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PODCAST

Longevity Roadmap

Dr. Buck Joffrey sits down with leading scientists in the field of longevity to explore cutting-edge research, emerging therapies, and what it really takes to live longer—healthier.

health & fitness alternative health

All Episodes

23:29

87: The Longevity Clinic Paradigm

Longevity Roadmap ·

2024/06/10

Buck discusses the concept of longevity clinics with the CEO of Humanaut. Show Notes: 03:53 What Does Humanaut Do? 06:07 The Team Behind Humanaut 14:49 How Does the Program Work?

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29:20

86: The Science of Human Attraction

Longevity Roadmap ·

2024/06/03

Buck Joffrey, MD reviews the literature on the topic of human attraction. Topics include the brain, perception of beauty, specific aspects of beauty, and sexual dimorphism. Also included is a discussion on the role of human pheromones and attraction. Show Notes: 01:20 Facial Attraction & Cues 08:30 Facial Symmetry 11:12 The Averageness of Facial Features 13:59 Clear and Unblemished Skin 15:44 Sexual Dimorphic Traits 22:23 Smell and Pheromone

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29:45

85: Fasting, Protein, and Full Body MRI with Dr. Matt...

Longevity Roadmap ·

2024/05/27

Buck has a conversation with fellow physician, Dr. Matt Brill, on the topic of intermittent fasting. They bring up the American Heart Association study as well as associated studies of breakfast skippers to reconsider the issue of eight-hour time-restricted feeding. Also discussed are the topics of ideal, protein, intake, and full-body MRI. Show Notes: 01:33 8 Hours Or Less Fasting Window = Higher Chance of Cardiovascular Disease? 04:58 Why the Study that Claimed the Correlation Was Wonky 08:02 Why

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34:42

84: Keto Diet 101

Longevity Roadmap ·

2024/05/20

Buck Joffrey, MD discusses the basics of the keto diet with Amy Berger, a certified nutrition specialist. Topics include the definition of the diet, its health benefits and its role in the treatment of various disease processes including type 2 diabetes and Alzheimer’s Disease. Show Notes: 03:08 Why the Keto Diet? 04:15 How Does the Keto Diet Help You Lose Weight? 05:51 Other Benefits of the Keto Diet 09:14 How Does High Blood Sugar Result in Insulin Resistance? 11:44 What Defines a Keto Diet 16:13

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22:55

83: Sexually Transmitted Cancer

Longevity Roadmap ·

2024/05/13

Buck Joffrey, MD reviews what is known about sexually transmitted cancers. Discussion includes HIV and Hepatitis but focuses on Human Papilloma Virus which Buck believes is grossly underappreciated by people and by physicians. 01:18 HIV 05:26 Hepatitis 09:20 HPV

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24:47

82: Intro to the Microbiome

Longevity Roadmap ·

2024/05/06

Buck Joffrey, MD provides an introduction to the microbiome and discusses its importance. Topics also include prebiotics, probiotics, and postbiotics.

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37:18

81: Ask the Doctor 04/29/24

Longevity Roadmap ·

2024/04/29

Buck Joffrey, MD, takes questions from the audience. Topics include human growth hormones, the potentially harmful effects of an MN, 40 Hz therapy, and visceral fat. Show Notes: 00:47 Is It Fine That I Sleep Too Much? 08:08 The 40hz Gamma Frequency and How It Relates to Brain Health 13:28 The Anti-Aging Effects of Human Growth Hormone 20:31 Reconsideration of How to Fast 29:22 Potentially Harmful Effect of NMN 33:08 Visceral vs Subcutaneous Fat

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54:08

80: The Longevity Diet with Valter Longo, PhD

Longevity Roadmap ·

2024/04/22

Buck Joffrey, MD, discusses the fasting regimen with Dr. Valter Longo, PhD. Dr. Longo is a world, renowned researcher in longevity and the author of: The Longevity Diet. Show Notes: 01:10 Types of Fasting 03:31 Why Fasting is Beneficial From a Cellular Level 07:00 Intermittent Fasting VS Fast Mimicking Diet 14:05 How Does Fasting Help Cancer Patients 20:37 What Is in the Fast Mimicking Diet 33:38 Pills and Supplements for Fasting Mimicking Diet 41:23 Time-Restricted Feeding Based on Circadian

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38:44

79: Lies Taught in Medical School: Robert Lufkin, M.D.

Longevity Roadmap ·

2024/04/15

Buck Joffrey, MD interviews Robert Lufkin, MD about his book Lies I Taught in Medical School: And the Truths That Can Save Your Life Topics include metabolic syndrome, intermittent fasting, and various outdated information still used in mainstream medicine that may have deleterious effects on people’s health. Show Notes: 01:35 Dr. Lufkin’s Personal Journey to Question the Medicine Establishment 04:14 When Did People Start to Take Metabolic Syndrome Seriously? 08:33 What Exactly is Metabolic

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31:56

78: The Age of Data Driven Wellness is Here

Longevity Roadmap ·

2024/04/08

Dr. Buck Joffrey, M.D. interviews, Dr. Nathan Price, PhD from Thorne about a new paradigm in medicine driven by data, technology, and self-empowerment. Show Notes: 00:58 What Really is Healthspan? 05:06 Biological Age VS Chronological Age 07:41 The Factors that Determine Biological Aging 12:08 What Happens When You Artificially Suppress These Factors 16:58 What is Phenomics and how can it predict diseases? 24:21 How Can You Do Self Tests?

