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PODCAST

Mendelspod Podcast

Offering a front row seat to the Century of Biology, veteran podcast host Theral Timpson interviews the who"s who in genomics and genomic medicine. www.mendelspod.com

science & medicine natural sciences

All Episodes

52:14

14th Season Opener: Michael Levin on ‘The New Biology’

Mendelspod Podcast ·

2024/08/22

For over a hundred years, biologists have been working to fully understand biology at the level of chemistry, in other words unite biology with chemistry. This is considered the reductive approach inspired by the unification of chemistry with physics in the early 20th century with the Periodic Table and the Bohr model of the atom. In the attempt to reduce biology to chemistry, the gene has been the star player. The gene linked phenotype to the molecules of chemistry and to the more abstract and

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31:14

The Success of ctDNA Testing in Colorectal Cancer:...

Mendelspod Podcast ·

2024/08/20

Adham Jurdi was an oncologist at the Austin Cancer Center when the pandemic hit. His cancer patients were a doubly vulnerable population. Office visits, follow-up care — every interaction between the patient and the healthcare system put them at risk for COVID-19 infection, which would hit extra hard because of their compromised immunity. It was then that he discovered a blood test that could monitor the patient’s cancer using ctDNA and keep the patient more at home.Jurdi is now the medical director

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40:27

Henrik Zetterberg on the Current Excitement Around...

Mendelspod Podcast ·

2024/08/14

Alzheimer’s disease is now one of the hottest areas of research despite little progress in the decades up to about five years ago. The disease was proving especially difficult to diagnose early and to treat.Today researchers are largely on board with the amyloid cascade hypothesis. There are several FDA-approved drugs for treating the disease, with another just around the corner. New biomarkers for Alzheimer’s enabled by a new generation of proteomics tools promise to change care by giving patients

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44:03

The Reboot of Consumer Genomics? with Kian Sadeghi,...

Mendelspod Podcast ·

2024/08/06

There’s a new company in the consumer genomics space that last month released results for the first adopters of its new consumer-facing whole genome product. Nucleus Genomics, founded by Kian Sadeghi, aims to reinvent direct-to-consumer genomic testing with "the consumer reach of 23andMe and the clinical consequence of Myriad Genetics.”Kian joins us today to talk about his vision for the company and why consumer genomics is still a great idea.“To know that we can potentially give someone an insight

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5:09

From Geospatial to Biospatial: Avi Veidman of Nucleai

Mendelspod Podcast ·

2024/07/25

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comAvi Veidman spent over 20 years in the IDF (Israel Defense Forces), leading multi-disciplinary teams in the use of AI, machine learning, and data science. One of his key projects involved developing systems that mapped the world with satellite images to spot adversaries from space. Upon retirement, he co-founded Nucleai with a couple of his former defense colleagues, believing that the AI technology they had seen and

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26:19

New Proteomics Technology Brings Unprecedented...

Mendelspod Podcast ·

2024/07/18

Yuling Luo is a serial entrepreneur who has founded three significant companies in life science tools. Most recently, he is the founder and CEO of Alamar Biosciences which this year commercially launched its ARGO HT instrument as well as a powerful new panel to detect inflammatory proteins called NULISA.Before founding Alamar, Luo was the founder and CEO of Advanced Cell Diagnostics, which was acquired by BioTechne in 2016. He was also a co-founder of Panomics, which was scooped up by

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7:30

Diagnostic Trends in 2024 with Mara Aspinall,...

Mendelspod Podcast ·

2024/06/27

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comOne might think the pandemic would have been good for diagnostic companies. So why the financial hangover?Mara Aspinall has 30 years of leadership in genomics and the diagnostics industry. This has led her to her current role as a new partner at Illumina Ventures, a venture fund independent from Illumina that is focused on funding diagnostics and tools companies.Mara publishes the fantastic newsletter Sensitive and

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26:38

The Actionable Epigenome with Bret Barnes, Illumina

Mendelspod Podcast ·

2024/06/18

The genome has been the core focus of biomedical research for twenty years. Although the genome is prewritten and predetermined, much biology happens after it appears. One area is epigenomics, which is the modification of genomic outcomes.Bret Barnes has spent his career at Illumina developing the DNA methylation Infinium arrays that have become the workhorse of epigenomic studies around the world. Barnes says he was torn as a young person between biochemistry and computer science. He fortuitously

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6:04

Not All Prenatal Screens Are the Same: Jennifer...

Mendelspod Podcast ·

2024/06/13

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comNot content to offer “me too” products, a new company in the prenatal arena, Billion to One (BTO), is reimagining prenatal testing. Last year, their new Unity Fetal Risk Screen was featured in the American Journal of Human Genomics as a top advancement in applying genomics to clinical care. Joining us today is Jennifer Hoskovec, Senior Director of Medical Affairs at BTO. She says the new Unity Screen offers two steps in

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30:20

Harvard's Marc Lipsitch on the New White House Policy...

