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PODCAST

Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist

The Go-to Podcast for Biotech Scientists Who Want to Master Biopharma CMC Development and Biomanufacturing.**TOP 10 LIFE SCIENCES PODCAST**Are you ready to simplify bioprocess development and scale with confidence to reduce time to market?Are you feeling overwhelmed by the complexity and guesswork of biologics development and biomanufacturing?Do you wish you had more time to enjoy the beauty of science, without worrying about failing your cell culture process development and

science life sciences

All Episodes

20:31

126: How to Enhance Cell Engineering Using Mechanical...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/02/06

Send us a text As biotechnology rapidly evolves, cell therapies are emerging as a groundbreaking frontier with the potential to transform medicine. In this episode of the Smart Biotech Scientist Podcast, host David Brühlmann speaks with Armon Sharei, founder and CEO of Portal Bio, about the complexities, challenges, and future of cell therapies. Cell therapies could revolutionize medicine in ways similar to antibiotics and vaccines. However, the current manufacturing process is costly and tim...

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21:35

125: How to Enhance Cell Engineering Using Mechanical...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/02/04

Send us a text Intracellular delivery is essential for advancing research and clinical applications, yet it presents unique challenges when working with different cell types and biomolecules. In a recent episode of the Smart Biotech Scientist podcast, David Brühlmann spoke with Armon Sharei, the founder and CEO of Portal Bio, about the future of cell therapy, the hurdles of intracellular delivery, and groundbreaking innovations in drug screening. Armon’s journey began at MIT, where his initia...

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17:32

124: Manufacturability: Why Most Protein Candidates...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/01/30

Send us a textIn part two of our insightful conversation, Dr. Susan Sharfstein builds on our previous discussion of developability assessment to explore how AI is revolutionizing protein manufacturability predictions.As a Professor of Nanoscale Science and Engineering at the University of Albany, she shares groundbreaking insights from her collaboration with DeepSeq AI, demonstrating how artificial intelligence is transforming our ability to assess and predict protein manufacturability early ...

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22:35

123: Manufacturability: Why Most Protein Candidates...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/01/28

Send us a textIn this eye-opening episode, we dive deep into the critical yet often overlooked world of protein manufacturability with Dr. Susan Sharfstein, Professor of Nanoscale Science and Engineering at the University of Albany. As part of the broader developability assessment process, manufacturability evaluation helps determine whether a therapeutic candidate can be successfully produced at commercial scale.Drawing from her extensive experience in bioprocessing and cell culture technolo...

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17:58

122: The Transformative World of Digital Solutions in...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/01/23

Send us a textIn the second part of this conversation on digital solutions in bioprocessing, David Brühlmann and Simon Wieninger, Business Manager Digital Solutions at Eppendorf Group, discuss real-world examples of labs revolutionizing their workflows through smart digitalization. From real-time data monitoring to intercontinental data sharing, Simon highlights the practical benefits and exciting future potential of digital technologies in bioprocessing.Missed Part 1? In the previous episode...

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23:05

121: The Transformative World of Digital Solutions in...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/01/21

Send us a textDigital transformation is reshaping industries worldwide, and biotech is no exception. With the integration of cloud technologies, AI, and data harmonization, bioprocessing is becoming smarter, more efficient, and more innovative. Catching up with digital revolutions in other sectors, biotech now stands at the threshold of tremendous change.In this episode of the Smart Biotech Scientist Podcast, David Brühlmann sat down with Simon Wieninger, Business Manager Digital Solutions at...

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21:23

120: Innovating Protein Purification Using Synthetic...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/01/16

Send us a textIn the ever-evolving world of biotechnology, the integration of artificial intelligence (AI) and synthetic biology is driving unprecedented advancements. This transformative power was the focus of this podcast episode of the Smart Biotech Scientist, where host David Brühlmann engaged in a thought-provoking conversation with Haotian Guo, CEO and Founder of Ailurus on the role of AI in bioprocessing, the significance of wet lab validation, and the exciting future of programmable b...

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19:55

119: Innovating Protein Purification Using Synthetic...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/01/14

Send us a textBiotechnology is rapidly evolving as innovation addresses real-world needs. At the cutting edge of this evolution, synthetic biology and AI-driven protein design are revolutionizing our approach to complex processes like protein purification.In this episode of the Smart Biotech Scientist podcast, host David Brühlmann talks with Haotian Guo, CEO and Founder of Ailurus, about the modern advancements in synthetic organelles and their transformative impact on protein purification.Ha...

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15:16

118: Critical Bottlenecks and Breakthroughs in Cell...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/01/09

Send us a textIn the second part of our conversation with Andrea Gough, Senior Director for Advanced Instruments’ Solentim Portfolio, we’ll explore how AI and machine learning have, in recent years, begun to transform various aspects of biotechnology, including cell line development (CLD). Andrea shares insights into how these cutting-edge technologies are being applied to the early stages of clone selection.AI's capability to analyze images and classify clone viability is another breakthroug...

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23:33

117: Critical Bottlenecks and Breakthroughs in Cell...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/01/07

Send us a textCell line development (CLD) is a cornerstone of biologics production. This intricate process involves establishing a cell line capable of consistently producing a desired product, such as a therapeutic protein. While advancing science has refined numerous aspects of CLD, bottlenecks still exist, perpetuating challenges for scientists and industry professionals.In this episode of the Smart Biotech Scientist Podcast, Andrea Gough, Senior Director for Advanced Instruments’ Solentim...

