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PODCAST

This Week in Parasitism

Vincent Racaniello

TWiP is a monthly netcast about eukaryotic parasites. Vincent Racaniello and Dickson Despommier, science Professors from Columbia University, deconstruct parasites, how they cause illness, and how you can prevent infections.

science life sciences

All Episodes

01:20:51

TWiP 186: Not rationing rationality

This Week in Parasitism ·

2020/08/01

Dickson, Daniel and Vincent solve the case of the Elder Gardener Feeling Poorly, and discuss the three-dimensional ultrastructure of Plasmodium falciparum during cytokinesis. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Three-dimensional structure of malaria parasite (PLoS Path) Support Floating Doctors at PWB Letters read on TWiP 186 Become a patron of TWiP Case Study for TWiP 186 Middle aged woman

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01:03:43

TWiP 185: Latrinalia

This Week in Parasitism ·

2020/07/03

Dickson, Daniel and Vincent solve the case of the Wife of a Guy with Cyclospora Diarrhea, and discuss the discovery of an intrinsic oscillator that drives the bloodstream stage cycle of the malaria parasite. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Intrinsic oscillator in malaria parasite (Science) Malaria parasite has intrinsic clock (Science) Letters read on TWiP 185 Become a patron of TWiP

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01:03:55

TWiP 184: The hunter gets captured by the game

This Week in Parasitism ·

2020/06/06

Dickson, Daniel and Vincent solve the case of the Safari Goer With Watery Diarrhea, and explain how a microsporidian endosymbiont of Anopheles mosquitoes might impair the transmission of malaria. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Contribute to Parasites Without Borders Microsporidian impairs Plasmodium transmission (Nat Comm) Hero: Eugene T. Lyons (obituary) Image credit: Josh Letters read

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01:11:43

TWiP 183: When they dry they die

This Week in Parasitism ·

2020/05/08

Dickson, Daniel and Vincent solve the case of the Female with Itchy Anus, and reveal the structure of a roundworm membrane protein involved in digestion of nutrients. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Structure of roundworm digestive complex (PLoS Path) Hero: Dr. Anthony Fauci Fauci Pharmacy (TWiV 219) Letters read on TWiP 183 Become a patron of TWiP. Case Study for TWiP 183

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01:14:53

TWiP 182: Super spreaders of science

This Week in Parasitism ·

2020/04/11

Dickson, Daniel and Vincent solve the case of the Ugandan Volunteer With Morning Bites and discuss integration of HIV-1 into the Schistosome genome, with a sprinkling of COVID-19 throughout. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB social media: Facebook, Instagram, Twitter Daniel on TWiV HIV-1 integration into Schistosome genome (PLoS Path) Image from John Southall's Treatise of Buggs, 1730

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01:20:33

TWiP 181: Daniel's drive-through

This Week in Parasitism ·

2020/03/14

Dickson, Daniel and Vincent solve the case of the Two Volunteers With Watery Diarrhea, discuss diagnosis of SARS-CoV-2 in the New York area, and reveal an approach to preventing honeybee colony collapse by imbuing their gut bacteria with the ability to produce antiviral and antiparasite double-stranded RNAs. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB social media: Facebook, Instagram, Twitter

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01:21:57

TWiP 180: A spleen palaver

This Week in Parasitism ·

2020/02/08

The TWiP professors solve the case of the Ugandan Child with Splenomegaly, and reveal that mutations in the P. falciparum genome that confer artemisinin resistance interfere with endocytic uptake of hemoglobin. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB social media: Facebook, Instagram, Twitter Endocytosis pathway mediates artemisinin resistance in malaria parasites (Science) Letters read on

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01:43:07

TWiP 179: Verminous visitors

This Week in Parasitism ·

2020/01/11

The TWiP DVD solve the case of the Child Who Passed Worms, and discuss a non-human primate model for severe malarial anemia. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB social media: Facebook, Instagram, Twitter Primate model of severe malarial anemia (Sci Rep) Ascaris skirt (and more!) Hero: Harold W. Brown Letters read on TWiP 179 Become a patron of TWiP. Case Study for TWiP 179 From Uganda,

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01:51:59

TWiP 178: The shadowlands of medicine

This Week in Parasitism ·

2019/12/04

The Knights of the TWiP solve the case of the Man Who Lost Weight, and discuss a Plasmodium protein kinase that is a malarial drug target. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB social media: Facebook, Instagram, Twitter Protein kinase as malaria drug target (Science) Hero: Myron Schultz Letters read on TWiP 178 Become a patron of TWiP. Case Study for TWiP 178 Eastern border of Uganda with

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01:29:39

TWiP 177: A scabrous education

This Week in Parasitism ·

2019/11/06

The TWiPsters solve the case of the Rashy Schoolteacher, and reveal a drug from rotifers that live on the snail intermediate host which paralyzes schistosome cercariae and prevents infection of mice. Hosts: Vincent Racaniello, Dand Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Progress towards global eradication of dracunculiasis (MMWR) Rotifer compound that paralyzes schistosome cercariae (PLoS Biol) Image credit Letters read on TWiP 177 Become

