STAT Stitch Deep Dive Podcast Beyond The Bedside

22:38

CC | PRIMER HTN

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

Hemodynamic Pathophysiology: Blood pressure (BP) is determined by cardiac output (CO) multiplied by systemic vascular resistance (SVR). Hypertension occurs when regulatory mechanisms (sympathetic nervous, vascular endothelium, renal, and endocrine) fail. The hallmark is persistently increased SVR, leading to vessel remodeling, atherosclerosis, and ischemia.Diagnostic Classification: Based on two or more accurate readings on separate occasions, BP is categorized as:Normal: <120 SBP and <80 DBP

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20:58

CC | PRIMER Cards Assessment

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

1. Anatomy, Perfusion & ConductionLayers & Chambers: Heart layers: endocardium, myocardium, epicardium. Pericardium contains 10-15 mL of fluid. LV is 2-3x thicker than RV to pump into systemic circulation.Coronary Flow: Perfusion occurs primarily during diastole. LCA (branches into LAD, circumflex) supplies LV/LA/septum. RCA supplies RA/RV/posterior LV. In 90% of people, RCA supplies the AV node/bundle of His; blockages cause conduction defects.Electrical System: SA Node → AV Node → Bundle

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22:57

CC | PRIMER Fluid and e- Balance

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

Fluid Compartments & HomeostasisDistribution: Water is 50%–60% of adult weight (varies with fat). ICF holds 2/3 of water; ECF holds 1/3 (interstitial fluid/plasma). Weight change is the best fluid shift indicator (1 kg = 1 L).Capillary Exchange: Governed by hydrostatic (pushes out) and plasma oncotic (albumin pulls in) pressures. Edema occurs if hydrostatic pressure rises, oncotic falls, or lymphatics are blocked. Third-spacing traps nonfunctional fluid.Regulatory MechanismsHormones: Dehydration

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25:57

CC | PRIMER ARDS/ ARF

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

Acute Respiratory Failure (ARF) and Acute Respiratory Distress Syndrome (ARDS) are critical pulmonary conditions where gas exchange is insufficient to support systemic organs.The 80/20 Core: Pathophysiology & Clinical Care1. Classification of ARF ARF is a symptom of inadequate lung function, categorized into two types:Hypoxemic (Oxygenation Failure): PaO2<60 mm Hg on room air. The core defect is inadequate O2 exchange, caused by V/Q mismatch, shunt, diffusion impairment, or alveolar

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23:27

CC | PRIMER Lower Resp. Complications

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

1. Lower Respiratory Infections: Pneumonia & Tuberculosis (TB)Pneumonia: Acute lung parenchymal infection where pathogens invade via aspiration, inhalation, or blood. Inflammation increases vascular permeability, causing capillary leakage and alveolar fluid consolidation, impairing gas exchange. Clinical Rule: Initiate empiric antibiotic therapy immediately upon suspicion to reduce mortality; adjust only after culture results. Prevent aspiration pneumonia by elevating the head of the bed to ≥30°

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25:15

CC | PRIMER Obstructive Resp Complications

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

1. Bronchiectasis: Mucus StasisPathophysiology & Presentation: Inflammation destroys elastic and muscular wall structures, causing permanent dilation and impaired mucus clearance. It presents as a persistent cough with thick, purulent sputum. Massive hemoptysis is a life-threatening complication.Care: CT scan is the gold standard. Care involves antibiotics (minimum 14 days), bronchodilators, and ACTs with hydration (2-3 L/day).2. Cystic Fibrosis (CF): Ion Transport DefectPathophysiology &

