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PODCAST

Clinical Chemistry Podcast

Association for Diagnostics and Laboratory Medicine

This free monthly podcast is offered by Clinical Chemistry. Clinical Chemistry is the leading forum for peer-reviewed, original research on innovative practices in today"s clinical laboratory.

science chemistry

All Episodes

08:39

Maternal Plasma RNA Sequencing for Genome-Wide...

Clinical Chemistry Podcast ·

2014/09/16

Analysis of circulating RNA in the plasma of pregnant women can be a powerful tool for noninvasive prenatal testing and research. However, unbiased and high throughput detection of circulating RNA in plasma is a technical challenge.

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07:05

Podcasts Go Platinum!

Clinical Chemistry Podcast ·

2014/09/16

The cover of the September 2014 issue of Clinical Chemistry tells it all: one million downloads! That's the number of Clinical Chemistry podcasts that have been downloaded since the feature was initiated in 2009. It's a relatively new feature in the 60 years of publication of the journal, and the word podcast itself is only been in the vernacular for about 10 years.

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18:02

Measurements for 8 Common Analytes in Native Sera...

Clinical Chemistry Podcast ·

2014/09/02

Performing measurements that are comparable over time and location and across assays is essential for insuring appropriate clinical and public health practice. One step toward achieving this goal is using assays that are traceable to a higher-order reference measurement system or harmonized by using internationally recognized procedures.

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06:56

FullIssueSummary September2014

Clinical Chemistry Podcast ·

2014/09/01

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13:06

Immunoextraction - tandem mass spectrometry method...

Clinical Chemistry Podcast ·

2014/08/18

Analysis of Human Chorionic Gonadotropin or hCG is usually associated with monitoring or detecting pregnancy. It is also a protein tumor marker for some cancers. In males, hCG stimulates testosterone production and has the potential to be abused by athletes in an attempt to enhance performance in sports.

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10:45

To P or not to P: that is the question

Clinical Chemistry Podcast ·

2014/08/11

There are few scientific papers that do not include the use of the P value to evaluate the statistical significance of results. However, use of this statistic may be misleading, as noted by a recent paper by Regina Nuzzo in the journal Nature. That paper served as a basis for commentary with additional examples by Drs. Jim Boyd and Tom Annesley in the July 2014 issue of Clinical Chemistry.

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12:56

Weekly and 90-Minute Biological Variations in Cardiac...

Clinical Chemistry Podcast ·

2014/08/04

Chronic kidney disease is an important risk factor for cardiovascular morbidity and mortality. This risk is all the more important for patients undergoing hemodialysis. In the presence of clinical signs of an acute myocardial infarction, the universal definition includes the finding of a serum cardiac troponin concentration above the 99 percentile as defined by healthy individuals, together with time dependant changes in serum and troponin concentrations. But in contrast to individuals with normal

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08:26

FullIssueSummary August2014

Clinical Chemistry Podcast ·

2014/08/01

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12:43

Biomarkers of Brain Injury in Cerebral Infections

Clinical Chemistry Podcast ·

2014/07/28

Central nervous system infections, including diseases like meningitis and encephalitis, are important public heath concerns across the globe, as they occur commonly and/or associated with high rates of mortality and morbidity. Measurement of biomarkers provide objective indicators of normal function or pathology, and can present information that may assist diagnosis, assessment of health condition, and evaluation of treatment safety and efficacy.

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10:30

Novel Biomarkers for Acute Myocardial Infarction: Is...

Clinical Chemistry Podcast ·

2014/07/24

Early detection of acute myocardial infarction is crucial for deciding the course of treatment to preserve and prevent further damage to the myocardial tissue. During the last several years there has been a burgeoning interest in circulating microRNAs as potential novel biomarkers for acute myocardial infarction.

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14:48

ClinChem 201406 deLemos Khalili

Clinical Chemistry Podcast ·

2014/07/14

The universal definition of myocardial infarction requires both an increase in cardiac troponin concentrations and changes in values over serial measurements. However, exact criteria regarding the magnitude of change in troponin remain elusive. In the June 2014 issue of Clinical Chemistry, two studies on biological variation of serum troponins helped shed further light on the kinetics of this important cardiac marker.!

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07:40

FullIssueSummary July2014

Clinical Chemistry Podcast ·

2014/07/01

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10:17

Harmonization of Test Results: What Are the...

Clinical Chemistry Podcast ·

2014/06/30

Laboratory test results are used to aid decisions in the diagnosis and treatment of disease. Consistent and comparable results from different measurement procedures are important for developing clinical practice guidelines, and for those guidelines to be applied to decisions about patient care. Yet results for many analytes are neither consistent nor comparable when measured using different clinical laboratory procedures.

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16:56

The FDA and 23andMe: Violating the First Amendment or...

Clinical Chemistry Podcast ·

2014/06/24

One of the largest direct consumer genetic testing facilities, 23andMe, was ordered by the US Food and Drug Administration to cease marketing its Personal Genome Service test in late 2013. This occurred after 23andMe failed to respond to questions that the FDA had about the analytical and clinical validity of this test. While some support the FDA's actions because of the test potential for harm to consumers, some advocates of the technology fault the FDA for being overly paternalistic and impeding

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09:43

When a Disease-Causing Mutation Is Not a Pathogenic...

Clinical Chemistry Podcast ·

2014/06/17

The clinical utility of molecular genetic testing relies on an accurate and comprehensive knowledge about the relationships between genes and variants, and diseases. Correctly interpreting the clinical significance of variants that may be detected continues to be a constant challenge for molecular diagnostic practice. This challenge has become substantially enlarged as next generation sequencing-based testing becomes rapidly integrated into routine clinical practice.

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11:08

Genetically Low Triglycerides and Mortality: Further...

Clinical Chemistry Podcast ·

2014/06/03

In the May issue of Clinical Chemistry, researchers involved in the Copenhagen City Heart Study found that lower nonfasting, circulating triglyceride concentrations are associated with lower all-cause mortality.

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06:42

FullIssueSummary June2014

Clinical Chemistry Podcast ·

2014/06/01

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11:40

Low Nonfasting Triglycerides and Reduced All-Cause...

Clinical Chemistry Podcast ·

2014/05/28

Increased nonfasting plasma triglycerides indicating increase amounts of cholesterol in remnant liver proteins and are important risk factors for cardiovascular disease. In the May issue of Clinical Chemistry, researchers involved in the Copenhagen City Heart Study found that lower circulating triglyceride concentrations are associated with lower all-cause mortality.

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12:33

Interlaboratory Agreement of Insulin-like Growth...

Clinical Chemistry Podcast ·

2014/05/19

This is a podcast from Clinical Chemistry, sponsored by the Department of Laboratory Medicine at Boston Children's Hospital.

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11:27

Development of an Immunoassay for the Kidney-Specific...

Clinical Chemistry Podcast ·

2014/05/12

In well-resourced countries with a low incidence of tuberculosis, a major focus of TB control efforts is the detection and treatment of latent TB infection to prevent reactivation to active TB disease. This approach is particularly relevant for healthcare workers. Interferon Gamma Release Assays are used to detect the release of interferon from T cells stimulated by tuberculosis specific antigens. However, these tests differ in cost and complexity than the conventional tuberculin skin test.

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1,086 results

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