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PODCAST

Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist

The Go-to Podcast for Biotech Scientists Who Want to Master Biopharma CMC Development and Biomanufacturing.**TOP 10 LIFE SCIENCES PODCAST**Are you ready to simplify bioprocess development and scale with confidence to reduce time to market?Are you feeling overwhelmed by the complexity and guesswork of biologics development and biomanufacturing?Do you wish you had more time to enjoy the beauty of science, without worrying about failing your cell culture process development and

science life sciences

All Episodes

13:28

136: 5 Roadblocks to Affordable Biologics (And How to...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/03/13

Send us a text Sickle cell disease, a genetic disorder affecting thousands, presents a daily struggle akin to having shards of glass tearing through one's veins. Despite breakthrough gene therapies approved by the FDA, the prohibitive cost of $2.2 million per treatment limits their accessibility. In the latest episode of the Smart Biotech Scientist Podcast, host David Brühlmann discusses five critical challenges the bioprocessing industry must overcome to make these life-saving therapies acce...

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12:46

135: Beyond Breakthroughs: Making Biotherapeutics...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/03/11

Send us a text In a world of rapid advancements in medical science and biotechnology, bioprocessing is at the forefront of healthcare innovation. Yet, despite remarkable progress, life-saving biotherapeutics remain out of reach for much of the global population. A staggering 80% of patients worldwide lack access to the biotherapeutics they need. While bioprocessing has made impressive strides, the high cost and slow development of these treatments create significant barriers. Addressing these...

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16:53

134: Seamless Seed Trains: Simplify Without...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/03/06

Send us a text The biotechnology industry is on a transformative path. With emerging technologies and innovative ideas, bioprocessing professionals are poised to revolutionize how therapies are developed and delivered. In this episode of the Smart Biotech Scientist Podcast, host David Brühlmann continues his conversation with François Carruzzo, the CTO of Bioscibex, as they delve into the challenges and opportunities present in the biotech landscape. Bioprocess automation boosts efficiency an...

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22:30

133: Seamless Seed Trains: Simplify Without...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/03/04

Send us a text Biologics manufacturing relies heavily on optimizing various stages, yet the seed train step - often overlooked - plays a critical role in determining overall efficiency. The seed train involves expanding cells from a small working cell bank to scales suitable for production bioreactors. Francois Carruzzo, Co-founder and CTO of Bioscibex, is rethinking how this process can be simplified, streamlined, and made more reliable, using a fully automated, closed system. However, the c...

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14:57

132: Combining AI and Biomanufacturing for...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/02/27

Send us a text Artificial Intelligence (AI) is transforming industries worldwide, and biotechnology is no exception. In bioprocess development, AI is proving to be a game-changer, accelerating workflows, optimizing processes, and driving innovation. On the Smart Biotech Scientist Podcast, Reza Farahani, founder and CEO of Catalyze AI, shares his insights on how AI is reshaping biomanufacturing and the future of the industry. As AI continues to integrate into bioprocessing, the role of scienti...

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26:55

131: Combining AI and Biomanufacturing for...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/02/25

Send us a text The real-world applications of AI in biomanufacturing are transformative. From reducing drug development timelines to optimizing production yields, AI is making biomanufacturing more efficient and cost-effective. This, in turn, enhances global access to life-saving therapies. As AI continues to evolve, its potential to drive even greater innovations in biologics manufacturing becomes increasingly promising. In the latest episode of the Smart Biotech Scientist Podcast, David Brü...

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20:15

130: Revolutionizing Cell Therapy Manufacturing:...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/02/20

Send us a text The intricacies of tech transfer and the challenges of scaling manufacturing processes are often underestimated in the biotechnology industry. Understanding these complexities is crucial for translating innovative scientific breakthroughs into commercially viable products. In the second part of the conversation with Jason Foster, CEO of Ori Biotech, host David Brühlmann explores the complexities of cell therapy manufacturing. Their discussion highlights key challenges, includin...

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22:10

129: Revolutionizing Cell Therapy Manufacturing:...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/02/18

Send us a text One of the most urgent challenges in modern medicine is making cell and gene therapies widely accessible. These therapies, while groundbreaking in their safety and efficacy, often fall short when it comes to reaching patients. The reasons are manifold—high manufacturing costs, logistical complexities, and inefficiencies in the production pipeline. We're joined by Jason Foster, CEO and Executive Director of Ori Biotech, a company that's revolutionizing cell and gene therapy manu...

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17:42

128: The 7 Hidden Innovation Habits That Top Biotech...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/02/13

Send us a text The world of bioprocess development in biotechnology is evolving at an unprecedented pace, driven by the quest for breakthrough innovations. While new technologies play a significant role, what truly sets successful innovators apart are fundamental habits that foster an environment ripe for groundbreaking discoveries. In today's discussion, we'll delve into three essential habits that, when combined with the four habits previously discussed, can redefine your approach to biopro...

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15:53

127: The 7 Hidden Innovation Habits That Top Biotech...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/02/11

Send us a text In the fast-paced and highly regulated world of biotech development, maintaining an innovative spirit can sometimes feel like a Herculean task. Between optimizing cell culture processes and navigating strict regulatory requirements, it’s no wonder many scientists feel the weight of daily operations pressing down on their creativity. However, fostering innovation is crucial for breakthroughs in our field. David Brühlmann shares practices that have transformed how scientists appr...