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27:19

CC | PRIMER Supporting Resp System

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

I. Oxygen Therapy & Delivery SystemsTarget: Maintain SpO2 >92% (or >88% in chronic COPD) or PaO2 >60 mmHg. Supplementing FiO2 >60% for >24 hours risks oxygen toxicity, causing severe pulmonary edema and inflammatory alveolar damage.Low-Flow Systems: Nasal Cannula (1–6 L/min, 24%-44% FiO2), Simple Mask (6–12 L/min, 35%-50% FiO2, requires >=6 L/min), Non-Rebreather (10–15 L/min, 60%-90% FiO2, keep reservoir bag inflated).High-Flow Systems: Venturi Mask (delivers precise, fixed

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16:38

CC | PRIMER Assessment of the Resp System

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

Gas Exchange: Primary goal: O2/CO2 exchange across alveolar-capillary membrane.Anatomy: Upper tract warms/humidifies/filters air; epiglottis covers larynx to prevent aspiration. Carina is highly sensitive, triggering vigorous cough on stimulation.Aspiration: Right mainstem bronchus is shorter, wider, straighter than left; aspiration is far more common in right lung.Dead Space: Normal tidal volume (VT) is ~500 mL (~150 mL is anatomical dead space [VD] without gas exchange).Alveoli & Surfactant:

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36:08

CC Pharm Milrinone

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

Core Profile & Mechanism Milrinone is a parenteral positive inotrope and vasodilator with selective phosphodiesterase III (PDE3) inhibitor activity. By preventing cyclic adenosine monophosphate (cAMP) breakdown in cardiac and vascular muscle cells, it increases myocardial contractility, causes vasodilation, and improves diastolic relaxation (lusitropy). This dual action reduces preload, afterload, and systemic vascular resistance with little to no chronotropic activity. Therapeutic effects occur

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65:04

CC | Coronary Artery Disease and ACS

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

Atherosclerosis is the foundational pathology of coronary artery disease (CAD). It is a progressive inflammatory disease characterized by lipid deposition within the intima of the arterial wall, triggered by chronic endothelial injury from factors like tobacco smoking, hypertension, hyperlipidemia, and diabetes. The disease progresses through three key developmental stages over several decades:Fatty Streak: The earliest lesions, consisting of lipid-filled smooth muscle cells that appear yellow,

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64:04

CC | Heart Failure

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

1. Core Typology & Risk FactorsHFrEF (Systolic): EF < 40%. LV is dilated/hypertrophied, unable to eject blood effectively, reducing CO.HFpEF (Diastolic): EF ≥ 50%. LV is stiff, noncompliant, causing high filling pressures and decreased filling volume.Causes: HTN and CAD are primary. Long-term HTN control reduces HF incidence by 50%.2. Pathophysiology: The Compensation TrapTrigger: Myocardial injury -> decreased CO.Cascade:RAAS: Renal hypoperfusion triggers renin release, converting

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59:51

CC | HTN

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

Hemodynamic Pathophysiology: Blood pressure (BP) is determined by cardiac output (CO) multiplied by systemic vascular resistance (SVR). Hypertension occurs when regulatory mechanisms (sympathetic nervous, vascular endothelium, renal, and endocrine) fail. The hallmark is persistently increased SVR, leading to vessel remodeling, atherosclerosis, and ischemia.Diagnostic Classification: Based on two or more accurate readings on separate occasions, BP is categorized as:Normal: <120 SBP and <80 DBP

en

48:31

CC | Cards Assessment

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

1. Anatomy, Perfusion & ConductionLayers & Chambers: Heart layers: endocardium, myocardium, epicardium. Pericardium contains 10-15 mL of fluid. LV is 2-3x thicker than RV to pump into systemic circulation.Coronary Flow: Perfusion occurs primarily during diastole. LCA (branches into LAD, circumflex) supplies LV/LA/septum. RCA supplies RA/RV/posterior LV. In 90% of people, RCA supplies the AV node/bundle of His; blockages cause conduction defects.Electrical System: SA Node → AV Node → Bundle

