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PODCAST

Talking Biotech with Dr. Kevin Folta

Talking Biotech is a weekly podcast that uncovers the stories, ideas and research of people at the frontier of biology and engineering. Each episode explores how science and technology will transform agriculture, protect the environment, and feed 10 billion people by 2050. Interviews are led by Dr. Kevin Folta, a professor of molecular biology and genomics.

science life sciences

All Episodes

45:42

Sustainable Chemistry through Synthetic Biology - Dr....

Talking Biotech with Dr. Kevin Folta ·

2023/08/12

Many consumer products contain chemistries that originate from an unsustainable source. Dr. Chance Elliott VP of R&D at Amyris describes how his company is using synthetic biology to engineer yeast to produce these same compounds from sustainable substrates. We also discuss the current business climate, how companies change with new technology, as well as how to prepare for a future for jobs in this rapidly evolving space.

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57:22

A Look at the Color of Future Medical Care - Dr....

Talking Biotech with Dr. Kevin Folta ·

2023/08/05

The company Color has taken innovative approaches to varied aspects of public health. From at-home kits that can assess cancer risk, to efforts to curb COVID19, to finding attractive ways to make health care more accessible, Color has launched an array of programs that seek to improve public health. Dr. Alicia Zhou is the Chief Science Officer of Color. We discuss Color's efforts in cancer and disease detection, it's inroads into personalized, precision medicine, and a look at how

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38:53

Breaking Barriers in Protein Therapeutics - Dr. Dan...

Talking Biotech with Dr. Kevin Folta ·

2023/07/29

This is one hot tech discussion! Protein therapeutics have great potential, but significant limitations to their utility. Dr. Dan Mandell of GRO Biosciences explains how they are using a non-standard library of amino acids to increase protein presentation. Along with glycosylation and other modifications, the proteins are more therapeutically active, as such changes can improve issues like stability and visibility to the immune system. The technologies are being used to design therapeutic

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47:40

Innovations in High Throughput Proteomics - Dr. Parag...

Talking Biotech with Dr. Kevin Folta ·

2023/07/22

While many global genomics analyzes gene variants or RNA expression products, the levels of proteins are usually the most informative. At the same time, quantifying proteins is relatively difficult, especially when trying to obtain a snapshot of the proteome from a single cell or tissue. Dr. Parag Mallick of Stanford University and Nautilus Biotechnology describes the utility of high-throughput proteomics, and how the technology incorporates a novel detection method and machine learning to

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43:51

The Amazing Potential of Cell Transplants - Brian Culley

Talking Biotech with Dr. Kevin Folta ·

2023/07/15

Many diseases or disorders originate with a loss of cellular function. Cell death or damage is at the root of many problems associated with aging or injury. But what if the cells lost could simply be replaced to restore function? Brian Culley, CEO of Lineage Cell Therapeutics, discusses how his company has identified ways to generate specific cell types that can functionally replace lost cells in various contexts, restoring function. We discus applications in macular degeneration, hearing

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55:35

Adjusting to the Changing Biotech Landscape - Dr....

Talking Biotech with Dr. Kevin Folta ·

2023/07/08

Dr. Mike Tarselli, CSO of Tetra Science and Kevin Folta have a conversation about careers in biotech, where the discipline is going, along with observations about what makes someone successful in the field. We share many personal experiences as well as projections, and lessons we learned along the way. This is a great episode if you are considering a career in biotechnology.

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42:06

Drug Discovery in a Simulated Cell - Dr. Daniel Veres

Talking Biotech with Dr. Kevin Folta ·

2023/07/01

What can be learned about biology from massive datasets, and can that information unveil opportunities for new therapeutics? This is the approach by Turbine. Today's podcast discusses Turbine's approach with Dr. Dan Veres, CSO and Co-Founder of the company. He describes how data sets from multi-omics analysis are merged and analyzed to identify potential drug targets. and in silico information informs wet lab tests. The outcome is new therapeutics to treat recalcitrant disease. Webiste:

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58:20

COVID19 Misinformation "We Want Them Infected" - Dr....

Talking Biotech with Dr. Kevin Folta ·

2023/06/24

The COVID19 pandemic was a challenge in public health, but became much worse through politicization of science and a thriving misinformation network. Over a short time, a cadre of personalities emerged in a willing media that made claims contrary to public health guidance, stoking suspicion and eroding trust in the messaging from public health experts. Dr. Jonathan Howard's book, "We Want Them Infected" is a collection of social and traditional media comments by contrarian physicians and

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54:30

Rebuttal to RFKj's Glyphosate Comments on Joe Rogan

Talking Biotech with Dr. Kevin Folta ·

2023/06/20

Robert F. Kennedy Jr. is recognized for his bad science around critical issues like vaccination and agricultural chemistry. Recently he enjoyed a long-form, virtually uncontested platform on the Joe Rogan Experience where he rattled misinformation after falsehood about everything from vaccination to disease to glyphosate to cell phones. Because Rogan has a massive audience, this information is particularly dangerous. Here I refute, point-by-point, the false assertions made by Kennedy, and

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34:52

Happy Green Guacamole - The Non-Browning Avocado. ...