Mendelspod Podcast ·

2024/06/04

This week, we saw Dr. Anthony Fauci being grilled by an angry congress over, among other things, the origin of COVID-19, which is estimated killed at least 25 million people. He was asked about how the National Institute of Allergy and Infectious Diseases, which he directed until 2022, funded risky virus research at the Wuhan lab in China.Ever since the pandemic broke out, scientists, as well as policymakers, have been debating new restrictions on pathogen research, and last month, the White House

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24:12

Liquid Biopsy Goes Beyond Cancer: Diana Abdueva and...

Mendelspod Podcast ·

2024/05/23

A new precision medicine startup has launched that uses transcriptomic and epigenetic information to help with therapy for a wide range of chronic disorders. Hayward, California-based Aqtual emerged from stealth at the end of last year with data on its first assay, a blood-based test for rheumatoid arthritis.Today, we’re joined by Diana Abdueva, Aqtual’s Founder and CEO, and Maggie Louie, VP of Translational Research and Strategic Partnerships."We are complex organisms that work beautifully for many

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6:17

Cell Therapy Will Transform Medicine as We Know It,...

Mendelspod Podcast ·

2024/05/16

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comToday, we pursue an exciting area of medicine for the first time: cell therapy for solid tumors.Most, if not all, of our audience will be familiar with the success of CAR-T therapies for blood cancers. But only 10% of cancer is in the blood. The other 90% develop solid tumors. Jason Bock is the CEO and founder of CTMC, a new company aiming to speed the advancement of the entire field of cell therapies. First, we cover

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32:38

Two Industry Leaders on Dealing with the Growing...

Mendelspod Podcast ·

2024/05/14

The Clinical Knowledge Base (CKB) powered by The Jackson Laboratory (JAX) is a dynamic digital resource for interpreting complex cancer genomic profiles in the context of gene variant knowledge and protein impact, therapies, and clinical trials. Illumina has teamed up with JAX in the newly released Connected Insights software, which integrates CKB as a knowledge source.We’re joined by Cara Statz from JAX and Erica Schnettler from Illumina to discuss how their combined technologies are helping

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19:25

Single Cell Spatial Proteomics with Filip Karlsson,...

Mendelspod Podcast ·

2024/05/09

A paper out this week in Nature Methods demonstrates a new technology which shows novel patterns of protein spatial polarization and co-localization in immune cells. The technology launched by Swedish startup Pixelgen has been dubbed “molecular pixelation” because it uses DNA pixels to tag and reveal relative locations. Unlike most other spatial technologies, molecular pixelation does not involve microscopy.Lead author of the paper, Filip Karlsson, joins us today to explain the technology and how it

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33:59

The Precision Medicine Optimist: Damon Hostin, Illumina

Mendelspod Podcast ·

2024/05/07

Damon Hostin has had an active and exciting journey in genomic medicine. He’s now at Illumina, where his title is illuminative: Lead, Health System Market Access.A regular on the precision medicine stage, Damon has some insights into what he calls the “blindingly fast progression” of genomic medicine that should convince the most jaded of its critics. Compared to other areas of medicine, we are witnessing a rapid uptake of new science. Damon’s biography includes work at Celera in the age of the

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5:24

An Ethics First Approach to Genetic Research and Drug...

Mendelspod Podcast ·

2024/05/02

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comSarah LeBaron von Baeyer studied anthropology at Yale. Today she serves as the Director of Ethics Engagement at the new drug development company, Variant Bio, not a job she ever imagined at university.

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28:46

How Do You Train Genomics AI? On Natural Selection...

Mendelspod Podcast ·

2024/04/30

In today’s show, we talk with Kyle Fahr, the VP and Distinguished Scientist leading Illumina’s Artificial Intelligence Lab."We lack a way of training genomics AI as readily as you would for natural language processing, says Fahr. "There are vast amounts of data, but there are no labels, no supervision. One of the most powerful tools that we’ve found is using clues from natural selection.Fahr says the company began the AI lab seven years ago when deep learning took off. Two of the team’s AI

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5:41

The Pre-Symptomatic Space with Patrick Short, Sano...

Mendelspod Podcast ·

2024/04/25

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comToday, we continue our look into the gap in the adoption of precision medicine. Why are those who need it not getting genetic testing? Patrick Short is the Host of The Genetics Podcast and CEO and Co-founder of Sano Genetics.

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8:02

Systemwide Implementation of Precision Medicine at...

Mendelspod Podcast ·

2024/04/18

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comThrough its Center for Personalized Medicine, the University of Colorado Health offers its 2.2 million patients some of the country's most advanced precision medicine initiatives.

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5:03

Is this New Tech a Game Changer for Spatial Biology?

Mendelspod Podcast ·

2024/04/11

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comA new spatial biology company is promising to shake up the field. Last month, Curio Bioscience launched a new technology to early access customers that provides transcriptomic spatial data without the need to b…

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