en

65:26

CC | Fluid & e- Balance

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

Fluid Compartments & HomeostasisDistribution: Water is 50%–60% of adult weight (varies with fat). ICF holds 2/3 of water; ECF holds 1/3 (interstitial fluid/plasma). Weight change is the best fluid shift indicator (1 kg = 1 L).Capillary Exchange: Governed by hydrostatic (pushes out) and plasma oncotic (albumin pulls in) pressures. Edema occurs if hydrostatic pressure rises, oncotic falls, or lymphatics are blocked. Third-spacing traps nonfunctional fluid.Regulatory MechanismsHormones: Dehydration

en

49:39

CC | ARDS and ARF

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

Acute Respiratory Failure (ARF) and Acute Respiratory Distress Syndrome (ARDS) are critical pulmonary conditions where gas exchange is insufficient to support systemic organs.The 80/20 Core: Pathophysiology & Clinical Care1. Classification of ARF ARF is a symptom of inadequate lung function, categorized into two types:Hypoxemic (Oxygenation Failure): PaO2<60 mm Hg on room air. The core defect is inadequate O2 exchange, caused by V/Q mismatch, shunt, diffusion impairment, or alveolar

en

25:15

CC | Obstructive Respiratory Complications

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

Core Concept: Expiratory Airflow ResistanceObstructive lung diseases—bronchiectasis, cystic fibrosis (CF), asthma, and COPD—share increased expiratory airflow resistance from airway obstruction or narrowing. Drug therapy plays a key role in their clinical management.1. Bronchiectasis: Mucus StasisPathophysiology & Presentation: Inflammation destroys elastic and muscular wall structures, causing permanent dilation and impaired mucus clearance. It presents as a persistent cough with thick,

en

48:43

CC | Lower Respiratory Complications

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

1. Lower Respiratory Infections: Pneumonia & Tuberculosis (TB)Pneumonia: Acute lung parenchymal infection where pathogens invade via aspiration, inhalation, or blood. Inflammation increases vascular permeability, causing capillary leakage and alveolar fluid consolidation, impairing gas exchange. Clinical Rule: Initiate empiric antibiotic therapy immediately upon suspicion to reduce mortality; adjust only after culture results. Prevent aspiration pneumonia by elevating the head of the bed to ≥30°

en

67:53

CC | Supporting Ventilation/ Respiratory System

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

Oxygen Therapy & Delivery SystemsTarget: Maintain SpO2 >92% (or >88% in chronic COPD) or PaO2 >60 mmHg. Supplementing FiO2 >60% for >24 hours risks oxygen toxicity, causing severe pulmonary edema and inflammatory alveolar damage.Low-Flow Systems: Nasal Cannula (1–6 L/min, 24%-44% FiO2), Simple Mask (6–12 L/min, 35%-50% FiO2, requires >=6 L/min), Non-Rebreather (10–15 L/min, 60%-90% FiO2, keep reservoir bag inflated).High-Flow Systems: Venturi Mask (delivers precise, fixed FiO2

en

53:12

CC } Respiratory Assessment

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

Gas Exchange: Primary goal: O2/CO2 exchange across alveolar-capillary membrane.Anatomy: Upper tract warms/humidifies/filters air; epiglottis covers larynx to prevent aspiration. Carina is highly sensitive, triggering vigorous cough on stimulation.Aspiration: Right mainstem bronchus is shorter, wider, straighter than left; aspiration is far more common in right lung.Dead Space: Normal tidal volume (VT) is ~500 mL (~150 mL is anatomical dead space [VD] without gas exchange).Alveoli & Surfactant:

en

11:29

CC | Critical Care Intro

STAT Stitch Deep Dive Podcast Beyond The Bedside ·

2026/08/11

this is the final season for our Nursing school program. Thank you all for listening and support. Also, remember if you need ACLS, PALS, NRP, TCRN, CCRN, CEN or other certs always comeback to listen. The AHA courses are very difficult on their own. but these host make it easy. if you have a nursing cert you would like uploaded then please send them to me at statstitch@gmail.com and I'll to upload them to the podcast. thank you all again for the massive support through this program! I wish you all

en

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