Talking Biotech with Dr. Kevin Folta ·

2023/06/17

The avocado is a wonderful fruit that is gaining in popularity, full of healthful oils and other nutrients. However, consumers consistently note the obvious drawback of the short life of fresh avocados, especially when used in recipes, like guacamole. Oxidative browning occurs within minutes, and causes food waste and supply chain loss. Green Venus is a technology company that has used site-specific nucleases to edit the genome of avocado. Dr. Jeff Touchman discusses the challenges and

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64:49

Talking Biotech Past, Present and Future

Talking Biotech with Dr. Kevin Folta ·

2023/06/15

The 400th episode also represents the first episode of the 9th year-- an amazing run for a tiny, self-produced podcast. Where did it come from? In this episode I talk about the genesis of the Talking Biotech podcast, from the Vern Blazek Science Power Hour, to an arm twisting by Joe Rogan, to being banned from podcasting by my university-- this is a behind-the-scenes history of this effort. I also recognize the guests that are no longer with us, yet remain a vital part of this archive.

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30:25

Next Generation Livestock Vaccines - Joel Harris

Talking Biotech with Dr. Kevin Folta ·

2023/06/03

Vaccination is a cornerstone of animal health, and is critically important in animal agricultural operations. A number of devastating livestock diseases are prevented with vaccination, yet vaccines have not been developed for some of the most devastating diseases for several reasons. Long before the COVID pandemic and its slate of next-gen vaccine strategies, Harris Vaccines was using rapidly adaptable RNA-based vaccine technologies. The current suite of RNA-based vaccines have been used

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38:27

Telling Science's Story - Sam Kean

Talking Biotech with Dr. Kevin Folta ·

2023/05/27

Sam Kean is a prolific author that has a unique talent for sharing the stories of science. Trained in physics, Kean's work describes seminal events in science using a deeply researched narrative style that transforms textbook information into better-than-fiction stories of discovery. In today's episode guest co-host Gracelyn Byrd joins the podcast to discuss the state of science communication, how we can do better as scientists and science institutions, and discuss how today's events may

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41:06

Constructing Brain Maps with Machine Learning - Dr....

Talking Biotech with Dr. Kevin Folta ·

2023/05/20

The human brain is complex, but over the years massive data have been gathered regarding the relationship between structure and function. From functional MRI to many other techniques, researchers slowly are resolving the relationship between brain anatomy and how it actually works. Dr. Stephan Doyen of Omniscient Neurotechnology have designed tools to parse massive collections of data relating brain structure to function, and now provide a set of tools to guide surgeons, as well as

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34:00

Novel Solutions for Chronic Kidney Disease -Dr....

Talking Biotech with Dr. Kevin Folta ·

2023/05/13

The kidney is one of the organs necessary to filter blood, composed of tiny functional units that separate waste products from molecules the body should retain. Chronic kidney disease is a significant international problem, with up to 10% of the population requiring treatment, and extreme cases requiring dialysis and/or transplantation with significant personal and public health costs. In today's episode we speak with Dr. Andrew King, Chief Scientific Officer of Chinook Therapeutics. We

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37:30

395 Synthetic Circuits in Plant Biology - Dr. James...

Talking Biotech with Dr. Kevin Folta ·

2023/05/06

Plant biologists use a set of tools to modulate gene expression. The well-established set of molecular switches are rather crude, with limited control of spatial or temporal expression. Dr. James Lloyd discusses the newest tools in synthetic circuits, molecules that can tailor a response with a given input. These new tools add needed nuance to the regulation of gene expression and stand to revise how we control specific genes in the lab and field.

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48:26

The Uphill Battle Against Scientific Disinformation -...

Talking Biotech with Dr. Kevin Folta ·

2023/04/29

Scientists are encouraged to step into the public conversation around controversial work, especially when that work seems to deliberately misinform, and can negatively affect public health. A series of authors have used to COVID pandemic to use the peer-reviewed literature to push claims that are poorly supported by legitimate evidence. These papers find favorable review from poor-quality reviewers, leading to eventual publication, and earning the patina of legitimacy, despite the poor

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36:13

How AI Has Changed the Business of Drug Discovery -...

Talking Biotech with Dr. Kevin Folta ·

2023/04/22

The companies on the front edge of pharmaceutical development have identified the value of massive data sets in the future of drug design. Ironically, personalization of therapies will be improved tremendously through examination of massive data sets. Dr. Michael Zaizac from Novartis of Europe discusses how his company has they have integrated artificial intelligence and analysis of patient data sets for new discoveries in patient care.

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34:16

Renewing This Old Brain - Dr. Jean Hebert

Talking Biotech with Dr. Kevin Folta ·

2023/04/15

As we age, the brain undergoes changes that lead to various disorders that affect physical ability and mental acuity. There are many processes at play, ranging from alterations in the extracellular environment, to accumulation of deleterious proteins, to a breakdown in connections between neurons. Can these processes be reversed? Dr. Jean Herbert from the Albert Einstein School of Medicine has led efforts to reconstitute brain function through use of stem cells. Current steps in animal

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26:53

Countering Livestock mRNA Vaccine Disinformation -...

Talking Biotech with Dr. Kevin Folta ·

2023/04/08

The COVID pandemic accelerated development of a new class of vaccines. This class, called mRNA vaccines, allows ease in manufacture, rapid response to disease or disease variants, and many other benefits. But just like any technology, an industry has arisen to stand in its way, promoting false information that painfully mischaracterizes what these new veterinary tools truly are. A cadre of internet personalities now capitalizes off of the manufactured fear that can help farmers, consumers

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486 results

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