Johns Hopkins Mosquito Minute

08:31

EXTENDED: What Genomics Can Reveal about Malaria’s...

Johns Hopkins Mosquito Minute ·

2023/09/25

In 1951, malaria was eliminated from the US. But just this past summer, the parasite that causes the disease has re-infected local mosquitoes and caused a handful of cases of malaria in three US states. In this interview podcast, we ask: What should we make of these cases? Is the public possibly at risk of this once-eliminated disease? How can genomics help us to better understand what’s happened? With Jane Carlton, Director of the Johns Hopkins Malaria Research Institute:

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01:17

Malaria Is Making a Comeback to the US. Why?

Johns Hopkins Mosquito Minute ·

2023/09/12

Malaria returns to the US for the first time in decades. We share what we know so far. Transcript Today, another reminder that infectious diseases respect no borders. Malaria, a disease that was once endemic globally, has returned to the US for the first time in two decades. A number of cases have been confirmed in Florida, Texas and, most recently, one in Maryland. Crucially, in each of those cases, the people who got the disease hadn’t traveled to any malaria-endemic regions. The transmission was

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12:36

EXTENDED: How Scientific Collaboration Across Three...

Johns Hopkins Mosquito Minute ·

2023/08/28

In 2013, on the outskirts of Madrid, GSK was gearing up to test new medicines against malaria. But they had a problem. In this month's podcast, we're joined by Janneth Rodrigues from GSK, Marcelo Jacobs-Lorena from Johns Hopkins University, and Etienne Bilgo from IRSS to share a story of collaboration that spans three continents, and which turned a headache into a success story. Source Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes About The Podcast The

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01:22

A Naturally Occurring Bacterium Inhibits Malaria...

Johns Hopkins Mosquito Minute ·

2023/08/14

A naturally occurring bacterium renders the mosquito a poor transmitter of the malaria parasite. Transcript Scientists often grow mosquitos in the laboratory and infect them with malaria parasites to test new drugs and explore vector control. Unexpectedly, in a lab run by GSK in Spain, mosquitoes gradually lost the ability to sustain parasite development. To unwind this mystery, GSK turned to Marcelo Jacobs-Lorena, a researcher at Johns Hopkins University and sent him a bacterium they suspected was

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10:02

EXTENDED: Will the Malaria Vaccine Mean a World Free...

Johns Hopkins Mosquito Minute ·

2023/06/27

After decades of research, the world’s first malaria vaccine is finally being rolled out in Africa. It’s a landmark in malaria success – but will it deliver a public health victory? In this podcast, we reveal the elusive target of the malaria vaccine and unpack the complex story of its development.

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01:08

How the Malaria Parasite Searches for Blood Vessels...

Johns Hopkins Mosquito Minute ·

2023/06/12

To locate blood vessels and establish infection, malaria parasites alternate between two states of movement in the skin – fast and slow. Interestingly, this shift in state might be guided by a cell found on the walls of capillaries. Transcript Of the dozens of malaria parasites the mosquito injects, only a handful will make it. To survive, the parasite needs to forage around for a blood vessel, enter it, and hitch a ride to the liver, where it can set up the infection. 3D imaging and statistical

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11:37

EXTENDED: Beyond Biology: The Head, Heart and Social...

Johns Hopkins Mosquito Minute ·

2023/05/29

Behavioral science is essential if the tools we develop in the lab are to generate impact in the field. So, in this episode, we take a break from malaria biology to delve deep into human psychology of malaria control. We explore the theory behind behavioral science and its implications for malaria control, and discuss a new tool from the Johns Hopkins Center for Communication Programs: the Malaria Behavior Survey. With Doug Storey and Mike Toso of the Johns Hopkins Center for Communication

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01:04

How Can Behavioral Science Improve Bed Net Use?

Johns Hopkins Mosquito Minute ·

2023/05/15

Bed nets are a staple tool in malaria control - but how do we make sure people actually use them? We discuss behavioral science, and the Malaria Behavior Survey from the Johns Hopkins Center for Communication Programs. Transcript Bed nets are a staple tool in malaria control. They’re reliable, effective, affordable and reusable. But how do we make sure people actually use them: sleep under one every night and store them properly when not in use? This is where behavioral science comes in – in

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16:59

EXTENDED: Meet the Americans Passionate About Ending...

Johns Hopkins Mosquito Minute ·

2023/04/24

Without funding, there can be no malaria fight. No bed nets distributed, no homes sparayed with insecticide and no scientific research to develop new tools. For World Malaria Day 2023, we head to Washington D.C. to meet advocates in the U.S. who are passionate about rallying political support around the fight against malaria and raising the bar for the role young people play in global health advocacy. Featuring Margaret Reilly McDonnell (United to Beat Malaria), Himaja Nagireddy (US Youth Observer

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01:15

Malaria Champions Meet in Washington D.C.

Johns Hopkins Mosquito Minute ·

2023/04/11

Malaria champions meet in Washington D.C. for the UN Foundation's 'United to Beat Malaria' Leadership Summit. Transcript In the centre of Washinton DC – just a five-minute walk from the White House – is a campaign at the forefront of malaria advocacy. The UN Foundation’s ‘United to Beat Malaria’ campaign connects Americans with the global movement to end malaria. Every year, it briefs advocates from across the country on the big challenges facing malaria. Drug and insecticide resistance. Limited

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11:26

EXTENDED: The Invasive Mosquito Threatening to Worsen...

