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PODCAST

The Joe Cohen Show

Unlock the secrets of your DNA and optimize your health with The Joe Cohen Show. Join Joe, biohacker and founder of SelfDecode, as he interviews world-class health experts and shares cutting-edge research and strategies for biohacking your body and brain. From functional medicine tips and supplement recommendations to longevity and performance optimization, each episode is packed with insights to help you achieve your health goals. Whether you"re interested in genetics, biohacking, alternative

health & fitness alternative health

All Episodes

01:06:24

Mastering Skin Health: Essential Biohacks and...

The Joe Cohen Show ·

2024/03/15

In this episode, Joe discusses skin health, anti-aging strategies, and the science behind skincare with biohacker and beauty industry leader Amitay Eshel, CEO of Young Goose. Amitay shares his expertise on improving skin health through a combination of internal health, high-quality skincare products, and biohacking techniques. The conversation covers topics such as the efficacy of various skincare ingredients, the impact of sun exposure, and innovative approaches to anti-aging. Amitay also delves

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00:04:26

Navigating your Circadian Rhythm, Sleep, and CLOCK...

The Joe Cohen Show ·

2024/03/12

In this episode, we uncover the significance of the CLOCK and PER2 genes, pivotal players in regulating your body's circadian rhythm. Learn how these genes influence your sleep patterns, alertness levels, and even your predisposition to certain health conditions.Discover how variants in the CLOCK gene can impact your circadian rhythm, sleep duration, and daily activity patterns. Explore the associations between genetic variations in the PER2 gene and your tendency to be an early riser or a

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01:37:17

The Science of Methylation and MTHFR with Dr. Ben Lynch

The Joe Cohen Show ·

2024/03/08

In this episode, Joe brings on Dr. Ben Lynch - renowned geneticist and author of Dirty Genes - to unreavel the science of methylation, MTHFR, folates, and homocysteine.Dr. Lynch intricately unpacks the complexities of methylation pathways, shedding light on how genetic variations can impact these crucial processes. Joe and Ben then delve into the specifics of homocysteine metabolism and the role of B vitamins in maintaining optimal levels. They provide invaluable insights into personalized

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00:04:03

A Gene That Affects Longevity More Than Smoking? |...

The Joe Cohen Show ·

2024/03/06

In this episode of SNPit, we delve into the fascinating world of the FOXO3 gene, a genetic guardian that holds the key to a longer life. But here's the twist: did you know that certain variants of this gene could impact your lifespan more than smoking a pack of cigarettes every day for 25 years? We uncover the research behind this startling revelation and discuss the implications for our health and well-being. Plus, we reveal actionable steps you can take to optimize your FOXO3 gene for

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00:52:38

A Deep-Dive Into Gut Health And Microbiome With...

The Joe Cohen Show ·

2024/03/01

Joe delves deep into the world of biohacking alongside esteemed naturopath Michael Smith. Drawing on two decades of expertise, Michael shares invaluable insights into optimizing health, particularly focusing on gut health and the microbiome. From his personal journey to professional practice, Michael discusses the latest advancements in gut health research, tackling issues such as fatigue, autoimmune conditions, and more. Michael shares some practical strategies for enhancing gut health and

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00:55:23

Top 6 Health Transformation Tips You Need To Hear

The Joe Cohen Show ·

2024/02/23

Today, we're excited to bring you the cream of the crop – the top 6 health advice of Season 5 - that have not only resonated most with our listeners but have the power to transform your approach to health and wellness.These highlights encapsulate the essence of what it means to live well in today's world. Each clip has been handpicked for its impact, insight, and potential to inspire positive change in your life. Whether you're a long-time listener or just joining us, this episode is

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00:28:03

Master The 3 Pillars Of Immune Health

The Joe Cohen Show ·

2024/02/16

Get an in-depth overview of the components of the immune system, learn how to identify when they're compromised, and get insights on how to support them to prepare your body for illness. Joe discusses the importance of focusing on immune support before illness occurs, diving deep into the roles of mitochondria, extracellular matrix, and inflammation, and how their strengths affects the immune system - sharing key supplements that help optimize each component! - Check out SelfDecode:

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00:05:45

Understanding Appetite, Emotional Eating, and Fat...

The Joe Cohen Show ·

2024/02/14

In this episode, we focus on the FTO gene's pivotal role in fat metabolism, appetite, and weight management. Get an in-depth analysis of how the FTO gene not only influences body weight and obesity risk but also regulates appetite and fat metabolism, alongside managing emotional eating and hunger levels. We discuss the gene's connection to weight-related challenges, including its effects on insulin resistance, blood sugar levels, and energy expenditure. By understanding one’s genetic

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01:08:19

Exploring Rapamycin, Longevity and Healthspan with...

