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PODCAST

Metabolism Made Easy

A J Ghalayini, Ph.D.

This podcast describes selected biochemistry content that could be useful to premedical/medical students. Similar content (podcasts and videos) is available at: https://medbiochem.org/ or check out my YouTube channel: Metabolism Made Easy These podcasts and videos cover selected topics in medical biochemistry. A J Ghalayini, Ph.D. Bio for Dr. Ghalayini: Dr. Ghalayini received his Ph.D. in Biochemistry from the University of Houston, Houston, Texas. He has over 3 decades of experience in

education courses

All Episodes

00:05:28

Cell-Cell Communication

Metabolism Made Easy ·

2024/11/17

Cell-Cell Communication is a fundamental process that is essential for the regulation of metabolism in various organs. Through hormones of the endocrine system, signals are chemically transmitted through the bloostream between different organs. The outcome of a hormone binding its specific receptor in target tissues can produce profound effects on metabolism. Insulin and its effects on the liver, is used as an example of the outcome of communication between the pancreas and the liver.

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00:05:51

Catabolism of Alanine, Glutamate & Aspartate

Metabolism Made Easy ·

2024/10/29

This podcast covers the catabolism of alanine, glutamate and aspartate, including the roles of 3 important enzymes alanine transaminase (ALT), aspartate transaminase (AST) and glutamate dehydrogenage in this process. Input of nitrogen into the Urea cycle is provided directly or indirectly through the metabolism of the 3 discussed amino acids.

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00:07:06

Catabolism of Amino Acids: An Overview

Metabolism Made Easy ·

2024/10/09

This podcast is an overview of the catabolism of amino acids including the initial phase of transferring amines through transaminases to an acceptor keto acid like Alpha-ketoglutarate to produce glutamate.

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00:01:00

Fatty acid mobilization from adipose tissue

Metabolism Made Easy ·

2024/09/25

During fasting, fatty acids are mobilized from stored triacylglycerol in adipose tissue through the activation of Hormone-Sensitive Lipase by epinephrine which results in the release of 3 fatty acids to the bloodstream.

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00:06:11

3 Misconceptions About Dietary Fat

Metabolism Made Easy ·

2024/08/31

This podcast covers three misconceptions dietary fat and covers the crucial contributions of dietary fat to energy production/ storage, membrane synthesis, and inflammation. The key roles of cholesterol in cellular functions are also summarized.

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00:04:20

Misconceptions About Glucose

Metabolism Made Easy ·

2024/08/07

This podcast covers some misconceptions about glucose and its perceived bad effects on health. Glucose is an essential energy source for many tissues that almost exclusively depend on it availability in the bloodstream. In fact, through coordinated release of hormones and their various tissue effects, glucose is maintained between 80-100 mg/ dl during fasting and sleep with the purpose of supplying glucose to tissues that depend on it. Restoring blood glucose under fasting conditions is primarily

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00:00:51

The Brain &Hypoglycemia

Metabolism Made Easy ·

2024/07/26

This podcast the dependence of the brain on glucose as an energy source. Although the brain can use ketone bodies, it only does that in prolonged fasts. Instead the brain can instruct other organs to release hormones that will restore blood glucose.

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00:09:27

Glucose & Insulin Secretion by The Pancreas

Metabolism Made Easy ·

2024/07/10

This pocast covers the endocrine pancreas and the role of the beta cells in secretion of insulin. The rise in bloodstream glucose triggers the increase of glucose uptake by the pancreas by glut-2 transporter, followed by an increase in glycolysiss and a rise in ATP in the cytoplasm. This rise triggers a cascade of events inside the beta cells leading to insulin release.

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00:07:56

Glucose Transporters( Video)

Metabolism Made Easy ·

2024/06/25

This podcast covers the major glucose transporters, their tissue distribution, and regulation by hormones. The key role of these transporters is to pick up glucose from the bloodstream so it can be further metabolized by the cell.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:10:25

Hormonal Regulation of Metabolism in a Nutshell

Metabolism Made Easy ·

2024/05/21

This podcast covers 4 distinct classes of receptors and their respective hormones, including the mechanism of transducing their intracellular signals. The receptors covered in detail are the steroid receptor, the insulin receptor, and 3 distinct G-protein coupled receptors, including the second messengers they produce.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:04:38

The Brain's Energy Sources

Metabolism Made Easy ·

2024/05/07

This podcast covers the use of glucose and ketone bodies as energy sources by the brain. During sleep and short fasts, the brain is completely dependent on the output of glucose by the liver. Glucose is oxidized all the way to CO2 by the brain under aerobic conditions to produce up to 38ATPs. --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:07:56

GLucose Transporters

Metabolism Made Easy ·

2024/05/05

This podcast covers the tissue distribution of various glucose transporters and their specific role in those tissues, including regulation of one transporter by insulin.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:07:00

The Purine Salvage Pathway

Metabolism Made Easy ·

2024/04/23

This podcast covers the salvage of Hypoxanthine, guanine and adenine by two important enzymes Hypoxanthine-guanine phosphoribosyl transferase (HGPRT) and Adeneine phosphoribosyl transferase (APRT), including the outcome of an inherited deficiency in HGPRT. --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:02:42

Glucose Uptake by Muscle & Adipose Tissue

Metabolism Made Easy ·

2024/04/11

This podcast covers the insulin-dependent uptake of glucose by GLUT-4 in muscle and adipose tissue. This insulin-dependent uptake by these tissues contributes to the reduction of plasma glucose after a meal.Check out the link below for the video podcast: https://youtu.be/_vyijJKL4oY --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:03:01

Glucose: The Essential Nutrient

Metabolism Made Easy ·

2024/04/05

This podcast covers the essential role of glucose as an energy source for several tissues. Most notably, red blood cells and the brain. Red blood cells are entirely dependent on glucose for their energy needs while the brain is highly dependent on glucose for its energy. Glucose in the bloodstream is produced by the liver and maintained around 80-100mg/dl during fasting to provide red blood cells and the brain with their energy needs.--- Send in a voice message:

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00:02:16

Hormones & Receptors: 4 Distinct Types

Metabolism Made Easy ·

2024/03/25

This podcast covers the four different classes of receptors that illicit intracellular signals, including steroid receptors, ion channel receptors, receptor enzymes, and G-protein coupled receptors.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:03:55

Insulin Effects on Carbohydrate & Lipid metabolism

Metabolism Made Easy ·

2024/03/13

This episode summarizes the key effects on carbohydrate and lipid metabolism, including the processes that are activated by insulin and the ones inhibited by it.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:04:26

Enzyme Inhibition

Metabolism Made Easy ·

2024/03/01

This podcast describes 4 distinct types of enzyme inhibitors and their mechanism of inhibition, including: substrate analogues, toxins, allosteric inhibitors, and heavy metals.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:08:32

Glycolysis: Regulation of Pyruvate Kinase

Metabolism Made Easy ·

2024/02/19

This podcast covers the regulation of pyruvate kinase allosterically and by hormone-dependent (insulin & glucagon) covalent modification.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:04:28

Metabolism in The Well-Fed State

Metabolism Made Easy ·

2024/02/05

This podcast covers the metabolic changes in various organs and key organ uses of the available nutrients in the bloodstream. --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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213 results

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