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PODCAST

Clinical Chemistry Podcast

Association for Diagnostics and Laboratory Medicine

This free monthly podcast is offered by Clinical Chemistry. Clinical Chemistry is the leading forum for peer-reviewed, original research on innovative practices in today"s clinical laboratory.

science chemistry

All Episodes

18:21

The Promise-and Pitfalls-of Computerized Provider...

Clinical Chemistry Podcast ·

2016/08/15

It is no secret that laboratory tests are overordered in the clinical environment; a recent metaanalysis demonstrated that tests are overused by 20.6% on average. The ordering of unnecessary tests on such a massive scale may impact not only direct healthcare costs, but also patient safety, and may lead to unnecessary follow-up investigation and iatrogenic blood loss due to excess phlebotomy. Unfortunately, in large hospitals with high patient volumes, it would be impractical for laboratory directors

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17:56

Ready, Set, Type! Proteomics vs Agglutination for...

Clinical Chemistry Podcast ·

2016/08/15

Initial detection and reporting by clinical microbiology laboratories is a sentinel marker for foodborne outbreak surveillance systems. Initiation of a public health investigation is reliant on the rapid initial identification of pathogens of interest. Diagnostics for Escherichia coli have evolved to reduce identification turnaround time, incorporating technologies for rapid identification (MALDI-TOF MS) and serogrouping (O157 antiserum or latex agglutination). Reporting of these isolates to a

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16:06

Classifying Germline Sequence Variants in the Era of...

Clinical Chemistry Podcast ·

2016/07/18

Next generation sequencing is increasingly available in clinical laboratories, enabling the sequencing of more genes for relatively lower costs.

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17:16

A 30-Year-Old Patient Who Refuses to Be Drug Tested

Clinical Chemistry Podcast ·

2016/07/11

The practice of medicine is not always clear-cut. Healthcare providersare often faced with difficult decisions such as what test to perform on patients, what treatment should be given, and what type of follow-up is needed. Providers have a duty to enhance the wellbeing and minimize harm to their patients.

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0:52

Full Audio Summary July16

Clinical Chemistry Podcast ·

2016/07/01

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11:36

Incorporating Clinical Considerations into...

Clinical Chemistry Podcast ·

2016/06/30

The basic problem shared by many of the biostatistical methods used in marker research is that they relate numbers to other numbers, rather than to anything that we might care about in the real world.

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10:54

Plasma Branched-Chain Amino Acids and Incident...

Clinical Chemistry Podcast ·

2016/06/30

The role of branched-chain amino acids (BCAAs) in cardiovascular disease (CVD) remains poorly understood. We hypothesized that baseline BCAA concentrations predict future risk of CVD and that a Mediterranean diet (MedDiet) intervention may counteract this effect.

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07:12

Smartphones Can Monitor Medical Center Pneumatic Tube...

Clinical Chemistry Podcast ·

2016/06/27

Pneumatic tube systems have become a primary way of automating the transport of clinical specimens in medical centers. These may travel within the floors of a building and also between buildings. Although this provides convenience and speed of transport, the excessive acceleration forces and the prolonged time and distance travelled have been linked to pre-analytical variation including hemolysis of blood specimens. As a result, it has been suggested that users regularly assess the forces

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24:48

Postmarket Surveillance of Point-of-Care Glucose...

Clinical Chemistry Podcast ·

2016/06/21

Postmarket surveillance is an important monitor of the safety of pharmaceuticals and medical devices after regulatory approval and entry to the market. Although premarket studies are substantial, costs prohibit examination of heterogeneous populations or rare events over long durations.

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15:00

Pharmacists in the Laboratory Space: Friends or Foes?

Clinical Chemistry Podcast ·

2016/06/13

There are nearly 60,000 community pharmacies in the United States today. In addition to being sources of prescriptions and medications, they're also often a site for wellness visits, vaccinations, acute illness diagnosis and treatment, as well as monitoring of chronic disease. Pharmacies often offer a convenient alternative to physician offices because of their accessible locations and extended service hours. Approximately 18% of pharmacies in the U.S. have CLIA-waived status, which means they can

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07:37

FullIssueSummary June2016

Clinical Chemistry Podcast ·

2016/06/01

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09:57

Different Susceptibility of B-Type Natriuretic...

Clinical Chemistry Podcast ·

2016/05/31

Protease neprilysin is known to be responsible for the degradation of natriuretic peptides. A recent heart failure (HF) drug, LCZ696 (EntrestoTM), that combines a neprilysin inhibitor and an angiotensin II receptor inhibitor was suggested to augment circulating B-type natriuretic peptide (BNP) concentrations, making the results of BNP measurements diagnostically ambiguous. Because the main form of measured BNP in HF patients is represented by its uncleaved precursor, proBNP, it is important to know

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09:27

Soluble CRTC3: A Newly Identified Protein Released by...

Clinical Chemistry Podcast ·

2016/05/23

CREB-regulated transcription coactivator 3 (CRTC3) is found in adipocytes, where it may promote obesity through disruption of catecholamine signaling. We wished to assess whether CRTC3 is a soluble protein secreted by adipose tissue, explore whether CRTC3 is detectable and quantifiable in the circulation, and ascertain whether CRTC3 serum concentrations are related to metabolic markers in children.

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10:08

Effect of Dried Blood Spot Quality on Newborn...

Clinical Chemistry Podcast ·

2016/05/03

The analysis of dried blood spots has been used routinely for newborn screening since the early 1970s, and the number of disorders screened has expanded substantially in recent years. However, there is a lack of evidence regarding minimum blood spot quality acceptance criteria for sample analysis.

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07:36

FullIssueSummary May2016

Clinical Chemistry Podcast ·

2016/05/01

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13:05

Nonfasting Sample for the Determination of Routine...

Clinical Chemistry Podcast ·

2016/04/26

For many years the determination of a routine lipid profile (total, LDL, and HDL cholesterol and triglycerides) has been done routinely in the clinical laboratory using a blood specimen that is collected in the fasting state.

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14:43

Mass SpectrometryBased Adrenal and Peripheral Venous...

Clinical Chemistry Podcast ·

2016/04/19

Primary aldosteronism,also known as Conn's syndrome,is a form of endocrine hypertension that results from excess product of aldosterone by the adrenal glands.

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10:20

Paper-Based Quantification of Male Fertility Potential

Clinical Chemistry Podcast ·

2016/04/05

More than 70 million couples worldwide are affected by infertility, with male-factor infertility accounting for about half of the cases. Semen analysis is critical for determining male fertility potential, but conventional testing is costly and complex. Here, we demonstrate a paper-based microfluidic approach to quantify male fertility potential, simultaneously measuring 3 critical semen parameters in 10 min: live and motile sperm concentrations and sperm motility.

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09:05

FullIssueSummary April2016

Clinical Chemistry Podcast ·

2016/04/01

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18:17

Clostridium difficile—Diagnostic and Clinical Challenges

Clinical Chemistry Podcast ·

2016/03/15

Clostridium difficile is the most common cause of healthcare associated infections in the United States and is increasingly recognized as a pathogen in the community. This organism is considered to be one of the most urgent antibiotic resistant threats to public health, and can cause a variety of clinical manifestations ranging from asymptomatic to mild diarrhea, to toxic megacolon, and even death.

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1,086 results

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