was a famous American Physician who provided some very simple common sense approach to treating patients know as:1. If what you are doing is doing good, keep doing it.2. If what you are doing is not doing good, stop doing it.3. If you do not know what to do, do nothing.4. Never make the treatment worse than the disease.The last ‘law’ in present times is often replaced with:“If at all

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01:02:43

Freely Filtered 013 COVID-19 and the Kidney

Freely Filtered, a NephJC Podcast ·

2020/03/25

NephJC’s COVID-19 and the Kidney PatientCast:Joel TopfSwapnil HiremathSamira FaroukJennie LinMatt SparksShow Notes:The NephJC Page on ACE2 and COVID-19Nature Letter showing AER2’s central role in lung injury (in mice). This was SARS from 2005.Losartan RCT in COVID-19; University of Minnesota:Outpatient NCT04311177Inpatient NCT04312009France's health ministry says NSAIDs may be bad in COVID-19 coverage by CNNWHO Tweets its position on NSAIDs.Early case report on COVID-19 and (heart) transplantMatt’s

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01:17:07

Freely Filtered 012 PEXIVAS

Freely Filtered, a NephJC Podcast ·

2020/03/21

Plasma Exchange and Glucocorticoids in Severe ANCA-Associated VasculitisSummary on NephJCCast:Joel TopfSwapnil HiremathSamira FaroukJennie LinJordy CohenShow Notes:55th ERS-EDTA Congress, late breaking and high impact trials. June 2018The CJASN Review recommended by JennieMEPEX studyC5a antagonist, Avacopan in ANCA-Associated VasculitisThe fragility index as described in JAMA SurgeryMichael Walsh looks at the Fragility Index in 399 trials in medical literatureThe EVOLVE trial of Cinacalcet

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00:59:30

Freely Filtered 011 Gadolinium Meta-analysis

Freely Filtered, a NephJC Podcast ·

2020/03/10

Just the dudes gathered to talk about the JAMA Internal Medicine Meta Analysis on Gadolinium in CKD stage 4 and 5.Risk of Nephrogenic Systemic Fibrosis in Patients With Stage 4 or 5 Chronic Kidney Disease Receiving a Group II Gadolinium-Based Contrast AgentA Systematic Review and Meta-analysis.Summary on NephJCCast:Joel TopfSwapnil HiremathMatt SparksShow Notes:Swap has a disclosure!He was an author on the Canadian Association of Radiology guidelines on use of Gad in CKD.Grobner’s original paper

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0:54:03

Freely Filtered 010 Difelakefalin

Freely Filtered, a NephJC Podcast ·

2020/01/31

Cast:Joel TopfJennie LinSwapnil HiremathMatt SparksShow Notes:The NephJC discussion can be found here.The study was published in the NEJM.NephJC summary of the AJKD systematic review of uremic pruritusAtul Gawande on itching.Pinnacle MountainComprehensive review on toxicodendron dermatitis: poison ivy, oak, and sumac.KIDNEYconTom Oates 12 days of Poems on Twitter

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0:58:38

Freely Filtered 009 AMBER

Freely Filtered, a NephJC Podcast ·

2019/12/27

Cast:Joel TopfJennie LinSwapnil HiremathMatt SparksSamira FaroukShow Notes:Pathway 2 Trialhttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00257-3/fulltextNephJC discussion of Pathway2http://www.nephjc.com/pathwayThe DIAMOND Trial. Much more ambitious than I described in the podcast.https://clinicaltrials.gov/ct2/show/NCT03888066SPRINThttps://www.nejm.org/doi/full/10.1056/NEJMoa1511939Omron 907 BP cuffonly $678 from Amazon:

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