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PODCAST

The Optispan Podcast with Matt Kaeberlein

Optispan is a vision for what health should be. The typical person gives up 10-20 years of quality life in exchange for disability, frailty, and early death. We call this "the lost decade". Time that should be spent with loved ones doing the activities you enjoy are instead spent suffering from multiple diseases and taking a cabinet full of medications that probably do as much harm as good. We believe that the current practice of medicine is disease care, not health care. We believe that

science

All Episodes

00:19:13

Trametinib & Rapamycin = Greater Effect on Lifespan?...

The Optispan Podcast with Matt Kaeberlein ·

2024/09/10

Subscribe to our channel: https://www.youtube.com/@optispan Check out paper #1 on IL-11 signaling: https://www.nature.com/articles/s41586-024-07701-9.pdf Check out paper #2 on combination trametinib/rapamycin treatment: https://www.biorxiv.org/content/biorxiv/early/2024/07/25/2024.07.25.605097.full.pdf Related episodes: An introduction to the study of RAPAMYCIN: https://www.youtube.com/watch?v=czx_-DqnnrQ&t=1s In this episode, Matt discusses two recent mouse lifespan studies: one focused

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01:06:57

Matt Kaeberlein reflects on "David Sinclair’s...

The Optispan Podcast with Matt Kaeberlein ·

2024/09/05

Subscribe to our channel: https://www.youtube.com/@optispan Check out Scott Carney's channel: https://www.youtube.com/@sgcarney Related episodes: The True Story of David Sinclair's Longevity Lie: https://www.youtube.com/watch?v=xQrXs7CxIjk DON'T Take Resveratrol Until You Watch This Video: https://youtu.be/MmIBdqsQYfw Scientists Debate How to Live Longer & Longevity Drugs: https://youtu.be/EebH_taOlAA An introduction to the study of RAPAMYCIN: https://youtu.be/czx_-DqnnrQ In

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00:24:57

Does NMN Actually Increase VO2 MAX? | 61 - Longevity...

The Optispan Podcast with Matt Kaeberlein ·

2024/09/03

Subscribe to our channel: https://www.youtube.com/@optispanRelated episodes: Scientists Debate How to Live Longer & Longevity Drugs: https://youtu.be/EebH_taOlAA Supplement Industry Secrets: What They Aren't Telling You About NAD+ & NMN" https://youtu.be/OgsfIUfuyqk NAD+ boosters are supplements designed to enhance levels of nicotinamide adenine dinucleotide (NAD+), a central coenzyme found in all living cells and involved in innumerable biochemical reactions that include DNA

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01:36:01

The Horribly Under-Researched Science of Menopause,...

The Optispan Podcast with Matt Kaeberlein ·

2024/08/27

Subscribe to our channel: https://www.youtube.com/@optispanCheck out Productive Health: https://productivehealth.org/ Check out the Garrison Lab: https://garrisonlab.com/ We had a great time hosting Dr. Jennifer Garrison from the Buck Institute for Research on Aging to talk about her areas of expertise: reproductive aging and neuropeptide signaling. Jennifer and Matt go over the fascinating and chronically under-researched science of menopause, misconceptions about hormone replacement therapy,

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00:25:55

Trying Cold Plunge & Sauna w/ Mike Mutzel (Risks &...

The Optispan Podcast with Matt Kaeberlein ·

2024/08/22

Subscribe to our channel: https://www.youtube.com/@optispanRelated episodes: Scientists Discuss Longevity Interventions & Optimisms: https://youtu.be/Itx1FvJfDXc This summer, Matt and Nick visited MYOXCIENCE Nutrition founder and content creator Mike Mutzel at his home to give saunas and cold plunges a try. In this episode, they share their personal experiences with both, noting the mental and physical effects they experienced during and afterward, and emphasize the importance of

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00:43:48

Responding to Comments that Disagree with Us on...

