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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

12:33

🎙️ Flu Trials Unmasked: Dose, Data & Difference

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/29

🦠💉 Five landmark studies shed new light on influenza vaccines! 🇪🇸 GALFLU (Spain, NEJM): High-dose vaccine cut influenza/pneumonia hospitalizations. 🇩🇰 DANFLU-2 (Denmark, NEJM & JAMA): Neutral primary outcome but signals for fewer CV & HF hospitalizations. 🇨🇳 PANDA II (China, Lancet): In-hospital vaccination lowered mortality & readmissions in acute HF. 📊 JAMA Editorial by Robert Califf: Calls for a true learning health system. ✨ Together, they show small gains per patient can yield huge

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03:38

Longevity 🔑 Genetics 🧬, Metabolism ⚡, and Microbiota 🌱

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/29

🌟 New insights into extreme longevity! 🌟 Our latest read on the multiomics blueprint of a 117-year-old supercentenarian reveals how genetics 🧬, metabolism ⚡, microbiome 🌱, and epigenetics 🕰️ can decouple aging from disease. 📊 Findings: Ultra-short telomeres but no cancer 📉 Protective genetic variants and robust mitochondria 💪 Efficient lipid metabolism (high HDL, low triglycerides) 💧 Low inflammation 🔥 Youth-like microbiome (rich in Bifidobacterium) 🦠 Epigenetic age decades

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07:39

Paclitaxel ⚖️ PAD 🚫 Promise or Peril?

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/28

🚨 New Evidence Alert 🚨 The SWEDEPAD 1 & 2 trials + a powerful Lancet commentary have reshaped how we view paclitaxel-coated devices in peripheral artery disease. 👉 No benefit for amputation or quality of life. 👉 A concerning signal for higher 5-year mortality in claudication. 👉 Registry-based RCTs prove invaluable for real-world insights. ⚖️ Message: Harm may outweigh benefit — time to rethink strategies and explore alternatives like sirolimus. #PAD #ClinicalTrials #Cardiology

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05:14

Huntingtons Disease: From Chorea to Cure 💃🧬💡

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/28

🚨 Breakthrough in Huntington’s Disease 🧬🧠✨ Exciting results from the pivotal Phase I/II AMT-130 gene therapy trial show a 75% slowing of disease progression at 36 months compared to controls. Key functional and cognitive endpoints (cUHDRS, TFC, SWRT, SDMT) also demonstrated significant benefit, alongside biomarker reduction in CSF neurofilament light chain 📊🔑. 💉 Delivered via precision stereotactic neurosurgery, AMT-130 was well-tolerated and shows clear evidence of a dose–response effect

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06:09

🧠💪 From Cravings to Composition: Expanding GLP-1...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/27

🚨 GLP-1 Medicines: Beyond Diabetes! 💉🧠💪 From weight loss to brain health, the future of GLP-1 therapies is unfolding fast! 🌍✨ New agents like retatrutide and MariTide are redefining outcomes in obesity, neurodegeneration, and substance use disorders. 🔬 Oral options, muscle-sparing combos, and triple agonists are here. 🧪 Dive into 15+ FAQs from the latest JAMA 2025 Perspective — formatted with emojis, clinical pearls, and clear takeaways. 📥 Message me if you’d like the .pptx version

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06:37

🫀⚖️ Balance After a Meal: The Autonomic Heart Story

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/26

💡 Fresh insights from a randomized crossover trial in people with Type 2 Diabetes (T2D)! 🍽️🚶‍♂️ High-fat 🥑 and high-carb 🍞 meals, with or without a light post-meal walk, showed no adverse effects on cardiac autonomic modulation or ECG intervals. ✅ Heart rate variability held steady, and walking even gave a gentle boost without risk. 🫀 Key Takeaway: Flexible dietary choices and safe postprandial walking may support everyday life in T2D without destabilizing the heart. #DiabetesCare

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03:28

💥 Force, Fibroblasts & 🫀 Failure

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/25

🚨 New Insights in Dilated Cardiomyopathy (DCM)! 🫀 Fibroblasts aren’t just bystanders — they’re mechanical rheostats shaping disease severity. 🧬 This groundbreaking study shows that blocking p38 signaling halts fibrosis, boosts contractility, and may redefine how we treat DCM. 💥 🧠 Think beyond myocytes. Think collective cell behavior. 🧪 Read the full paper in Science: “Preventing Hypocontractility-Induced Fibroblast Expansion Alleviates DCM” #Cardiology #HeartFailure #Fibrosis #ECM