Johns Hopkins Mosquito Minute ·

2023/03/28

An invasive mosquito species, Anopheles stephensi, is threatening to redefine malaria in Africa. In this episode, we speak to Eric Ochomo from the Kenya Medical Research Institute, and Seth Irish from the World Health Organization, about the rise of the Anopheles stephensi in Africa. We discuss why the mosquito is in Africa, what this means for malaria, and—more importantly—what can be done.

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01:01

Anopheles stephensi Found in Marsabit, Kenya

Johns Hopkins Mosquito Minute ·

2023/03/06

The migration of Anopheles stephensi, an invasive mosquito species, threatens to redefine malaria in Africa. Transcript Malaria in Africa is mainly rural, and peaks during the rainy season. The primary culprit is Africa’s main malaria vector: Anopheles gambiae. But another malaria vector – called Anopheles stephensi – is making its way into the continent from SE Asia. Anopheles stephensi can transmit malaria in both rural and urban settings, and breed in small volumes of water. Because it’s not

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04:49

EXTENDED: The Genetics of Drug Resistance (and...

Johns Hopkins Mosquito Minute ·

2023/02/27

The malaria parasite is becoming increasingly resistant to the drugs we use against it. Caroline Simmons, a geneticist at the University of South Florida, is trying to understand what's driving this. By creating mutants of the parasite, and testing drugs against them, she's piecing together the complex puzzle of antimalarial drug resistance.

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01:07

KIC5: A New Piece in the Puzzle of Artemisinin...

Johns Hopkins Mosquito Minute ·

2023/02/13

Drug resistance is on the rise, but genetics can help us understand what's driving it. Here, researchers identify a protein associated with resistance to artemisinin, a key malaria drug. Transcript Artemisinin-based combination therapies (ACT) are considered the most effective method to treat malaria. Yet drug resistance to them is on the rise, spreading from Southeast Asia to Africa, becoming a real problem. A genetic approach to drug resistance can help us understand the genes responsible for

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04:33

EXTENDED: African Leadership in the Push for Malaria...

Johns Hopkins Mosquito Minute ·

2023/01/30

When Clive Shiff completed his entomology training, he was told that malaria was on its way out. But as we know, the disease persisted, continuing to claim lives and livelihoods. In January's Malaria Minute Extended, we speak with Clive Shiff, Professor Emeritus at Johns Hopkins University, on the rise of the bed net and the importance of African leadership in the push for malaria eradication.

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01:01

Humidity from Trees Helps Sustain Malaria in Dry Season

Johns Hopkins Mosquito Minute ·

2023/01/16

How can we account for malaria cases during the dry season, when mosquitoes are typically dormant? It turns out that trees might be the root of the problem... Transcript Malaria is often thought of as a seasonal disease. Transmission peaks during the rainy season – when standing water creates the ideal conditions for mosquitoes to thrive – and falls in the dry season when mosquitoes become dormant. But in those dryer months, the disease doesn’t go away completely. In some areas, mosquitoes remain

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05:23

EXTENDED: How Does Epigenetics Give Plasmodium the...

Johns Hopkins Mosquito Minute ·

2022/12/16

The malaria parasite has a lot of genes: over 5,000. But how does it know when to express certain genes versus others? And what purpose do these different genes serve in malaria virulence and transmission? We dive deep into the nucleus of the cell with Catherine Merrick of the University of Cambridge to find out. She reveals the role of epigenetics in malaria transmission and the discovery of a new epigenetic mechanism that might help us gain the upper hand on malaria.

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01:01

Histone Lactylation: A New Epigenetic Marker for...

Johns Hopkins Mosquito Minute ·

2022/12/02

A newly-discovered epigenetic marker may reveal how the parasite survives in the human host Transcript The malaria parasite is resilient, with thousands of genes that can be differentially expressed to evade the immune system. The expression of those genes is determined by environmental factors and controlled through ‘epigenetic markers’. They turn the genes on or off – and give the parasite flexibility in the human host. A new marker has recently been discovered in Plasmodium falciparum. It’s

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05:54

EXTENDED: How Can You Get Rid of Malaria in...

Johns Hopkins Mosquito Minute ·

2022/11/18

In 2010, the NIH launched the ICEMRs, a global network of research centers focused on eliminating malaria. They track malaria over time - across the globe - to help inform government policy with the mission to move the needle toward a malaria-free world. Malaria is a spectacularly complex disease, and this mission is challenging. Here, we zoom in on the Southern and Central Africa ICEMR to learn more. With Principal Investigator William Moss, Deputy Director of the Johns Hopkins Malaria Research

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01:01

Science and Policy: Marking the Global Impact of the...

Johns Hopkins Mosquito Minute ·

2022/11/04

A special supplement in the American Journal of Tropical Medicine and Hygiene marks the global impact of the International Centers of Excellence for Malaria Research. Transcript Open the most recent edition of the American Journal of Tropical Medicine and Hygiene, and you’ll find a Special Supplement. A series of papers to highlight the global impact of the ICEMRs, the International Centers of Excellence for Malaria Research. Funded by the NIH, the research network spans the globe – in 17

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