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PODCAST

Talking Biotech with Dr. Kevin Folta

Talking Biotech is a weekly podcast that uncovers the stories, ideas and research of people at the frontier of biology and engineering. Each episode explores how science and technology will transform agriculture, protect the environment, and feed 10 billion people by 2050. Interviews are led by Dr. Kevin Folta, a professor of molecular biology and genomics.

science life sciences

All Episodes

34:52

Happy Green Guacamole - The Non-Browning Avocado. ...

Talking Biotech with Dr. Kevin Folta ·

2023/06/17

The avocado is a wonderful fruit that is gaining in popularity, full of healthful oils and other nutrients. However, consumers consistently note the obvious drawback of the short life of fresh avocados, especially when used in recipes, like guacamole. Oxidative browning occurs within minutes, and causes food waste and supply chain loss. Green Venus is a technology company that has used site-specific nucleases to edit the genome of avocado. Dr. Jeff Touchman discusses the challenges and

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64:49

Talking Biotech Past, Present and Future

Talking Biotech with Dr. Kevin Folta ·

2023/06/15

The 400th episode also represents the first episode of the 9th year-- an amazing run for a tiny, self-produced podcast. Where did it come from? In this episode I talk about the genesis of the Talking Biotech podcast, from the Vern Blazek Science Power Hour, to an arm twisting by Joe Rogan, to being banned from podcasting by my university-- this is a behind-the-scenes history of this effort. I also recognize the guests that are no longer with us, yet remain a vital part of this archive.

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30:25

Next Generation Livestock Vaccines - Joel Harris

Talking Biotech with Dr. Kevin Folta ·

2023/06/03

Vaccination is a cornerstone of animal health, and is critically important in animal agricultural operations. A number of devastating livestock diseases are prevented with vaccination, yet vaccines have not been developed for some of the most devastating diseases for several reasons. Long before the COVID pandemic and its slate of next-gen vaccine strategies, Harris Vaccines was using rapidly adaptable RNA-based vaccine technologies. The current suite of RNA-based vaccines have been used

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38:27

Telling Science's Story - Sam Kean

Talking Biotech with Dr. Kevin Folta ·

2023/05/27

Sam Kean is a prolific author that has a unique talent for sharing the stories of science. Trained in physics, Kean's work describes seminal events in science using a deeply researched narrative style that transforms textbook information into better-than-fiction stories of discovery. In today's episode guest co-host Gracelyn Byrd joins the podcast to discuss the state of science communication, how we can do better as scientists and science institutions, and discuss how today's events may

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41:06

Constructing Brain Maps with Machine Learning - Dr....

Talking Biotech with Dr. Kevin Folta ·

2023/05/20

The human brain is complex, but over the years massive data have been gathered regarding the relationship between structure and function. From functional MRI to many other techniques, researchers slowly are resolving the relationship between brain anatomy and how it actually works. Dr. Stephan Doyen of Omniscient Neurotechnology have designed tools to parse massive collections of data relating brain structure to function, and now provide a set of tools to guide surgeons, as well as

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34:00

Novel Solutions for Chronic Kidney Disease -Dr....

Talking Biotech with Dr. Kevin Folta ·

2023/05/13

The kidney is one of the organs necessary to filter blood, composed of tiny functional units that separate waste products from molecules the body should retain. Chronic kidney disease is a significant international problem, with up to 10% of the population requiring treatment, and extreme cases requiring dialysis and/or transplantation with significant personal and public health costs. In today's episode we speak with Dr. Andrew King, Chief Scientific Officer of Chinook Therapeutics. We

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37:30

395 Synthetic Circuits in Plant Biology - Dr. James...

Talking Biotech with Dr. Kevin Folta ·

2023/05/06

Plant biologists use a set of tools to modulate gene expression. The well-established set of molecular switches are rather crude, with limited control of spatial or temporal expression. Dr. James Lloyd discusses the newest tools in synthetic circuits, molecules that can tailor a response with a given input. These new tools add needed nuance to the regulation of gene expression and stand to revise how we control specific genes in the lab and field.

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48:26

The Uphill Battle Against Scientific Disinformation -...

Talking Biotech with Dr. Kevin Folta ·

2023/04/29

Scientists are encouraged to step into the public conversation around controversial work, especially when that work seems to deliberately misinform, and can negatively affect public health. A series of authors have used to COVID pandemic to use the peer-reviewed literature to push claims that are poorly supported by legitimate evidence. These papers find favorable review from poor-quality reviewers, leading to eventual publication, and earning the patina of legitimacy, despite the poor

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36:13

How AI Has Changed the Business of Drug Discovery -...

Talking Biotech with Dr. Kevin Folta ·

2023/04/22

The companies on the front edge of pharmaceutical development have identified the value of massive data sets in the future of drug design. Ironically, personalization of therapies will be improved tremendously through examination of massive data sets. Dr. Michael Zaizac from Novartis of Europe discusses how his company has they have integrated artificial intelligence and analysis of patient data sets for new discoveries in patient care.

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34:16

Renewing This Old Brain - Dr. Jean Hebert

Talking Biotech with Dr. Kevin Folta ·

2023/04/15

As we age, the brain undergoes changes that lead to various disorders that affect physical ability and mental acuity. There are many processes at play, ranging from alterations in the extracellular environment, to accumulation of deleterious proteins, to a breakdown in connections between neurons. Can these processes be reversed? Dr. Jean Herbert from the Albert Einstein School of Medicine has led efforts to reconstitute brain function through use of stem cells. Current steps in animal

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26:53

Countering Livestock mRNA Vaccine Disinformation -...