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07:03

🧠 Dysreflexia Decoded & Pressure Rebooted: Circuits,...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/25

🚨 New frontier in #NeuroRehab & #BioelectronicMedicine! Just explored two groundbreaking studies on autonomic dysreflexia and implantable neurostimulation in spinal cord injury (SCI) 🧠💥 ⚡ One reveals the neuronal circuitry driving dangerous BP spikes 🔌 The other shows how epidural stimulation at T11–L1 can restore BP within 2 minutes 💡 Together, they mark a paradigm shift—from managing symptoms to rewiring circuits. #SCI #SpinalCordInjury #Neuroscience #CardiovascularHealth

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04:58

🫀 Coronary Artery Bypass Blues: Does Lower LDL-C Save...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/24

🫀 NEWTON-CABG Trial: Can intensive LDL-C lowering prevent vein graft failure after CABG? 💉 Evolocumab slashed LDL-C by ~50%, but did not improve SVG patency at 2 years. Why? Timing is everything. 🧠 Early SVG failure = thrombosis & hyperplasia—not classic atherosclerosis. LDL-C ≠ magic bullet here. #Cardiology #CABG #LDL #PCSK9 #Evolocumab #CardioTrials #Lipids #HeartHealth #GraftPatency #ClinicalResearch #JACC #TheLancet #SurgeryMeetsPrevention

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07:11

From Rest to Reset: 🛌 The Motor Theory &...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/24

🧠💤 Why do we sleep? A groundbreaking Neuron article explores this timeless question through a bold new lens: 🛌 The Motor Theory & Catecholamine Hypothesis of Sleep. Instead of a single “sleep center,” 🧬 sleep emerges from distributed motor control circuits regulating both somatic & autonomic activity. And the “why”? 😴 Suppressing dopamine, noradrenaline & adrenaline may be key to healing our brain, body, & immune system. 📉 Sleep isn’t passive—it’s active neural choreography for recovery

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04:53

Culprit, Complete, or Cautious? 🔧❤️🕰️”: Decoding...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/23

🚨 New insights from the Lancet! 🚑 In the OPTION–STEMI trial, immediate multivessel PCI during the index procedure failed to show non-inferiority compared to staged revascularisation in STEMI patients with multivessel disease. 🧠 Key takeaway? Timing matters. ⚠️ Higher risk in those with heart failure (Killip II/III) 💡 Safer strategy: staged PCI for high-risk patients 📊 Fractional flow reserve, procedural MI, and guideline implications all in focus. A must-read for interventionalists &

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04:28

Dr RR Baliga's Philosophical Discourses: Thomas...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/23

✨ St. Thomas Aquinas (1225–1274) — Dominican friar, philosopher & theologian — is among the most influential thinkers in Western tradition. 📖 His Summa Theologica shaped Catholic theology, blending Aristotle’s philosophy with Christian faith. 🕊️ Known as the Doctor Angelicus, he championed faith & reason, natural law ⚖️, and virtue ethics 💡— principles that still guide philosophy, theology, and even modern healthcare ethics 🏥. 🌍 #Philosophy #Theology #Healthcare #Leadership #Wisdom

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07:54

Squeezing the Heart Failure Curve: Risk, Reward, and...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/22

🚨 New Podcast Drop! 🎙️ “VICTOR, Vericiguat, and Victory?” unpacks the Lancet trilogy — the VICTOR trial, pooled analysis, and expert commentary 🧠📊💊. We explore Vericiguat’s evolving role across the heart failure spectrum 💓📉 and what it means for clinical care in HFrEF patients. 📚 Trials discussed: VICTOR, VICTORIA 🎧 Tune in for insights on risk-based treatment effects, NT-proBNP thresholds, and more! #HeartFailure #Vericiguat #HFrEF #Lancet #Cardiology #RCT #NTproBNP #Podcast

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03:17

🎨 Art, Health & Hope: Preventing noncommunicable...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/21

