Immune

01:14:58

Immune 82: Bat antibodies are hot

Immune ·

2024/07/30

Immune reviews the local and systemic responses after human SARS-CoV-2 challenge infection, and how bat antibodies display elevated antigen binding strength and diversity at higher temperatures that are characteristic of flight. Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Responses to human SARS-CoV-2 challenge (Nature) Temperature-sensitivity

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19:51

Immune Booster #4: Human autoimmunity with Jane Buckner

Immune ·

2024/07/23

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Jane Buckner to talk about her career, and the research of her laboratory on mechanisms by which regulation of the adaptive immune response fails or is overcome in the setting of human autoimmunity. Hosts: Cindy Leifer and Steph Langel Guest: Jane Buckner Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Music by Tatami. Logo image by Blausen Medical Send your immunology

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29:01

Immune Booster #3: NKT cells and cancer, and DEI in...

Immune ·

2024/07/16

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Tonya Webb to talk about her career, the role of NKT cells in cancer, and her efforts to ensure diversity, equity, and inclusion in research. Hosts: Cindy Leifer and Brianne Barker Guest: Tonya Webb Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Content in

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27:41

Immune Booster #2: Sex differences in immune...

Immune ·

2024/07/09

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Michal Tal to talk about her career, sex differences in immune responses, and how one giant mouse uterus changed the trajectory of her research career. Hosts: Cindy Leifer and Brianne Barker Guest: Michal Tal Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

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25:47

Immune Booster #1: From bench to bedside to beat HIV...

Immune ·

2024/07/02

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne where meet up with Luis Montaner to talk about his career and his research on boosting the immune system to combat viral diseases or cancer progression. Hosts: Cindy Leifer and Brianne Barker Guest: Luis Montaner Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode Community engagement in research (Res Involv Engag) Susceptibility to HIV bnAbs during ART (AIDS)

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41:23

Immune 81: T cells and tolerance with Joseph Larkin III

Immune ·

2024/06/25

Immune travels to Chicago for the American Association of Immunologists conference where they meet up with Joseph Larkin III to talk about his career and his research on the contribution of T lymphocyte subsets and functions in maintaining tolerance. Hosts: Stephanie Langel and Brianne Barker Guest: Joseph Larkin III Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Th17 cells in immunity and autoimmunity (J Immunol Res) COVID-19

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01:15:56

Immune 80: Intranasal neomycin; sex hormones and skin...

Immune ·

2024/05/28

Immune presents three stories: intranasal neomycin and antiviral immunity, sexual dimorphism in skin immunity, and maternal diet changes infant microbes that alter gut DC responses and respiratory health. Hosts: Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Intranasal neomycin as antiviral (PNAS) Sexual dimorphism in skin immunity (Science) Maternal diet and infant

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01:04:21

Immune 79: Spa therapy for the immune system

Immune ·

2024/05/26

Immune explains how antibody-mediated depletion of myeloid-hematopoietic stem cells in aged mice restores characteristic features of a more youthful immune system, including increasing common lymphocyte progenitors, naive T cells and B cells, while decreasing age-related markers of immune decline. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server

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01:24:03

Immune 78: Tolerance and tolerating many vaccines

Immune ·

2024/03/26

Immune discusses responses in a COVID hypervaccinated individual, synthetically glycosylated antigens for the antigen-specific suppression of established immune responses, gut bacteria–derived serotonin promotes immune tolerance in early life, and mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge. Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become

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56:58

Immune 77: Squeezing the most killing out of neutrophils

Immune ·

2024/02/27

Immune reviews research showing that the migration of neutrophils between endothelial cells activates bactericidal function via mechanosensing. Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Trans endothelial migration activates neutrophil killing (Immunity) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image

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01:07:07

Immune 76: Macrophages to the rescue with Juliet...

Immune ·

2024/01/30

Juliet Morrison joins Immune to discuss her career and the research of her laboratory showing that pleural macrophages translocate to the lung during infection to promote improved influenza outcomes. Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker Guest: Juliet Morrison Click arrow to play Download Immune 76 (48 MB .mp3, 67 min) Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server

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01:15:03

Immune 75: Ang Cui unveils the cytokine symphony

Immune ·

2023/12/28

Ang Cui joins Immune to discuss her career and her work on establishing the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Guest: Ang Cui Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server

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01:11:19

Immune 74: Germinal center dynamics with Carla Nowosad

Immune ·

2023/12/11

Carla Nowosad joins Immune to discuss her career and her work on germinal centers, the structure in secondary lymphoid tissues where B cells proliferate, differentiate, and diversify their immunoglobulin genes by somatic hypermutation. Hosts: Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Carla R. Nowosad Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server B cells and the intestinal microbiome (Sem

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01:14:32

Immune 73: Big macs

Immune ·

2023/11/08

Immune reveals the total mass (1.2kg), number (1.8 trillion), and distribution of immune cells in the human body, with macrophages contributing nearly 50% of the total cellular mass. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Immune cells in the human body (PNAS) Letters read on Immune 73 Time stamps by Jolene. Thanks! Music by Steve Neal

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57:29

Immune 72: After dark in the library with Ellen...

Immune ·

2023/09/23

From Cornell University in Ithaca New York, Vincent and Cindy meet with Ellen Rothenberg to review her career in science, starting with work on retroviruses to unraveling transcriptional networks underlying T-cell development and signaling. Hosts: Vincent Racaniello and Cynthia Leifer Guest: Ellen Rothenberg Click arrow to play Download Immune 72 (53 MB .mp3, 73 min) Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord

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01:13:33

Immune 71: Can parasitic worms prevent pandemics?

Immune ·

2023/09/08

Immune explains how, in a mouse model of roundworm infection with Nippostrongylus brasiliensis, exposure to lung-migrating helminths protects mice against SARS-CoV-2 infection. Hosts: Cynthia Leifer, Stephanie Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Helminth protects against murine SARS-CoV-2 infection (Sci Immunol) Pandemic spared Africa (ScienceInsider) Letters read on

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01:07:32

Immune 70: Immunology of picky eating

Immune ·

2023/07/26

Immune explains how mast cells, IgE antibody, and the brain collaborate to promote avoidance of certain foods to evade allergic responses. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Mast cells and immune avoidance behavior (Nature) Immune sensing of food allergens promotes avoidance (Nature) Immunology that underlies picky eating (Nature) Time

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01:09:50

Immune 69: Lung cancer and retroviruses

Immune ·

2023/06/15

Kevin joins Immune to discuss his work showing that antibodies against endogenous retroviruses promote immunotherapy of lung cancer. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guest: Kevin Ng Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Antibodies against ERVs and lung cancer (Nature) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical

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01:07:42

Immune 68: Sins and blessings of immunity

Immune ·

2023/05/18

Immune discusses immunological imprinting, also called original antigenic sin, in the context of infection with SARS-CoV-2 and influenza virus. Hosts: Vincent Racaniello, Cynthia Leifer, and Steph Langel Download Immune 66 (45 MB .mp3, 76 min) Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Immunological imprinting (Immunity) COVID-19 vaccine imprinting (bioRxiv) Original antigenic sin (J Inf Dis) Are

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01:15:32

Immune 67: Can T cells live forever?

Immune ·

2023/05/03

Immune explains the results of a study which show that in mice, functional T cells respond to vaccination for over 10 years and 51 successive immunizations, exhibiting supernumerary cell division and longevity. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server T cells capable of supernumerary division (Nature) Time stamps by Jolene

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