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PODCAST

The Poison Lab

Clinical Toxicology LLC

Dive into the captivating world of poisons with The Poison Lab! Hosted by Clinical Toxicologist Ryan Feldman (@EMPoisonPharmD), who has over a decade of managing poisoning and drug overdose via poison centers and in the emergency department. Also occasional co-hosted by his robo cohost Toxo! (@LabPoison). This show unpacks the fascinating history, cutting-edge science, and life-saving medical management of toxins from around the globe. From stories of those impacted to expert insights from pioneers

education life sciences

All Episodes

01:07:32

Episode #5- Toxicologists vs The Internet (#1) With...

The Poison Lab ·

2020/11/04

Article authored by Ryan and Matt regarding potential toxicity of vitamin e acetate in THC vape cartridgeshttps://pubmed.ncbi.nlm.nih.gov/32451600/https://pubmed.ncbi.nlm.nih.gov/33528766/News article about the man arrested 1 floor below our Host where co-author of above paper is quouted. for selling vape cartridgeshttps://www.jsonline.com/story/news/2019/08/29/vaping-deaths-thc-cartridges-investigated-wisconsin-cases/2154799001/False Positive for

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00:15:27

Mini Episode: The Saga of the Cardiac Action Potential

The Poison Lab ·

2020/08/26

Action potentialSodium/Potassium ATPase pumps create more positively charged ions outside the cell than inside the cell, this creates a relative negative charge in the cellPhase 4- Resting (~ -90 mv)Phase 0- Sodium enters the cell (+10 mv) Phase 1- Potassium efflux from cell as now there is no negative charge holding it in (0 mv) Phase 2- Calcium channels open and allow calcium in, calcium triggers the ryandoine receptor and allows for calcium dependent calcium release from the sarcoplasmic

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00:11:47

Mini episode: Early After Depolarizations and...

The Poison Lab ·

2020/08/26

Great review of potential torsades mechanisms based off experimental data- https://www.sciencedirect.com/science/article/pii/S1880427611800050

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00:58:43

Episode #4- The Rise of Lethal Loperamide

The Poison Lab ·

2020/08/26

Buying as much loperamide as you possibly can Loperamide history1969- Synthesized (1)1976 FDA Approved as schedule V (2)Jaffe trial of "abuse potential"- https://pubmed.ncbi.nlm.nih.gov/7438696/1982- Descheduled (3)2010-Annually Increasing in # of poison center calls, cases of arrhythmia and hospitalization (4,5,6)2016- Submission to DEA for rescheduling of loperamide denied (7)2019- FDA works with manufactures to reduce package size to 48 tablets (8)Pharmacist knowledge of abuse remains low

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01:07:24

Episode #3- Toddler Time Bombs (Poison Center Triage)

The Poison Lab ·

2020/07/22

Case report from beginning of showhttps://pediatrics.aappublications.org/content/130/6/e1700"One Pill Can Kill Resources"http://missouripoisoncenter.org/wp-content/uploads/2015/02/2011-One-Pill-Can-Kill.pdfhttps://pubmed.ncbi.nlm.nih.gov/16419734/https://www.healthychildren.org/English/safety-prevention/at-home/medication-safety/Pages/Poison-Prevention-One-Pill-Can-Kill.aspxRespiratory centers and the effects drugs can have on themhttps://www.ncbi.nlm.nih.gov/books/NBK482414Buprenorphne

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01:10:40

Episode #2- The Other Problem With Bullets (Lead and...

The Poison Lab ·

2020/06/24

Excellent review of sources, clinical effects, and managementCalello DP, Henretig FM. Lead. In: Goldfrank's Toxicologic Emergencies, 10th ed, Hoffman RS, Howland MA, Lewin NA, et al (Eds), McGraw Hill Education, New York 2015. p.1219.Toxic substances database for lead https://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=96&tid=22Clinical Case from today's showhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353372/Weiss D, Lee D, Feldman R, Smith KE. Severe lead toxicity attributed to bullet fragments

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00:27:03

Mini Episode: Fundamentals: Testings Tests,...

The Poison Lab ·

2020/06/10

Concepts in this episodetesting our testsSensitivity: Rate of Positive test in those who have the diseaseSpecificity: Rate of negative test in those without the diseasePositive predictive value: True positive/ True Positive + False PositiveNegative predictive value: True negative/True negative + False negative(PK) Bioavailablity = Amount of drug available to be used by the bodyOral Bioavailablity= Dose- Fraction excreted unchanged- Fraction metabolized in gut- Fraction metabolized by liver How drugs

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00:32:57

Episode #1- Cleaning with War Gas and Drinking Javel...

The Poison Lab ·

2020/05/27

Ryan and Toxo talk about the the history of a commonly used disinfectant. They break down the many ways it can cause harm if not used appropriately, including creating chemical weapons and turning you...Key pointsBleach mixed with various chemicals can make many toxic substancesBleach + acid= chlorine gasBartholette original Cl2 + H2O ⇄ HCl + HClOTo drive the reaction to the right, a base was added, to neutralize HCl and reduce the amount of productThe reaction is reversed when an acid is

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00:23:33

Prequel- Introductions, What is a Toxicologist, What...

The Poison Lab ·

2020/05/27

Ryan and Toxo introduce their roles while explaining the current state of toxicology and what exactly a poison is. Information about medical and clinical toxicology can be found at American Academy of Clinical Toxicology (AACT)- clintox.orgAmerican College of Medical Toxicology (ACMT)- acmt.net

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00:03:21

Welcome to The Poison Lab

The Poison Lab ·

2020/05/22

Welcome to the poison lab! Tune in to satisfy your taste for the history, science, and medical management of the infinite poisons the world has to offer!

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70 results

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