🎭 Just explored a landmark Nature Medicine review on how the arts can prevent noncommunicable diseases (NCDs) across 27 countries! 🎨 From dance and drama to gardening and storytelling, arts-based interventions improved physical activity, diet, and mental well-being—especially in underserved communities. 📊 A must-read for anyone interested in health equity, cultural relevance, and community-led innovation in public health. 👇 Dive into the power of creativity for prevention! #NCDs #ArtsInHealth

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03:25

🌍 Obesity, Orals, Outcomes: Rewriting the GLP-1 Script

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/21

💊 Orforglipron: A new era in obesity treatment? In the ATTAIN-1 trial, this oral, nonpeptide GLP-1 receptor agonist delivered up to 11.2% weight loss over 72 weeks—with significant drops in waist circumference, triglycerides, and blood pressure 📉🌡️ 🔥 Nearly 1 in 5 patients lost ≥20% body weight 💡 A promising alternative to injectable therapies Accessible. Effective. Oral. 👉 A game-changer for global obesity care? #Obesity #GLP1 #Orforglipron #WeightLoss #CardiometabolicHealth #NEJM

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07:08

HCM in Two Acts 🎭: Aficamten, Mavacamten & Dueling...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/20

🚨 New Podcast Drop! 🎙️ “Myosin, Metrics & Momentum 🧬📈🫀” dives into 3 landmark NEJM articles on Aficamten vs Mavacamten in hypertrophic cardiomyopathy. We decode: 🔹 MAPLE-HCM (obstructive HCM) 🔹 ODYSSEY-HCM (nonobstructive HCM) 🔹 Expert editorial insights on PROs, EF, & trial design 🎯 Learn what matters: peak VO₂ vs PROs, safety signals, and the road ahead in precision cardiomyopathy care. 🎧 Tune in and share! #HCM #CardioTwitter #NEJM #HeartFailure #MyosinInhibitors #Podcast

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04:12

🧬 Science, Slimming, and Semaglutide Redefining...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/20

💊 New Hope in a Pill for Obesity? The 71-week OASIS 4 trial shows that oral semaglutide 25 mg led to a 13.6% weight loss, improved physical function, and reversed prediabetes in 71% of cases—all without injections. 📉 Effective. 🧬 Metabolically beneficial. 📦 Orally delivered. #ObesityCare #GLP1 #Semaglutide #NEJM #DigitalHealth #Cardiometabolic

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03:23

🌞 Sun, Skin & Science: The Bright Side of Exposure

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/20

☀️ Walking on Sunshine? Rethinking Our Relationship with the Sun! 🧴🧬 New research—spotlighted in The Economist (Sep 20, 2025)—challenges old assumptions: Could moderate sun exposure reduce cardiovascular mortality? ❤️📉 From nitric oxide to vitamin D, this FAQ explores the science, nuance, and shifting global guidelines. Let’s talk melanin, mortality, and medicine! 🌍💡 #Sunlight #CardiovascularHealth #TheEconomist #PublicHealth #MedicalEducation

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04:46

🫀 Cardiogenic Shock Survival: Impella’s Decade-Long...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/18

🚨 Cardiogenic Shock—A Decade Later The DanGer Shock Trial shows that patients with STEMI and shock treated with the Impella CP microaxial flow pump lived 600 more days over 10 years vs standard care alone. 📉 Mortality: 52.5% vs 68.8% (HR 0.70) 🛠️ Despite higher adverse events, the survival benefit endured a full decade. 📊 This changes how we think about long-term outcomes in mechanical support. 🔗 Time to revisit your shock protocols? #DanGerShock #Impella #CardiogenicShock #STEMI

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07:06

💓 Genes, Gradients, and Game-Changers: FAQs on...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/17

🧠 Hypertrophic Cardiomyopathy — A Masterclass from Eugene Braunwald 🧬 📌 Just published in NEJM (Aug 2025): a sweeping, state-of-the-art review on HCM — from Teare’s first autopsy to myosin inhibitors, AI diagnostics, and gene therapy. 💥 Clinical insights, historical depth, trial data (EXPLORER-HCM, SEQUOIA-HCM, VALOR-HCM), and future-facing advances—all distilled into one must-read. 📉 SCD prevention, 🫀 LVOT obstruction, 🧪 MYBPC3/MYH7 mutations, 🧬 proteomics, and more. 🔗 Essential

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