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PODCAST

Metabolism Made Easy

A J Ghalayini, Ph.D.

This podcast describes selected biochemistry content that could be useful to premedical/medical students. Similar content (podcasts and videos) is available at: https://medbiochem.org/ Check out my podcast on YouTube below: https://youtube.com/playlist?list=PLXy2KYiCd9rlg0JmfA392WrEiOYNu39xn&si=Nu2LkpYOjHPZpxd5 These podcasts and videos cover selected topics in medical biochemistry. A J Ghalayini, Ph.D. Bio for Dr. Ghalayini: Dr. Ghalayini received his Ph.D. in Biochemistry from the

education courses

All Episodes

00:04:38

The Brain's Energy Sources

Metabolism Made Easy ·

2024/05/07

This podcast covers the use of glucose and ketone bodies as energy sources by the brain. During sleep and short fasts, the brain is completely dependent on the output of glucose by the liver. Glucose is oxidized all the way to CO2 by the brain under aerobic conditions to produce up to 38ATPs. --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:07:56

GLucose Transporters

Metabolism Made Easy ·

2024/05/05

This podcast covers the tissue distribution of various glucose transporters and their specific role in those tissues, including regulation of one transporter by insulin.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:07:00

The Purine Salvage Pathway

Metabolism Made Easy ·

2024/04/23

This podcast covers the salvage of Hypoxanthine, guanine and adenine by two important enzymes Hypoxanthine-guanine phosphoribosyl transferase (HGPRT) and Adeneine phosphoribosyl transferase (APRT), including the outcome of an inherited deficiency in HGPRT. --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:02:42

Glucose Uptake by Muscle & Adipose Tissue

Metabolism Made Easy ·

2024/04/11

This podcast covers the insulin-dependent uptake of glucose by GLUT-4 in muscle and adipose tissue. This insulin-dependent uptake by these tissues contributes to the reduction of plasma glucose after a meal.Check out the link below for the video podcast: https://youtu.be/_vyijJKL4oY --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:03:01

Glucose: The Essential Nutrient

Metabolism Made Easy ·

2024/04/05

This podcast covers the essential role of glucose as an energy source for several tissues. Most notably, red blood cells and the brain. Red blood cells are entirely dependent on glucose for their energy needs while the brain is highly dependent on glucose for its energy. Glucose in the bloodstream is produced by the liver and maintained around 80-100mg/dl during fasting to provide red blood cells and the brain with their energy needs.--- Send in a voice message:

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00:02:16

Hormones & Receptors: 4 Distinct Types

Metabolism Made Easy ·

2024/03/25

This podcast covers the four different classes of receptors that illicit intracellular signals, including steroid receptors, ion channel receptors, receptor enzymes, and G-protein coupled receptors.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:03:55

Insulin Effects on Carbohydrate & Lipid metabolism

Metabolism Made Easy ·

2024/03/13

This episode summarizes the key effects on carbohydrate and lipid metabolism, including the processes that are activated by insulin and the ones inhibited by it.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:04:26

Enzyme Inhibition

Metabolism Made Easy ·

2024/03/01

This podcast describes 4 distinct types of enzyme inhibitors and their mechanism of inhibition, including: substrate analogues, toxins, allosteric inhibitors, and heavy metals.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:08:32

Glycolysis: Regulation of Pyruvate Kinase

Metabolism Made Easy ·

2024/02/19

This podcast covers the regulation of pyruvate kinase allosterically and by hormone-dependent (insulin & glucagon) covalent modification.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:04:28

Metabolism in The Well-Fed State

Metabolism Made Easy ·

2024/02/05

This podcast covers the metabolic changes in various organs and key organ uses of the available nutrients in the bloodstream. --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:02:43

The Brain Loves Glucose

Metabolism Made Easy ·

2024/01/19

With the exception of ketone bodies, the brain is entirely dependent on glucose as an energy source under most circumstances. Glucose is oxidized all the way to CO2 by the brain, producing up to 38 ATPs. This catabolism is dependent on oxygen, which is used to convert the energy in NADH and FADH2 to ATP through the Electron Transport Chain and Oxidative Phosphorylation. --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:04:34

DIETARY TRIACYLGLYCEROL (Fat): Digestion, Absorption...

Metabolism Made Easy ·

2024/01/04

This podcast covers the digestion of the major dietary fat, triacylglycerol, including digestion uptake into intestinal mucosa, delivery through the bloodstream, uptake and storage of fatty acids from chylomicrons in the bloodstream. --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:04:06

Transport of Ammonia by Glutamine

Metabolism Made Easy ·

2023/12/14

This podcast describes the transport of ammonia produced in peripheral tissues by incorporating it into glutamine through glutamine synthase. Glutamine is transported in the bloodstream to either the liver or kidney for further metabolism. --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:08:31

Metabolism During Fasting

Metabolism Made Easy ·

2023/11/07

This podcast provides an overview of metabolic changes associated with fasting, including key metabolic changes in the liver and adipose tissue. The liver will increase its output of glucose and ketone bodies, while adipose tissue will provide fatty acids to the bloodstream for other peripheral tissues to use during fasting. --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:14:52

METABOLISM: A Biochemical Summary

Metabolism Made Easy ·

2023/09/14

This podcast summarizes the key biochemical components of metabolism, including: 1. definition; 2. cellular location; 3. the major catabolic pathways; 4. the 3 stages of catabolism; 5. the 12 major metabolic uses of glucose, fatty acids and amino acids; 6. the energy output of catabolism of glucose, fatty acids, and ketone bodies. --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:09:15

Enzyme Regulation

Metabolism Made Easy ·

2023/09/05

This podcast covers 5 distinct enzyme regulatory mechanisms and their effects on enzyme structure and activity. --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:11:12

The Urea cycle : Key Features and Enzymes

Metabolism Made Easy ·

2023/07/27

This podcast covers the function and the location of the urea cycle, including some key features and the sequence of the enzymes as well as their location. --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:04:11

TRANSAMINASES: Amino acid degradation

Metabolism Made Easy ·

2023/06/28

This podcast covers the role of transaminases the initial step in the degradation of amino acids. This includes the role of glutamate dehydrogenase in producing ammonia. The ammonia and aspartate produced are then able to enter the urea cycle in the liver. --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:05:40

Adipocytes, lipolysis, and energy reserves

Metabolism Made Easy ·

2023/06/16

This podcast covers the role of adipocytes in energy storage and their role in initiating lypolysis of stored triacylglycerols to provide various tissues with fatty acids as a energy source. The role of fatty acid Beta-oxidation in providing energy from both dietary or stored triacylglycerols is also covered. --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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00:00:58

The Cori Cycle

Metabolism Made Easy ·

2023/05/24

This podcast covers the details of the conversion of lactate produced during exercise to glucose in the liver and ultimately releasing it to the bloodstream. --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message

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223 results

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