The Optispan Podcast with Matt Kaeberlein ·

2024/08/15

Subscribe to our channel: https://www.youtube.com/@optispanRelated episodes: Comparing Bryan Johnson's RAPAMYCIN DATA: INTERESTING RESULTS: https://youtu.be/1-ZKzfQDQYk Why Drinking a Banana Smoothie IS the Same as Eating a Banana: https://youtu.be/Dg7S33-75_E Supplement Industry Secrets: What They Aren't Telling You About NAD+ & NMN: https://youtu.be/OgsfIUfuyqk Scientists Discuss Longevity Interventions & Optimisms: https://youtu.be/Itx1FvJfDXc Scientists Debate How to Live

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00:37:17

Scientist Reacts to Greg Doucette's Controversial...

The Optispan Podcast with Matt Kaeberlein ·

2024/08/13

Subscribe to our channel: https://www.youtube.com/@optispanRelated episodes: Why DEXA Scans Are NOT the HOLY GRAIL of BODYFAT Testing - Science Explained: https://www.youtube.com/watch?v=2Gg4Jm5KS1Y Are DEXA scans ACCURATE? What YOU NEED to KNOW: https://youtu.be/SsDJZMlM1ko The UNEXPECTED Ozempic Weight Loss Body Scan Results (DEXA): https://youtu.be/C_Z7qPVRA5M Coach, bodybuilder, and powerlifter Greg Doucette published a video on his Youtube channel discussing what he sees as the

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00:32:38

Most Longevity Experts Don't Tell You This About...

The Optispan Podcast with Matt Kaeberlein ·

2024/08/08

Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: Biological Age & what it REALLY means: https://youtu.be/DcxgEwQKx8Q The Surprising Way Body Size Relates to Lifespan: https://youtu.be/Fjh6WbkZkvw The Benefits of Protein Restriction, How Protein Affects Hormones & FGF21: https://youtu.be/Nf1GhkAFiWY An introduction to the study of RAPAMYCIN: https://youtu.be/czx_-DqnnrQ Depending on how you look at them, aging genes are genes whose expression changes in a

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02:20:57

Scientists Debate How to Live Longer & Longevity...

The Optispan Podcast with Matt Kaeberlein ·

2024/08/07

Subscribe to our channel: https://www.youtube.com/@optispanCheck out the Brenner lab: https://brennerlab.net Related episodes: The Benefits of Protein Restriction, How Protein Affects Hormones & FGF21: https://youtu.be/Nf1GhkAFiWY Matt and City of Hope Alfred E. Mann Family Foundation Chair of Diabetes and Cancer Metabolism Charles Brenner have had several public disagreements on social media. We love a good conversation between two distinguished scientists whose views may not entirely

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00:18:52

This Company's New Longevity Senolytic Drug & The...

The Optispan Podcast with Matt Kaeberlein ·

2024/08/01

Subscribe to our channel: https://www.youtube.com/@optispanCheck out Vertical Longevity Pharma: https://vertical-longevity-pharma.com/ Matt recently attended the 52nd annual meeting of the American Aging Association (AGE) in Madison, Wisconsin and met with several people doing fascinating work in or adjacent to the geroscience field. His last guest from the AGE meeting is David Scieszka, a longevity entrepreneur with a unique background that includes work as a PsyOps specialist for the US Army

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00:36:43

A Longevity Breakthrough w/ Yamanaka Factor...

The Optispan Podcast with Matt Kaeberlein ·

2024/07/30

Subscribe to our channel: https://www.youtube.com/@optispanRelated episodes: You Can Live Longer!: https://www.aspenideas.org/sessions/you-can-live-longer Estriol Shown to Increase Lifespan as Winner of Intervention Testing Program: https://youtu.be/1DQEuT0dtWk The Best Strategies for Living Longer RANKED: Longevity Tier List: https://youtu.be/41WUYgEkQeA Reversing Biological Age: Have we finally found the answer?: https://youtu.be/ivP3QTyQ2d4 In June 2024, the Aspen Ideas Festival held a

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00:49:05

The Benefits of Protein Restriction, How Protein...

The Optispan Podcast with Matt Kaeberlein ·

2024/07/25

Subscribe to our channel: https://www.youtube.com/@optispanCheck out Cristal's page at USC: https://gero.usc.edu/faculty/cristal-m-hill-phd/ Matt recently attended the 52nd annual meeting of the American Aging Association in Madison, Wisconsin and met with several people doing fascinating work in or adjacent to the geroscience field. One of these was Cristal Hill. Cristal is an Assistant Professor of Gerontology at the University of Southern California Leonard Davis School of Gerontology,

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00:48:18

The Benefits of Protein Restriction, How Protein...