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16:43

116: Revolutionizing Biologics Development with Hyper...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/12/19

Send us a textThe intersection of artificial intelligence and biology presents immense opportunities for transforming bioprocess development. As the biotech industry continues to evolve, data-driven innovations are critical to optimizing biologics manufacturing. High-quality datasets stand at the forefront of this transformation, empowering researchers to make informed predictions and advance therapeutic discoveries. As AI tools become more commoditized, the focus shifts toward generating rob...

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19:49

115: Revolutionizing Biologics Development with Hyper...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/12/17

Send us a textBioprocess development is transforming the biotech industry, driving innovations in life-changing therapies. Success hinges on simplifying complex mechanisms and adopting advanced technologies. By integrating high-throughput screening and artificial intelligence, we can streamline workflows, reduce trial-and-error, and speed up biologics development. Embracing cutting-edge tools empowers scientists to maximize biology's potential, delivering efficient and impactful biotech solut...

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18:08

114: Weighing of Single-Use Bag Systems: Why...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/12/12

Send us a textIs your bioprocess facility wasting precious time and resources on traditional weighing system calibrations? In this eye-opening episode, Anders Tvegaard, COO of Eilersen Electric, reveals how digital load cell innovation is revolutionizing bioprocess monitoring and validation.Discover why weighing systems aren't the commodity technology you might think they are, and how choosing the right solution can dramatically reduce deviations and maintenance costs. Anders shares groundbre...

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22:22

113: Weighing of Single-Use Bag Systems: Why...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/12/10

Send us a textWhat do furniture manufacturing and bioprocess weighing have in common? In this fascinating episode, Anders Tvegaard, COO of Eilersen Electric Digital Systems shares the remarkable story of how his company evolved from solving a furniture maker's wood humidity measurement problems to revolutionizing pharmaceutical manufacturing.Fifty years ago, a simple request to build a more robust scale for weighing wood in sofa production led to the development of groundbreaking contactless ...

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23:41

112: AI Meets Biology: Why Domain Expertise Still...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/12/05

Send us a textCan artificial intelligence revolutionize drug development and reduce the staggering 90% failure rate in clinical trials? In this insightful episode, Lars Brandén, Director of Biology at Kolibri, shares his vision for the future of personalized medicine.Drawing from his extensive experience bridging academia and industry, Lars explores how AI models could transform our understanding of human disease by simulating body-wide cell signaling. He reveals an innovative approach to dru...

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19:08

111: AI Meets Biology: Why Domain Expertise Still...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/12/03

Send us a textIn this episode, we explore the delicate dance between artificial intelligence and biological research with Lars Brandén, Director of Biology at Kolibri. From his early fascination with gene therapy to pioneering high-throughput screening centers at prestigious institutions, Lars shares invaluable insights on bridging the gap between academic innovation and industrial application.What sets this conversation apart is Lars' compelling perspective on why the popular "agile developm...

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16:24

110: Spinning Like Earth: Designing Low-Shear...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/11/28

Send us a textCould Earth's gentle movements hold the key to scaling up cell therapy production? In this fascinating episode, cellular biologist and entrepreneur Olivier Detournay (CSO of Cellura) reveals how his groundbreaking bioreactor design, inspired by geophysics, is transforming difficult cell culture processes.By mimicking natural planetary motions, his team at Celura has developed a low-shear stress bioreactor that elegantly solves common scale-up challenges.Key takeaways for biotech...

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19:27

109: Spinning Like Earth: Designing Low-Shear...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/11/26

Send us a textWhat if the secret to growing sensitive cells lies in mimicking Earth's own movement? In this fascinating episode, cellular biologist Olivier Detournay, CSO of Cellura, reveals how studying planetary motion led to a groundbreaking bioreactor design that could transform cell therapy manufacturing.Drawing inspiration from geophysics research on magma flows, Olivier and his colleagues developed a revolutionary impeller-free bioreactor that creates gentle, uniform mixing through pre...

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26:35

108: From 1 Billion to 100: How AI is Cracking the...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/11/21

Send us a textIn this captivating episode, we dive deep into the groundbreaking intersection of artificial intelligence and enzyme engineering with David Schönauer, founder and CEO of Aminoverse.From university lab benches to pioneering AI-driven enzyme discovery, David shares how his startup is transforming the biotech landscape by making enzyme development faster, more predictable, and increasingly efficient.Highlights:Discover how AI is revolutionizing enzyme prediction and design, potenti...

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19:11

107: From 1 Billion to 100: How AI is Cracking the...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2024/11/19

Send us a textEver wondered how scientists find the perfect enzyme among billions of possibilities? In this fascinating episode of the Smart Biotech Scientist podcast, host David Brühlmann sits down with David Schönauer, CEO of Aminoverse, who's revolutionizing enzyme engineering through artificial intelligence.As a biotech entrepreneur who transformed his academic passion into a groundbreaking startup, Schönauer shares how his company is solving one of biotechnology's biggest challenges: eff...

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174 results

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