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20:31

126: How to Enhance Cell Engineering Using Mechanical...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/02/06

Send us a text As biotechnology rapidly evolves, cell therapies are emerging as a groundbreaking frontier with the potential to transform medicine. In this episode of the Smart Biotech Scientist Podcast, host David Brühlmann speaks with Armon Sharei, founder and CEO of Portal Bio, about the complexities, challenges, and future of cell therapies. Cell therapies could revolutionize medicine in ways similar to antibiotics and vaccines. However, the current manufacturing process is costly and tim...

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21:35

125: How to Enhance Cell Engineering Using Mechanical...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/02/04

Send us a text Intracellular delivery is essential for advancing research and clinical applications, yet it presents unique challenges when working with different cell types and biomolecules. In a recent episode of the Smart Biotech Scientist podcast, David Brühlmann spoke with Armon Sharei, the founder and CEO of Portal Bio, about the future of cell therapy, the hurdles of intracellular delivery, and groundbreaking innovations in drug screening. Armon’s journey began at MIT, where his initia...

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17:32

124: Manufacturability: Why Most Protein Candidates...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/01/30

Send us a textIn part two of our insightful conversation, Dr. Susan Sharfstein builds on our previous discussion of developability assessment to explore how AI is revolutionizing protein manufacturability predictions.As a Professor of Nanoscale Science and Engineering at the University of Albany, she shares groundbreaking insights from her collaboration with DeepSeq AI, demonstrating how artificial intelligence is transforming our ability to assess and predict protein manufacturability early ...

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22:35

123: Manufacturability: Why Most Protein Candidates...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/01/28

Send us a textIn this eye-opening episode, we dive deep into the critical yet often overlooked world of protein manufacturability with Dr. Susan Sharfstein, Professor of Nanoscale Science and Engineering at the University of Albany. As part of the broader developability assessment process, manufacturability evaluation helps determine whether a therapeutic candidate can be successfully produced at commercial scale.Drawing from her extensive experience in bioprocessing and cell culture technolo...

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17:58

122: The Transformative World of Digital Solutions in...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/01/23

Send us a textIn the second part of this conversation on digital solutions in bioprocessing, David Brühlmann and Simon Wieninger, Business Manager Digital Solutions at Eppendorf Group, discuss real-world examples of labs revolutionizing their workflows through smart digitalization. From real-time data monitoring to intercontinental data sharing, Simon highlights the practical benefits and exciting future potential of digital technologies in bioprocessing.Missed Part 1? In the previous episode...

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23:05

121: The Transformative World of Digital Solutions in...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/01/21

Send us a textDigital transformation is reshaping industries worldwide, and biotech is no exception. With the integration of cloud technologies, AI, and data harmonization, bioprocessing is becoming smarter, more efficient, and more innovative. Catching up with digital revolutions in other sectors, biotech now stands at the threshold of tremendous change.In this episode of the Smart Biotech Scientist Podcast, David Brühlmann sat down with Simon Wieninger, Business Manager Digital Solutions at...

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21:23

120: Innovating Protein Purification Using Synthetic...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/01/16

Send us a textIn the ever-evolving world of biotechnology, the integration of artificial intelligence (AI) and synthetic biology is driving unprecedented advancements. This transformative power was the focus of this podcast episode of the Smart Biotech Scientist, where host David Brühlmann engaged in a thought-provoking conversation with Haotian Guo, CEO and Founder of Ailurus on the role of AI in bioprocessing, the significance of wet lab validation, and the exciting future of programmable b...

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19:55

119: Innovating Protein Purification Using Synthetic...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/01/14

Send us a textBiotechnology is rapidly evolving as innovation addresses real-world needs. At the cutting edge of this evolution, synthetic biology and AI-driven protein design are revolutionizing our approach to complex processes like protein purification.In this episode of the Smart Biotech Scientist podcast, host David Brühlmann talks with Haotian Guo, CEO and Founder of Ailurus, about the modern advancements in synthetic organelles and their transformative impact on protein purification.Ha...

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15:16

118: Critical Bottlenecks and Breakthroughs in Cell...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/01/09

Send us a textIn the second part of our conversation with Andrea Gough, Senior Director for Advanced Instruments’ Solentim Portfolio, we’ll explore how AI and machine learning have, in recent years, begun to transform various aspects of biotechnology, including cell line development (CLD). Andrea shares insights into how these cutting-edge technologies are being applied to the early stages of clone selection.AI's capability to analyze images and classify clone viability is another breakthroug...

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23:33

117: Critical Bottlenecks and Breakthroughs in Cell...

Smart Biotech Scientist | Master Bioprocess CMC... ·

2025/01/07

Send us a textCell line development (CLD) is a cornerstone of biologics production. This intricate process involves establishing a cell line capable of consistently producing a desired product, such as a therapeutic protein. While advancing science has refined numerous aspects of CLD, bottlenecks still exist, perpetuating challenges for scientists and industry professionals.In this episode of the Smart Biotech Scientist Podcast, Andrea Gough, Senior Director for Advanced Instruments’ Solentim...

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184 results

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