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01:33:17

TWiP 176: Blood schmear

This Week in Parasitism ·

2019/10/09

The TWiPpers of the bite fantastic solve the case of the Indian Man Who Hiked, and discuss the effects of schistosome soluble egg antigen on infection of lymphocytes with HIV-1. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Effect of schistosome soluble egg antigen on HIV-1 infection (PLoS P) Hero: Lawson Soulsby Letters read on TWiP 176 Become a patron of TWiP. Case Study for TWiP 176 Recent case,

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01:47:57

TWiP 175: None alone pathognomonic

This Week in Parasitism ·

2019/09/04

The TWiP'ers solve the case of the Sudanese Boy With Fever, and reveal antibodies against that slow invasion of red blood cells potentiate other malaria-blocking antibodies. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Antibodies that slow malaria invasion (Cell) Hero: Sir Leonard Rogers (pdf) Letters read on TWiP 175 Become a patron of TWiP. Case Study for TWiP 175 70 yo man born in India, came to US

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01:13:35

TWiP 174: Fat cat

This Week in Parasitism ·

2019/08/01

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The TWiPloid organisms solve the case of the Doctor with Chronic Epigastric Pain, and reveal how levels of linoleic acid in the intestine enable the sexual cycle of Toxoplasma gondii in cats. Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode: Determinant of T. gondii sexual cycle(bioRxiv) A Year's Worth of TWiP by Kevin Carney Hero: William Trager Letters read on TWiP 174 Become a patron of TWiP. Case

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01:50:43

TWiP 173: Rose colored spots

This Week in Parasitism ·

2019/07/13

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The podcastellani hosts solve the case of the Sailor With Dysentery, and reveal the first virus discovered in Plasmodium species. Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode: Matryoshka RNA virus of Plasmodium (bioRxiv) Hero: Rose Gana Fomban Leke Letters read on TWiP 173 Become a patron of TWiP. Case Study for TWiP 173 Successful individual in NY area with 9 months of epigastric pain. Did upper

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01:43:33

TWiP 172: A painless lesion

This Week in Parasitism ·

2019/06/14

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The metacyclic TWiPomastigotes solve the case of the Child With a Painless Leg Lesion, and reveal how to kill mosquitoes with a genetically modified fungus. Subscribe (free): iTunes, Google Podcasts, RSS, email Transgenic Metarhizium kills mosquitoes (Science) Hero: Veena Tandon Letters read on TWiP 172 Links for this episode: Become a patron of TWiP. Case Study for TWiP 172 Retired US Navy physician, lives aboard his sailboat, just

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01:34:55

TWiP 171: Better than a sharp stick in the eye

This Week in Parasitism ·

2019/05/23

The Leishmaniacs solve the case of the Child With Band Keratopathy, and reveal a eukaryotic parasite with functional mitochondria but without mitochondrial genomes. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: Elmer Pfefferkorn, 87 Eukaryotic parasite without mitochondrial genomes (Sci Adv) Hero: Charles Wardell Stiles Letters read on TWiP 171 Case Study for TWiP 171 By boat

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01:30:57

TWiP 170: A worm's eye view

This Week in Parasitism ·

2019/05/08

The TWiPlicates solve the case of the Child With Retinal Granuloma, and discuss an association of the complement protein collectin-11 with the pathophysiology of Chagas disease. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: Chagas disease pathophysiology and collectin-11 (PLoS NTD) Hero: Theobald Smith Image credit: Toxocara canis by Ben Liffner Letters read on TWiP 170 Case

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01:20:51

TWiP 169: What goes on in the snail

This Week in Parasitism ·

2019/04/11

The TriTWiPomonads solve the case of the Child Who Passed a Worm, and reveal recombination between bovine and human schistosome species. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: S. bovis and S. haematobiumhybrids (PLoS Path) Hero: Ann Bishop Letters read on TWiP 169 Case Study for TWiP 169 9 yo boy brought into mobile clinic set up in small village Bocas del Toro

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01:32:37

TWiP 168: Kleptoparasitism and the stercoraceous...

This Week in Parasitism ·

2019/03/27

The Giardians of the Galaxy solve the case of the Woman With a Colonic Stowaway from Hispaniola, and discuss activation of intestinal tuft cells by Trichinella spiralis. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: T. spiralisand intestinal tuft cells (PNAS) Hero: Carl Theodore Ernst Van Siebold Letters read on TWiP 168 Case Study for TWiP 168 18 month old child, on medical

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01:31:43

TWiP 167: The constipated mathematician

This Week in Parasitism ·

2019/02/27

The Tremendous Trio solve the case of the Woman With Foul Steatorrhea, and reveal breakdown of the glycocalyx associated with severe and fatal malaria. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: Glycocalyx and severe malaria (Clin Inf Dis) Hero: Bridget Ogilvie Letters read on TWiP 167 Case Study for TWiP 167 Woman 30 yo, traveled to DR, went to tourist part. On return for

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