Talking Biotech with Dr. Kevin Folta ·

2023/04/08

The COVID pandemic accelerated development of a new class of vaccines. This class, called mRNA vaccines, allows ease in manufacture, rapid response to disease or disease variants, and many other benefits. But just like any technology, an industry has arisen to stand in its way, promoting false information that painfully mischaracterizes what these new veterinary tools truly are. A cadre of internet personalities now capitalizes off of the manufactured fear that can help farmers, consumers

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41:59

The Changing Biotech Business and Big Data Ecosystem...

Talking Biotech with Dr. Kevin Folta ·

2023/04/01

In a rapidly changing technology environment, how do established businesses tackle smart growth and continue transformative change? In this special edition of Talking Biotech Podcast we examine the business climate of Regeneron, and how growth in the era of genomics and massive data sets from human health changed the process of drug discovery, but also changed how the company would respond to new opportunities and challenges. Dr. Jeffery Reid, Chief Data Officer, explains where the company

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44:58

Science Controversies in Social Media - Dr. Liza Dunn

Talking Biotech with Dr. Kevin Folta ·

2023/03/25

In this episode Dr. Kevin Folta shares a spontaneous conversation with Dr. Liza Dunn. Dr. Dunn is an emergency medicine physician with a specialty in medical toxicology, now working as the Medical Affair Lead at Bayer CropScience. The discussion covers the current scientific environment in social media, and emphasizes the need for scientists to be engaging. Topics from communication about vaccines to genetic engineering are covered. Follow Dr. Dunn at @DrLizaMD

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27:56

Biotech Potatoes and Food Security - Dr. David Douches

Talking Biotech with Dr. Kevin Folta ·

2023/03/18

The potato is a world food staple, yet it is constantly threated by fungal and viral pathogens in all of its growing regions. Farmers combat these problems with chemistry, which cuts farmers profits and has potential consequences for applicators and the environment. Dr. David Douches from Michigan State University discusses the USAID project that installed a cassette of disease resistance genes from wild potato species in the cultivated potato. The result is a potato that can survive better

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16:21

Students Against Misinformation -Special Episode-

Talking Biotech with Dr. Kevin Folta ·

2023/03/06

Whereas we used to be challenged with finding information, today we are flooded with information, and our job has switched to vetting it's merits. Three students from the University of Florida spoke to me about their efforts in a national competition to study the origins of false information and communicate how to identify good information to the public. Tammy, Heather and Courtney were amazing guests that discussed their mission, along with a suite of online resources to help guide the

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38:06

Treating Mental Illness through Nasal Drug Delivery -...

Talking Biotech with Dr. Kevin Folta ·

2023/03/04

Mental illnesses such as anxiety and depression are being diagnosed with increasing frequency. At the same time, treatment is frequently dependent on legacy drugs that oftentimes to do not work well, have drug interactions, or can lead to addiction or dependence. New therapies are also available, yet they they are systemic and can also have drug interactions and unfavorable side effects. New therapies are needed, especially those with more direct delivery to the relevant regions of the

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28:02

Reinventing Lipid Nanoparticles - Dr. John Lewis

Talking Biotech with Dr. Kevin Folta ·

2023/02/25

Lipid nanoparticles have been around for decades, but they took a spotlight in the delivery of the COVID19 mRNA-based vaccines. This chemical cage can fuse with cell membranes and deliver a specific payload to a cell. While the delivery to specific cells is routine, are there ways to improve the system to have more specific therapeutic benefit. Dr. John Lewis of Entos discusses lipid nanoparticle chemistry and new formulations that exhibit enhanced capacity to target specific locations and

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36:54

Gene Therapy to Cure Rare Disease - Dr. Gaurav Shah

Talking Biotech with Dr. Kevin Folta ·

2023/02/18

There are many rare diseases that originate with a single letter change in DNA, and they can cause tremendous physical and financial hardship for families affected. Viral-based gene therapies have been a promise for decades, and modern technology is now bringing these concepts to fruition. Dr. Gaurav Shah, CEO of Rocket Pharma, describes the power of the current gene therapy approaches, along with the pipeline of potential therapeutics that could represent cures for rare disease.

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47:10

Inspiring Innovations; State of Alzheirmer's...

Talking Biotech with Dr. Kevin Folta ·

2023/02/11

This week's podcast has two parts. Dr. Leen Kawas , Managing General Partner at Propel Biopartners, speaks about how biotech startups can benefit from skilled oversight and capital provided from experts that understand the business/science ecosystem. In the second part we discuss the latest therapies for Alzheimer's Disease, and how trials and regulation can't follow traditional trajectories. Alzheimer's has variation in etiology, patients start treatments after a diagnosis which may be

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37:23

Nature's Transgenics - Evidence of Lateral Gene...

Talking Biotech with Dr. Kevin Folta ·

2023/02/04

As the amount of plant genomic DNA sequence increases, scientists have detected DNA sequence information that simply does not conveniently fit into genome assemblies, and clearly appears to be from somewhere else. Dr. Lara Pereira from the University of Sheffield explains the surprising frequency of lateral gene transfer between grass species. The mechanism of crossing the species barrier is discussed, along with the frequency of horizontal transfer. We discuss the ramifications of

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477 results

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