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29:40

77: Ask the Doctor (April Fools Edition)

Longevity Roadmap ·

2024/04/01

In this April Fools special, Buck answers the burning questions of his number one fan, Phil Ferragamo.

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27:48

76: Intermittent Fasting Correlated to Higher Risk of...

Longevity Roadmap ·

2024/03/25

In this episode of Sapio, Dr. Buck Joffrey, MD addresses the recent American Heart Association study correlating intermittent fasting/time restricted, feeding to higher rates of cardiovascular death. Buck breaks down what we already know about the data behind intermittent fasting in both animals and in humans and tries to put the most recent study into context. He provides feedback on the study itself, including some suggestions on how to use this new information. Show Notes: 02:01 Intermittent

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46:58

75: Stress, Cortisol and Prevention Strategies

Longevity Roadmap ·

2024/03/18

Buck Joffrey, MD talks to Romie Mushtaq, MD regarding stress, cortisol levels and prevention strategies including meditation and anti-inflammatory diets. Show Notes: 02:14 The definition of stress 13:16 Why does stress disrupt circadian rhythms and sleep 16:08 How do we treat stress? 21:23 Nootropics 24:39 Vagal nerve stimulator 28:34 Digital detox and meditation 33:02 Diet for stress

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45:32

74: Aggressive Male TRT Approach, Erectile...

Longevity Roadmap ·

2024/03/11

Buck Joffrey MD speaks to Justin Houman MD who is a urologist regarding the idea of aggressive testosterone treatment to decrease the risk of metabolic syndrome and therefore multiple other disease processes that are downstream. Other topics disgust include erectile dysfunction, early treatment with ED meds and the correlation with Alzheimer’s disease. Show Notes: 1:27 Is it true that the testosterone in men in general has gone down? 02:43 Common symptoms of low testosterone 05:15 Normal level of

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34:50

73: Is a Vegan Diet Healthy?

Longevity Roadmap ·

2024/03/04

Buck Joffrey, MD and Linda Tyler, PhD discuss the topic of plant-based only/Vegan diets. The conversation includes topics on inflammation and nutritional concerns. Show Notes: 2:55 A plant-based diet for better health? 11:53 Balancing nutritions for the plant-based diet 20:39 Accessibility of the plant-based diet 22:30 Processed plant-based food

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49:29

72: A Different Framework for Health?

Longevity Roadmap ·

2024/02/26

Buck Joffrey, MD interviews Anoop Kumar, MD on his perspective on health and wellness. Dr. Kumar is an emergency medicine doctor who is also knowledgeable about traditional Indian Philosophy and medicine. Show Notes: 00:43 Near-Death Experience and Shift in Perspective 07:04 The Three Minds Framework 23:03 Reevaluating the Model of Human Anatomy 27:20 The Four Engines: Nutrition, Movement, Connection, and Rest 39:24 The Four Engines of Health and Healing 41:01 Harnessing the Placebo Effect and

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26:28

71: Ask the Doctor 02/19

Longevity Roadmap ·

2024/02/19

In this episode, Buck addresses questions from listeners. Topics include: 00:34 What is a healthy range in your weight? 04:28 The dangerous kind of fat 07:53 Male hormone replacement and cancer 13:12 How long does it take for the circadian rhythm to adjust to a new time zone? 18:35 The risk of cell phones?

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37:06

70: The Science Behind Music and Mental Health

Longevity Roadmap ·

2024/02/12

Buck Joffrey, MD interviews Dr. Daniel Bowling from Stanford University on the science behind music and mental health. Bowling discusses the fundamentals of musicality and the research that has been done in this relatively new field of music as treatment for health-related issues. Show Notes: 02:59 What is musicality? 04:47 What is tonality? 07:05 How does music affect the brain? 11:20 Music as treatment for mental health 22:22 Does music sharpen our intellect? 27:05 Musical vs pharmaceutical

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48:16

69: Glutathione: The Master Antioxidant

Longevity Roadmap ·

2024/02/05

Buck Joffrey, MD welcomes pharmacist and glutathione expert Dr. Nayan Patel. This podcast discusses the role of glutathione as an antioxidant including why it is known as the "master" antioxidant. The discussion reviews the physiology of glutathione in the body focussing on disease prevention and also discusses different mechanisms of supplementation. Show Notes: 00:48 What is oxidative stress? 04:12 What is an antioxidant and how does it work? 10:24 Glutathione and its relationship to longevity

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39:02

68: Food Allergy 101 with Tina Sindher, MD

Longevity Roadmap ·

2024/01/29

Buck welcomes Tina Sindher, a specialist in food allergy from Stanford University Medical Center to discuss the basics of food allergy. Topics include root causes of food allergy, prevention, diagnosis, and treatment. Show Notes: 04:33 Does where you live affect your allergies? 06:46 How do you know you have an allergy and not something else? 09:40 Life-threatening allergies explained 13:41 Does allergy develop from childhood? 16:28 What makes some foods trigger allergies? 20:22 Rising gluten

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