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PODCAST

Clinical Chemistry Podcast

Association for Diagnostics and Laboratory Medicine

This free monthly podcast is offered by Clinical Chemistry. Clinical Chemistry is the leading forum for peer-reviewed, original research on innovative practices in today"s clinical laboratory.

science chemistry

All Episodes

06:14

Paper-Based Quantification of Male Fertility Potential

Clinical Chemistry Podcast ·

2016/03/05

More than 70 million couples worldwide are affected by infertility, with male-factor infertility accounting for about half of the cases. Semen analysis is critical for determining male fertility potential, but conventional testing is costly and complex. Here, we demonstrate a paper-based microfluidic approach to quantify male fertility potential, simultaneously measuring 3 critical semen parameters in 10 min: live and motile sperm concentrations and sperm motility.

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09:34

FullIssueSummary March2016

Clinical Chemistry Podcast ·

2016/03/01

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07:14

Impact of Implementing Preanalytical Laboratory...

Clinical Chemistry Podcast ·

2016/02/22

Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes, but risk is reduced with identification and early treatment. Glucose measurements are affected by preanalytical sample handling, such as temperature of storage, phlebotomy–analysis interval, and use of a glycolysis inhibitor. We evaluated glucose concentrations and the incidence of GDM after strict implementation of the American Diabetes Association (ADA) preanalytical guidelines, compared with usual hospital

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08:13

Effect of Vitamin D or Activated Vitamin D on...

Clinical Chemistry Podcast ·

2016/02/16

Evidence is accumulating that circulating 1,25-dihydroxyvitamin D [1,25(OH)2D] concentrations are inversely related to overall mortality.

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09:54

Serum Total Testosterone Concentrations in the US...

Clinical Chemistry Podcast ·

2016/02/01

Limited information is available about testosterone concentrations representative of the general US population, especially children, women, and non-Hispanic Asians.

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08:58

FullIssueSummary February2016

Clinical Chemistry Podcast ·

2016/02/01

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08:52

US Food and Drug Administration Perspectives on...

Clinical Chemistry Podcast ·

2016/01/27

Mass spectrometry–based in vitro diagnostic devices that measure proteins and peptides are underutilized in clinical practice, and none has been cleared or approved by the Food and Drug Administration (FDA) for marketing or for use in clinical trials. One way to increase their utilization is through enhanced interactions between the FDA and the clinical mass spectrometry community to improve the validation and regulatory review of these devices.

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21:50

Measurement by a Novel LC-MS/MS Methodology Reveals...

Clinical Chemistry Podcast ·

2016/01/27

There are now numerous epidemiological studies that have demonstrated that low plasma concentrations of vitamin D are associated with not only bone related disorders, but with a wide variety of adverse health outcomes.

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21:36

Ambient Ionization Mass Spectrometry for...

Clinical Chemistry Podcast ·

2016/01/08

A driving force in the development of point-of-care diagnostics is to conveniently provide information without delay so that healthcare decisions can be made while the patient is on-site. Most point-of-care devices are based on immunochemical, electrochemicalor colorimetric techniques that can be miniaturized and made portable.

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10:05

Mass Spectrometry Selectivity, Specifically

Clinical Chemistry Podcast ·

2016/01/04

A mass spectrometer is a sensitive and specific instrument." In some form or another, this is often the label applied to the platform by all manner of professions (chemists, physicists, biologists, physicians, clinicians, and laboratorians, novice and expert alike). This is a view of mass spectrometry (MS) through rose-colored glasses. It should be properly said that MS can be sensitive and specific, but not without due consideration for the measurement to be performed. In clinical laboratories,

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07:16

Protein-Specific Glycoprofiling for Patient Diagnostics

Clinical Chemistry Podcast ·

2016/01/04

Protein glycosylation is increasingly recognized as a crucial modulator of protein function, offering a third layer of biological information over genomics and proteomics. Modern tools for analyzing released N-glycans from cells and body fluids, i.e., the glycome, have shown abnormal protein glycosylation in numerous human diseases. These include both genetic and acquired diseases, ranging from diabetes, cancer, and inflammatory disease to neurodegenerative and neuromuscular disease. Insights from

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11:39

Clonotypic Light Chain Peptides Identified for...

Clinical Chemistry Podcast ·

2016/01/04

Analytically sensitive techniques for measuring minimal residual disease (MRD) in multiple myeloma (MM) currently require invasive and costly bone marrow aspiration. These methods include immunohistochemistry (IHC), flow cytometry, quantitative PCR, and next-generation sequencing. An ideal MM MRD test would be a serum-based test sensitive enough to detect low concentrations of Ig secreted from multifocal lesions.

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19:49

High-Resolution Mass Spectrometry for Characterizing...

Clinical Chemistry Podcast ·

2016/01/04

Despite increasing prevalence of novel psychoactive substances, no human metabolism data are currently available, complicating laboratory documentation of intake in urine samples and assessment of the drugs' pharmacodynamic, pharmacokinetic, and toxicological properties. In 2014, THJ-018 and THJ-2201, synthetic cannabinoid indazole analogs of JWH-018 and AM-2201, were identified, with the National Forensic Laboratory Information System containing 220 THJ-2201 reports. Because of numerous adverse

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15:33

FullIssueSummary January2016

Clinical Chemistry Podcast ·

2016/01/01

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08:26

Performance of Cystatin C and Creatinine-Based...

Clinical Chemistry Podcast ·

2015/12/29

The Kidney Disease Improving Global Outcomes (KDIGO) guideline recommends use of a cystatin C–based estimated glomerular filtration rate (eGFR) to confirm creatinine-based eGFR between 45 and 59 mL · min−1 · (1.73 m2)−1. Prior studies have demonstrated that comorbidities such as solid-organ transplant strongly influence the relationship between measured GFR, creatinine, and cystatin C. Our objective was to evaluate the performance of cystatin C–based eGFR equations compared with creatinine-based

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33:17

"Big Data" in Laboratory Medicine

Clinical Chemistry Podcast ·

2015/12/21

Informatics is changing the processes behind laboratory medicine. With ever-growing demands on laboratory medicine professionals not only to collect and interpret omics data in the era of the Precision Medicine Initiative, but also to ensure high-quality, low-cost patient management in the structure of accountable care organizations, we have invited several experts to discuss their take on "big data."

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10:48

Optimizing Early Rule-Out Strategies for Acute...

Clinical Chemistry Podcast ·

2015/12/08

Combined testing of high-sensitivity cardiac troponin T (hs-cTnT) and copeptin at presentation provides a very high—although still imperfect—negative predictive value (NPV) for the early rule-out of acute myocardial infarction (AMI). We hypothesized that a second copeptin measurement at 1 h might further increase the NPV.

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07:22

Obese Nondiabetic Pregnancies and High Maternal...

Clinical Chemistry Podcast ·

2015/11/17

We investigated whether obese pregnant women negative for gestational diabetes (GDM) still experience dysglycemia, as indicated by high glycated hemoglobin (Hb A1c) at delivery, and whether this impacts offspring and long-term maternal outcomes.

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09:42

STARD 2015: An updated list of essential items for...

Clinical Chemistry Podcast ·

2015/11/04

STARD 2015: An updated list of essential items for reporting diagnostic accuracy studies

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07:40

FullIssueSummary November2015

Clinical Chemistry Podcast ·

2015/11/01

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