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PODCAST

Oncology Brothers: Practice-Changing Cancer Discussions

Oncology Brothers

On a mission to disseminate information to the community and bridge the gap between academia and community oncology in this rapidly changing field of hematology & oncology. Drs. Rahul & Rohit Gosain interview world-renowned hematologists/oncologists to present the practice-changing data in a small bite-sized format where one could immediately apply that information in their daily practice to provide the best cancer care to their patients close to home. Privacy Policy:

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All Episodes

00:21:59

ASH 2024 CLL Highlights - SEQUOIA, AMPLIFY,...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/12/26

Welcome to the Oncology Brothers podcast! In this episode, hosts Rahul and Rohit Gosain are joined by Dr. John Allan from New York Presbyterian Hospital to discuss the latest highlights from ASH 2024, focusing on Chronic Lymphocytic Leukemia (CLL). We dived into three key studies: 1.⁠ ⁠SEQUOIA Update: Discover how this study led to the approval of Zanubrutinib in the frontline setting and its impressive progression-free survival rates compared to traditional chemotherapy. 2.⁠ ⁠AMPLIFY Study: Learn

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00:21:42

CAR-T Toxicity Check: From Approval to Practice,...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/12/21

Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain dive deep into the rapidly evolving world of CAR T cell therapy, a groundbreaking treatment for various hematologic malignancies. Joined by experts Dr. Surbhi Sidana from Stanford University and Dr. Jason Westin from MD Anderson Cancer Center, we explore the mechanism of action of CAR T cells, their side effects, and management strategies. Episode Highlights: • Understanding CAR T cell therapy

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00:17:59

Leukemia ASH 2024 Highlights - Menin Inhibitors, CPX...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/12/19

Welcome back to the Oncology Brothers podcast! In this episode, we dive into the highlights from ASH 2024, focusing on key studies in leukemia. Join hosts Drs. Rahul and Rohit Gosain as they discuss groundbreaking research with Dr. Uma Borate from The Ohio State University. Episode Highlights: •⁠ ⁠KOMET 007 Study: An in-depth look at the Phase 1 study on the Menin inhibitor Ziftomenib, exploring its promising results in frontline settings for patients with NPM1 mutations and KMT2A

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00:26:18

2nd line treatment in advanced HCC and when to switch

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/12/13

In the second episode of a 4-part podcast series on HCC, the Oncology Brothers, Drs Rahul and Rohit Gosain, host a podcast discussion between Dr Lorenza Rimassa and Prof. Arndt Vogel on 2nd line treatment selection in advanced HCC and when to switch. The discussion covers a range of topics, including 2nd line options for advanced HCC after progression on 1st line TKIs and IO-based therapies, as well as: • How to approach sequencing in clinical practice • The available data

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00:17:56

From Approval to Practice: Managing Side Effects of...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/12/02

Welcome to another episode of the Oncology Brothers! In this episode, hosts Drs. Rahul and Rohit Gosain dive into the complexities of managing side effects associated with antibody drug conjugates (ADCs). Joined by expert guests Dr. Tian Zhang, a GU medical oncologist from UT Southwestern, and Dr. Erika Hamilton from Sarah Cannon Research Institute, the discussion focuses on three key ADCs: Enfortumab vedotin, Sacituzumab govitecan, and Trastuzumab deruxtecan (TDXD). Episode Highlights:•⁠

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00:23:21

The use of Immunotherapy in unresectable...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/11/28

Experts provide an overview of current systemic treatment options for 1st line uHCC, discussing the role of IO and IO-based combinations, along with emerging therapies and the latest clinical data. Topics also include: • Efficacy and safety of IO and IO combinations in HCC• How to select between the two 1st-line IO-based treatment options based on clinical factors• Future treatment in unresectable HCC Clinical Takeaways• Two 1st-line IO and IO-based combinations are approved for patients with

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00:23:24

INAVO120 - FDA Approval of Inavolisib in...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/11/25

Welcome to another episode of the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain dive deep into the recent FDA approval of Inavolisib for metastatic hormone receptor-positive breast cancer, based on the groundbreaking INAVO120 study. Join us as we chat with Dr. Komal Jhaveri, a medical oncologist and senior author of the study from Memorial Sloan Kettering Cancer Center. We explored the study design, key findings, and the implications of this new treatment option for

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00:22:27

How to Approach and Treat Pancreatic Cancer

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/11/21

Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rohit and Rahul Gosain are joined by Dr. Eileen O'Reilly, a leading medical oncologist and section head of hepatobiliary and pancreatic cancer at Memorial Sloan Kettering Cancer Center. Together, they delve into the complex treatment landscape of pancreatic cancer. Episode Highlights:•⁠ ⁠The initial workup for newly diagnosed pancreatic cancer patients, including the importance of imaging and genetic testing.•⁠ ⁠Treatment

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00:18:28

Understanding the Impact of Nutrition & Exercise on...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/11/18

In this episode of the Oncology Brothers podcast, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Neil Iyengar, a medical oncologist from Memorial Sloan Kettering Cancer Center, to discuss the critical role of nutrition and exercise in cancer care and recurrence prevention. They tackle common questions from cancer survivors about lifestyle modifications that can help reduce the risk of cancer recurrence. With the current hype around various diets, the discussion delves into the evidence

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00:21:03

How to Diagnose, Treat, and Follow Neuroendocrine...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/11/14

In this episode of the Oncology Brothers podcast, hosts Drs. Rohit and Rahul Gosain welcome Dr. Pamela Kunz, a world-renowned medical oncologist from the Yale Cancer Center, to discuss the complex landscape of neuroendocrine tumors (NETs). Join us as we explore:•⁠ ⁠The classification of neuroendocrine tumors based on grade, histological features, and the significance of KI-67.•⁠ ⁠The role of imaging modalities, including Gallium PET-CT and its importance in evaluating disease extent.•⁠ ⁠Treatment