The Joe Cohen Show ·

2024/02/09

In this episode, Dr. Matt Kaeberlein, CEO of OptiSpan and co-director of the Dog Aging Project, and Joe explore the fascinating realm of rapamycin and its implications for longevity and healthspan. Dr. Kaeberlein delves into the biological mechanisms underlying rapamycin's effects, the best way to take it, and its impact on immune system processes. Gain insights from Dr. Kaeberlein's research on the mTor mechanism and rapamycin, uncovering their promising potential in extending healthspan

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00:47:52

A Practical Guide to Lab Tests for Optimal Health

The Joe Cohen Show ·

2024/02/02

Dive into the world of lab testing and unlock the secrets to optimal health. In this episode, Joe sheds light on the crucial role lab tests play in understanding our health, cautioning against the limitations of standard tests often offered by conventional medicine. Delve deep into the realm of comprehensive testing as Joe shares his insights on a variety of essential lab markers, including Complete Metabolic Panel, Complete Blood Count, Thyroid Panel, and Amino Acid Panel, among others. Learn why

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00:03:36

How Your Body Uses Vitamin D & The VDR Gene | SNPit #09

The Joe Cohen Show ·

2024/01/30

We unravel the intricate relationship between sunlight, Vitamin D, and your genetic makeup, as we explore the pivotal role of Vitamin D in optimizing health and well-being. At the heart of this discussion lies the VDR gene, a genetic blueprint responsible for producing the Vitamin D receptor, as we uncover it’s role alongside Vitamin D in the body. We delve into the fascinating journey of Vitamin D synthesis, from sun-kissed skin to the activation of calcitriol, the biologically active form of

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01:12:55

Energy, Mental Clarity and NAD: Biohacking with James...

The Joe Cohen Show ·

2024/01/26

Join Joe in a conversation with successful biohacker and CEO of Neurohacker Collective, James Schmachtenberger. James shares his two-decade-long journey with biohacking, focusing on improved energy, cognitive function and how NAD changed his life. Learn about utilizing research, software solutions like genetics and lab tests, lifestyle changes, and supplementation for optimizing your health. - Use code “SELFDECODE” to get 15% OFF any product at neurohacker.com - Check out SelfDecode:

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00:03:26

The IL6 Puzzle: Unraveling Genetic Threads of...

The Joe Cohen Show ·

2024/01/23

Ever wondered why some people seem to avoid sickness effortlessly, while others catch every bug in the vicinity? It turns out, luck and genetics may both play a role. In this episode, we uncover the secrets of the IL6 gene, responsible for coding interleukin 6 (IL-6), a crucial immune messenger. Discover how certain variants of the IL6 gene, such as rs1800795, are linked to higher or lower IL-6 levels, affecting immunity and susceptibility to infections. But the story doesn't end there – we

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01:49:45

Biohacking Longevity: Navigating Lab Tests,...

The Joe Cohen Show ·

2024/01/19

Unlock the secrets to longevity with our deep dive into biohacking, lab tests, and supplements! In this episode, we explore the crucial role of lab markers in longevity, optimal lab test ranges, and associations that impact aging. Dive into the world of supplements, addressing concerns about tolerance and when is the right time to supplement for lifespan. Joe and Michael discuss the Dunedin Pace Test and its significance in aging, while shedding light on the impact of lifestyle changes and immune

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00:04:38

Can This Gene Help With Your Body’s Detox? | SNPit #07

The Joe Cohen Show ·

2024/01/16

This episode explores the transformative potential of the UGT1A1 gene in your body’s ability to detox toxins. Uncover the role of this gene in Glucuronidation, a crucial chemical reaction that enhances the body's ability to detoxify. Learn about the impact of genetic variations which can reduce the activity of the UGT enzyme, hindering the body's detox capabilities. Discover practical solutions to counteract toxic buildup and support the body's natural detoxification processes. This

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00:31:34

How to Optimize Your Methylation

The Joe Cohen Show ·

2024/01/12

In this episode, Joe discusses the fascinating topic of methylation and its importance for overall health. From explaining the tests that can determine if you're an over or under methylator, to providing recommendations on how to support your methylation process, Joe covers everything you need to know. Discover how genetic variations, such as MTHFR and MTRR, can impact your need for nutrients like folate and B12. Get insights into specific lab markers and supplements that can help optimize

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00:05:36

PEMT, Choline, and Cellular Health | SNPit #06

The Joe Cohen Show ·

2024/01/09

Join us on an exhilarating journey into the intricate world of choline and the PEMT gene. Delve into the significance of choline and how it impacts cellular health, brain function, and beyond, and how PEMT plays a role in choline production. Discover the intricate genetic variants within PEMT, unravelling how certain alleles influence susceptibility to choline deficiency and associated risks. Plus, learn how estrogen stimulation plays a crucial role, posing unique challenges for different

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01:00:53

Boosting Immunity and Biohacking to Prevent Illness...

The Joe Cohen Show ·

2024/01/05

In this episode, we delve deep into the importance of the immune system and how you can optimize it for peak performance. Immunity isn't just about avoiding the common cold; it can impact all areas of health, from physical wellness to mental clarity. Joe, a seasoned biohacker, shares his personal experiences and strategies for ramping up immunity, shedding light on how a data-driven approach can yield significant benefits. We also explore a comprehensive protocol for when you do get sick,

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00:23:40

Navigating Your MTHFR Gene: Essential Lab Markers and...

The Joe Cohen Show ·

2023/12/29

In this episode, Joe dives deep into the fascinating world of MTHFR and what you can do if you carry the negative variants! Join us as we unravel the mysteries surrounding these important topic and explore everything you need to know about genetic variations, folate metabolism, and the crucial role of methylation in our bodies. Joe breaks down the science behind MTHFR, explains how to interpret your genetic results, and shares valuable insights on optimizing your folate levels. Discover the

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00:05:22

SNPit #05 | Do MTR & MTRR Deserve as Much Attention...

The Joe Cohen Show ·

2023/12/15

You’ve probably heard of the hype around MTHFR and how it affects methylation, but what about other genes implicated in the methylation process? In this SNPit the spotlight shifts to MTR and MTRR, and how they can affect levels of homocysteine in the body. Learn all about why homocysteine is important, how genetic variants can affect your levels, and other factors that affect methylation. … Because MTHFR doesn’t tell the whole story.

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