The Optispan Podcast with Matt Kaeberlein ·

2024/07/23

Subscribe to our channel: https://www.youtube.com/@optispan Matt recently attended the 52nd annual meeting of the American Aging Association in Madison, Wisconsin and met with several people doing fascinating work in or adjacent to the geroscience field. One of these was Cristal Hill. Cristal is an Assistant Professor of Gerontology at the University of Southern California Leonard Davis School of Gerontology, where she runs a lab focused on how dietary protein might affect adipose tissue (body

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00:13:30

Longevity Scientist Critiques Mike Israetel's...

The Optispan Podcast with Matt Kaeberlein ·

2024/07/23

Subscribe to our channel: https://www.youtube.com/@optispanCheck out Mike Israetel's channel: https://www.youtube.com/@RenaissancePeriodization Related episodes: Exercise Scientist Critiques Bryan Johnson's INSANE Anti-Aging Protocol: https://www.youtube.com/watch?v=AAZespwbj6k The Surprising Way Body Size Relates to Lifespan: https://youtu.be/Fjh6WbkZkvw Entrepreneur and competitive bodybuilder Mike Israetel recently released a video discussing Bryan Johnson's anti-aging

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00:50:32

Longevity Scientist Reacts to Bryan Johnson's "I...

The Optispan Podcast with Matt Kaeberlein ·

2024/07/18

Subscribe to our channel: https://www.youtube.com/@optispanCheck out the Bryan Johnson video: https://www.youtube.com/watch?v=bax8to_s07Q Last month, entrepreneur and venture capitalist Bryan Johnson released a Youtube video detailing his trip to Prospera, Honduras to receive follistatin gene therapy from the Minicircle Gene Therapy clinic. Bryan describes Minicircle's gene therapy as "a pioneering technology with the potential to improve muscle and strength, slow the speed of aging,

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00:38:41

Stem Cells, Aging Hallmarks & Rapamycin | 49 - Kevin...

The Optispan Podcast with Matt Kaeberlein ·

2024/07/16

Subscribe to our channel: https://www.youtube.com/@optispan Check out Prime Health Associates: https://www.primehealthassociates.com/ Matt recently attended the 52nd annual meeting of the American Aging Association in Madison, Wisconsin and met with several people doing fascinating work in or adjacent to the gerosciencefield. One of these was Kevin White, physician at longevity-focused clinic Prime Health Associates in Oklahoma City, Oklahoma. Kevin spent two decades in emergency medicine before

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01:06:36

DNA Damage, Senescence & Apoptosis | 48 - Aditi Gurkar

The Optispan Podcast with Matt Kaeberlein ·

2024/07/11

Subscribe to our channel: https://www.youtube.com/@optispan Check out the Gurkar lab: http://agresearchlab.com/ In May 2024, Matt delivered a talk at the 2024 Glenn AFAR Grantee Conference in Santa Barbara, California and met with several people doing interesting work in the longevity field. One of these was Aditi Gurkar, an assistant professor in the University of Pittsburgh's Aging Institute, Division of Geriatric Medicine whose lab focuses on the downstream effects of DNA damage on aging

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00:41:47

Answering Questions on Gold Standard Longevity...

The Optispan Podcast with Matt Kaeberlein ·

2024/07/09

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00:41:02

Disproving a Doctor's Statement on NR & Rapamycin |...

The Optispan Podcast with Matt Kaeberlein ·

2024/07/04

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00:47:57

Scientists Discuss Longevity Interventions &...

The Optispan Podcast with Matt Kaeberlein ·

2024/07/02

Subscribe to our channel: https://www.youtube.com/@optispanRelated episode: The Two New Highest Ranked Compounds For Lifespan Extension According to the ITP: https://youtu.be/b4VaXqeli8c Matt, who ran the Kaeberlein lab at the University of Washington from 2006 to 2023, rounded up several former lab members for a chat at the recent 52nd annual meeting of the American Aging Association (AGE) in Madison, Wisconsin. The group included assistant and tenured professors at various institutions around

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149 results

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