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00:26:18

Palliative Care Management in Cancer

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/11/08

In this episode of the Oncology Brothers podcast, hosts Drs. Rahul and Rohit Gosain are joined by esteemed palliative care experts Dr. Janet Abrahm from Dana-Farber Cancer Institute and Dr. Ishwaria Subbiah from Sarah Cannon Research Institute. Together, they delve into the critical topic of palliative care, exploring its evolution from a focus on end-of-life care to an integral part of cancer treatment that enhances both longevity and quality of life. Key discussion points include:•⁠ ⁠The

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00:20:13

How to Approach to Ovarian Cancer from Community...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/10/31

In this episode of the Oncology Brothers podcast, hosts Drs. Rahul and Rohit Gosain welcome Dr. Martina Murphy, an Associate Professor of Medicine and Senior Associate Dean of Graduate Medical Education at the University of Florida, to discuss the current landscape of ovarian cancer. Join us as we dive into the critical aspects of diagnosing and managing ovarian cancer, including:•⁠ ⁠The importance of surgical staging and primary debulking surgery•⁠ ⁠The role of genetic testing, including BRCA and

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00:25:23

How to Approach to Endometrial Cancer from Community...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/10/24

Join us for an insightful episode of the Oncology Brothers podcast as we dive deep into the world of gynecologic oncology, focusing specifically on endometrial cancer. Hosted by Drs. Rohit and Rahul Gosain, this episode features Dr. Shannon Westin, a Professor of Gynecology, Oncology, and Reproductive Medicine at the MD Anderson Cancer Center. In this episode, we explored: •⁠ ⁠The different histologies of endometrial cancer, including endometrioid, serous, clear cell, and undifferentiated types. •⁠

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00:18:15

DeLLphi-301 - FDA Approval of Tarlatamab in Patients...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/10/22

In this episode of the Oncology Brothers podcast, hosts Drs. Rahul and Rohit Gosain dive into the recent FDA approval of tarlatamab, a groundbreaking bispecific antibody for patients with extensive stage small cell lung cancer. Joined by Dr. Misty Shields from Indiana University, they explore the DeLLphi-301 study design, the efficacy of tarlatamab, and the operational challenges associated with its use. Key topics discussed include:•⁠ ⁠The study's primary endpoint of objective response rate and

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00:19:13

AEGEAN Study - FDA Approval of Durvalumab in...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/10/20

Welcome to another episode of the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain dive into the recent approval of Durvalumab in the perioperative settings for non-small cell lung cancer, based on the AEGEAN trial. Join us as we welcome Dr. Sandip Patel, a medical oncologist from UCSD, and Dr. Mara Antonoff, a thoracic surgeon from MD Anderson, to discuss the implications of this new treatment option. We explore the study design of the AEGEAN trial, its differences from

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00:16:09

Lung Cancer ESMO 2024 Highlights: Key Studies...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/10/17

Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Stephen Liu, Associate Professor and Director of Thoracic Oncology at the Georgetown Lombardi Comprehensive Cancer Center. Together, they dive into the latest findings from ESMO 2024, focusing on key studies in lung cancer that every community oncologist should be aware of. Episode Highlights:•⁠ ⁠LAURA Trial: Discussing the role of osimertinib in locally advanced unresectable EGFR-mutant

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00:21:34

AGAVE-201 Study - FDA Approval of Axatilimab for...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/10/15

In this episode of the Oncology Brothers Podcast, hosts Drs. Rohit and Rahul Gosain welcome Dr. Shernan Holtan from Roswell Park Comprehensive Cancer Center to discuss the recent approval of Axatilimab, a novel monoclonal antibody for the treatment of chronic graft-versus-host disease (GVHD). Join us as we explore the differences between acute and chronic GVHD, the challenges faced by community oncologists in managing this condition, and the exciting results from the AGAVE-201 study that led to

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00:22:20

How to Approach to Acute Myeloid Leukemia (AML) from...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/10/13

In this episode of the Oncology Brothers podcast, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Mikkael Sekeres, Professor of Medicine and Chief of the Division of Hematology at the University of Miami. Together, they explore the complex landscape of acute myeloid leukemia (AML), discussing the latest advancements in diagnosis, treatment options, and risk stratification. Key topics included: •⁠ ⁠The importance of molecular testing in AML diagnosis and treatment planning •⁠ ⁠The role of

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00:15:06

GI Cancer ESMO 2024 Highlights: Key Studies Discussed...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/10/10

Join us in this exciting episode of the Oncology Brothers podcast as we dive into the highlights from ESMO 2024, focusing on gastrointestinal malignancies. Hosts Drs. Rohit and Rahul Gosain are joined by Dr. Kristen Ciombor, a GI medical oncologist from Vanderbilt University, to discuss four key studies that have significant implications for clinical practice. In this episode, we covered: •⁠ ⁠LEAP-012 Study: An update on HCC treatment with Lenvatinib and Pembrolizumab combined with TACE, exploring

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00:20:58

GU Cancer ESMO 2024 Highlights: Key Studies Discussed...

Oncology Brothers: Practice-Changing Cancer Discussions ·

2024/10/03

Join us as we dive into four pivotal studies: 1.⁠ ⁠NIAGARA Trial: Explore the groundbreaking findings on the combination of chemotherapy and immunotherapy in the perioperative setting for patients with resectable muscle-invasive bladder cancer, which may now set a new standard of care. 2.⁠ ⁠TiNiVO-2 Study: Learn why re-challenging patients with immunotherapy after progression on prior immunotherapy is not recommended, and what alternative treatments may be more effective. 3.⁠ ⁠PEACE-3 Study:

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